{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T19:42:15Z","timestamp":1770061335234,"version":"3.49.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 81271780"],"award-info":[{"award-number":["NSFC 81271780"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2013R1A1A2058427"],"award-info":[{"award-number":["NRF-2013R1A1A2058427"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016804","name":"Natural Science Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["JCYJ20190809103805589"],"award-info":[{"award-number":["JCYJ20190809103805589"]}],"id":[{"id":"10.13039\/100016804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p><jats:italic>Yersinia pestis<\/jats:italic>, the cause of plague, is a newly evolved Gram-negative bacterium. Through the acquisition of the plasminogen activator (Pla), <jats:italic>Y. pestis<\/jats:italic> gained the means to rapidly disseminate throughout its mammalian hosts. It was suggested that <jats:italic>Y. pestis<\/jats:italic> utilizes Pla to interact with the DEC-205 (CD205) receptor on antigen-presenting cells (APCs) to initiate host dissemination and infection. However, the evolutionary origin of Pla has not been fully elucidated. The PgtE enzyme of <jats:italic>Salmonella enterica<\/jats:italic>, involved in host dissemination, shows sequence similarity with the <jats:italic>Y. pestis<\/jats:italic> Pla. In this study, we demonstrated that both <jats:italic>Escherichia coli<\/jats:italic> K-12 and <jats:italic>Y. pestis<\/jats:italic> bacteria expressing the PgtE-protein were able to interact with primary alveolar macrophages and DEC-205-transfected CHO cells. The interaction between PgtE-expressing bacteria and DEC-205-expressing transfectants could be inhibited by the application of an anti-DEC-205 antibody. Moreover, PgtE-expressing <jats:italic>Y. pestis<\/jats:italic> partially re-gained the ability to promote host dissemination and infection. In conclusion, the DEC-205-PgtE interaction plays a role in promoting the dissemination and infection of <jats:italic>Y. pestis<\/jats:italic>, suggesting that Pla and the PgtE of <jats:italic>S. enterica<\/jats:italic> might share a common evolutionary origin.<\/jats:p>","DOI":"10.3389\/fimmu.2022.791799","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:14:06Z","timestamp":1648512846000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["PgtE Enzyme of Salmonella enterica Shares the Similar Biological Roles to Plasminogen Activator (Pla) in Interacting With DEC-205 (CD205), and Enhancing Host Dissemination and Infectivity by Yersinia pestis"],"prefix":"10.3389","volume":"13","author":[{"given":"Qiao","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenglin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sizhe","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chae Gyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingmiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling-Yu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxia","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huahua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Hui","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia Adhiambo","family":"Njiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Mambwe","family":"Tembo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman Ahmad","family":"Alkraiem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An-Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Yong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Ying","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Kan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xixiang","family":"Huo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Klena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Skurnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey P.","family":"Anisimov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Fu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiding","family":"Xiamu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yicheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"Yersinia Pestis\u2013Etiologic Agent of Plague","volume":"10","author":"Perry","year":"1997","journal-title":"Clin Microbiol Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/s1473-3099(04)00923-5","article-title":"Was the Black Death Caused by Yersinia Pestis","volume":"4","author":"Prentice Michael","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nature10549","article-title":"A Draft Genome of Yersinia Pestis From Victims of the Black Death","volume":"478","author":"Bos Kirsten","year":"2011","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.012","article-title":"Historical Y. Pestis Genomes Reveal the European Black Death as the Source of Ancient and Modern Plague Pandemics","volume":"19","author":"Spyrou","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/biom10111554","article-title":"Yersinia Pestis Plasminogen Activator","volume":"10","author":"Sebbane","year":"2020","journal-title":"Biomolecules"},{"key":"B6","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.cell.2018.11.005","article-title":"Emergence and Spread of Basal Lineages of Yersinia Pestis During the Neolithic Decline","volume":"176","author":"Rascovan","year":"2019","journal-title":"Cell"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2002.00501.x","article-title":"Biological Warfare in a Historical Perspective","volume":"8","author":"Roffey","year":"2002","journal-title":"Clin Microbiol Infect"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.14043","article-title":"Yersinia Pestis, the Cause of Plague, Is a Recently Emerged Clone of Yersinia Pseudotuberculosis","volume":"96","author":"Achtman","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408026101","article-title":"Microevolution and History of the Plague Bacillus, Yersinia Pestis","volume":"101","author":"Achtman","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404012101","article-title":"Insights Into the Evolution of Yersinia Pestis Through Whole-Genome Comparison With Yersinia Pseudotuberculosis","volume":"101","author":"Chain","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/ng.705","article-title":"Yersinia Pestis Genome Sequencing Identifies Patterns of Global Phylogenetic Diversity","volume":"42","author":"Morelli","year":"2010","journal-title":"Nat Genet"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197007232830404","article-title":"Mesenteric Lymphadenitis and Terminal Ileitis Due to Yersinia Pseudotuberculosis","volume":"283","author":"Weber","year":"1970","journal-title":"N Engl J Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-45-6-440","article-title":"Virulence of Ppst+ and Ppst- Strains of Yersinia Pestis for Guinea-Pigs","volume":"45","author":"Samoilova","year":"1996","journal-title":"J Med Microbiol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.1997.0154","article-title":"Studies on the Role of Plasminogen Activator in Systemic Infection by Virulent Yersinia Pestis Strain C092","volume":"23","author":"Welkos","year":"1997","journal-title":"Microb Pathog"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.2.434-464.2004","article-title":"Intraspecific Diversity of Yersinia Pestis","volume":"17","author":"Anisimov","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"B16","doi-asserted-by":"publisher","first-page":"7487","DOI":"10.1038\/ncomms8487","article-title":"Early Emergence of Yersinia Pestis as a Severe Respiratory Pathogen","volume":"6","author":"Zimbler","year":"2015","journal-title":"Nat Commun"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00025","article-title":"Environmental Regulation of Yersinia Pathophysiology","volume":"6","author":"Chen","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3682.422","article-title":"Pasteurella Pestis: Role of Pesticin I and Iron in Experimental Plague","volume":"149","author":"Brubaker","year":"1965","journal-title":"Science"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439793","article-title":"A Surface Protease and the Invasive Character of Plague","volume":"258","author":"Sodeinde","year":"1992","journal-title":"Science"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137195","article-title":"A Plasminogen-Activating Protease Specifically Controls the Development of Primary Pneumonic Plague","volume":"315","author":"Lathem","year":"2007","journal-title":"Science"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01595-13","article-title":"Deletion of Braun Lipoprotein and Plasminogen-Activating Protease-Encoding Genes Attenuates Yersinia Pestis in Mouse Models of Bubonic and Pneumonic Plague","volume":"82","author":"van Lier","year":"2014","journal-title":"Infect Immun"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12932","article-title":"Fibrinolytic and Procoagulant Activities of Yersinia Pestis and Salmonella Enterica","author":"Korhonen","year":"2015","journal-title":"J Thromb Haemost"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01086-15","article-title":"Impact of the Pla Protease Substrate Alpha2-Antiplasmin on the Progression of Primary Pneumonic Plague","volume":"83","author":"Eddy","year":"2015","journal-title":"Infect Immun"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005222","article-title":"Dissociation of Tissue Destruction and Bacterial Expansion During Bubonic Plague","volume":"11","author":"Guinet","year":"2015","journal-title":"PloS Pathog"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1128\/iai.57.5.1517-1523.1989","article-title":"Nucleotide Sequence of the Plasminogen Activator Gene of Yersinia Pestis: Relationship to ompT of Escherichia Coli and Gene E of Salmonella Typhimurium","volume":"57","author":"Sodeinde","year":"1989","journal-title":"Infect Immun"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.06.004","article-title":"Activation of Pro-Matrix Metalloproteinase-9 and Degradation of Gelatin by the Surface Protease PgtE of Salmonella Enterica Serovar Typhimurium","volume":"298","author":"Ramu","year":"2008","journal-title":"Int J Med Microbiol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2004.00483.x","article-title":"Antiprotease Inactivation by Salmonella Enterica Released From Infected Macrophages","volume":"7","author":"L\u00e4hteenm\u00e4ki","year":"2004","journal-title":"Cell Microbiol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1046\/j.1462-5822.2003.00296.x","article-title":"Dynamics of Bacterial Growth and Distribution Within the Liver During Salmonella Infection","volume":"5","author":"Sheppard","year":"2003","journal-title":"Cell Microbiol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.micinf.2003.12.009","article-title":"Salmonella Infections in the Mouse Model: Host Resistance Factors and In Vivo Dynamics of Bacterial Spread and Distribution in the Tissues","volume":"6","author":"Mastroeni","year":"2004","journal-title":"Microbes Infect"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2004.00451.x","article-title":"Salmonella-Induced Macrophage Death: Multiple Mechanisms, Different Outcomes","volume":"6","author":"Hueffer","year":"2004","journal-title":"Cell Microbiol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.4161\/viru.22761","article-title":"Interactions of Salmonella Enterica With Dendritic Cells","volume":"3","author":"Swart","year":"2014","journal-title":"Virulence"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804646200","article-title":"Plasminogen Activator Pla of Yersinia Pestis Utilizes Murine DEC-205 (CD205) as a Receptor to Promote Dissemination","volume":"283","author":"Zhang","year":"2008","journal-title":"J Biol Chem"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/375151a0","article-title":"The Receptor DEC-205 Expressed by Dendritic Cells and Thymic Epithelial Cells is Involved in Antigen Processing","volume":"375","author":"Jiang","year":"1995","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.151.3.673","article-title":"The Dendritic Cell Receptor for Endocytosis, DEC-205, can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II-Positive Lysosomal Compartments","volume":"151","author":"Mahnke","year":"2000","journal-title":"J Cell Biol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610383104","article-title":"DEC-205 Receptor on Dendritic Cells Mediates Presentation of HIV Gag Protein to CD8+ T Cells in a Spectrum of Human MHC I Haplotypes","volume":"104","author":"Bozzacco","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"B36","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1749-6632.2009.04933.x","article-title":"The Human Cancer Antigen Mesothelin Is More Efficiently Presented to the Mouse Immune System When Targeted to the DEC-205\/CD205 Receptor on Dendritic Cells","volume":"1174","author":"Wang","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1900\/rds.2010.7.47","article-title":"Dendritic Cell-Targeted Pancreatic \u03b2-Cell Antigen Leads to Conversion of Self-Reactive Cd4+T Cells Into Regulatory T Cells and Promotes Immunotolerance in NOD Mice","volume":"7","author":"Petzold","year":"2010","journal-title":"Rev Diabetes Stud"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01246-07","article-title":"Human Dendritic Cell-Specific Intercellular Adhesion Molecule-Grabbing Nonintegrin (CD209) Is a Receptor for Yersinia Pestis That Promotes Phagocytosis by Dendritic Cells","volume":"76","author":"Zhang","year":"2008","journal-title":"Infect Immun"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001297","article-title":"Loss of the Virulence Plasmid by Shigella Sonnei Promotes its Interactions With CD207 and CD209 Receptors","volume":"70","author":"Wu","year":"2021","journal-title":"J Med Microbiol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2015.46","article-title":"Host Langerin (CD207) Is a Receptor for Yersinia Pestis Phagocytosis and Promotes Dissemination","volume":"93","author":"Yang","year":"2015","journal-title":"Immunol Cell Biol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00654-18","article-title":"Yersinia Pseudotuberculosis Exploits CD209 Receptors for Promoting Host Dissemination and Infection","volume":"87","author":"He","year":"2019","journal-title":"Infect Immun"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.2.511","article-title":"Adherence of Pilus- Opa+ Gonococci to Epithelial Cells In Vitro Involves Heparan Sulfate","volume":"182","author":"Chen","year":"1995","journal-title":"J Exp Med"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.9.1557","article-title":"Several Carcinoembryonic Antigens (CD66) Serve as Receptors for Gonococcal Opacity Proteins","volume":"185","author":"Chen","year":"1997","journal-title":"J Exp Med"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010609200","article-title":"The CGM1a (CEACAM3\/CD66d)-Mediated Phagocytic Pathway of Neisseria Gonorrhoeae Expressing Opacity Proteins Is Also the Pathway to Cell Death","volume":"276","author":"Chen","year":"2001","journal-title":"J Biol Chem"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00096","article-title":"Yersinia Pestis Interacts With SIGNR1 (CD209b) for Promoting Host Dissemination and Infection","volume":"10","author":"Yang","year":"2019","journal-title":"Front Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00100-19","article-title":"Salmonella Enterica Serovar Typhimurium Interacts With CD209 Receptors to Promote Host Dissemination and Infection","volume":"87","author":"Ye","year":"2019","journal-title":"Infect Immun"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.56.5.1242-1248.1988","article-title":"Evidence for Two Genetic Loci in Yersinia Enterocolitica That can Promote Invasion of Epithelial Cells","volume":"56","author":"Miller","year":"1988","journal-title":"Infect Immun"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.103993","article-title":"Invasiveness of the Yersinia Pestis Ail Protein Contributes to Host Dissemination in Pneumonic and Oral Plague","volume":"141","author":"Zhang","year":"2020","journal-title":"Microb Pathog"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.15.5147-5152.2004","article-title":"Genetics of Metabolic Variations Between Yersinia Pestis Biovars and the Proposal of a New Biovar, Microtus","volume":"186","author":"Zhou","year":"2004","journal-title":"J Bacteriol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/11.3.179","article-title":"Complete Genome Sequence of Yersinia Pestis Strain 91001, an Isolate Avirulent to Humans","volume":"11","author":"Song","year":"2004","journal-title":"DNA Res"},{"key":"B51","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.jprot.2011.10.004","article-title":"A Proteome Reference Map and Virulence Factors Analysis of Yersinia Pestis 91001","volume":"75","author":"Zhou","year":"2012","journal-title":"J Proteomics"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02451.x","article-title":"Protein Regions Important for Plasminogen Activation and Inactivation of Alpha(2)-Antiplasmin in the Surface Protease Pla of Yersinia Pestis","volume":"40","author":"Kukkonen","year":"2001","journal-title":"Mol Microbiol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03817.x","article-title":"Lack of O-Antigen is Essential for Plasminogen Activation by Yersinia Pestis and Salmonella Enterica","volume":"51","author":"Kukkonen","year":"2003","journal-title":"Mol Microbiol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.14.4077-4086.2000","article-title":"A PhoP-Regulated Outer Membrane Protease of Salmonella Enterica Serovar Typhimurium Promotes Resistance to Alpha-Helical Antimicrobial Peptides","volume":"182","author":"Guina","year":"2000","journal-title":"J Bacteriol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00947-17","article-title":"CRISPR-Cas12a-Assisted Recombineering in Bacteria","volume":"83","author":"Yan","year":"2017","journal-title":"Appl Environ Microbiol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297","article-title":"One-Step Inactivation of Chromosomal Genes in Escherichia Coli K-12 Using PCR Products","volume":"97","author":"Datsenko","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"B57","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ijmm.2004.01.003","article-title":"The Omptin Family of Enterobacterial Surface Proteases\/Adhesins: From Housekeeping in Escherichia Coli to Systemic Spread of Yersinia Pestis","volume":"294","author":"Kukkonen","year":"2004","journal-title":"Int J Med Microbiol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.4931","article-title":"Enhanced Macrophage Activity in Granulomatous Lesions of Immune Mice Challenged With Mycobacterium Tuberculosis","volume":"176","author":"Diane","year":"2006","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04550-9","article-title":"Analysis of 3800-Year-Old Yersinia pestis Genomes Suggests Bronze Age Origin for Bubonic Plague","volume":"9","author":"Spyrou","year":"2018","journal-title":"Nat Commun"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1205750110","article-title":"Historical Variations in Mutation Rate in an Epidemic Pathogen, Yersinia Pestis","volume":"110","author":"Cui","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-024-0890-4_6","article-title":"Genome and Evolution of Yersinia Pestis","volume":"918","author":"Cui","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80694-7","article-title":"DC-SIGN, a Dendritic Cell-Specific HIV-1-Binding Protein That Enhances Trans-Infection of T Cells","volume":"100","author":"Geijtenbeek","year":"2000","journal-title":"Cell"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0179","article-title":"Subset of DC-SIGN(+) Dendritic Cells in Human Blood Transmits HIV-1 to T Lymphocytes","volume":"100","author":"Engering","year":"2002","journal-title":"Blood"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084238","article-title":"Recruitment of HIV and its Receptors to Dendritic Cell-T Cell Junctions","volume":"300","author":"McDonald","year":"2003","journal-title":"Science"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.5.1710-1715.2005","article-title":"The Core Lipopolysaccharide of Escherichia Coli is a Ligand for the Dendritic-Cell-Specific Intercellular Adhesion Molecule Nonintegrin CD209 Receptor","volume":"187","author":"Klena","year":"2005","journal-title":"J Bacteriol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0405184","article-title":"DC-SIGN (CD209) Recognition of Neisseria Gonorrhoeae is Circumvented by Lipooligosaccharide Variation","volume":"79","author":"Zhang","year":"2006","journal-title":"J Leukoc Biol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.6.4002","article-title":"Role of N-Acetylglucosamine Within Core Lipopolysaccharide of Several Species of Gram-Negative Bacteria in Targeting the DC-SIGN (CD209)","volume":"177","author":"Zhang","year":"2006","journal-title":"J Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00656","article-title":"CD209 C-Type Lectins Promote Host Invasion, Dissemination, and Infection of Toxoplasma Gondii","volume":"11","author":"Njiri Adhiambo","year":"2020","journal-title":"Front Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00457","article-title":"Murine SIGNR1 (CD209b) Contributes to the Clearance of Uropathogenic Escherichia Coli During Urinary Tract Infections","volume":"9","author":"Zhang","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.579010","article-title":"Proteus Mirabilis Targets Atherosclerosis Plaques in Human Coronary Arteries via DC-SIGN (CD209)","volume":"11","author":"Xue","year":"2021","journal-title":"Front Immunol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"7995","DOI":"10.4049\/jimmunol.174.12.7995","article-title":"Neisseria Gonorrhoeae Enhances Infection of Dendritic Cells by HIV Type 1","volume":"174","author":"Zhang","year":"2005","journal-title":"J Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.791799\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:14:11Z","timestamp":1648512851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.791799\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,24]]},"references-count":71,"alternative-id":["10.3389\/fimmu.2022.791799"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.791799","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,24]]},"article-number":"791799"}}