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Immunol."],"abstract":"<jats:p>Trace element iron affects T cell biology, but the knowledge about the role of iron in regulating Treg cell expansion is limited. Treg cells play an important role in keeping peripheral T cell tolerance, increasing Treg cell expansion is a promising therapeutic method for SLE. Here we showed that iron deficiency promotes Treg cell expansion by reducing ROS accumulation, improving the disease progression of pristane-induced lupus. Increased oxidative stress inhibits Treg cell differentiation by inducing cell apoptosis. Our data suggest that altering iron metabolism promotes Treg cell expansion by preventing oxidation-induced cell death, which may provide a potential therapeutic strategy for SLE.<\/jats:p>","DOI":"10.3389\/fimmu.2022.799331","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T23:28:39Z","timestamp":1646004519000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Insufficient Iron Improves Pristane-Induced Lupus by Promoting Treg Cell 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