{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:40:28Z","timestamp":1789501228256,"version":"build-2803163510"},"reference-count":155,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a complex disease which immune response can be more or less potent. In severe cases, patients might experience a cytokine storm that compromises their vital functions and impedes clearance of the infection. Gamma delta (\u03b3\u03b4) T lymphocytes have a critical role initiating innate immunity and shaping adaptive immune responses, and they are recognized for their contribution to tumor surveillance, fighting infectious diseases, and autoimmunity. \u03b3\u03b4 T cells exist as both circulating T lymphocytes and as resident cells in different mucosal tissues, including the lungs and their critical role in other respiratory viral infections has been demonstrated. In the context of SARS-CoV-2 infection, \u03b3\u03b4 T cell responses are understudied. This review summarizes the findings on the antiviral role of \u03b3\u03b4 T cells in COVID-19, providing insight into how they may contribute to the control of infection in the mild\/moderate clinical outcome.<\/jats:p>","DOI":"10.3389\/fimmu.2022.819574","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T07:47:02Z","timestamp":1660204022000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Defying convention in the time of COVID-19: Insights into the role of \u03b3\u03b4 T cells"],"prefix":"10.3389","volume":"13","author":[{"given":"Marta","family":"Sanz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan 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