{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:36:04Z","timestamp":1792672564133,"version":"4.5.0"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1365 Project 394046635, Subproject A03, Project 419826430"],"award-info":[{"award-number":["CRC1365 Project 394046635, Subproject A03, Project 419826430"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["PACE #733006, HIPGEN #779293, Marie Sklodowska-Curie #812699"],"award-info":[{"award-number":["PACE #733006, HIPGEN #779293, Marie Sklodowska-Curie #812699"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Peritoneal dialysis (PD) is a valuable \u2018home treatment\u2019 option, even more so during the ongoing Coronavirus pandemic. However, the long-term use of PD is limited by unfavourable tissue remodelling in the peritoneal membrane, which is associated with inflammation-induced angiogenesis. This appears to be driven primarily through vascular endothelial growth factor (VEGF), while the involvement of other angiogenic signaling pathways is still poorly understood. Here, we have identified the crucial contribution of mesothelial cell-derived angiogenic CXC chemokine ligand 1 (CXCL1) to peritoneal angiogenesis in PD. CXCL1 expression and peritoneal microvessel density were analysed in biopsies obtained by the International Peritoneal Biobank (NCT01893710 at<jats:uri>www.clinicaltrials.gov<\/jats:uri>), comparing 13 children with end-stage kidney disease before initiating PD to 43 children on chronic PD. The angiogenic potential of mesothelial cell-derived CXCL1 was assessed<jats:italic>in vitro<\/jats:italic>by measuring endothelial tube formation of human microvascular endothelial cells (HMECs) treated with conditioned medium from human peritoneal mesothelial cells (HPMCs) stimulated to release CXCL1 by treatment with either recombinant IL-17 or PD effluent. We found that the capillary density in the human peritoneum correlated with local CXCL1 expression. Both CXCL1 expression and microvessel density were higher in PD patients than in the age-matched patients prior to initiation of PD. Exposure of HMECs to recombinant CXCL1 or conditioned medium from IL-17-stimulated HPMCs resulted in increased endothelial tube formation, while selective inhibition of mesothelial CXCL1 production by specific antibodies or through silencing of relevant transcription factors abolished the proangiogenic effect of HPMC-conditioned medium. In conclusion, peritoneal mesothelium-derived CXCL1 promotes endothelial tube formation<jats:italic>in vitro<\/jats:italic>and associates with peritoneal microvessel density in uremic patients undergoing PD, thus providing novel targets for therapeutic intervention to prolong PD therapy.<\/jats:p>","DOI":"10.3389\/fimmu.2022.821681","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T05:46:09Z","timestamp":1643953569000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Angiogenic Role of Mesothelium-Derived Chemokine CXCL1 During Unfavorable Peritoneal Tissue Remodeling in Patients Receiving Peritoneal Dialysis as Renal Replacement Therapy"],"prefix":"10.3389","volume":"13","author":[{"given":"Rusan Ali","family":"Catar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bartosova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Kawka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iva","family":"Marinovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zickler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honorata","family":"Stadnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Karczewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Kamhieh-Milz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"J\u00f6rres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Moll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Peter","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Witowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60439-0","article-title":"Evolving Importance of Kidney Disease: From Subspecialty to Global Health Burden","volume":"382","author":"Eckardt","year":"2013","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60438-9","article-title":"Kidney Failure: Aims for the Next 10 Years and Barriers to Success","volume":"382","author":"Remuzzi","year":"2013","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30788-2","article-title":"Global Kidney Health 2017 and Beyond: A Roadmap for Closing Gaps in Care, Research, and Policy","volume":"390","author":"Levin","year":"2017","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, Regional, and National Burden of Chronic Kidney Disease, 1990\u20132017: A Systematic Analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"Lancet"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-00356-5","article-title":"COVID-19-Associated Acute Kidney Injury: Consensus Report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup","volume":"16","author":"Nadim","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.12968\/hmed.2020.0574","article-title":"COVID-19 Infection and the Kidney","volume":"81","author":"Alvarez-Belon","year":"2020","journal-title":"Br J Hosp Med (London Engl 2005)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-020-0284-7","article-title":"Kidney Involvement in COVID-19 and Rationale for Extracorporeal Therapies","volume":"16","author":"Ronco","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.774052","article-title":"Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-\u03b1 and AP-1 Signaling","author":"Catar","year":"2021","journal-title":"Front Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi159","article-title":"ESRD Patients in 2004: Global Overview of Patient Numbers, Treatment Modalities and Associated Trends","volume":"20","author":"Grassmann","year":"2005","journal-title":"Nephrol Dialysis Transplant Off Publ Eur Dialysis Transplant Assoc - Eur Renal Assoc"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020050729","article-title":"Increasing Peritoneal Dialysis Use in Response to the COVID-19 Pandemic: Will It Go Viral","volume":"31","author":"Brown","year":"2020","journal-title":"J Am Soc Nephrol JASN"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09240620","article-title":"Peritoneal Dialysis for Acute Kidney Injury During the COVID-19 Pandemic","volume":"15","author":"Shimonov","year":"2020","journal-title":"Clin J Am Soc Nephrol CJASN"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1159\/000511390","article-title":"Peritoneal Dialysis Is an Option for Acute Kidney Injury Management in Patients With COVID-19","volume":"50","author":"Rodr\u00edguez-Chagolla","year":"2021","journal-title":"Blood Purif"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2020.04.001","article-title":"Peritoneal Dialysis During the Coronavirus Disease-2019 (COVID-19) Pandemic: Acute Inpatient and Maintenance Outpatient Experiences","volume":"2","author":"El Shamy","year":"2020","journal-title":"Kidney Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.06.001","article-title":"Urgent Peritoneal Dialysis in Patients With COVID-19 and Acute Kidney Injury: A Single-Center Experience in a Time of Crisis in the United States","volume":"76","author":"Sourial","year":"2020","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/0896860820921657","article-title":"Peritoneal Dialysis in the Time of COVID-19","volume":"40","author":"Wilkie","year":"2020","journal-title":"Perit Dial Int"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.217","article-title":"The Proto-Oncogene C-Fos Transcriptionally Regulates VEGF Production During Peritoneal Inflammation","volume":"84","author":"Catar","year":"2013","journal-title":"Kidney Int"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015101169","article-title":"IL-6 Trans-Signaling Links Inflammation With Angiogenesis in the Peritoneal Membrane","volume":"28","author":"Catar","year":"2017","journal-title":"J Am Soc Nephrol JASN"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy175","article-title":"Chronic Inflammation in End-Stage Renal Disease and Dialysis","volume":"33","author":"Cobo","year":"2018","journal-title":"Nephrol Dialysis Transplant Off Publ Eur Dialysis Transplant Assoc - Eur Renal Assoc"},{"key":"B19","doi-asserted-by":"publisher","first-page":"910","DOI":"10.3390\/cells10040910","article-title":"Transcriptional Regulation of Thrombin-Induced Endothelial VEGF Induction and Proangiogenic Response","volume":"10","author":"Catar","year":"2021","journal-title":"Cells"},{"key":"B20","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1093\/oxfordjournals.ndt.a027318","article-title":"Longitudinal Changes in Peritoneal Kinetics: The Effects of Peritoneal Dialysis and Peritonitis","volume":"11","author":"Davies","year":"1996","journal-title":"Nephrol dialysis Transplant Off Publ Eur Dialysis Transplant Assoc - Eur Renal Assoc"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2011.01.006","article-title":"Determinants of Peritoneal Membrane Function Over Time","volume":"31","author":"Davies","year":"2011","journal-title":"Semin Nephrol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1177\/089686080402400616","article-title":"Analysis of the Prevalence and Causes of Ultrafiltration Failure During Long-Term Peritoneal Dialysis: A Cross-Sectional Study","volume":"24","author":"Smit","year":"2004","journal-title":"Perit Dial Int"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V132470","article-title":"Morphologic Changes in the Peritoneal Membrane of Patients With Renal Disease","volume":"13","author":"Williams","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1177\/089686089901900605","article-title":"Vascular and Interstitial Changes in the Peritoneum of CAPD Patients With Peritoneal Sclerosis","volume":"19","author":"Mateijsen","year":"1999","journal-title":"Perit Dial Int"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.02.022","article-title":"Neutral pH and Low-Glucose Degradation Product Dialysis Fluids Induce Major Early Alterations of the Peritoneal Membrane in Children on Peritoneal Dialysis","volume":"94","author":"Schaefer","year":"2018","journal-title":"Kidney Int"},{"key":"B26","doi-asserted-by":"crossref","DOI":"10.1177\/089686080302300507","article-title":"Peritoneal Function and Assessment of Reference Values Using a 3.86% Glucose Solution","volume":"23","author":"Smit","year":"2003","journal-title":"Perit Dial Int"},{"key":"B27","doi-asserted-by":"crossref","DOI":"10.1681\/ASN.V13112787","article-title":"Acquired Ultrafiltration Dysfunction in Peritoneal Dialysis Patients","volume":"13","author":"Margetts","year":"2002","journal-title":"J Am Soc Nephrol JASN"},{"key":"B28","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.pathol.2.010506.134925","article-title":"VEGF-A and the Induction of Pathological Angiogenesis","volume":"2","author":"Nagy","year":"2007","journal-title":"Annu Rev Pathol"},{"key":"B29","first-page":"8968608211004683","article-title":"Vascular Endothelial Growth Factor-Mediated Peritoneal Neoangiogenesis in Peritoneal Dialysis","volume":"2021","author":"Shi","year":"","journal-title":"Perit Dial Int"},{"key":"B30","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.3389\/fphys.2018.01853","article-title":"Biocompatible Peritoneal Dialysis: The Target Is Still Way Off","volume":"9","author":"Bartosova","year":"2018","journal-title":"Front Physiol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V114717","article-title":"Vascular Proliferation and Enhanced Expression of Endothelial Nitric Oxide Synthase in Human Peritoneum Exposed to Long-Term Peritoneal Dialysis","volume":"11","author":"Combet","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051222","article-title":"Preferential Attachment of Peritoneal Tumor Metastases to Omental Immune Aggregates and Possible Role of a Unique Vascular Microenvironment in Metastatic Survival and Growth","volume":"169","author":"Gerber","year":"2006","journal-title":"Am J Pathol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002016","article-title":"Mesothelial RAGE Activation by AGEs Enhances VEGF Release and Potentiates Capillary Tube Formation","volume":"71","author":"Boulanger","year":"2007","journal-title":"Kidney Int"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00143.x","article-title":"Vascular Endothelial Growth Factor Production and Regulation in Human Peritoneal Mesothelial Cells","volume":"61","author":"Mandl-Weber","year":"2002","journal-title":"Kidney Int"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3333","article-title":"IL-17 Mediates Resistance to Anti-VEGF Therapy","volume":"19","author":"Maniati","year":"2013","journal-title":"Nat Med"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30562","article-title":"The Role of CXC Chemokines in Pulmonary Fibrosis","volume":"117","author":"Strieter","year":"2007","journal-title":"J Clin Invest"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0677-7","article-title":"The Role of Chemokines and Their Receptors in Angiogenesis","volume":"68","author":"Kiefer","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"792","DOI":"10.3390\/ijms23020792","article-title":"CXCL1: Gene, Promoter, Regulation of Expression, mRNA Stability, Regulation of Activity in the Intercellular Space","volume":"23","author":"Korbecki","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B39","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.cytogfr.2005.04.007","article-title":"CXC Chemokines in Angiogenesis","volume":"16","author":"Strieter","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.10.020","article-title":"Chemokines as Mediators of Tumor Angiogenesis and Neovascularization","volume":"317","author":"Keeley","year":"2011","journal-title":"Exp Cell Res"},{"key":"B41","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cellsig.2018.11.004","article-title":"How do Chemokines Navigate Neutrophils to the Target Site: Dissecting the Structural Mechanisms and Signaling Pathways","volume":"54","author":"Rajarathnam","year":"2019","journal-title":"Cell Signal"},{"key":"B42","article-title":"Chemokines Produced by Mesothelial Cells: huGRO-Alpha, IP-10, MCP-1 and RANTES","volume":"112","author":"Visser","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/path.5438","article-title":"Control of Neutrophil Influx During Peritonitis by Transcriptional Cross-Regulation of Chemokine CXCL1 by IL-17 and IFN-\u03b3","volume":"251","author":"Catar","year":"2020","journal-title":"J Pathol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.10.5814","article-title":"IL-17 Stimulates Intraperitoneal Neutrophil Infiltration Through the Release of GRO Alpha Chemokine From Mesothelial Cells","volume":"165","author":"Witowski","year":"2000","journal-title":"J Immunol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.immuni.2020.03.011","article-title":"Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants","volume":"52","author":"Jackson-Jones","year":"2020","journal-title":"Immunity"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01694","article-title":"IL-17 in Peritoneal Dialysis-Associated Inflammation and Angiogenesis: Conclusions and Perspectives","volume":"9","author":"Witowski","year":"2018","journal-title":"Front Physiol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"21344","DOI":"10.1038\/srep21344","article-title":"Quantitative Histomorphometry of the Healthy Peritoneum","volume":"6","author":"Schaefer","year":"2016","journal-title":"Sci Rep"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1177\/089686080602600207","article-title":"Peritoneal Mesothelial Cell Culture and Biology","volume":"26","author":"Yung","year":"2006","journal-title":"Perit Dial Int"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02474","article-title":"Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties","volume":"10","author":"Andrzejewska","year":"2019","journal-title":"Front Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"11568","DOI":"10.1038\/s41598-020-67289-8","article-title":"Angiogenesis Analyzer for ImageJ - A Comparative Morphometric Analysis of \"Endothelial Tube Formation Assay\" and \"Fibrin Bead Assay\"","volume":"10","author":"Carpentier","year":"2020","journal-title":"Sci Rep"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx316","article-title":"Tumour Necrosis Factor-Alpha in Uraemic Serum Promotes Osteoblastic Transition and Calcification of Vascular Smooth Muscle Cells via Extracellular Signal-Regulated Kinases and Activator Protein 1\/C-FOS-Mediated Induction of Interleukin 6 Expression","volume":"33","author":"Zickler","year":"2018","journal-title":"Nephrol Dialysis Transplant Off Publ Eur Dialysis Transplant Assoc - Eur Renal Assoc"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.1","article-title":"Human Peritoneal Fibroblasts Are a Potent Source of Neutrophil-Targeting Cytokines: A Key Role of IL-1beta Stimulation","volume":"89","author":"Witowski","year":"2009","journal-title":"Lab Invest; J Tech Methods Pathol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013040332","article-title":"Pathogen-Specific Local Immune Fingerprints Diagnose Bacterial Infection in Peritoneal Dialysis Patients","volume":"24","author":"Lin","year":"2013","journal-title":"J Am Soc Nephrol JASN"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2011.01.002","article-title":"Kinetics and Involvement of Interleukin-17 in the Outcome of Peritonitis in Nondiabetic Patients Undergoing Peritoneal Dialysis","volume":"74","author":"Wang","year":"2011","journal-title":"J Chin Med Assoc JCMA"},{"key":"B55","doi-asserted-by":"publisher","first-page":"481","DOI":"10.3747\/pdi.2016.00078","article-title":"ISPD Peritonitis Recommendations: 2016 Update on Prevention and Treatment","volume":"36","author":"Li","year":"2016","journal-title":"Perit Dial Int"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.12.006","article-title":"Intravascular Mesenchymal Stromal\/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines","volume":"25","author":"Moll","year":"2019","journal-title":"Trends Mol Med"},{"key":"B57","doi-asserted-by":"publisher","first-page":"m3734","DOI":"10.1136\/bmj.m3734","article-title":"Regulatory T Cells for Minimising Immune Suppression in Kidney Transplantation: Phase I\/IIa Clinical Trial","volume":"371","author":"Roemhild","year":"2020","journal-title":"Bmj"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.739987","article-title":"RESTORE Survey on the Public Perception of Advanced Therapies and ATMPs in Europe - Why the European Union Should Invest More","author":"Goldsobel","year":"2021","journal-title":"Front Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021010080","article-title":"Acquired Decline in Ultrafiltration in Peritoneal Dialysis: The Role of Glucose","volume":"32","author":"Krediet","year":"2021","journal-title":"J Am Soc Nephrol JASN"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00605.x","article-title":"Genetic Polymorphism of VEGF: Impact on Longitudinal Change of Peritoneal Transport and Survival of Peritoneal Dialysis Patients","volume":"65","author":"Szeto","year":"2004","journal-title":"Kidney Int"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.8.1480","article-title":"Plasma and Dialysate IL-6 and VEGF Concentrations are Associated With High Peritoneal Solute Transport Rate","volume":"17","author":"Pecoits-Filho","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"B62","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/82_2010_21","article-title":"Chemokines in Angiogenesis","volume":"341","author":"Dimberg","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208231200","article-title":"Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells are Mediated by CXCR2","volume":"278","author":"Heidemann","year":"2003","journal-title":"J Biol Chem"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/ph10030070","article-title":"Glycosaminoglycan Interactions With Chemokines Add Complexity to a Complex System","volume":"10","author":"Proudfoot","year":"2017","journal-title":"Pharm (Basel)"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006111292","article-title":"Epithelial to Mesenchymal Transition and Peritoneal Membrane Failure in Peritoneal Dialysis Patients: Pathologic Significance and Potential Therapeutic Interventions","volume":"18","author":"Aroeira","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300581","article-title":"Identification of a Tissue-Specific, C\/Ebp\u03b2-Dependent Pathway of Differentiation for Murine Peritoneal Macrophages","volume":"191","author":"Cain","year":"2013","journal-title":"J Immunol"},{"key":"B67","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.162.3.1685","article-title":"Role of Resident Peritoneal Macrophages and Mast Cells in Chemokine Production and Neutrophil Migration in Acute Inflammation: Evidence for an Inhibitory Loop Involving Endogenous IL-10","volume":"162","author":"Ajuebor","year":"1999","journal-title":"J Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2013.71","article-title":"Expression of CXCL1 in Human Endothelial Cells Induces Angiogenesis Through the CXCR2 Receptor and the ERK1\/2 and EGF Pathways","volume":"93","author":"Miyake","year":"2013","journal-title":"Lab Invest"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.33","article-title":"IL-17A is a Novel Player in Dialysis-Induced Peritoneal Damage","volume":"86","author":"Rodrigues-D\u00edez","year":"2014","journal-title":"Kidney Int"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048733","article-title":"Peritoneal Dialysate-Range Hypertonic Glucose Promotes T-Cell IL-17 Production That Induces Mesothelial Inflammation","volume":"51","author":"Helmke","year":"2021","journal-title":"Eur J Immunol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1159\/000430197","article-title":"Interleukin-17 Stimulates STAT3-Mediated Endothelial Cell Activation for Neutrophil Recruitment","volume":"36","author":"Yuan","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319310","article-title":"Glucose Derivative Induced Vasculopathy in Children on Chronic Peritoneal Dialysis","volume":"129","author":"Bartosova","year":"2021","journal-title":"Circ Res"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-018-1679-7","article-title":"Effects of Long-Term Treatment With Low-GDP, pH-Neutral Solutions on Peritoneal Membranes in Peritoneal Dialysis Patients","volume":"23","author":"Tawada","year":"2019","journal-title":"Clin Exp Nephrol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-021-02078-9","article-title":"Low-GDP, pH-Neutral Solutions Preserve Peritoneal Endothelial Glycocalyx During Long-Term Peritoneal Dialysis","author":"Sugiyama","year":"2021","journal-title":"Clin Exp Nephrol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.821681\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T20:30:42Z","timestamp":1674678642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.821681\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,4]]},"references-count":74,"alternative-id":["10.3389\/fimmu.2022.821681"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.821681","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,4]]},"article-number":"821681"}}