{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:41:40Z","timestamp":1793392900295,"version":"4.5.0"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>CLEC5A is a member of the C-type lectin superfamily. It can activate macrophages and lead to a series of immune-inflammation reactions. Previous studies reveal the role of CLEC5A in infection and inflammation diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We acquire and analyze data from The Cancer Genome Atlas (TCGA) database, Genotype-Tissue Expression (GTEx) database, and other comprehensive databases <jats:italic>via<\/jats:italic> GSCALite, cBioPortal, and TIMER 2.0 platforms or software. Single-cell sequencing analysis was performed for quantifying the tumor microenvironment of several types of cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>CLEC5A<\/jats:italic> is differentially expressed in a few cancer types, of which overexpression accompanies low overall survival of patients. DNA methylation mainly negatively correlates with <jats:italic>CLEC5A<\/jats:italic> expression. Moreover, <jats:italic>CLEC5A<\/jats:italic> is positively related to immune infiltration, including macrophages, cancer-associated fibroblasts (CAFs), and regulatory T cells (Tregs). Immune checkpoint genes are significantly associated with <jats:italic>CLEC5A<\/jats:italic> expression in diverse cancers. In addition, <jats:italic>CLEC5A<\/jats:italic> expression correlates with mismatch repair (MMR) in several cancers. Tumor mutation burden (TMB), microsatellite instability (MSI), and neoantigens show a positive association with <jats:italic>CLEC5A<\/jats:italic> expression in several cancers. Furthermore, <jats:italic>CLEC5A<\/jats:italic> in cancer correlates with signal transduction, the immune system, EMT, and apoptosis process. The drug sensitivity analysis screens out potential therapeutic agents associated with <jats:italic>CLEC5A<\/jats:italic> expression, including FR-180204, Tivozanib, OSI-930, Linifanib, AC220, VNLG\/124, Bexarotene, omacetaxine mepesuccinate, narciclasine, leptomycin B, PHA-793887, LRRK2-IN-1, and CR-1-31B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CLEC5A overexpresses in multiple cancers in contrast to normal tissues, and high CLEC5A expression predicts poor prognosis of patients and immune infiltration. CLEC5A is a potential prognostic biomarker of diverse cancers and a target for anti-tumor therapy.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2022.831542","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T04:44:00Z","timestamp":1659329040000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["A Pan-Cancer Analysis Reveals CLEC5A as a Biomarker for Cancer Immunity and Prognosis"],"prefix":"10.3389","volume":"13","author":[{"given":"Rui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wantao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Peng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaoqu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1093\/annonc\/mdy495","article-title":"Development of Tumor Mutation Burden as an Immunotherapy Biomarker: Utility for the Oncology Clinic","volume":"30","author":"Chan","year":"2019","journal-title":"Annals of Oncology : Official Journal of the European Society for Medical Oncology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-14-0983","article-title":"PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy","volume":"14","author":"Patel","year":"2015","journal-title":"Mol Cancer Ther"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27172","article-title":"PD-1\/PD-L1 Immune Checkpoint: Potential Target for Cancer Therapy","volume":"234","author":"Dermani","year":"2019","journal-title":"J Cell Physiol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s13046-021-01987-7","article-title":"Regulatory Mechanisms of Immune Checkpoints PD-L1 and CTLA-4 in Cancer","volume":"40","author":"Zhang","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02867","article-title":"CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections","volume":"10","author":"Sung","year":"2019","journal-title":"Front Immunol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-7877-6_40","article-title":"Targeting C-Type Lectin for the Treatment of Flavivirus Infections","volume":"705","author":"Chen","year":"2011","journal-title":"Adv Exp Med Biol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9792","article-title":"Myeloid DAP12-Associating Lectin (MDL)-1 is a Cell Surface Receptor Involved in the Activation of Myeloid Cells","volume":"96","author":"Bakker","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B8","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41467-017-00356-3","article-title":"CLEC5A is a Critical Receptor in Innate Immunity Against Listeria Infection","volume":"8","author":"Chen","year":"2017","journal-title":"Nat Commun"},{"key":"B9","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s12016-015-8521-8","article-title":"A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts","volume":"51","author":"Humphrey","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jcv.2010.06.009","article-title":"Expression Profile of Japanese Encephalitis Virus Induced Neuroinflammation and its Implication in Disease Severity","volume":"49","author":"Gupta","year":"2010","journal-title":"J Clin Virol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002655","article-title":"CLEC5A Regulates Japanese Encephalitis Virus-Induced Neuroinflammation and Lethality","volume":"8","author":"Chen","year":"2012","journal-title":"PloS Pathog"},{"key":"B12","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1182\/blood-2012-05-430090","article-title":"CLEC5A is Critical for Dengue Virus-Induced Inflammasome Activation in Human Macrophages","volume":"121","author":"Wu","year":"2013","journal-title":"Blood"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1038\/s41467-019-10360-4","article-title":"Extracellular Vesicles From CLEC2-Activated Platelets Enhance Dengue Virus-Induced Lethality via CLEC5A\/Tlr2","volume":"10","author":"Sung","year":"2019","journal-title":"Nat Commun"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086105","article-title":"A Potential Role of Myeloid DAP12-Associating Lectin (MDL)-1 in the Regulation of Inflammation in Rheumatoid Arthritis Patients","volume":"9","author":"Chen","year":"2014","journal-title":"PloS One"},{"key":"B15","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s11658-019-0162-0","article-title":"Transcriptome Profiling Revealed Multiple Genes and ECM-Receptor Interaction Pathways That may be Associated With Breast Cancer","volume":"24","author":"Bao","year":"2019","journal-title":"Cell Mol Biol Lett"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3550","article-title":"Molecular Profiling of Peripheral Blood is Associated With Circulating Tumor Cells Content and Poor Survival in Metastatic Castration-Resistant Prostate Cancer","volume":"6","author":"Mar\u00edn-Aguilera","year":"2015","journal-title":"Oncotarget"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12584","article-title":"C-Type Lectin Domain Family 5, Member A (CLEC5A, MDL-1) Promotes Brain Glioblastoma Tumorigenesis by Regulating PI3K\/Akt Signalling","volume":"52","author":"Fan","year":"2019","journal-title":"Cell Prolif"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22985","article-title":"Transcription Factor CEBPB Inhibits the Proliferation of Osteosarcoma by Regulating Downstream Target Gene CLEC5A","volume":"33","author":"Lu","year":"2019","journal-title":"J Clin Lab Anal"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.10.122","article-title":"CLEC5A Promotes the Proliferation of Gastric Cancer Cells by Activating the PI3K\/AKT\/mTOR Pathway","volume":"524","author":"Wang","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2019.0235","article-title":"Screening of Critical Genes Involved in Metastasis and Prognosis of High-Grade Serous Ovarian Cancer by Gene Expression Profile Data","volume":"27","author":"Wang","year":"2020","journal-title":"J Comput Biol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-019-0140-8","article-title":"CLEC5A Expressed on Myeloid Cells as a M2 Biomarker Relates to Immunosuppression and Decreased Survival in Patients With Glioma","volume":"27","author":"Tong","year":"2020","journal-title":"Cancer Gene Ther"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1186-3","article-title":"Next-Generation Characterization of the Cancer Cell Line Encyclopedia","volume":"569","author":"Ghandi","year":"2019","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-Based Map of the Human Proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M500279-MCP200","article-title":"A Human Protein Atlas for Normal and Cancer Tissues Based on Antibody Proteomics","volume":"4","author":"Uhl\u00e9n","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174515","article-title":"Mining Expression and Prognosis of Topoisomerase Isoforms in non-Small-Cell Lung Cancer by Using Oncomine and Kaplan-Meier Plotter","volume":"12","author":"Hou","year":"2017","journal-title":"PloS One"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty411","article-title":"GSCALite: A Web Server for Gene Set Cancer Analysis","volume":"34","author":"Liu","year":"2018","journal-title":"Bioinformatics"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The Cbio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discovery"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.634617","article-title":"CD96 Correlates With Immune Infiltration and Impacts Patient Prognosis: A Pan-Cancer Analysis","volume":"11","author":"Ye","year":"2021","journal-title":"Front Oncol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0307","article-title":"TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells","volume":"77","author":"Li","year":"2017","journal-title":"Cancer Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"D1056","DOI":"10.1093\/nar\/gky1133","article-title":"Open Targets Platform: New Developments and Updates Two Years on","volume":"47","author":"Carvalho-Silva","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/npp.2012.112","article-title":"DNA Methylation and its Basic Function","volume":"38","author":"Moore","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"B32","doi-asserted-by":"publisher","first-page":"D1340","DOI":"10.1093\/nar\/gkab851","article-title":"OncoSplicing: An Updated Database for Clinically Relevant Alternative Splicing in 33 Human Cancers","volume":"50","author":"Zhang","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.36","article-title":"Mechanism-Driven Biomarkers to Guide Immune Checkpoint Blockade in Cancer Therapy","volume":"16","author":"Topalian","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"B34","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.pharmthera.2018.04.004","article-title":"DNA Mismatch Repair in Cancer","volume":"189","author":"Baretti","year":"2018","journal-title":"Pharmacol Ther"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0522","article-title":"Tumor Mutational Burden as a Predictive Biomarker in Solid Tumors","volume":"10","author":"Sha","year":"2020","journal-title":"Cancer Discovery"},{"key":"B36","doi-asserted-by":"crossref","DOI":"10.1038\/s41588-018-0312-8","article-title":"Tumor Mutational Load Predicts Survival After Immunotherapy Across Multiple Cancer Types","volume":"51","author":"Samstein","year":"2019","journal-title":"Nat Genet"},{"key":"B37","doi-asserted-by":"crossref","DOI":"10.1007\/s00262-015-1776-3","article-title":"Improving Cancer Immunotherapy With DNA Methyltransferase Inhibitors","volume":"65","author":"Saleh","year":"2016","journal-title":"Cancer Immunol Immunother"},{"key":"B38","doi-asserted-by":"crossref","DOI":"10.7150\/ijbs.11218","article-title":"DNA Methylation, its Mediators and Genome Integrity","volume":"11","author":"Meng","year":"2015","journal-title":"Int J Biol Sci"},{"key":"B39","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.cels.2018.03.003","article-title":"Pan-Cancer Alterations of the MYC Oncogene and Its Proximal Network Across the Cancer Genome Atlas","volume":"6","author":"Schaub","year":"2018","journal-title":"Cell Syst"},{"key":"B40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2019.11.010","article-title":"Detrimental Role of Neutrophil Extracellular Traps During Dengue Virus Infection","volume":"41","author":"Schulz","year":"2020","journal-title":"Trends Immunol"},{"key":"B41","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01813-16","article-title":"CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo","volume":"91","author":"Teng","year":"2017","journal-title":"J Virol"},{"key":"B42","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12967-017-1336-z","article-title":"The Macrophage C-Type Lectin Receptor CLEC5A (MDL-1) Expression is Associated With Early Plaque Progression and Promotes Macrophage Survival","volume":"15","author":"Xiong","year":"2017","journal-title":"J Transl Med"},{"key":"B43","doi-asserted-by":"crossref","first-page":"9473497","DOI":"10.1155\/2020\/9473497","article-title":"Elevated Expression of C-Type Lectin Domain Family 5-Member A (CLEC5A) and Its Relation to Inflammatory Parameters and Disease Course in Adult-Onset Still's Disease","volume":"2020","author":"Chen","year":"2020","journal-title":"J Immunol Res"},{"key":"B44","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-15-3278","article-title":"DNA Methylation in Cancer and Aging","volume":"76","author":"Klutstein","year":"2016","journal-title":"Cancer Res"},{"key":"B45","doi-asserted-by":"crossref","DOI":"10.1002\/1878-0261.12684","article-title":"SST Gene Hypermethylation Acts as a Pan-Cancer Marker for Pancreatic Ductal Adenocarcinoma and Multiple Other Tumors: Toward its Use for Blood-Based Diagnosis","volume":"14","author":"Manoochehri","year":"2020","journal-title":"Mol Oncol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.11.009","article-title":"Immune Cells Within the Tumor Microenvironment: Biological Functions and Roles in Cancer Immunotherapy","volume":"470","author":"Lei","year":"2020","journal-title":"Cancer Lett"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3962","article-title":"The Tumor Microenvironment Innately Modulates Cancer Progression","volume":"79","author":"Hinshaw","year":"2019","journal-title":"Cancer Res"},{"key":"B48","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12943-022-01513-z","article-title":"Glioma Targeted Therapy: Insight Into Future of Molecular Approaches","volume":"21","author":"Yang","year":"2022","journal-title":"Mol Cancer"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095-3941.2019.0353","article-title":"Neutrophil Extracellular Traps Mediate the Crosstalk Between Glioma Progression and the Tumor Microenvironment via the HMGB1\/RAGE\/IL-8 Axis","volume":"17","author":"Zha","year":"2020","journal-title":"Cancer Biol Med"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32102","article-title":"Immunogenomic Analysis Reveals LGALS1 Contributes to the Immune Heterogeneity and Immunosuppression in Glioma","volume":"145","author":"Chen","year":"2019","journal-title":"Int J Cancer"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.573619","article-title":"BRCA1-Associated Protein Is a Potential Prognostic Biomarker and Is Correlated With Immune Infiltration in Liver Hepatocellular Carcinoma: A Pan-Cancer Analysis","volume":"7","author":"Ju","year":"2020","journal-title":"Front Mol Biosci"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.08.019","article-title":"The Molecular Feature of Macrophages in Tumor Immune Microenvironment of Glioma Patients","volume":"19","author":"Zhang","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.691811","article-title":"Immune Infiltrating Cells-Derived Risk Signature Based on Large-Scale Analysis Defines Immune Landscape and Predicts Immunotherapy Responses in Glioma Tumor Microenvironment","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.694490","article-title":"Novel Immune Infiltrating Cell Signature Based on Cell Pair Algorithm Is a Prognostic Marker in Cancer","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12885-017-3074-2","article-title":"The Yin\/Yan of CCL2: A Minor Role in Neutrophil Anti-Tumor Activity In Vitro But a Major Role on the Outgrowth of Metastatic Breast Cancer Lesions in the Lung In Vivo","volume":"17","author":"Lavender","year":"2017","journal-title":"BMC Cancer"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxu090","article-title":"IL-10 Enhances the Phenotype of M2 Macrophages Induced by IL-4 and Confers the Ability to Increase Eosinophil Migration","volume":"27","author":"Makita","year":"2015","journal-title":"Int Immunol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"3580719","DOI":"10.1155\/2020\/3580719","article-title":"NFE2L2 Is a Potential Prognostic Biomarker and Is Correlated With Immune Infiltration in Brain Lower Grade Glioma: A Pan-Cancer Analysis","volume":"2020","author":"Ju","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2020-0672","article-title":"CLEC5A Knockdown Protects Against the Cardiac Dysfunction After Myocardial Infarction by Suppressing Macrophage Polarization, NLRP3 Inflammasome Activation and Pyroptosis","author":"Wang","year":"2021","journal-title":"Biochem Cell Biol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57682","article-title":"Activation of MDL-1 (CLEC5A) on Immature Myeloid Cells Triggers Lethal Shock in Mice","volume":"121","author":"Cheung","year":"2011","journal-title":"J Clin Invest"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.831542\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T04:44:13Z","timestamp":1659329053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.831542\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":59,"alternative-id":["10.3389\/fimmu.2022.831542"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.831542","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,1]]},"article-number":"831542"}}