{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:50:45Z","timestamp":1785883845580,"version":"3.56.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Psoriasis is a chronic skin disorder associated with multiple sequelae, such as psoriatic arthritis and cardiovascular diseases. Increasing evidence has shown that \u03b3\u03b4 T cells, as sources of IL-17A, play critical roles in psoriatic inflammations. However, there still lack effective ways to manipulate these pathogenic \u03b3\u03b4 T cells, which are less well studied than \u03b1\u03b2 T cells. The present study aims to characterize the phenotype of \u03b3\u03b4 T cells and evaluate the impact of D-mannose (a C-2 epimer of glucose) on \u03b3\u03b4 T cell-mediated psoriasis. We found that skin-draining LN \u03b3\u03b4 T cells underwent robust proliferation and acquired an IL-17-producing phenotype during psoriasis. The transcriptomic profiles of these psoriatic \u03b3\u03b4 T cells had elevated glycolytic signatures. Importantly, D-mannose treatment suppressed the \u03b3\u03b4 T cell reaction and successfully alleviated the local and systematic inflammation induced by imiquimod. The decreased AKT\/mTOR\/HIF-1\u03b1 signaling and glycolytic ability may contribute to the suppression of \u03b3\u03b4 T cells achieved by D-mannose. Our study increased understanding of \u03b3\u03b4 T cells in psoriasis and promoted D-mannose utilization as a potential clinical application for autoimmune diseases driven by \u03b3\u03b4 T cells.<\/jats:p>","DOI":"10.3389\/fimmu.2022.840755","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T07:00:54Z","timestamp":1646031654000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["D-Mannose Suppresses \u03b3\u03b4 T Cells and Alleviates Murine 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