{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:44:52Z","timestamp":1781649892528,"version":"3.54.5"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Previous reports showed that some patients with minimal change disease (MCD) had high serum immunoglobulin E (IgE) levels. This study aimed to explore the proportion of MCD patients with high serum IgE levels and evaluate the correlation between serum IgE levels and MCD remission and relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study enrolled 222 new-onset patients with renal biopsy-confirmed MCD from October 2012 to October 2019 at the First Affiliated Hospital of Zhejiang University in Hangzhou, China. Patients\u2019 demographics and clinical parameters were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results indicated that 70.3% of 222 MCD patients had high serum IgE levels (IgE &amp;gt; 100.0 IU\/mL). Moreover, 134 patients were treated with glucocorticoids alone and divided into the low- and high-IgE groups, according to the median serum IgE level (523.5 IU\/mL). The mean time to complete remission of the low- and high-IgE groups was 29.0 \u00b1 2.2 and 45.7 \u00b1 4.2 days, respectively (log-rank test; <jats:italic>P<\/jats:italic> = 0.002). The mean time to total remission was 19.1 \u00b1 1.4 and 31.6 \u00b1 3.2 days of the low- and high-IgE groups, respectively (log-rank test; <jats:italic>P<\/jats:italic> &amp;lt; 0.001). The mean time to first relapse in the low- and high-IgE groups was 701.2 \u00b1 65.0 and 425.0 \u00b1 52.6 days, respectively (log-rank test; <jats:italic>P<\/jats:italic> = 0.002). Serum IgE \u2265 523.5 IU\/mL was an independent correlation factor affecting the patients\u2019 remission and relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum IgE level was an independent correlation factor for MCD remission and relapse. MCD patients with high serum IgE levels were prone to delayed remissions and early relapses.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2022.840857","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T10:27:00Z","timestamp":1647512820000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Serum IgE Levels Are Associated With the Prognosis of Minimal Change Disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Heng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lefeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"332","DOI":"10.2215\/CJN.05000516","article-title":"Minimal Change Disease","volume":"12","author":"Vivarelli","year":"2017","journal-title":"Clin J Am Soc Nephro"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.06.002","article-title":"KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Glomerulonephritis","volume":"62","author":"Beck","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1042\/cs20040095","article-title":"Role of the Immune System in the Pathogenesis of Idiopathic Nephrotic Syndrome","volume":"107","author":"van den Berg","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2012070734","article-title":"The Treatment of Minimal Change Disease in Adults","volume":"24","author":"Hogan","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"B5","doi-asserted-by":"crossref","DOI":"10.1007\/BF00447472","article-title":"IgE in Patients With Glomerulonephritis and Minimal-Change Nephrotic Syndrome","volume":"131","author":"Schulte-Wissermann","year":"1979","journal-title":"Eur J Pediatr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-13725-4_1","article-title":"Biology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses","volume":"388","author":"He","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(70)90770-1","article-title":"Nephrotic Syndrome Associated With Inhaled Allergens","volume":"1","author":"Wittig","year":"1970","journal-title":"Lancet"},{"key":"B8","article-title":"Nephrotic Syndrome and Respiratory Allergy in Childhood","volume":"2","author":"Florido","year":"1992","journal-title":"J Investig Allergol Clin Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(87)90567-8","article-title":"Food Allergy in Steroid-Resistant Nephrotic Syndrome","volume":"1","author":"Genova","year":"1987","journal-title":"Lancet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/s0140-6736(82)92718-0","article-title":"Nephrotic Syndrome Induced by Insect Sting","volume":"2","author":"Tareyeva","year":"1982","journal-title":"Lancet"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.03.019","article-title":"Idiopathic Nephrotic Syndrome and Atopy: Is There a Common Link","volume":"54","author":"Abdel-Hafez","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1159\/000184981","article-title":"Serum IgE in Primary Glomerular Diseases and Its Clinical Significance","volume":"49","author":"Shu","year":"1988","journal-title":"Nephron"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A More Accurate Method to Estimate Glomerular Filtration Rate From Serum Creatinine: A New Prediction Equation. 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