{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:57:11Z","timestamp":1793649431789,"version":"4.5.1"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    The\n                    <jats:italic>N<\/jats:italic>\n                    -glycome of immunoglobulin G (IgG), the most abundant glycoprotein in human blood serum, reflects pathological conditions of autoimmunity and is sensitive to medicines applied in disease therapy. Due to the high sensitivity of\n                    <jats:italic>N<\/jats:italic>\n                    -glycosylation, the IgG\n                    <jats:italic>N<\/jats:italic>\n                    -glycan profile may serve as an indicator of an ongoing inflammatory process. The IgG structure and its effector functions are strongly dependent on the composition of\n                    <jats:italic>N<\/jats:italic>\n                    -glycans attached to the Fc fragment, and the binding of antigens is regulated by Fab sugar moieties. Because of the crucial role of\n                    <jats:italic>N<\/jats:italic>\n                    -glycans in IgG function, remodeling of its\n                    <jats:italic>N<\/jats:italic>\n                    -oligosaccharides can induce pathological changes that ultimately contribute to the development of autoimmunity; restoration of their physiological structure is critical to the reduction of disease symptoms. Our recently published data have shown that the pathology of autoimmune thyroid diseases (AITDs), including Hashimoto\u2019s thyroiditis (HT) and Graves\u2019 disease (GD), is accompanied by alterations of the composition of IgG\n                    <jats:italic>N<\/jats:italic>\n                    -glycans. The present study is a more in-depth investigation of IgG glycosylation in both AITDs, designed to determine the relationship between the severity of thyroid inflammation and IgG\n                    <jats:italic>N<\/jats:italic>\n                    -glycan structures in HT, and to assess the impact of immunosuppressive therapy on the\n                    <jats:italic>N<\/jats:italic>\n                    -glycan profile in GD patients. The study material consisted of human serum samples collected from donors with elevated anti-thyroglobulin (Tg) and\/or anti-thyroperoxidase (TPO) IgGs without symptoms of hypothyroidism (n=68), HT patients characterized by high autoantibody titers and advanced destruction of the thyroid gland (n=113), GD patients with up-regulated IgG against thyroid-stimulating hormone receptor (TSHR) before (n=62) and after (n=47) stabilization of TSH level as a result of methimazole therapy (study groups), and healthy donors (control group, n=90). IgG was isolated from blood serum using protein G affinity chromatography.\n                    <jats:italic>N<\/jats:italic>\n                    -glycans were released from IgG by PNGase F digestion and analyzed by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) after 2-aminobenzamide (2-AB) labeling. UPLC-MS chromatograms were integrated into 25 peaks (GP) in the Waters UNIFI Scientific Information System, and\n                    <jats:italic>N<\/jats:italic>\n                    -glycans were assigned based on the glucose unit values and mass-to-charge ratios (m\/z) of the detected ions. The Kruskal-Wallis non-parametric test was used to determine the statistical significance of the results (p&amp;lt;0.05). The obtained results suggest that modifications of IgG sialylation, galactosylation and core-fucosylation are associated with the severity of HT symptoms. Methimazole therapy implemented in GD patients affected the IgG\n                    <jats:italic>N<\/jats:italic>\n                    -glycan profile; as a result, the content of the sialylated and galactosylated oligosaccharides with core fucose differed after treatment. Our results suggest that\n                    <jats:italic>N<\/jats:italic>\n                    -glycosylation of IgG undergoes dynamic changes during the intensification of thyroiditis in HT, and that in GD autoimmunity it is affected significantly by immunosuppressive therapy.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2022.841710","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T04:49:17Z","timestamp":1647319757000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Changes of IgG N-Glycosylation in Thyroid Autoimmunity: The Modulatory Effect of Methimazole in Graves\u2019 Disease and the Association With the Severity of Inflammation in Hashimoto\u2019s Thyroiditis"],"prefix":"10.3389","volume":"13","author":[{"given":"Sara","family":"Trzos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Link-Lenczowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Soko\u0142owski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Poche\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.046","article-title":"Structure and Function of Immunoglobulins","volume":"125","author":"Schroeder","year":"2010","journal-title":"J Allergy Clin 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