{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:22:55Z","timestamp":1793748175545,"version":"4.6.1"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870908, U1801283, 81903541"],"award-info":[{"award-number":["31870908, U1801283, 81903541"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015287","name":"Scholarship for Academic Leader of Yunnan Province","doi-asserted-by":"publisher","award":["202005AE160005"],"award-info":[{"award-number":["202005AE160005"]}],"id":[{"id":"10.13039\/501100015287","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Inflammatory bowel diseases (IBDs) are increasingly common diseases characterized by chronic and relapsing inflammation of the gastrointestinal tract. NLRP3 might be a crucial regulator of the homeostatic balance of the intestine, but its upregulation leads to pyroptosis. Munronoid I is extracted and purified from <jats:italic>Munronia sinica<\/jats:italic>, which has shown an anti-inflammatory effect, but the efficacy of Munronoid I in IBD remains unproven. In this study, we attempted to determine the effect of Munronoid I on NLRP3 to regulate the inflammasome activation and pyroptosis in IBD. Our data demonstrated that Munronoid I treatment attenuated DSS-induced body weight loss, pathological injury of the colon, the production of IL-1\u03b2 and IL-18, and the expression of pyroptosis-associated proteins in colon tissue in mice. Moreover, Munronoid I inhibited LPS\/ATP-induced pyroptosis in mouse peritoneal macrophages, MODE-K cells, and DSS-induced pyroptosis in mouse colonic epithelial cells, and decreased the release of inflammatory cytokines IL-1\u03b2 and IL-18 in mouse peritoneal macrophages. Mechanically, Munronoid I could suppress the NLRP3 inflammasome activation and pyroptosis by promoting the K48-linked ubiquitination and NLRP3 degradation. It is suggested that Munronoid I might be a potential therapeutic candidate for IBD.<\/jats:p>","DOI":"10.3389\/fimmu.2022.853194","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T08:09:19Z","timestamp":1657008559000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Munronoid I Ameliorates DSS-Induced Mouse Colitis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Via Modulation of NLRP3"],"prefix":"10.3389","volume":"13","author":[{"given":"Xingyu","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xibao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazheng","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zherui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilie","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory Bowel Disease","volume":"361","author":"Abraham","year":"2009","journal-title":"New Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","article-title":"Crohn's Disease","volume":"6","author":"Roda","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"B3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative Colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"B4","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1093\/jcag\/gwy054","article-title":"The Impact of Inflammatory Bowel Disease in Canada 2018: Epidemiology","volume":"2","author":"Kaplan","year":"2019","journal-title":"J Can Assoc Gastroenterol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.150","article-title":"The Global Burden of IBD: From 2015 to 2025","volume":"12","author":"Kaplan","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s11894-019-0705-6","article-title":"Evolving Epidemiology of IBD","volume":"21","author":"Windsor","year":"2019","journal-title":"Curr Gastroenterol Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1159\/000447283","article-title":"The Search for Causative Environmental Factors in Inflammatory Bowel Disease","author":"Rogler","year":"2016","journal-title":"Digestive Dis (Basel Switzerland)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i29.3814","article-title":"Impact of Environmental and Dietary Factors on the Course of Inflammatory Bowel Disease","volume":"18","author":"Cabr\u00e9","year":"2012","journal-title":"World J Gastroenterol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw106","article-title":"IBD: In Food We Trust","volume":"10","author":"Marion-Letellier","year":"2016","journal-title":"J Crohn's Colitis"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.08.001","article-title":"Genetics of Inflammatory Bowel Diseases","volume":"149","author":"McGovern","year":"2015","journal-title":"Gastroenterology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104892","article-title":"Genetics and Epigenetics of IBD","volume":"159","author":"Annese","year":"2020","journal-title":"Pharmacol Res"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(07)60750-8","article-title":"Inflammatory Bowel Disease: Cause and Immunobiology","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet (London England)"},{"key":"B13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3109\/00365521.2014.966321","article-title":"The Innate Immune System and Inflammatory Bowel Disease","volume":"50","author":"Davies","year":"2015","journal-title":"Scandinavian J Gastroenterol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10208","article-title":"Intestinal Homeostasis and its Breakdown in Inflammatory Bowel Disease","volume":"474","author":"Maloy","year":"2011","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2668","DOI":"10.3390\/ijms21082668","article-title":"Gut Microbiota Beyond Bacteria-Mycobiome, Virome, Archaeome, and Eukaryotic Parasites in IBD","volume":"21","author":"Matija\u0161i\u0107","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B16","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1590\/1414-431x20143774","article-title":"Classical and Recent Advances in the Treatment of Inflammatory Bowel Diseases","volume":"48","author":"Sales-Campos","year":"2015","journal-title":"Braz J Med Biol Res  Rev Bras Pesquisas Med  Biol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.03.002","article-title":"Induction and Maintenance Treatment of Inflammatory Bowel Disease: A Comprehensive Review","volume":"18","author":"Jeong","year":"2019","journal-title":"Autoimmun Rev"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1080\/1744666x.2019.1646127","article-title":"Overall and Comparative Safety of Biologic and Immunosuppressive Therapy in Inflammatory Bowel Diseases","volume":"15","author":"Holmer","year":"2019","journal-title":"Expert Rev Clin Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s12028-017-0387-6","article-title":"Neurologic Complications of Transplantation","volume":"28","author":"Dhar","year":"2018","journal-title":"Neurocritical Care"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/s0966-842x(00)01936-3","article-title":"Pro-Inflammatory Programmed Cell Death","volume":"9","author":"Cookson","year":"2001","journal-title":"Trends Microbiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"R568","DOI":"10.1016\/j.cub.2016.02.019","article-title":"Pyroptosis","volume":"26","author":"Vande Walle","year":"2016","journal-title":"Curr Biol CB"},{"key":"B22","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/nyas.12458","article-title":"Mechanism of NLRP3 Inflammasome Activation","volume":"1319","author":"Sutterwala","year":"2014","journal-title":"Ann New York Acad Sci"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 Inflammasome: Molecular Activation and Regulation to Therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting Edge: NF-kappaB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/nature04515","article-title":"Cryopyrin Activates the Inflammasome in Response to Toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nri1086","article-title":"NODs: Intracellular Proteins Involved in Inflammation and Apoptosis","volume":"3","author":"Inohara","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151790","article-title":"A Single Domain Antibody Fragment That Recognizes the Adaptor ASC Defines the Role of ASC Domains in Inflammasome Assembly","volume":"213","author":"Schmidt","year":"2016","journal-title":"J Exp Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(02)00599-3","article-title":"The Inflammasome: A Molecular Platform Triggering Activation of Inflammatory Caspases and Processing of proIL-Beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6154","article-title":"Apoptosis-Associated Speck-Like Protein Containing a Caspase Recruitment Domain is a Regulator of Procaspase-1 Activation","volume":"171","author":"Stehlik","year":"2003","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.16.9378","article-title":"Expression, Refolding, and Autocatalytic Proteolytic Processing of the Interleukin-1 Beta-Converting Enzyme Precursor","volume":"270","author":"Ramage","year":"1995","journal-title":"J Biol Chem"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.1998.tb08307.x","article-title":"Interleukin-1 Beta, Interleukin-18, and the Interleukin-1 Beta Converting Enzyme","author":"Dinarello","year":"1998","journal-title":"Ann New York Acad Sci"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by Inflammatory Caspases Determines Pyroptotic Cell Death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nature13683","article-title":"Inflammatory Caspases are Innate Immune Receptors for Intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nature10558","article-title":"Non-Canonical Inflammasome Activation Targets Caspase-11","volume":"479","author":"Kayagaki","year":"2011","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541","article-title":"Caspase-11 Cleaves Gasdermin D for Non-Canonical Inflammasome Signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw219","article-title":"The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans","volume":"11","author":"Liu","year":"2017","journal-title":"J Crohn's Colitis"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.03.003","article-title":"The NLRP3 Inflammasome Protects Against Loss of Epithelial Integrity and Mortality During Experimental Colitis","volume":"32","author":"Zaki","year":"2010","journal-title":"Immunity"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160462","article-title":"Myeloid-Derived miR-223 Regulates Intestinal Inflammation via Repression of the NLRP3 Inflammasome","volume":"214","author":"Neudecker","year":"2017","journal-title":"J Exp Med"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/nature18590","article-title":"Pore-Forming Activity and Structural Autoinhibition of the Gasdermin Family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694696","article-title":"GSDMD Membrane Pore Formation Constitutes the Mechanism of Pyroptotic Cell Death","volume":"35","author":"Sborgi","year":"2016","journal-title":"EMBO J"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an Executor of Pyroptosis and Required for Interleukin-1\u03b2 Secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res"},{"key":"B42","doi-asserted-by":"publisher","first-page":"3\u201314","DOI":"10.1093\/jmcb\/mjaa055","article-title":"The Molecular Mechanisms of MLKL-Dependent and MLKL-Independent Necrosis","volume":"13","author":"Li","year":"2020","journal-title":"J Mol Cell Biol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545772","article-title":"Caspase-11 Activates a Canonical NLRP3 Inflammasome by Promoting K(+) Efflux","volume":"45","author":"R\u00fchl","year":"2015","journal-title":"Eur J Immunol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2017.05.005","article-title":"Gasdermins: Effectors of Pyroptosis","volume":"27","author":"Kovacs","year":"2017","journal-title":"Trends Cell Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1152\/physrev.00037.2007","article-title":"Physiology of Cell Volume Regulation in Vertebrates","volume":"89","author":"Hoffmann","year":"2009","journal-title":"Physiol Rev"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0228-2","article-title":"The Gasdermins, a Protein Family Executing Cell Death and Inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy Drugs Induce Pyroptosis Through Caspase-3 Cleavage of a Gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.11.003","article-title":"Munronoids A\u2013J, Ten New Limonoids From Munronia Unifoliolata Oliv","volume":"68","author":"Ge","year":"2012","journal-title":"Tetrahedron"},{"key":"B49","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s13659-012-0001-8","article-title":"Chemical Constituents From Munronia Sinica and Their Bioactivities","volume":"2","author":"Li","year":"2012","journal-title":"Natural Prod Bioprospecting"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111543","article-title":"Natural Molecule Munronoid I Attenuates LPS-Induced Acute Lung Injury by Promoting the K48-Linked Ubiquitination and Degradation of TAK1","volume":"138","author":"Xingyu","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nature12599","article-title":"Paneth Cells as a Site of Origin for Intestinal Inflammation","volume":"503","author":"Adolph","year":"2013","journal-title":"Nature"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1159\/000007822","article-title":"Characterisation of Acute Murine Dextran Sodium Sulphate Colitis: Cytokine Profile and Dose Dependency","volume":"62","author":"Egger","year":"2000","journal-title":"Digestion"},{"key":"B53","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.3791\/3678","article-title":"Investigating Intestinal Inflammation in DSS-Induced Model of IBD","author":"Kim","year":"2012","journal-title":"J Visualized Exp JoVE"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2157-1","article-title":"NEK7 Interacts With NLRP3 to Modulate the Pyroptosis in Inflammatory Bowel Disease via NF-\u03bab Signaling","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1755","article-title":"Lipopolysaccharide\/adenosine Triphosphate Induces IL\u22121\u03b2 and IL-18 Secretion Through the NLRP3 Inflammasome in RAW264.7 Murine Macrophage Cells","volume":"34","author":"Xie","year":"2014","journal-title":"Int J Mol Med"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2255-5","article-title":"The Recognition of Ubiquitinated Proteins by the Proteasome","volume":"73","author":"Grice","year":"2016","journal-title":"Cell Mol Life Sci CMLS"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/nature18629","article-title":"Inflammasome-Activated Gasdermin D Causes Pyroptosis by Forming Membrane Pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1960","article-title":"Caspase-1-Induced Pyroptosis is an Innate Immune Effector Mechanism Against Intracellular Bacteria","volume":"11","author":"Miao","year":"2010","journal-title":"Nat Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151613","article-title":"Pyroptosis Triggers Pore-Induced Intracellular Traps (PITs) That Capture Bacteria and Lead to Their Clearance by Efferocytosis","volume":"213","author":"Jorgensen","year":"2016","journal-title":"J Exp Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"8145","DOI":"10.3390\/ijms21218145","article-title":"Contradictory Effects of NLRP3 Inflammasome Regulatory Mechanisms in Colitis","volume":"21","author":"Wagatsuma","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00886-5","article-title":"NLRP3 Inflammasome in Cancer and Metabolic Diseases","volume":"22","author":"Sharma","year":"2021","journal-title":"Nat Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1600-065X.2008.00730.x","article-title":"Inflammasomes: Guardians of Cytosolic Sanctity","volume":"227","author":"Lamkanfi","year":"2009","journal-title":"Immunol Rev"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.016","article-title":"K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter","volume":"38","author":"Mu\u00f1oz-Planillo","year":"2013","journal-title":"Immunity"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/nri2725","article-title":"NLRP3 Inflammasome Activation: The Convergence of Multiple Signalling Pathways on ROS Production","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516","article-title":"Gout-Associated Uric Acid Crystals Activate the NALP3 Inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156995","article-title":"Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Sci (New York NY)"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1631","article-title":"Silica Crystals and Aluminum Salts Activate the NALP3 Inflammasome Through Phagosomal Destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2022","article-title":"Fatty Acid-Induced NLRP3-ASC Inflammasome Activation Interferes With Insulin Signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/nature08938","article-title":"NLRP3 Inflammasomes are Required for Atherogenesis and Activated by Cholesterol Crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The Inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.645549","article-title":"Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase","volume":"290","author":"Han","year":"2015","journal-title":"J Biol Chem"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13727","article-title":"The E3 Ubiquitin Ligase TRIM31 Attenuates NLRP3 Inflammasome Activation by Promoting Proteasomal Degradation of NLRP3","volume":"7","author":"Song","year":"2016","journal-title":"Nat Commun"},{"key":"B73","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cell.2014.11.047","article-title":"Dopamine Controls Systemic Inflammation Through Inhibition of NLRP3 Inflammasome","volume":"160","author":"Yan","year":"2015","journal-title":"Cell"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700184","article-title":"ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages","volume":"199","author":"Kawashima","year":"2017","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B75","doi-asserted-by":"publisher","first-page":"e100376","DOI":"10.15252\/embj.2018100376","article-title":"ABRO1 Promotes NLRP3 Inflammasome Activation Through Regulation of NLRP3 Deubiquitination","volume":"38","author":"Ren","year":"2019","journal-title":"EMBO J"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.11.009","article-title":"Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity","volume":"49","author":"Py","year":"2013","journal-title":"Mol Cell"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008335","article-title":"STING Promotes NLRP3 Localization in ER and Facilitates NLRP3 Deubiquitination to Activate the Inflammasome Upon HSV-1 Infection","volume":"16","author":"Wang","year":"2020","journal-title":"PloS Pathogens"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.853194\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T08:09:23Z","timestamp":1657008563000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.853194\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,5]]},"references-count":77,"alternative-id":["10.3389\/fimmu.2022.853194"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.853194","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,5]]},"article-number":"853194"}}