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Immunol."],"abstract":"<jats:p>D-mannose can be transported into a variety of cells <jats:italic>via<\/jats:italic> glucose transporter (GLUT), and supraphysiological levels of D-mannose impairs tumor growth and modulates immune cell function through mechanisms such as interference with glycolysis and induction of oxidative stress. Blood-stage <jats:italic>Plasmodium<\/jats:italic> mainly depends on glycolysis for energy supply and pathological immune response plays a vital role in cerebral malaria. However, it is not clear whether mannose affects malaria blood-stage infection. Here, we fed D-mannose to <jats:italic>Plasmodium berghei<\/jats:italic>-infected mice and found weight loss and reduced parasitemia without apparent side effects. Compromised parasitemia in C57BL\/6 mice was accompanied by an increase in splenic macrophages compared to an untreated group. When mannose was applied to a rodent experimental cerebral malaria (ECM) model, the incidence of ECM decreased. Expression of activation marker CD69 on T cells in peripheral blood and the brain were reduced, and cerebral migration of activated T cells was prevented by decreased expression of CXCR3. These findings suggest that mannose inhibits <jats:italic>Plasmodium<\/jats:italic> infection by regulating multiple host immune responses and could serve as a potential strategy for facilitating malaria treatment.<\/jats:p>","DOI":"10.3389\/fimmu.2022.859228","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T13:20:14Z","timestamp":1663939214000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Mannose inhibits Plasmodium parasite growth and cerebral malaria development\u00a0via regulation of host immune 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