{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:29:23Z","timestamp":1793179763820,"version":"4.5.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:00:00Z","timestamp":1649030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The pathogenesis of the prototypical chronic autoimmune disorder primary Sj\u00f6gren syndrome (pSS) has been thought to be B-cell-centric, based on serum autoantibodies, the increased risk of B cell lymphoma, and altered B cell subsets in patients with pSS. Over the last 10 years, therapies targeting B cells have been investigated for pSS; however, current evidence for the efficacy of B cell targeted therapies in pSS is still sparse. Mesenchymal stem cells (MSCs) might represent a promising strategy for cell therapy of autoimmune diseases <jats:italic>via<\/jats:italic> regulation of immune cells. MSC-released exosomes carry various bioactive molecules and thus have been studied in MSC-based therapy. The newly discovered labial gland MSCs (LGMSCs) have exhibited enhanced performance. Herein, we aimed to determine the effects of LGMSC-derived exosomes (LGMSC-Exos) on the symptoms of a mouse model of pSS and their regulatory effect and mechanism on B cell subsets. <jats:italic>In vivo<\/jats:italic>, treatment of the spontaneous mouse model of pSS with LGMSC-Exos resulted in reduced inflammatory infiltration and restored saliva secretion in salivary glands. <jats:italic>In vitro<\/jats:italic>, coculture of LGMSC-Exos with peripheral blood mononuclear cells of patients with pSS markedly reduced the proportions of CD19<jats:sup>+<\/jats:sup>CD20<jats:sup>-<\/jats:sup>CD27<jats:sup>+<\/jats:sup>CD38<jats:sup>+<\/jats:sup> plasma cells among peripheral blood mononuclear cells. Further investigations provided evidence that LGMSC-Exo-derived microRNA-125b affected plasma cells of pSS by directly binding to its target gene, <jats:italic>PRDM1<\/jats:italic> (PR domain zinc finger protein 1, also known as BLIMP1), which might be developed as a target to treat pSS. Overall, these findings provided a possible exploitable therapeutic target in pSS and provide new insights into the potential therapeutic application of exosomes in pSS and other disease mediated by B-cells.<\/jats:p>","DOI":"10.3389\/fimmu.2022.871096","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T08:08:31Z","timestamp":1649059711000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":58,"title":["Labial Gland Mesenchymal Stem Cell Derived Exosomes-Mediated miRNA-125b Attenuates Experimental Sjogren\u2019s Syndrome by Targeting PRDM1 and Suppressing Plasma Cells"],"prefix":"10.3389","volume":"13","author":[{"given":"Yixiao","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1702514","article-title":"Primary Sjogren's Syndrome","volume":"378","author":"Mariette","year":"2018","journal-title":"N Engl J Of Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00634-x","article-title":"Current and Future Therapies for Primary Sj\u00f6gren Syndrome","volume":"17","author":"Seror","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.23736\/S0031-0808.20.04079-3","article-title":"Novel Insights on Lymphoma and Lymphomagenesis in Primary Sj\u00f6gren's Syndrome","volume":"63","author":"Alunno","year":"2021","journal-title":"Panminerva Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205375","article-title":"Epidemiology of Primary Sj\u00f6gren's Syndrome: A Systematic Review and Meta-Analysis","volume":"74","author":"Qin","year":"2015","journal-title":"Ann Rheumatic Dis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/ar2210","article-title":"B Cells in Sj\u00f6gren's Syndrome: Indications for Disturbed Selection and Differentiation in Ectopic Lymphoid Tissue","volume":"9","author":"Hansen","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278448","article-title":"Autoantibodies Present Before Symptom Onset in Primary Sj\u00f6gren Syndrome","volume":"310","author":"Jonsson","year":"2013","journal-title":"Jama"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.07.003","article-title":"The Role of Ectopic Germinal Centers in the Immunopathology of Primary Sj\u00f6gren's Syndrome: A Systematic Review","volume":"42","author":"Risselada","year":"2013","journal-title":"Semin Arthritis Rheumatism"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13192","article-title":"Sj\u00f6gren Syndrome-Associated Lymphomas: An Update on Pathogenesis and Management","volume":"168","author":"Nocturne","year":"2015","journal-title":"Br J Haematol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.08.001","article-title":"B Cell-Targeted Therapies in Sj\u00f6gren's Syndrome. 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