{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:04:10Z","timestamp":1792886650084,"version":"4.5.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Fibromyalgia (FM) is an idiopathic chronic disease characterized by widespread musculoskeletal pain, hyperalgesia and allodynia, often accompanied by fatigue, cognitive dysfunction and other symptoms. Autoimmunity and neuroinflammatory mechanisms have been suggested to play important roles in the pathophysiology of FM supported by recently identified interferon signatures in affected individuals. However, the contribution of different components in the immune system, such as the B-lymphocytes, in the progression to FM are yet unknown. Furthermore, there is a great need for biomarkers that may improve diagnostics of FM. Herein, we investigated the gene expression profile in peripheral B-cells, as well as a panel of inflammatory serum proteins, in 30 FM patients and 23 healthy matched control individuals. RNA sequence analysis revealed 60 differentially expressed genes when comparing the two groups. The group of FM patients showed increased expression of twenty-five interferon-regulated genes, such as\n                    <jats:italic>S100A8<\/jats:italic>\n                    and\n                    <jats:italic>S100A9, VCAM, CD163, SERPINA1, ANXA1<\/jats:italic>\n                    , and an increased interferon score. Furthermore, FM was associated with elevated levels of 19 inflammatory serum proteins, such as IL8, AXIN1, SIRT2 and STAMBP, that correlated with the FM severity score. Together, the results shows that FM is associated with an interferon signature in B-cells and increased levels of a set of inflammatory serum proteins. Our findings bring further support for immune activation in the pathogenesis of FM and highlight candidate biomarkers for diagnosis and intervention in the management of FM.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2022.874490","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:32:36Z","timestamp":1653525156000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Inflammation and Interferon Signatures in Peripheral B-Lymphocytes and Sera of Individuals With Fibromyalgia"],"prefix":"10.3389","volume":"13","author":[{"given":"Serena","family":"Fineschi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joakim","family":"Klar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin Ayoola","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"Itc33","DOI":"10.7326\/AITC202003030","article-title":"Fibromyalgia","volume":"172","author":"Bair","year":"2020","journal-title":"Ann Intern Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2016.10.004","article-title":"Prevalence of Fibromyalgia: Literature Review Update","volume":"57","author":"Marques","year":"2017","journal-title":"Rev Bras Reumatol Engl Ed"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00506-w","article-title":"Fibromyalgia: An Update on Clinical Characteristics, Aetiopathogenesis and Treatment","volume":"16","author":"Sarzi-Puttini","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"B4","first-page":"3","article-title":"One Year in Review 2019: Fibromyalgia","author":"Atzeni","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/pr9.0000000000000598","article-title":"Diagnostic Confounders of Chronic Widespread Pain: Not Always Fibromyalgia","volume":"2","author":"H\u00e4user","year":"2017","journal-title":"Pain Rep"},{"key":"B6","article-title":"Fibromyalgia Syndrome: Under-, Over- and Misdiagnosis","author":"H\u00e4user","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1097\/j.pain.0000000000001122","article-title":"Inflammation in the Pathophysiology of Neuropathic Pain","volume":"159","author":"Sommer","year":"2018","journal-title":"Pain"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11020156","article-title":"The Search for Biomarkers in Fibromyalgia","volume":"11","author":"Hackshaw","year":"2021","journal-title":"Diagnostics (Basel Switzerland)"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203","article-title":"The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. 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