{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:55:44Z","timestamp":1778648144485,"version":"3.51.4"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Alongside the wide distribution throughout sub Saharan Africa of schistosomiasis, the morbidity associated with this chronic parasitic disease in endemic regions is often coupled with infection-driven immunomodulatory processes which modify inflammatory responses. Early life parasite exposure is theorized to drive immune tolerance towards cognate infection as well as bystander immune responses, beginning with <jats:italic>in utero<\/jats:italic> exposure to maternal infection. Considering that 40 million women of childbearing-age are at risk of infection worldwide, treatment with Praziquantel during pregnancy as currently recommended by WHO could have significant impact on disease outcomes in these populations. Here, we describe the effects of anthelminthic treatment on parasite-induced changes to fetomaternal cross talk in a murine model of maternal schistosomiasis. Praziquantel administration immediately prior to mating lead to clear re-awakening of maternal anti-parasite immune responses, with persistent maternal immune activation that included enhanced anti-schistosome cytokine responses. Clearance of parasites also improved capacity of dams to endure the additional pressure of pregnancy during infection. Maternal treatment also drove lasting functional alterations to immune system development of exposed offspring. Prenatal anthelminthic treatment skewed offspring immune responses towards parasite clearance and reduced morbidity during cognate infection. Maternal treatment also restored offspring protective IgE antibody responses directed against schistosome antigens, which were otherwise suppressed following exposure to untreated maternal infection. This was further associated with enhanced anti-schistosome cytokine responses from treatment-exposed offspring during infection. In the absence of cognate infection, exposed offspring further demonstrated imprinting across cellular populations. We provide further evidence that maternal treatment can restore a more normalized immune profile to such offspring exposed <jats:italic>in utero<\/jats:italic> to parasite infection, particularly in B cell populations, which may underlie improved responsiveness to cognate infection, and support the WHO recommendation of anthelminthic treatment during pregnancy.<\/jats:p>","DOI":"10.3389\/fimmu.2022.878029","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T15:11:08Z","timestamp":1656342668000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Praziquantel Reduces Maternal Mortality and Offspring Morbidity by Enhancing Anti-Helminthic Immune Responses"],"prefix":"10.3389","volume":"13","author":[{"given":"Matthew","family":"Lacorcia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9ka","family":"Kugyelka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenz","family":"Spechtenhauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich Fabien","family":"Prodjinotho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssef","family":"Hamway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Spangenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarissa Prazeres","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70771-6","article-title":"Helminth Therapy or Elimination: Epidemiological, Immunological, and Clinical Considerations","volume":"14","author":"Wammes","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03158","article-title":"Modulation of Allergic Reactivity in Humans Is Dependent on Schistosoma Mansoni Parasite Burden, Low Levels of IL-33 or TNF-Alpha and High Levels of IL-10 in Serum","volume":"9","author":"Resende","year":"2018","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009260","article-title":"Maternal Schistosomiasis Impairs Offspring Interleukin-4 Production and B Cell Expansion","volume":"17","author":"Cortes-Selva","year":"2021","journal-title":"PLoS Pathog"},{"key":"B4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00436-010-1839-5","article-title":"Influence of Maternal Schistosomiasis on the Immunity of Adult Offspring Mice","volume":"107","author":"Santos","year":"2010","journal-title":"Parasitol Res"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.02.031","article-title":"Fetomaternal Immune Cross Talk Modifies T-Cell Priming Through Sustained Changes to DC Function","volume":"148","author":"Lacorcia","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"15776","DOI":"10.1038\/s41598-019-52074-z","article-title":"Placental Gene Expression and Antibody Levels of Mother-Neonate Pairs Reveal an Enhanced Risk for Inflammation in a Helminth Endemic Country","volume":"9","author":"Ludwig","year":"2019","journal-title":"Sci Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1590\/0074-02760150293","article-title":"Gestation and Breastfeeding in Schistosomotic Mothers Differently Modulate the Immune Response of Adult Offspring to Postnatal Schistosoma Mansoni Infection","volume":"111","author":"Santos","year":"2016","journal-title":"Memorias Do Instituto Oswaldo Cruz"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.647","article-title":"Placental and Oral Delivery of Schistosoma Mansoni Antigen From Infected Mothers to Their Newborns and Children","volume":"68","author":"Attallah","year":"2003","journal-title":"Am J Trop Med Hygiene"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-006-0127-x","article-title":"Susceptibility of Neonate Mice Born to Schistosoma Mansoni-Infected and Noninfected Mothers to Subsequent S. 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