{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:36:23Z","timestamp":1790840183049,"version":"4.1.0"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    T-lymphocytes play crucial roles for maintaining immune homeostasis by fighting against various pathogenic microorganisms and establishing self-antigen tolerance. They will go through several stages and checkpoints in the thymus from progenitors to mature T cells, from CD4\n                    <jats:sup>-<\/jats:sup>\n                    CD8\n                    <jats:sup>-<\/jats:sup>\n                    double negative (DN) cells to CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    double positive (DP) cells, finally become CD4\n                    <jats:sup>+<\/jats:sup>\n                    or CD8\n                    <jats:sup>+<\/jats:sup>\n                    single positive (SP) cells. The mature SP cells then emigrate out of the thymus and further differentiate into distinct subsets under different environment signals to perform specific functions. Each step is regulated by various transcriptional regulators downstream of T cell receptors (TCRs) that have been extensively studied both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>vitro via<\/jats:italic>\n                    multiple mouse models and advanced techniques, such as single cell RNA sequencing (scRNA-seq) and Chromatin Immunoprecipitation sequencing (ChIP-seq). This review will summarize the transcriptional regulators participating in the early stage of T cell development reported in the past decade, trying to figure out cascade networks in each process and provide possible research directions in the future.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2022.884569","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T04:56:03Z","timestamp":1648702563000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Transcriptional Regulation of Early T-Lymphocyte Development in Thymus"],"prefix":"10.3389","volume":"13","author":[{"given":"Xueyang","family":"Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linrong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00281-020-00830-z","article-title":"The Thymus Medulla and its Control of alphabetaT Cell Development","volume":"43","author":"Cosway","year":"2021","journal-title":"Semin Immunopathol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-1864-8","article-title":"Transcription Factors and Target Genes of Pre-TCR Signaling","volume":"72","author":"Lopez-Rodriguez","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-111315-125324","article-title":"TCR Signal Strength and T Cell Development","volume":"32","author":"Gascoigne","year":"2016","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2014.05.003","article-title":"Fine-Tuning T Cell Receptor Signaling to Control T Cell Development","volume":"35","author":"Fu","year":"2014","journal-title":"Trends Immunol"},{"key":"B5","first-page":"1","article-title":"Consequences of Blocking the Choreography of Double Negative Thymocyte Maturation","volume-title":"Signaling Mechanisms Regulating T Cell Diversity and Function","author":"Barnett","year":"2018"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01838","article-title":"The Thymus in Chagas Disease: Molecular Interactions Involved in Abnormal T-Cell Migration and Differentiation","volume":"11","author":"Perez","year":"2020","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"5605","DOI":"10.1038\/s41598-018-23774-9","article-title":"Global Dynamics of Stage-Specific Transcription Factor Binding During Thymocyte Development","volume":"8","author":"Hosoya","year":"2018","journal-title":"Sci Rep"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1016\/j.immuni.2020.03.019","article-title":"Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes","volume":"52","author":"Lavaert","year":"2020","journal-title":"Immunity"},{"key":"B9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41467-020-20306-w","article-title":"The Order and Logic of CD4 Versus CD8 Lineage Choice and Differentiation in Mouse Thymus","volume":"12","author":"Karimi","year":"2021","journal-title":"Nat Commun"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00426-6","article-title":"How Transcription Factors Drive Choice of the T Cell Fate","volume":"21","author":"Hosokawa","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/sciadv.aaw7313","article-title":"Functional Definition of a Transcription Factor Hierarchy Regulating T Cell Lineage Commitment","volume":"6","author":"Garcia-Perez","year":"2020","journal-title":"Sci Adv"},{"key":"B12","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/s41590-018-0077-3","article-title":"Establishing T Cell Lineage Identity","volume":"19","author":"Visan","year":"2018","journal-title":"Nat Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.immuni.2018.01.012","article-title":"Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells","volume":"48","author":"Johnson","year":"2018","journal-title":"Immunity"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00527-1","article-title":"Exploring the Stage-Specific Roles of Tcf-1 in T Cell Development and Malignancy at Single-Cell Resolution","volume":"18","author":"Wang","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13073-017-0481-6","article-title":"Nuclear Wiskott-Aldrich Syndrome Protein Co-Regulates T Cell Factor 1-Mediated Transcription in T Cells","volume":"9","author":"Kuznetsov","year":"2017","journal-title":"Genome Med"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.226126","article-title":"HES1 and HES4 Have Non-Redundant Roles Downstream of Notch During Early Human T-Cell Development","volume":"106","author":"De Decker","year":"2021","journal-title":"Haematologica"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00954.x","article-title":"From the Cradle to the Grave: Activities of GATA-3 Throughout T-Cell Development and Differentiation","volume":"238","author":"Hosoya","year":"2010","journal-title":"Immunol Rev"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01549-13","article-title":"Fbw7 Targets GATA3 Through Cyclin-Dependent Kinase 2-Dependent Proteolysis and Contributes to Regulation of T-Cell Development","volume":"34","author":"Kitagawa","year":"2014","journal-title":"Mol Cell Biol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01034-10","article-title":"HEB-Deficient T-Cell Precursors Lose T-Cell Potential and Adopt an Alternative Pathway of Differentiation","volume":"31","author":"Braunstein","year":"2011","journal-title":"Mol Cell Biol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/ni927","article-title":"Bcl11b is Required for Differentiation and Survival of \u03b1\u03b2 T Lymphocytes","volume":"4","author":"Wakabayashi","year":"2003","journal-title":"Nat Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.5871","article-title":"Expression of TCR Alpha Beta Partly Rescues Developmental Arrest and Apoptosis of Alpha Beta T Cells in Bcl11b-\/- Mice","volume":"176","author":"Inoue","year":"2006","journal-title":"J Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxr078","article-title":"Transcriptional Control of T-Cell Development","volume":"23","author":"Naito","year":"2011","journal-title":"Int Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2018-0132","article-title":"Alteration of Bcl11b Upon Stimulation of Both the MAP Kinase- and Gsk3-Dependent Signaling Pathways in Double-Negative Thymocytes","volume":"97","author":"Selman","year":"2019","journal-title":"Biochem Cell Biol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122727","article-title":"Interleukin-7 Receptor Mutants Initiate Early T Cell Precursor Leukemia in Murine Thymocyte Progenitors With Multipotent Potential","volume":"211","author":"Treanor","year":"2014","journal-title":"J Exp Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.09.008","article-title":"In Vivo Blockade of T Cell Development Reveals Alternative Pathways for Generation of Intraepithelial Lymphocytes in Mice","volume":"191","author":"Mondoon","year":"2017","journal-title":"Immunol Lett"},{"key":"B26","doi-asserted-by":"publisher","first-page":"11841","DOI":"10.1038\/ncomms11841","article-title":"A Threshold Level of NFATc1 Activity Facilitates Thymocyte Differentiation and Opposes Notch-Driven Leukaemia Development","volume":"7","author":"Klein-Hessling","year":"2016","journal-title":"Nat Commun"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2522","article-title":"Noncanonical NFATc1 Activation in DN Thymocytes","volume":"14","author":"Macian","year":"2013","journal-title":"Nat Immunol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2507","article-title":"An Alternative NFAT-Activation Pathway Mediated by IL-7 is Critical for Early Thymocyte Development","volume":"14","author":"Patra","year":"2013","journal-title":"Nat Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.6.2866","article-title":"Enforced Expression of Runx2 Perturbs T Cell Development at a Stage Coincident With Beta-Selection","volume":"169","author":"Vaillant","year":"2002","journal-title":"J Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1901610","article-title":"Epigenetic Propagation of CD4 Expression is Established by the Cd4 Proximal Enhancer in Helper T Cells","volume":"24","author":"Chong","year":"2010","journal-title":"Genes Dev"},{"key":"B31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1182\/blood-2006-05-021188","article-title":"T-Lymphoid, Megakaryocyte, and Granulocyte Development are Sensitive to Decreases in CBFbeta Dosage","volume":"109","author":"Talebian","year":"2007","journal-title":"Blood"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5796","article-title":"A Genome Wide Transcriptional Model of the Complex Response to Pre-TCR Signalling During Thymocyte Differentiation","volume":"6","author":"Sahni","year":"2015","journal-title":"Oncotarget"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003567","article-title":"Pre-TCR Signaling and CD8 Gene Bivalent Chromatin Resolution During Thymocyte Development","volume":"186","author":"Harker","year":"2011","journal-title":"J Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"dev192203","DOI":"10.1242\/dev.192203","article-title":"The Transcriptional Repressor Bcl6 Promotes Pre-TCR-Induced Thymocyte Differentiation and Attenuates Notch1 Activation","volume":"147","author":"Solanki","year":"2020","journal-title":"Development"},{"key":"B35","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1093\/intimm\/dxv022","article-title":"Fine-Tuning of T-Cell Development by the CD3gamma Di-Leucine-Based TCR-Sorting Motif","volume":"27","author":"Lauritsen","year":"2015","journal-title":"Int Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"435241","DOI":"10.1155\/2012\/435241","article-title":"A Role for Bcl-2 in Notch1-Dependent Transcription in Thymic Lymphoma Cells","volume":"2012","author":"Sionov","year":"2012","journal-title":"Adv Hematol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/ni.3122","article-title":"IL-7 Coordinates Proliferation, Differentiation and Tcra Recombination During Thymocyte Beta-Selection","volume":"16","author":"Boudil","year":"2015","journal-title":"Nat Immunol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100468","article-title":"Long-Distance Regulation of Fetal V\u03b4 Gene Segment TRDV4 by the Tcrd Enhancer","volume":"187","author":"Hao","year":"2011","journal-title":"J Immunol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3232","article-title":"A Discrete Chromatin Loop in the Mouse Tcra-Tcrd Locus Shapes the TCRdelta and TCRalpha Repertoires","volume":"16","author":"Chen","year":"2015","journal-title":"Nat Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500692","article-title":"Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation During Thymocyte Development","volume":"195","author":"Majumder","year":"2015","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-296616","article-title":"Lunatic Fringe Prolongs Delta\/Notch-Induced Self-Renewal of Committed Alphabeta T-Cell Progenitors","volume":"117","author":"Yuan","year":"2011","journal-title":"Blood"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002008","article-title":"Lunatic Fringe Enhances Competition for Delta-Like Notch Ligands But Does Not Overcome Defective Pre-TCR Signaling During Thymocyte Beta-Selection In Vivo","volume":"185","author":"Visan","year":"2010","journal-title":"J Immunol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-835850","article-title":"Stage-Specific Roles for Zmiz1 in Notch-Dependent Steps of Early T-Cell Development","volume":"132","author":"Wang","year":"2018","journal-title":"Blood"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004768","article-title":"SCL, LMO1 and Notch1 Reprogram Thymocytes Into Self-Renewing Cells","volume":"10","author":"Gerby","year":"2014","journal-title":"PloS Genet"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.198","article-title":"FADD Regulates Thymocyte Development at the Beta-Selection Checkpoint by Modulating Notch Signaling","volume":"5","author":"Zhang","year":"2014","journal-title":"Cell Death Dis"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018498","article-title":"Early Growth Response Gene-2 (Egr-2) Regulates the Development of B and T Cells","volume":"6","author":"Li","year":"2011","journal-title":"PloS One"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001430","article-title":"The Nuclear Effector of Wnt-Signaling, Tcf1, Functions as a T-Cell-Specific Tumor Suppressor for Development of Lymphomas","volume":"10","author":"Tiemessen","year":"2012","journal-title":"PloS Biol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070133","article-title":"The Role of the Runx Transcription Factors in Thymocyte Differentiation and in Homeostasis of Naive T Cells","volume":"204","author":"Egawa","year":"2007","journal-title":"J Exp Med"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03230.x","article-title":"Over-Expression of Runx1 Transcription Factor Impairs the Development of Thymocytes From the Double-Negative to Double-Positive Stages","volume":"130","author":"Wong","year":"2010","journal-title":"Immunology"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1475","article-title":"Dynamic Recruitment of Ets1 to Both Nucleosome-Occupied and -Depleted Enhancer Regions Mediates a Transcriptional Program Switch During Early T-Cell Differentiation","volume":"44","author":"Cauchy","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molimm.2017.03.014","article-title":"Expression and Splicing of Ikaros Family Members in Murine and Human Thymocytes","volume":"87","author":"Mitchell","year":"2017","journal-title":"Mol Immunol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1101\/gad.266999.115","article-title":"Regulation of Gene Expression Dynamics During Developmental Transitions by the Ikaros Transcription Factor","volume":"29","author":"Arenzana","year":"2015","journal-title":"Genes Dev"},{"key":"B53","doi-asserted-by":"publisher","first-page":"ra28","DOI":"10.1126\/scisignal.2004545","article-title":"The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells","volume":"7","author":"Geimer Le Lay","year":"2014","journal-title":"Sci Signal"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501916","article-title":"Yin Yang 1 Promotes Thymocyte Survival by Downregulating P53","volume":"196","author":"Chen","year":"2016","journal-title":"J Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-018-0002-6","article-title":"Transcription Factor YY1 is Essential for iNKT Cell Development","volume":"16","author":"Ou","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1RU0814-382","article-title":"CD4+\/CD8+ Double-Positive T Cells: More Than Just a Developmental Stage","volume":"97","author":"Overgaard","year":"2015","journal-title":"J Leukoc Biol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"eaam8939","DOI":"10.1126\/scisignal.aam8939","article-title":"RORgammat Limits the Amount of the Cytokine Receptor Gammac Through the Prosurvival Factor Bcl-xL in Developing Thymocytes","volume":"11","author":"Ligons","year":"2018","journal-title":"Sci Signal"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101205","article-title":"T Cell Factor 1 Regulates Thymocyte Survival via a Ror\u03b3t-Dependent Pathway","volume":"187","author":"Wang","year":"2011","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115803","article-title":"T Cell Factor-1 Controls the Lifetime of CD4+ CD8+ Thymocytes In Vivo and Distal T Cell Receptor \u03b1-Chain Rearrangement Required for NKT Cell Development","volume":"9","author":"Alberola-Ila","year":"2014","journal-title":"PloS One"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0459-y","article-title":"Zeb1 Represses TCR Signaling, Promotes the Proliferation of T Cell Progenitors and is Essential for NK1.1(+) T Cell Development","volume":"18","author":"Zhang","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701085","article-title":"Nur77 Regulates Nondeletional Mechanisms of Tolerance in T Cells","volume":"199","author":"Hu","year":"2017","journal-title":"J Immunol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217532110","article-title":"Murine Thymic Selection Quantified Using a Unique Method to Capture Deleted T Cells","volume":"110","author":"Stritesky","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab389","article-title":"NSrp70 is a Lymphocyte-Essential Splicing Factor That Controls Thymocyte Development","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2301","article-title":"Tespa1 is Involved in Late Thymocyte Development Through the Regulation of TCR-Mediated Signaling","volume":"13","author":"Wang","year":"2012","journal-title":"Nat Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"15732","DOI":"10.1038\/ncomms15732","article-title":"Tespa1 Regulates T Cell Receptor-Induced Calcium Signals by Recruiting Inositol 1,4,5-Trisphosphate Receptors","volume":"8","author":"Liang","year":"2017","journal-title":"Nat Commun"},{"key":"B66","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/s41423-019-0259-4","article-title":"Thymic-Specific Regulation of TCR Signaling by Tespa1","volume":"16","author":"Lyu","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"dev199754","DOI":"10.1242\/dev.199754","article-title":"The Pioneer Transcription Factors Foxa1 and Foxa2 Regulate Alternative RNA Splicing During Thymocyte Positive Selection","volume":"148","author":"Lau","year":"2021","journal-title":"Development"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617669114","article-title":"Gfi1-Foxo1 Axis Controls the Fidelity of Effector Gene Expression and Developmental Maturation of Thymocytes","volume":"114","author":"Shi","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939567","article-title":"Early Growth Response 2 Regulates the Survival of Thymocytes During Positive Selection","volume":"40","author":"Lawson","year":"2010","journal-title":"Eur J Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001179","article-title":"Histone Deacetylase 7 Regulates Cell Survival and TCR Signaling in CD4\/CD8 Double-Positive Thymocytes","volume":"186","author":"Kasler","year":"2011","journal-title":"J Immunol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700203","article-title":"Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation","volume":"199","author":"Michel","year":"2017","journal-title":"J Immunol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500082","article-title":"Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation","volume":"194","author":"Coder","year":"2015","journal-title":"J Immunol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140313","article-title":"Thymic Rejuvenation via FOXN1-Reprogrammed Embryonic Fibroblasts (FREFs) to Counteract Age-Related Inflammation","volume":"5","author":"Oh","year":"2020","journal-title":"JCI Insight"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-013-3014-0","article-title":"Thymic Epithelial Cell Development and Differentiation: Cellular and Molecular Regulation","volume":"4","author":"Sun","year":"2013","journal-title":"Protein Cell"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2011.00014","article-title":"Models of Aire-Dependent Gene Regulation for Thymic Negative Selection","volume":"2","author":"Danso-Abeam","year":"2011","journal-title":"Front Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.05.002","article-title":"Mouse Thymic Epithelial Cell Lines Expressing \"Aire\" and Peripheral Tissue-Specific Antigens Reproduce In Vitro Negative Selection of T Cells","volume":"317","author":"Yamaguchi","year":"2011","journal-title":"Exp Cell Res"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00964","article-title":"Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes","volume":"9","author":"Speck-Hernandez","year":"2018","journal-title":"Front Immunol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13099","article-title":"The Autoimmune Regulator (Aire) Transactivates HLA-G Gene Expression in Thymic Epithelial Cells","volume":"158","author":"Melo-Lima","year":"2019","journal-title":"Immunology"},{"key":"B79","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/s41467-017-00931-8","article-title":"NCoR1 Restrains Thymic Negative Selection by Repressing Bim Expression to Spare Thymocytes Undergoing Positive Selection","volume":"8","author":"Wang","year":"2017","journal-title":"Nat Commun"},{"key":"B80","doi-asserted-by":"publisher","first-page":"15928","DOI":"10.1038\/s41598-017-15918-0","article-title":"The Corepressor NCOR1 Regulates the Survival of Single-Positive Thymocytes","volume":"7","author":"Muller","year":"2017","journal-title":"Sci Rep"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.1RI0418-168R","article-title":"NCOR1-A New Player on the Field of T Cell Development","volume":"104","author":"Muller","year":"2018","journal-title":"J Leukoc Biol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.03.048","article-title":"HDAC3 Is a Master Regulator of mTEC Development","volume":"15","author":"Goldfarb","year":"2016","journal-title":"Cell Rep"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1101\/2021.07.11.451936","article-title":"Regulation of Positive and Negative Selection and TCR Signaling During Thymic T Cell Development by Capicua","volume":"10","author":"Park","year":"2021","journal-title":"Elife"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxy082","article-title":"Plasma Membrane Sphingomyelin Modulates Thymocyte Development by Inhibiting TCR-Induced Apoptosis","volume":"31","author":"Toshima","year":"2019","journal-title":"Int Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.884569\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T04:56:15Z","timestamp":1648702575000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.884569\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,31]]},"references-count":84,"alternative-id":["10.3389\/fimmu.2022.884569"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.884569","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,31]]},"article-number":"884569"}}