{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:29:20Z","timestamp":1788560960950,"version":"build-2803163510"},"reference-count":152,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2021M3A9D3026428, NRF-2021M3A9H3015688"],"award-info":[{"award-number":["NRF-2021M3A9D3026428, NRF-2021M3A9H3015688"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\u03b3\u03b4 T cells are a distinct subset of T cells expressing \u03b3\u03b4 T cell receptor (TCR) rather than \u03b1\u03b2TCR. Since their discovery, the critical roles of \u03b3\u03b4 T cells in multiple physiological systems and diseases have been investigated. \u03b3\u03b4 T cells are preferentially located at mucosal surfaces, such as the gut, although a small subset of \u03b3\u03b4 T cells can circulate the blood. Additionally, a subset of \u03b3\u03b4 T cells reside in the meninges in the central nervous system. Recent findings suggest \u03b3\u03b4 T cells in the meninges have critical roles in brain function and homeostasis. In addition, several lines of evidence have shown \u03b3\u03b4 T cells can infiltrate the brain parenchyma and regulate inflammatory responses in multiple diseases, including neurodegenerative diseases. Although the importance of \u03b3\u03b4 T cells in the brain is well established, their roles are still incompletely understood due to the complexity of their biology. Because \u03b3\u03b4 T cells rapidly respond to changes in brain status and regulate disease progression, understanding the role of \u03b3\u03b4 T cells in the brain will provide critical information that is essential for interpreting neuroimmune modulation. In this review, we summarize the complex role of \u03b3\u03b4 T cells in the brain and discuss future directions for research.<\/jats:p>","DOI":"10.3389\/fimmu.2022.886397","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T01:50:15Z","timestamp":1653529815000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["\u03b3\u03b4 T Cells in Brain Homeostasis and Diseases"],"prefix":"10.3389","volume":"13","author":[{"given":"Jang Hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heung Kyu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/312031a0","article-title":"A Third Type of Murine T-Cell Receptor Gene","volume":"312","author":"Chien","year":"1984","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90140-0","article-title":"Structure, Organization, and Somatic Rearrangement of T Cell Gamma Genes","volume":"40","author":"Hayday","year":"1985","journal-title":"Cell."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800934","article-title":"Gammadelta T Cell Update: Adaptate Orchestrators of Immune Surveillance","volume":"203","author":"Hayday","year":"2019","journal-title":"J Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302145","article-title":"IFN-Gamma-Producing and IL-17-Producing Gammadelta T Cells Differentiate at Distinct Developmental Stages in Murine Fetal Thymus","volume":"192","author":"Shibata","year":"2014","journal-title":"J Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00761","article-title":"Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications","volume":"8","author":"Lawand","year":"2017","journal-title":"Front Immunol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00452-4","article-title":"Gammadelta T Cells in Tissue Physiology and Surveillance","volume":"21","author":"Ribot","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/322836a0","article-title":"Diversity of Murine Gamma Genes and Expression in Fetal and Adult T Lymphocytes","volume":"322","author":"Heilig","year":"1986","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00576-0","article-title":"Function of Gammadelta T Cells in Tumor Immunology and Their Application to Cancer Therapy","volume":"53","author":"Park","year":"2021","journal-title":"Exp Mol Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00985","article-title":"Human Gammadelta T-Cell Control of Mucosal Immunity and Inflammation","volume":"9","author":"McCarthy","year":"2018","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2012.03582.x","article-title":"Understanding the Complexity of Gammadelta T-Cell Subsets in Mouse and Human","volume":"136","author":"Pang","year":"2012","journal-title":"Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01059","article-title":"Origin and Evolution of Dendritic Epidermal T Cells","volume":"9","author":"Sutoh","year":"2018","journal-title":"Front Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900838","article-title":"Meningeal Lymphatics: From Anatomy to Central Nervous System Immune Surveillance","volume":"204","author":"Papadopoulos","year":"2020","journal-title":"J Immunol"},{"key":"B13","first-page":"58","article-title":"Immunity to Homologous Grafted Skin; the Fate of Skin Homografts Transplanted to the Brain, to Subcutaneous Tissue, and to the Anterior Chamber of the Eye","volume":"29","author":"Medawar","year":"1948","journal-title":"Br J Exp Pathol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nature14432","article-title":"Structural and Functional Features of Central Nervous System Lymphatic Vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142290","article-title":"A Dural Lymphatic Vascular System That Drains Brain Interstitial Fluid and Macromolecules","volume":"212","author":"Aspelund","year":"2015","journal-title":"J Exp Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2020.12.040","article-title":"Functional Characterization of the Dural Sinuses as a Neuroimmune Interface","volume":"184","author":"Rustenhoven","year":"2021","journal-title":"Cell."},{"key":"B17","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1146\/annurev-immunol-102319-103410","article-title":"Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease","volume":"38","author":"Alves de Lima","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00508-z","article-title":"Neuromodulation by the Immune System: A Focus on Cytokines","volume":"21","author":"Salvador","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0776-4","article-title":"Meningeal Gammadelta T Cells Regulate Anxiety-Like Behavior via IL-17a Signaling in Neurons","volume":"21","author":"Alves de Lima","year":"2020","journal-title":"Nat Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aay5199","article-title":"Meningeal Gammadelta T Cell-Derived IL-17 Controls Synaptic Plasticity and Short-Term Memory","volume":"4","author":"Ribeiro","year":"2019","journal-title":"Sci Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.580304","article-title":"The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System","volume":"11","author":"Wo","year":"2020","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2265","article-title":"Thymic Emigration: When and How T Cells Leave Home","volume":"181","author":"Weinreich","year":"2008","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0345-y","article-title":"Thymic Development of Unconventional T Cells: How NKT Cells, MAIT Cells and Gammadelta T Cells Emerge","volume":"20","author":"Pellicci","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0304-y","article-title":"Gammadelta TCR Ligands: The Quest to Solve a 500-Million-Year-Old Mystery","volume":"20","author":"Willcox","year":"2019","journal-title":"Nat Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.4161\/onci.22892","article-title":"Tumor Cell Recognition by Gammadelta T Lymphocytes: T-Cell Receptor vs. NK-Cell Receptors","volume":"2","author":"Correia","year":"2013","journal-title":"Oncoimmunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00555","article-title":"Preferential Infiltration of Unique Vgamma9Jgamma2-Vdelta2 T Cells Into Glioblastoma Multiforme","volume":"10","author":"Lee","year":"2019","journal-title":"Front Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510127112","article-title":"Pre-T-Cell Receptor Binds MHC: Implications for Thymocyte Signaling and Selection","volume":"112","author":"Yang","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nri798","article-title":"T-Cell Development and the CD4-CD8 Lineage Decision","volume":"2","author":"Germain","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030050","article-title":"Age-Dependent Requirement for Gammadelta T Cells in the Primary But Not Secondary Protective Immune Response Against an Intestinal Parasite","volume":"198","author":"Ramsburg","year":"2003","journal-title":"J Exp Med"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/335443a0","article-title":"Developmentally Ordered Appearance of Thymocytes Expressing Different T-Cell Antigen Receptors","volume":"335","author":"Havran","year":"1988","journal-title":"Nature"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1084\/jem.20181206","article-title":"Epidermal Gammadelta T Cells Originate From Yolk Sac Hematopoiesis and Clonally Self-Renew in the Adult","volume":"215","author":"Gentek","year":"2018","journal-title":"J Exp Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.immuni.2012.06.003","article-title":"Development of Interleukin-17-Producing Gammadelta T Cells Is Restricted to a Functional Embryonic Wave","volume":"37","author":"Haas","year":"2012","journal-title":"Immunity"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.8","article-title":"Brokering the Peace: The Origin of Intestinal T Cells","volume":"1","author":"Hayday","year":"2008","journal-title":"Mucosal Immunol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00656-1","article-title":"Single-Cell Analysis Reveals the Origins and Intrahepatic Development of Liver-Resident IFN-Gamma-Producing Gammadelta T Cells","volume":"18","author":"Hu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B35","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.157.7.2873","article-title":"Extrathymic Origin of Human Gamma Delta T Cells During Fetal Development","volume":"157","author":"McVay","year":"1996","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01501","article-title":"Development and Selection of the Human Vgamma9Vdelta2(+) T-Cell Repertoire","volume":"9","author":"Willcox","year":"2018","journal-title":"Front Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1922588117","article-title":"Microbial Exposure Drives Polyclonal Expansion of Innate Gammadelta T Cells Immediately After Birth","volume":"117","author":"Ravens","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040800","article-title":"Human Gammadelta TCR Repertoires in Health and Disease","volume":"9","author":"Fichtner","year":"2020","journal-title":"Cells"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190834","article-title":"A Population of Proinflammatory T Cells Coexpresses Alphabeta and Gammadelta T Cell Receptors in Mice and Humans","volume":"217","author":"Edwards","year":"2020","journal-title":"J Exp Med"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072425","article-title":"T Cell Receptor-Instructed Alphabeta Versus Gammadelta Lineage Commitment Revealed by Single-Cell Analysis","volume":"205","author":"Kreslavsky","year":"2008","journal-title":"J Exp Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.immuni.2005.04.003","article-title":"Attenuation of gammadeltaTCR Signaling Efficiently Diverts Thymocytes to the Alphabeta Lineage","volume":"22","author":"Haks","year":"2005","journal-title":"Immunity"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444442","article-title":"Fli-1 Regulates the DN2 to DN3 Thymocyte Transition and Promotes Gammadelta T-Cell Commitment by Enhancing TCR Signal Strength","volume":"44","author":"Smeets","year":"2014","journal-title":"Eur J Immunol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131540","article-title":"The TCR Ligand-Inducible Expression of CD73 Marks Gammadelta Lineage Commitment and a Metastable Intermediate in Effector Specification","volume":"211","author":"Coffey","year":"2014","journal-title":"J Exp Med"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.071","article-title":"Strong TCRgammadelta Signaling Prohibits Thymic Development of IL-17a-Secreting Gammadelta T Cells","volume":"19","author":"Sumaria","year":"2017","journal-title":"Cell Rep"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aas9818","article-title":"Metabolic Signaling Directs the Reciprocal Lineage Decisions of Alphabeta and Gammadelta T Cells","volume":"3","author":"Yang","year":"2018","journal-title":"Sci Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00848-3","article-title":"Distinct Metabolic Programs Established in the Thymus Control Effector Functions of Gammadelta T Cell Subsets in Tumor Microenvironments","volume":"22","author":"Lopes","year":"2021","journal-title":"Nat Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700287","article-title":"IL-1beta and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) Gammadelta T Cells to Gammadeltat17 Cells","volume":"199","author":"Muschaweckh","year":"2017","journal-title":"J Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201744200","article-title":"IL-23 Drives Differentiation of Peripheral Gammadelta17 T Cells From Adult Bone Marrow-Derived Precursors","volume":"18","author":"Papotto","year":"2017","journal-title":"EMBO Rep"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646753","article-title":"Eomes Expression Reports the Progressive Differentiation of IFN-Gamma-Producing Th1-Like Gammadelta T Cells","volume":"47","author":"Lino","year":"2017","journal-title":"Eur J Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abf0125","article-title":"A Fetal Wave of Human Type 3 Effector Gammadelta Cells With Restricted TCR Diversity Persists Into Adulthood","volume":"6","author":"Tan","year":"2021","journal-title":"Sci Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500939","article-title":"PLZF Controls the Development of Fetal-Derived IL-17+Vgamma6+ Gammadelta T Cells","volume":"195","author":"Lu","year":"2015","journal-title":"J Immunol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501921","article-title":"Effector Gammadelta T Cell Differentiation Relies on Master But Not Auxiliary Th Cell Transcription Factors","volume":"196","author":"Barros-Martins","year":"2016","journal-title":"J Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1717","article-title":"CD27 is a Thymic Determinant of the Balance Between Interferon-Gamma- and Interleukin 17-Producing Gammadelta T Cell Subsets","volume":"10","author":"Ribot","year":"2009","journal-title":"Nat Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8464","article-title":"Development of Interleukin-17-Producing Vgamma2+ Gammadelta T Cells Is Reduced by ICOS Signaling in the Thymus","volume":"7","author":"Buus","year":"2016","journal-title":"Oncotarget"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/ng.108","article-title":"Skint1, the Prototype of a Newly Identified Immunoglobulin Superfamily Gene Cluster, Positively Selects Epidermal Gammadelta T Cells","volume":"40","author":"Boyden","year":"2008","journal-title":"Nat Genet"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.722066","article-title":"Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection","volume":"291","author":"Salim","year":"2016","journal-title":"J Biol Chem"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0253-5","article-title":"The gammadeltaTCR Combines Innate Immunity With Adaptive Immunity by Utilizing Spatially Distinct Regions for Agonist Selection and Antigen Responsiveness","volume":"19","author":"Melandri","year":"2018","journal-title":"Nat Immunol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.7.1223","article-title":"The Recognition of the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule, T10, by the Gammadelta T Cell, G8","volume":"185","author":"Crowley","year":"1997","journal-title":"J Exp Med"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay5516","article-title":"Butyrophilin 2A1 Is Essential for Phosphoantigen Reactivity by Gammadelta T Cells","volume":"367","author":"Rigau","year":"2020","journal-title":"Science"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2394","article-title":"Cytomegalovirus and Tumor Stress Surveillance by Binding of a Human Gammadelta T Cell Antigen Receptor to Endothelial Protein C Receptor","volume":"13","author":"Willcox","year":"2012","journal-title":"Nat Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621052114","article-title":"Sensing of Cell Stress by Human Gammadelta TCR-Dependent Recognition of Annexin A2","volume":"114","author":"Marlin","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.356709","article-title":"Target Specificity of an Autoreactive Pathogenic Human Gammadelta-T Cell Receptor in Myositis","volume":"287","author":"Bruder","year":"2012","journal-title":"J Biol Chem"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201270101","article-title":"Gammadelta T-Cell Conference 2012: Close Encounters for the Fifth Time","volume":"42","author":"Silva-Santos","year":"2012","journal-title":"Eur J Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.06.011","article-title":"Gammadelta T Cells Recognize a Microbial Encoded B Cell Antigen to Initiate a Rapid Antigen-Specific Interleukin-17 Response","volume":"37","author":"Zeng","year":"2012","journal-title":"Immunity."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242531","article-title":"The Majority of CD1d-Sulfatide-Specific T Cells in Human Blood Use a Semiinvariant Vdelta1 TCR","volume":"42","author":"Bai","year":"2012","journal-title":"Eur J Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502202","article-title":"Molecular Analysis of Lipid-Reactive Vdelta1 Gammadelta T Cells Identified by CD1c Tetramers","volume":"196","author":"Roy","year":"2016","journal-title":"J Immunol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190580","article-title":"The Human Fetal Thymus Generates Invariant Effector Gammadelta T Cells","volume":"217","author":"Tieppo","year":"2020","journal-title":"J Exp Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aav4036","article-title":"Generation and Molecular Recognition of Melanoma-Associated Antigen-Specific Human Gammadelta T Cells","volume":"3","author":"Benveniste","year":"2018","journal-title":"Sci Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.4.2144","article-title":"Activation of V Gamma 9V Delta 2 T Cells by NKG2D","volume":"175","author":"Rincon-Orozco","year":"2005","journal-title":"J Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838741","article-title":"In Vivo Application of mAb Directed Against the Gammadelta TCR Does Not Deplete But Generates \"Invisible\" Gammadelta T Cells","volume":"39","author":"Koenecke","year":"2009","journal-title":"Eur J Immunol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2773","article-title":"Innate-Like T Cells Straddle Innate and Adaptive Immunity by Altering Antigen-Receptor Responsiveness","volume":"15","author":"Wencker","year":"2014","journal-title":"Nat Immunol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1038\/s41467-020-17557-y","article-title":"Butyrophilin-Like Proteins Display Combinatorial Diversity in Selecting and Maintaining Signature Intraepithelial Gammadelta T Cell Compartments","volume":"11","author":"Jandke","year":"2020","journal-title":"Nat Commun"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010890108","article-title":"Skint-1 is a Highly Specific, Unique Selecting Component for Epidermal T Cells","volume":"108","author":"Barbee","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/343754a0","article-title":"Homing of a Gamma Delta Thymocyte Subset With Homogeneous T-Cell Receptors to Mucosal Epithelia","volume":"343","author":"Itohara","year":"1990","journal-title":"Nature"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2016.48","article-title":"The Majority of Murine Gammadelta T Cells at the Maternal-Fetal Interface in Pregnancy Produce IL-17","volume":"94","author":"Pinget","year":"2016","journal-title":"Immunol Cell Biol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1008","article-title":"Accumulation of IL-17(+) Vgamma6(+) Gammadelta T Cells in Pregnant Mice Is Not Associated With Spontaneous Abortion","volume":"7","author":"Polese","year":"2018","journal-title":"Clin Transl Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4068","article-title":"Commensal Microbiota Affects Ischemic Stroke Outcome by Regulating Intestinal Gammadelta T Cells","volume":"22","author":"Benakis","year":"2016","journal-title":"Nat Med"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.11.012","article-title":"Gammadelta T Cells Contribute to Injury in the Developing Brain","volume":"188","author":"Albertsson","year":"2018","journal-title":"Am J Pathol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016753","article-title":"CCR6 (CC Chemokine Receptor 6) Is Essential for the Migration of Detrimental Natural Interleukin-17-Producing Gammadelta T Cells in Stroke","volume":"48","author":"Arunachalam","year":"2017","journal-title":"Stroke"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.8191","article-title":"A Requirement for the Vgamma1+ Subset of Peripheral Gammadelta T Cells in the Control of the Systemic Growth of Toxoplasma Gondii and Infection-Induced Pathology","volume":"175","author":"Egan","year":"2005","journal-title":"J Immunol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"15632","DOI":"10.1038\/ncomms15632","article-title":"IL-17-Producing Gammadelta T Cells Switch Migratory Patterns Between Resting and Activated States","volume":"8","author":"McKenzie","year":"2017","journal-title":"Nat Commun"},{"key":"B82","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.154.9.4883","article-title":"Increased Frequency of Gamma Delta T Cells in Cerebrospinal Fluid and Peripheral Blood of Patients With Multiple Sclerosis. Reactivity, Cytotoxicity, and T Cell Receptor V Gene Rearrangements","volume":"154","author":"Stinissen","year":"1995","journal-title":"J Immunol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb23114.x","article-title":"Expression of Human Heat-Shock Protein 70 Antigens and Gamma\/Delta T-Cell Receptor Antigens in Human Central Nervous Tissue","volume":"741","author":"Muller","year":"1994","journal-title":"Ann NY Acad Sci"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(99)00204-0","article-title":"Evidence for Gammadelta T Cells With a Restricted Vgamma6 Junctional Region in the Normal Mouse Central Nervous System","volume":"100","author":"Szymanska","year":"1999","journal-title":"J Neuroimmunol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0314","article-title":"The Maternal Interleukin-17a Pathway in Mice Promotes Autism-Like Phenotypes in Offspring","volume":"351","author":"Choi","year":"2016","journal-title":"Science"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/nature23910","article-title":"Maternal Gut Bacteria Promote Neurodevelopmental Abnormalities in Mouse Offspring","volume":"549","author":"Kim","year":"2017","journal-title":"Nature"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/nature11984","article-title":"Induction of Pathogenic TH17 Cells by Inducible Salt-Sensing Kinase SGK1","volume":"496","author":"Wu","year":"2013","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/nature24628","article-title":"Salt-Responsive Gut Commensal Modulates TH17 Axis and Disease","volume":"551","author":"Wilck","year":"2017","journal-title":"Nature."},{"key":"B89","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s12974-019-1666-2","article-title":"Maternal Elevated Salt Consumption and the Development of Autism Spectrum Disorder in the Offspring","volume":"16","author":"Afroz","year":"2019","journal-title":"J Neuroinflamm"},{"key":"B90","doi-asserted-by":"publisher","first-page":"8364","DOI":"10.1038\/s41598-021-87678-x","article-title":"Altered Gut Microbiome and Autism Like Behavior Are Associated With Parental High Salt Diet in Male Mice","volume":"11","author":"Afroz","year":"2021","journal-title":"Sci Rep"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0059-z","article-title":"Dietary Salt Promotes Neurovascular and Cognitive Dysfunction Through a Gut-Initiated TH17 Response","volume":"21","author":"Faraco","year":"2018","journal-title":"Nat Neurosci"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.741518","article-title":"IFNgamma-Producing Gamma\/Delta T Cells Accumulate in the Fetal Brain Following Intrauterine Inflammation","volume":"12","author":"Lewis","year":"2021","journal-title":"Front Immunol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1002\/ana.410300608","article-title":"Peripheral Blood Gamma-Delta T Cells Lyse Fresh Human Brain-Derived Oligodendrocytes","volume":"30","author":"Freedman","year":"1991","journal-title":"Ann Neurol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.3.923","article-title":"Clonal Expansions of Activated Gamma\/Delta T Cells in Recent-Onset Multiple Sclerosis","volume":"90","author":"Shimonkevitz","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(96)00187-7","article-title":"Aggravation of Murine Experimental Allergic Encephalomyelitis by Administration of T-Cell Receptor Gammadelta-Specific Antibody","volume":"73","author":"Kobayashi","year":"1997","journal-title":"J Neuroimmunol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.3.1587","article-title":"Gamma Delta T Cell Regulation of IFN-Gamma Production by Central Nervous System-Infiltrating Encephalitogenic T Cells: Correlation With Recovery From Experimental Autoimmune Encephalomyelitis","volume":"173","author":"Ponomarev","year":"2004","journal-title":"J Immunol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.001","article-title":"Interleukin-1 and IL-23 Induce Innate IL-17 Production From Gammadelta T Cells, Amplifying Th17 Responses and Autoimmunity","volume":"31","author":"Sutton","year":"2009","journal-title":"Immunity"},{"key":"B98","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0165-5728(98)00047-2","article-title":"Mechanism of Gammadelta T Cell-Induced Human Oligodendrocyte Cytotoxicity: Relevance to Multiple Sclerosis","volume":"87","author":"Zeine","year":"1998","journal-title":"J Neuroimmunol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12974-019-1574-5","article-title":"Long-Term Use of Interferon-Beta in Multiple Sclerosis Increases Vdelta1(-)Vdelta2(-)Vgamma9(-) Gammadelta T Cells That Are Associated With a Better Outcome","volume":"16","author":"Maimaitijiang","year":"2019","journal-title":"J Neuroinflamm"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200839176","article-title":"Gammadelta T Cells in EAE: Early Trafficking Events and Cytokine Requirements","volume":"39","author":"Wohler","year":"2009","journal-title":"Eur J Immunol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.623451","article-title":"Lactobacillus Acidipiscis Induced Regulatory Gamma Delta T Cells and Attenuated Experimental Autoimmune Encephalomyelitis","volume":"12","author":"Ren","year":"2021","journal-title":"Front Immunol"},{"key":"B102","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4049\/jimmunol.156.1.5","article-title":"Mice With a Disrupted IFN-Gamma Gene Are Susceptible to the Induction of Experimental Autoimmune Encephalomyelitis (EAE)","volume":"156","author":"Ferber","year":"1996","journal-title":"J Immunol"},{"key":"B103","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.157.8.3223","article-title":"IFN-Gamma Plays a Critical Down-Regulatory Role in the Induction and Effector Phase of Myelin Oligodendrocyte Glycoprotein-Induced Autoimmune Encephalomyelitis","volume":"157","author":"Willenborg","year":"1996","journal-title":"J Immunol"},{"key":"B104","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12974-015-0352-2","article-title":"Evidence for the Involvement of Gamma Delta T Cells in the Immune Response in Rasmussen Encephalitis","volume":"12","author":"Owens","year":"2015","journal-title":"J Neuroinflamm"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135898","article-title":"Microglia Induce Neurotoxic IL-17+ Gammadelta T Cells Dependent on TLR2, TLR4, and TLR9 Activation","volume":"10","author":"Derkow","year":"2015","journal-title":"PloS One"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00368","article-title":"Gammadelta T Cells as Early Sensors of Tissue Damage and Mediators of Secondary Neurodegeneration","volume":"8","author":"Gelderblom","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-412726","article-title":"Neutralization of the IL-17 Axis Diminishes Neutrophil Invasion and Protects From Ischemic Stroke","volume":"120","author":"Gelderblom","year":"2012","journal-title":"Blood."},{"key":"B108","doi-asserted-by":"publisher","first-page":"107678","DOI":"10.1016\/j.intimp.2021.107678","article-title":"Vgamma4 T Cell-Derived IL-17A Is Essential for Amplification of Inflammatory Cascades in Ischemic Brain Tissue After Stroke","volume":"96","author":"Lu","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700533R","article-title":"Choroidal Gammadelta T Cells in Protection Against Retinal Pigment Epithelium and Retinal Injury","volume":"31","author":"Zhao","year":"2017","journal-title":"FASEB J"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.chom.2021.08.004","article-title":"Aberrant Gut-Microbiota-Immune-Brain Axis Development in Premature Neonates With Brain Damage","volume":"29","author":"Seki","year":"2021","journal-title":"Cell Host Microbe"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf7844","article-title":"Skull and Vertebral Bone Marrow Are Myeloid Cell Reservoirs for the Meninges and CNS Parenchyma","volume":"373","author":"Cugurra","year":"2021","journal-title":"Science"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf9277","article-title":"Heterogeneity of Meningeal B Cells Reveals a Lymphopoietic Niche at the CNS Borders","volume":"373","author":"Brioschi","year":"2021","journal-title":"Science"},{"key":"B113","doi-asserted-by":"publisher","first-page":"10928","DOI":"10.1038\/ncomms10928","article-title":"IL-17-Producing Gammadelta T Cells Enhance Bone Regeneration","volume":"7","author":"Ono","year":"2016","journal-title":"Nat Commun"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03225.x","article-title":"Inflammation in Neurodegenerative Diseases","volume":"129","author":"Amor","year":"2010","journal-title":"Immunology"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf7266","article-title":"CD4(+) T Cells Contribute to Neurodegeneration in Lewy Body Dementia","volume":"374","author":"Gate","year":"2021","journal-title":"Science"},{"key":"B116","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41586-019-1895-7","article-title":"Clonally Expanded CD8 T Cells Patrol the Cerebrospinal Fluid in Alzheimer's Disease","volume":"577","author":"Gate","year":"2020","journal-title":"Nature"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1038\/s41467-020-15626-w","article-title":"Alpha-Synuclein-Specific T Cell Reactivity Is Associated With Preclinical and Early Parkinson's Disease","volume":"11","author":"Lindestam Arlehamn","year":"2020","journal-title":"Nat Commun"},{"key":"B118","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/j.celrep.2019.12.097","article-title":"Microglial A20 Protects the Brain From CD8 T-Cell-Mediated Immunopathology","volume":"30","author":"Mohebiany","year":"2020","journal-title":"Cell Rep"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.02.007","article-title":"IL-17 Receptor Signaling and T Helper 17-Mediated Autoimmune Demyelinating Disease","volume":"32","author":"Zepp","year":"2011","journal-title":"Trends Immunol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00012","article-title":"Dissection of the Human T-Cell Receptor Gamma Gene Repertoire in the Brain and Peripheral Blood Identifies Age- and Alzheimer's Disease-Associated Clonotype Profiles","volume":"11","author":"Aliseychik","year":"2020","journal-title":"Front Immunol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.9287","article-title":"High Expression of a Specific T-Cell Receptor Gamma Transcript in Epithelial Cells of the Prostate","volume":"96","author":"Essand","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"B122","doi-asserted-by":"publisher","first-page":"109574","DOI":"10.1016\/j.celrep.2021.109574","article-title":"IL-17 Triggers the Onset of Cognitive and Synaptic Deficits in Early Stages of Alzheimer's Disease","volume":"36","author":"Brigas","year":"2021","journal-title":"Cell Rep"},{"key":"B123","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/0022-510X(94)90154-6","article-title":"Gamma Delta+ T Cells are Increased in Patients With Parkinson's Disease","volume":"121","author":"Fiszer","year":"1994","journal-title":"J Neurol Sci"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.6.2339-2345.1997","article-title":"Impaired Resistance to the Development of Toxoplasmic Encephalitis in Interleukin-6-Deficient Mice","volume":"65","author":"Suzuki","year":"1997","journal-title":"Infect Immun"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63954-5","article-title":"Cerebral Malaria in Mice: Interleukin-2 Treatment Induces Accumulation of Gammadelta T Cells in the Brain and Alters Resistant Mice to Susceptible-Like Phenotype","volume":"158","author":"Haque","year":"2001","journal-title":"Am J Pathol"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.6.3163","article-title":"Gamma\/delta T Cell-Deficient Mice Exhibit Reduced Disease Severity and Decreased Inflammatory Response in the Brain in Murine Neurocysticercosis","volume":"169","author":"Cardona","year":"2002","journal-title":"J Immunol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2008.00430.x","article-title":"Role of Two Distinct Gammadelta T Cell Subsets During West Nile Virus Infection","volume":"53","author":"Welte","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2011.00840.x","article-title":"Vgamma4+ T Cells Regulate Host Immune Response to West Nile Virus Infection","volume":"63","author":"Welte","year":"2011","journal-title":"FEMS Immunol Med Microbiol"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.02.013","article-title":"Redundancy in the Immune System Restricts the Spread of HSV-1 in the Central Nervous System (CNS) of C57BL\/6 Mice","volume":"400","author":"Kastrukoff","year":"2010","journal-title":"Virol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal Analysis Reveals High Prevalence of Epstein-Barr Virus Associated With Multiple Sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-1239863\/v1","article-title":"Clonally Expanded B Cells in Multiple Sclerosis Bind EBV EBNA1 and GlialCAM","volume":"603","author":"Lanz","year":"2022","journal-title":"Nature"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15037","article-title":"Inverse Correlation of Vdelta2(+) T-Cell Recovery With EBV Reactivation After Haematopoietic Stem Cell Transplantation","volume":"180","author":"Liu","year":"2018","journal-title":"Br J Haematol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00105","article-title":"Gammadelta T Cell-Mediated Immunity to Cytomegalovirus Infection","volume":"8","author":"Khairallah","year":"2017","journal-title":"Front Immunol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008596","article-title":"Infectious Hypothesis of Alzheimer Disease","volume":"16","author":"Seaks","year":"2020","journal-title":"PloS Pathog"},{"key":"B135","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.neuron.2018.05.023","article-title":"Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus","volume":"99","author":"Readhead","year":"2018","journal-title":"Neuron"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.11.043","article-title":"Alzheimer's Disease-Associated Beta-Amyloid Is Rapidly Seeded by Herpesviridae to Protect Against Brain Infection","volume":"100","author":"Eimer","year":"2018","journal-title":"Neuron"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3909","article-title":"The Prognostic Landscape of Genes and Infiltrating Immune Cells Across Human Cancers","volume":"21","author":"Gentles","year":"2015","journal-title":"Nat Med"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-00860-7","article-title":"Tumor Hypoxia Represses Gammadelta T Cell-Mediated Antitumor Immunity Against Brain Tumors","volume":"22","author":"Park","year":"2021","journal-title":"Nat Immunol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051305","article-title":"Gammadelta T Cells: The Ideal Tool for Cancer Immunotherapy","volume":"9","author":"Yazdanifar","year":"2020","journal-title":"Cells"},{"key":"B140","doi-asserted-by":"publisher","first-page":"iv1","DOI":"10.1093\/neuonc\/noaa200","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013-2017","volume":"22","author":"Ostrom","year":"2020","journal-title":"Neuro Oncol"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00840","article-title":"Real-World Evidence in Glioblastoma: Stupp's Regimen After a Decade","volume":"10","author":"Lakomy","year":"2020","journal-title":"Front Oncol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0003-5","article-title":"Current State of Immunotherapy for Glioblastoma","volume":"15","author":"Lim","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"B143","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41568-019-0224-7","article-title":"Brain Immunology and Immunotherapy in Brain Tumours","volume":"20","author":"Sampson","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.705580","article-title":"Optimizing T Cell-Based Therapy for Glioblastoma","volume":"12","author":"Karachi","year":"2021","journal-title":"Front Immunol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030751","article-title":"Immunotherapy in Glioblastoma: Current Shortcomings and Future Perspectives","volume":"12","author":"Weenink","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1295903","article-title":"Preclinical Efficacy of Immune-Checkpoint Monotherapy Does Not Recapitulate Corresponding Biomarkers-Based Clinical Predictions in Glioblastoma","volume":"6","author":"Garg","year":"2017","journal-title":"Oncoimmunol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2022.01.006","article-title":"Low Tumor Mutational Burden and Immunotherapy in Gliomas","volume":"8","author":"Brown","year":"2022","journal-title":"Trends Cancer"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2588","article-title":"Human Leukocyte Antigen and Antigen Processing Machinery Component Defects in Astrocytic Tumors","volume":"11","author":"Facoetti","year":"2005","journal-title":"Clin Cancer Res"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2008-111","article-title":"Characterization and Immunotherapeutic Potential of Gammadelta T-Cells in Patients With Glioblastoma","volume":"11","author":"Bryant","year":"2009","journal-title":"Neuro Oncol"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1168554","article-title":"Stereotaxic Administrations of Allogeneic Human Vgamma9Vdelta2 T Cells Efficiently Control the Development of Human Glioblastoma Brain Tumors","volume":"5","author":"Jarry","year":"2016","journal-title":"Oncoimmunol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122387","article-title":"Dynamics of Circulating Gammadelta T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma","volume":"10","author":"Beck","year":"2015","journal-title":"PloS One"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051805","article-title":"Engineered Drug Resistant Gammadelta T Cells Kill Glioblastoma Cell Lines During a Chemotherapy Challenge: A Strategy for Combining Chemo- and Immunotherapy","volume":"8","author":"Lamb","year":"2013","journal-title":"PloS One"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.886397\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T02:55:59Z","timestamp":1675652159000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.886397\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":152,"alternative-id":["10.3389\/fimmu.2022.886397"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.886397","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]},"article-number":"886397"}}