{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:58:31Z","timestamp":1793663911692,"version":"4.5.1"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Persistent arthritis pain after resolution of joint inflammation represents a huge health burden in patients with rheumatoid arthritis (RA). However, the underling mechanisms are poorly understood. We and other groups recently revealed that Fc\u03b3RI, a key immune receptor, is functionally expressed in joint nociceptors. Thus, we investigated a potential role of sensory neuron expressed Fc\u03b3RI in postinflammatory arthritis pain in a mouse model of collagen antibody-induced arthritis (CAIA). Here, we show that global deletion of <jats:italic>Fcgr1<\/jats:italic> significantly attenuated mechanical hyperalgesia in the ankle and hind paw of female mice in both inflammatory and postinflammatory phases of CAIA. No obvious differences in cartilage destruction were observed after resolution of joint inflammation between genotypes. <jats:italic>In situ<\/jats:italic> hybridization (ISH) revealed that a larger proportion of dorsal root ganglion (DRG) neurons expressed <jats:italic>Fcgr1<\/jats:italic> mRNA signal in the late phase of CAIA. Conditional deletion of <jats:italic>Fcgr1<\/jats:italic> in primary sensory neurons produced similar analgesic effects without affecting joint swelling. Knockdown of <jats:italic>Fcgr1<\/jats:italic> expression within DRG in the postinflammatory phase of CAIA alleviated persistent pain. Inflammation within DRG after resolution of joint inflammation in the CAIA model was evidenced by T cell and neutrophil infiltration and upregulated mRNA expression of numerous inflammatory mediators. Yet, such changes were not altered by genetic deletion of <jats:italic>Fcgr1<\/jats:italic>. We suggest that neuroinflammation within the DRG after resolution of joint inflammation might upregulate Fc\u03b3RI signaling in DRG neurons. Sensory neuron expressed Fc\u03b3RI thus merits exploration as a potential target for the treatment of arthritis pain that persists in RA patients in remission.<\/jats:p>","DOI":"10.3389\/fimmu.2022.889286","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T05:08:25Z","timestamp":1656306505000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Sensory Neuron Expressed Fc\u03b3RI Mediates Postinflammatory Arthritis Pain in Female Mice"],"prefix":"10.3389","volume":"13","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Caterina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lintao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38682","article-title":"Subgrouping of Patients With Rheumatoid Arthritis Based on Pain, Fatigue, Inflammation, and Psychosocial Factors","volume":"66","author":"Lee","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/art.37686","article-title":"Collagen Antibody-Induced Arthritis Evokes Persistent Pain With Spinal Glial Involvement and Transient Prostaglandin Dependency","volume":"64","author":"Bas","year":"2012","journal-title":"Arthritis Rheum"},{"key":"B3","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.pain.2010.07.030","article-title":"Characterization of the Acute and Persistent Pain State Present in K\/Bxn Serum Transfer Arthritis","volume":"151","author":"Christianson","year":"2010","journal-title":"Pain"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001394","article-title":"Exploring the Transcriptome of Resident Spinal Microglia After Collagen Antibody-Induced Arthritis","volume":"160","author":"Fernandez-Zafra","year":"2019","journal-title":"Pain"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23749","article-title":"Phenotypic Changes in Dorsal Root Ganglion and Spinal Cord in the Collagen Antibody-Induced Arthritis Mouse Model","volume":"523","author":"Su","year":"2015","journal-title":"J Comp Neurol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001908","article-title":"Imbalance of Proresolving Lipid Mediators in Persistent Allodynia Dissociated From Signs of Clinical Arthritis","volume":"161","author":"Allen","year":"2020","journal-title":"Pain"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03120","article-title":"Sensory Ganglia-Specific Tnf Expression Is Associated With Persistent Nociception After Resolution of Inflammation","volume":"10","author":"Goncalves","year":"2019","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214868","article-title":"Does Immunological Remission, Defined as Disappearance of Autoantibodies, Occur With Current Treatment Strategies? 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