{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:37:26Z","timestamp":1793839046277,"version":"4.6.1"},"reference-count":122,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Modern pharmacological research found that the chemical components of <jats:italic>Curcuma longa L.<\/jats:italic> are mainly curcumin and turmeric volatile oil. Several recent randomized controlled trials (RCT) have shown that curcumin improves symptoms and inflammation in patients with arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pubmed, Cochran Library, CNKI, and other databases were searched to collect the randomized controlled trials (RCTs). Then, the risk of bias of RCTs were assessed and data of RCTs were extracted. Finally, RevMan 5.3 was utilized for meta-analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty-nine (29) RCTs involving 2396 participants and 5 types of arthritis were included. The arthritis included Ankylosing Spondylitis (AS), Rheumatoid Arthritis (RA), Osteoarthritis (OA), Juvenile idiopathic arthritis (JIA) and gout\/hyperuricemia. Curcumin and Curcuma longa Extract were administered in doses ranging from 120 mg to 1500 mg for a duration of 4-36 weeks. In general, Curcumin and Curcuma longa Extract showed safety in all studies and improved the severity of inflammation and pain levels in these arthritis patients. However, more RCTs are needed in the future to elucidate the effect of Curcumin and Curcuma longa Extract supplementation in patients with arthritis, including RA, OA, AS and JIA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Curcumin and Curcuma longa Extract may improve symptoms and inflammation levels in people with arthritis. However, due to the low quality and small quantity of RCTs, the conclusions need to be interpreted carefully.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2022.891822","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T06:32:31Z","timestamp":1658471551000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":129,"title":["Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial"],"prefix":"10.3389","volume":"13","author":[{"given":"Liuting","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiejun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganpeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1080\/01634370802137819","article-title":"Arthritis Pain","volume":"50","author":"Yoon","year":"2008","journal-title":"J Gerontol Soc Work"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2017.04.005","article-title":"Ultrasound in Arthritis","volume":"55","author":"Sudo\u0142-Szopi\u0144ska","year":"2017","journal-title":"Radiol Clin North Am"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-017-0622-4","article-title":"Arthritis Models: Usefulness and Interpretation","volume":"39","author":"Bessis","year":"2017","journal-title":"Semin Immunopathol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2015.04.009","article-title":"Infections and Arthritis","volume":"28","author":"Mathew","year":"2015","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.10.005","article-title":"Update on the Epidemiology, Risk Factors, and Disease Outcomes of Rheumatoid Arthritis","volume":"32","author":"van der Woude","year":"2018","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.10.007","article-title":"Update on the Epidemiology, Risk Factors and Disease Outcomes of Osteoarthritis","volume":"32","author":"O\u2019Neill","year":"2018","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24131","article-title":"2019 American College of Rheumatology\/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee","volume":"72","author":"Kolasinski","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.mcna.2019.10.007","article-title":"Osteoarthritis: Pathology, Diagnosis, and Treatment Options","volume":"104","author":"Abramoff","year":"2020","journal-title":"Med Clin North Am"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2020.12.009","article-title":"Nonpharmacologic Pain Management in Inflammatory Arthritis","volume":"47","author":"Martin","year":"2021","journal-title":"Rheum Dis Clin North Am"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.02.037","article-title":"Osteoarthritis Phenotypes and Novel Therapeutic Targets","volume":"165","author":"VanSpil","year":"2019","journal-title":"BiochemPharmacol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19319","article-title":"Association of Pharmacological Treatments With Long-Term Pain Control in Patients With Knee Osteoarthritis: A Systematic Review and Meta-Analysis","volume":"320","author":"Gregori","year":"2018","journal-title":"JAMA"},{"key":"B14","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1080\/03602532.2019.1687511","article-title":"Systemic Drugs With Impact on Osteoarthritis","volume":"51","author":"Apostu","year":"2019","journal-title":"Drug Metab Rev"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000703","article-title":"Management Issues in Rheumatoid Arthritis-Associated Interstitial Lung Disease","volume":"32","author":"England","year":"2020","journal-title":"CurrOpinRheumatol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2019-001084","article-title":"Management of Fatigue in Rheumatoid Arthritis","volume":"6","author":"Pope","year":"2020","journal-title":"RMD Open"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Novel Treatment Strategies in Rheumatoid Arthritis","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet"},{"key":"B18","doi-asserted-by":"publisher","first-page":"599","DOI":"10.2174\/138945010791011938","article-title":"Goldring MB: NF-kappaB Signaling: Multiple Angles to Target OA","volume":"11","author":"Marcu","year":"2010","journal-title":"Curr Drug Targets"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.06.015","article-title":"Design, Study Quality and Evidence of Analgesic Efficacy in Studies of Drugs in Models of OA Pain: A Systematic Review and a Meta-Analysis","volume":"22","author":"Suokas","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"B20","doi-asserted-by":"publisher","first-page":"ITC1","DOI":"10.7326\/AITC201901010","article-title":"Rheumatoid Arthritis","volume":"170","author":"Sparks","year":"2019","journal-title":"Ann Intern Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0203-8","article-title":"Update on Guidelines for the Treatment of Chronic Musculoskeletal Pain","author":"Schnitzer","year":"2006","journal-title":"Clin Rheumatol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.09.027","article-title":"Side Effects of Methotrexate Therapy for Rheumatoid Arthritis: A Systematic Review","volume":"158","author":"Wang","year":"2018","journal-title":"Eur J Med Chem"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.3390\/ijms22052449","article-title":"Thromboembolic Adverse Drug Reactions in Janus Kinase (JAK) Inhibitors: Does the Inhibitor Specificity Play a Role","volume":"22","author":"Kotyla","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S247827","article-title":"Mechanism of Traditional Chinese Medicine in Treating Knee Osteoarthritis","volume":"13","author":"Wang","year":"2020","journal-title":"J Pain Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2015.06.002","article-title":"Traditional Chinese Medicine in Patients With Osteoarthritis of the Knee","volume":"5","author":"Hou","year":"2015","journal-title":"J Tradit Complement Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3390\/plants10010044","article-title":"Curcuma Longa L. Rhizome Essential Oil From Extraction to Its Agri-Food Applications. A Review","volume":"10","author":"Ib\u00e1\u00f1ez","year":"2020","journal-title":"Plants (Basel)"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1604490","article-title":"The Nanotech Potential of Turmeric (Curcuma Longa L.) in Food Technology: A Review","volume":"60","author":"Serpa Guerra","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.3390\/molecules24162930","article-title":"Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects","volume":"24","author":"Kotha","year":"2019","journal-title":"Molecules"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-46401-5_3","article-title":"Antioxidant and Anti-Inflammatory Properties of Curcumin","volume":"595","author":"Menon","year":"2007","journal-title":"Adv Exp Med Biol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13621","article-title":"Curcumin, the Golden Nutraceutical: Multitargeting for Multiple Chronic Diseases","volume":"174","author":"Kunnumakkara","year":"2017","journal-title":"Br J Pharmacol"},{"key":"B31","article-title":"Chapter 8: Assessing Risk of Bias in Included Studies","volume-title":"Cochrane Handbook or Systematic Reviews of Interventions Version 6.2.0.","author":"Deeks","year":"2021"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2017.0065","article-title":"A Placebo-Controlled Double-Blind Study Demonstrates the Clinical Efficacy of a Novel Herbal Formulation for Relieving Joint Discomfort in Human Subjects With Osteoarthritis of Knee","volume":"21","author":"Karlapudi","year":"2018","journal-title":"J Med Food"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6671","article-title":"Herbal Formulation \"Turmeric Extract, Black Pepper, and Ginger\" Versus Naproxen for Chronic Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Clinical Trial","volume":"34","author":"Heidari-Beni","year":"2020","journal-title":"Phytother Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3410","DOI":"10.1089\/107628002761574635","article-title":"Boswellia\u2013Curcumin Preparation for Treating Knee Osteoarthritis: A Clinical Evaluation","volume":"8","author":"Badria","year":"2022","journal-title":"Altern Complementary Ther"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1661","article-title":"Clinical Evaluation of a Formulation Containing Curcuma Longa and Boswellia Serrata Extracts in the Management of Knee Osteoarthritis","volume":"8","author":"Kizhakkedath","year":"2013","journal-title":"Mol Med Rep"},{"key":"B36","article-title":"Efficacy and Safety of Meriva\u00ae, a Curcumin-Phosphatidylcholine Complex, During Extended Administration in Osteoarthritis Patients","volume":"15","author":"Belcaro","year":"2010","journal-title":"Altern Med Rev"},{"key":"B37","article-title":"Meriva\u00ae+Glucosamine Versus Condroitin+Glucosamine in Patients With Knee Osteoarthritis: An Observational Study","volume":"18","author":"Belcaro","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1097\/HNP.0000000000000152","article-title":"Turmeric (Curcuma Longa): Effects of Curcuma Longa Extracts Compared With Ibuprofen for Reduction of Pain and Functional Improvement in Patients With Knee Osteoarthritis","volume":"30","author":"Ross","year":"2016","journal-title":"Holist NursPract"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2017.3930","article-title":"A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study","volume":"20","author":"Amalraj","year":"2017","journal-title":"J Med Food"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2018.06.001","article-title":"A Novel Bioavailable Hydrogenated Curcuminoids Formulation (CuroWhite\u2122) Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients - A Randomized, Double Blind and Placebo Controlled Study","volume":"9","author":"Jacob","year":"2018","journal-title":"J Tradit Complement Med"},{"key":"B41","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s13075-019-1960-5","article-title":"Bio-Optimized Curcuma Longa Extract is Efficient on Knee Osteoarthritis Pain: A Double-Blind Multicenter Randomized Placebo Controlled Three-Arm Study","volume":"21","author":"Henrotin","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4639","article-title":"A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients With Active Rheumatoid Arthritis","volume":"26","author":"Chandran","year":"2012","journal-title":"Phytother Res"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-012-0163-3","article-title":"Safety and Efficacy of Curcuma Longa Extract in the Treatment of Painful Knee Osteoarthritis: A Randomized Placebo-Controlled Trial","volume":"21","author":"Madhu","year":"2013","journal-title":"Inflammopharmacology"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13688","article-title":"Effect of Curcumin Nanomicelle on the Clinical Symptoms of Patients With Rheumatoid Arthritis: A Randomized, Double-Blind, Controlled Trial","volume":"22","author":"Javadi","year":"2019","journal-title":"Int J Rheum Dis"},{"key":"B45","article-title":"Curcumin Combined With Methotrexate in the Treatment of Rheumatoid Arthritis Bone Destruction","volume":"36","author":"Lin","year":"2019","journal-title":"Tianjin Tradit Chin Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/ptr.7422","article-title":"Effects of Curcumin Supplementation on Metabolic Parameters, Inflammatory Factors and Obesity Values in Women With Rheumatoid Arthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","volume":"2022","author":"Pourhabibi-Zarandi","year":"2022","journal-title":"Phytother Res"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.2174\/1874471013666191223152658","article-title":"The Effect of Nanocurcumin in Improvement of Knee Osteoarthritis: A Randomized Clinical Trial","volume":"16","author":"Hashemzadeh","year":"2007","journal-title":"CurrRheumatol Rev"},{"key":"B48","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12906-017-2062-z","article-title":"Efficacy and Safety of Curcumin and Its Combination With Boswellic Acid in Osteoarthritis: A Comparative, Randomized, Double-Blind, Placebo-Controlled Study","volume":"18","author":"Haroyan","year":"2018","journal-title":"BMC Complement Altern Med"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-014-0633-0","article-title":"Short-Term Effects of Highly-Bioavailable Curcumin for Treating Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Prospective Study","volume":"19","author":"Nakagawa","year":"2014","journal-title":"J Orthop Sci"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-016-0289-9","article-title":"Curcuma Longa Extract Reduces Inflammatory and Oxidative Stress Biomarkers in Osteoarthritis of Knee: A Four-Month, Double-Blind, Randomized, Placebo-Controlled Trial","volume":"24","author":"Srivastava","year":"2016","journal-title":"Inflammopharmacology"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2020.0128","article-title":"Curcumagalactomannoside\/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate\/Glucosamine: Double-Blinded, Randomized Controlled Study","volume":"26","author":"Khanna","year":"2020","journal-title":"J Altern Complement Med"},{"key":"B52","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s13063-019-3327-2","article-title":"Safety and Efficacy of Curcumin Versus Diclofenac in Knee Osteoarthritis: A Randomized Open-Label Parallel-Arm Study","volume":"20","author":"Shep","year":"2019","journal-title":"Trials"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6907","article-title":"Influence of a Low-Dose Supplementation of Curcumagalactomannoside Complex (CurQfen) in Knee Osteoarthritis: A Randomized, Open-Labeled, Active-Controlled Clinical Trial","volume":"35","author":"Thomas","year":"2021","journal-title":"Phytother Res"},{"key":"B54","article-title":"Extract as an Adjuvant Therapy in Primary Knee Osteoarthritis: A Randomized Control Trial","author":"Pinsornsak","year":"2012","journal-title":"J Med Assoc Thai"},{"key":"B55","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12906-020-03105-0","article-title":"The Effect of Curcumin Ointment on Knee Pain in Older Adults With Osteoarthritis: A Randomized Placebo Trial","volume":"20","author":"Jamali","year":"2020","journal-title":"BMC Complement Med Ther"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2008.0186","article-title":"Efficacy and Safety of Curcuma Domestica Extracts in Patients With Knee Osteoarthritis","volume":"15","author":"Kuptniratsaikul","year":"2009","journal-title":"J Altern Complement Med"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S58535","article-title":"Efficacy and Safety of Curcuma Domestica Extracts Compared With Ibuprofen in Patients With Knee Osteoarthritis: A Multicenter Study","volume":"9","author":"Kuptniratsaikul","year":"2014","journal-title":"Clin Interv Aging"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5174","article-title":"Curcuminoid Treatment for Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Trial","volume":"28","author":"Panahi","year":"2014","journal-title":"Phytother Res"},{"key":"B59","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3390\/nu14010041","article-title":"An Investigation Into the Effects of a Curcumin Extract (Curcugen\u00ae) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study","volume":"14","author":"Lopresti","year":"2021","journal-title":"Nutrients"},{"key":"B60","article-title":"Ability of Curcuminoid Compared to Diclofenac Sodium in Reducing the Secretion of Cycloxygenase-2 Enzyme by Synovial Fluid\u2019s Monocytes of Patients With Osteoarthritis","volume":"44","author":"Kertia","year":"2012","journal-title":"Acta Med Indones"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S205390","article-title":"Evaluation of the Efficacy and Safety of Capsule Longvida\u00ae Optimized Curcumin (Solid Lipid Curcumin Particles) in Knee Osteoarthritis: A Pilot Clinical Study","volume":"12","author":"Gupte","year":"2019","journal-title":"J Inflammation Res"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28901","article-title":"The Effects of Nanocurcumin on Treg Cell Responses and Treatment of Ankylosing Spondylitis Patients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","volume":"121","author":"Ahmadi","year":"2020","journal-title":"J Cell Biochem"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1136\/annrheumdis-2018-eular.6431%J","article-title":"FRI0726- HPR Study on the Efficacy of Curcurmin Therapy in Early Stages of Juvenile Oligoarthritis","author":"Ailioaie","year":"2018","journal-title":"Ann Rheumatic Dis"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1136\/annrheumdis-2018-eular.6975%JAnnalsoftheRheumaticDiseases","article-title":"FRI0728-HPR Cost: Reducing and Improving Quality of Life in Juvenile Arthritis by Blue Laser and Ultrabioavailablecurcumin","volume":"77","author":"Aloaic","year":"2018","journal-title":"Annual European Congress of Rheumatology"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1080\/19390211.2020.1757798","article-title":"Effect of Curcumin on Serum Urate in Asymptomatic Hyperuricemia: A Randomized Placebo-Controlled Trial","volume":"18","author":"Bupparenoo","year":"2021","journal-title":"J Diet Suppl"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3109\/19390211.2015.1008611","article-title":"Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial","author":"Panahi","year":"2016","journal-title":"J Diet"},{"key":"B67","article-title":"The Efficacy and Safety of a Combination of Glucosamine Hydrochloride, Chondroitin Sulfate and Bio-Curcumin With Exercise in the Treatment of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"52","author":"Sterzi","year":"2016","journal-title":"Eur J Phys Rehabil Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.7326\/M20-0990","article-title":"Effectiveness of Curcuma Longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial","volume":"173","author":"Wang","year":"2020","journal-title":"Ann Intern Med"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2017.0069.PMID:29028430","article-title":"Curcumin Prevents Osteoarthritis by Inhibiting the Activation of Inflammasome NLRP3","volume":"37","author":"Sun","year":"2017","journal-title":"J Interf Cytok Res"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5674","article-title":"Curcumininhibits Osteoclastogenic Potential in PBMCs From Rheumatoid Arthritis Patients via the Suppression of MAPK\/RANK\/c-Fos\/NFATc1 Signaling Pathways","volume":"14","author":"Shang","year":"2016","journal-title":"Mol Med Rep"},{"key":"B71","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ejpb.2019.01.012","article-title":"Potential Therapeutic Effect of Curcumin Loaded Hyalurosomes Against Inflammatory and Oxidative Processes Involved in the Pathogenesis of Rheumatoid Arthritis: The Use of Fibroblast-Like Synovial Cells Cultured in Synovial Fluid","volume":"136","author":"Manca","year":"2019","journal-title":"Eur J Pharm Biopharm"},{"key":"B72","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.intimp.2019.04.027","article-title":"Curcumin Attenuates Collagen-Induced Rat Arthritis via Anti-Inflammatory and Apoptotic Effects","volume":"72","author":"Wang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1159\/000494537","article-title":"Curcumin Inhibits Polyethylene-Induced Osteolysis via Repressing NF-\u03bab Signaling Pathway Activation","volume":"50","author":"An","year":"2018","journal-title":"Cell PhysiolBiochem"},{"key":"B74","article-title":"Effects of Curcumin on the Expression of HIF-1\u03b1, VEGF and VEGFR in Adjuvant Arthritis Model Rats","volume":"39","author":"Cai","year":"2015","journal-title":"J Shandong Univ Tradit Chin Med"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763","article-title":"The Global Burden of Hip and Knee Osteoarthritis: Estimates From the Global Burden of Disease 2010 Study","volume":"73","author":"Cross","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI Guidelines for the non-Surgical Management of Knee, Hip, and Polyarticular Osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"OsteoarthrCartil"},{"key":"B77","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.joca.2007.06.014","article-title":"OARSI Recommendations for the Management of Hip and Knee Osteoarthritis, Part I: Critical Appraisal of Existing Treatment Guidelines and Systematic Review of Current Research Evidence","volume":"15","author":"Zhang","year":"2007","journal-title":"OsteoarthrCartil"},{"key":"B78","doi-asserted-by":"publisher","first-page":"871","DOI":"10.2174\/1381612825666190402163940","article-title":"Ethnobotany, Phytochemistry and Traditional Uses of Curcuma Spp. And Pharmacological Profile of Two Important Species (C. Longa and C. Zedoaria): A Review","volume":"25","author":"Ayati","year":"2019","journal-title":"Curr Pharm Des"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700354","article-title":"Multi-Targeted Therapy by Curcumin: How Spicy Is it","volume":"52","author":"Goel","year":"2008","journal-title":"Mol Nutr Food Res"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2010.05.019","article-title":"Immunostimulatory Activities of Polysaccharide Extract Isolated From Curcuma Longa","volume":"47","author":"Yue","year":"2010","journal-title":"Int J Biol Macromol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5045","article-title":"Are Curcuminoids Effective C-Reactive Protein-Lowering Agents in Clinical Practice","volume":"28","author":"Sahebkar","year":"2014","journal-title":"Evid Meta-analysis Phytother Res"},{"key":"B82","doi-asserted-by":"publisher","first-page":"71","DOI":"10.4103\/0974-8490.110527","article-title":"Immune-Stimulatory and Anti-Inflammatory Activities of Curcuma Longa Extract and its Polysaccharide Fraction","volume":"5","author":"Chandrasekaran","year":"2013","journal-title":"Pharm Res"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100741","article-title":"Multitargeting by Turmeric, the Golden Spice: From Kitchen to Clinic","volume":"57","author":"Gupta","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2014.04.004","article-title":"Curcumin, a Component of Golden Spice: From Bedside to Bench and Back","volume":"32","author":"Prasad","year":"2014","journal-title":"Biotechnol Adv"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1111\/os.12183","article-title":"Role of Curcumin in Common Musculoskeletal Disorders: A Review of Current Laboratory, Translational, and Clinical Data","volume":"7","author":"Peddada","year":"2015","journal-title":"Orthop Surg"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.03.001","article-title":"Efficacy of Curcumin and Boswellia for Knee Osteoarthritis: Systematic Review and Meta-Analysis","volume":"48","author":"Bannuru","year":"2018","journal-title":"Semin Arthritis Rheumatol"},{"key":"B87","first-page":"43","article-title":"Efficacy and Side Effect of Curcumin for the Treatment of Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials","volume":"32","author":"Wu","year":"2019","journal-title":"Pak J Pharm Sci"},{"key":"B88","doi-asserted-by":"publisher","first-page":"104280","DOI":"10.1016\/j.phrs.2019.104280","article-title":"Oral Turmeric\/Curcumin Effects on Inflammatory Markers in Chronic Inflammatory Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"146","author":"White","year":"2019","journal-title":"Pharmacol Res"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206914","article-title":"Paracetamol: not as safe as we thought? A systematic literature review of observational studies","volume":"75","author":"Roberts","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"B90","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3892\/br.2014.262","article-title":"Effects of Tripterygium Glycosides on Interleukin-17 and CD4+CD25+CD127low Regulatory T-Cell Expression in the Peripheral Blood of Patients With Ankylosing Spondylitis","volume":"2","author":"Ji","year":"2014","journal-title":"BioMed Rep"},{"key":"B91","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1093\/rheumatology\/kev245","article-title":"Ankylosing Spondylitis Patients Display Altered Dendritic Cell and T Cell Populations That Implicate Pathogenic Roles for the IL-23 Cytokine Axis and Intestinal Inflammation","volume":"55","author":"Wright","year":"2015","journal-title":"Rheumatology"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1177\/147323001103900543","article-title":"Inverse Correlation Between CD4+CD25HighCD127low\/\u2013 Regulatory T-Cells and Serum Immunoglobulin A in Patients With New-Onset Ankylosing Spondylitis","volume":"39","author":"Zhao","year":"2011","journal-title":"J Int Med Res"},{"key":"B93","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/808724","article-title":"Adaptive Immunity in Ankylosing Spondylitis: Phenotype and Functional Alterations of T-Cells Before and During Infliximab Therapy","volume":"2012","author":"Szalay","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3892\/etm.2014.2046","article-title":"T Lymphocyte Subset Imbalances in Patients Contribute to Ankylosing Spondylitis","volume":"9","author":"Wang","year":"2015","journal-title":"Exp Ther Med"},{"key":"B95","doi-asserted-by":"publisher","first-page":"37559","DOI":"10.1038\/srep37559","article-title":"Functional Defects in CD4+ CD25high FoxP3+ Regulatory Cells in Ankylosing Spondylitis","volume":"6","author":"Guo","year":"2016","journal-title":"Sci Rep"},{"key":"B96","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/ar3257","article-title":"Reduced Immunomodulation Potential of Bone Marrow-Derived Mesenchymal Stem Cells Induced CCR4+ CCR6+ Th\/Treg Cell Subset Imbalance in Ankylosing Spondylitis","volume":"13","author":"Wu","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"B97","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s10875-012-9774-0","article-title":"Levels of Circulating Th17 Cells and Regulatory T Cells in Ankylosing Spondylitis Patients With an Inadequate Response to Anti-TNF-\u03b1 Therapy","volume":"33","author":"Xueyi","year":"2013","journal-title":"J Clin Immunol"},{"key":"B98","first-page":"19302","article-title":"Assessment of Ankylosing Spondylitis by Serum Cytokine Profile","volume":"9","author":"Zhong","year":"2016","journal-title":"Int J Clin Exp Med"},{"key":"B99","doi-asserted-by":"publisher","first-page":"461","DOI":"10.5114\/ceji.2015.56970","article-title":"Treatment of Low Doses Curcumin Could Modulate Th17\/Treg Balance Specifically on CD4+ T Cell Cultures of Systemic Lupus Erythematosus Patients","volume":"40","author":"Handono","year":"2015","journal-title":"Cent Eur J Immunol"},{"key":"B100","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.pcl.2018.04.005","article-title":"Systemic Juvenile Idiopathic Arthritis","volume":"65","author":"Lee","year":"2018","journal-title":"Pediatr Clin North Am"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2019.108322","article-title":"Juvenile Idiopathic Arthritis-Associated Uveitis","volume":"211","author":"Sen","year":"2020","journal-title":"Clin Immunol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2018.03.005","article-title":"Juvenile Idiopathic Arthritis: Oligoarthritis and Polyarthritis","volume":"65","author":"Crayne","year":"2018","journal-title":"Pediatr Clin North Am"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60244-4","article-title":"Juvenile Idiopathic Arthritis","volume":"377","author":"Prakken","year":"2011","journal-title":"Lancet"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1177\/1120672119892804","article-title":"Oral Phospholipidic Curcumin in Juvenile Idiopathic Arthritis-Associated Uveitis","volume":"30","author":"Miserocchi","year":"2020","journal-title":"Eur J Ophthalmol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2016.10.019","article-title":"Gout: Diagnosis and Treatment","volume":"148","author":"Sivera","year":"2017","journal-title":"Med Clin (Barc)"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00569-9","article-title":"Gout","volume":"397","author":"Dalbeth","year":"2021","journal-title":"Lancet"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0441-1","article-title":"Global Epidemiology of Gout: Prevalence, Incidence, Treatment Patterns and Risk Factors","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.04.008","article-title":"Gout Epidemiology and Comorbidities","volume":"50","author":"Singh","year":"2020","journal-title":"Semin Arthritis Rheumatol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.845684","article-title":"The Role of the Intestine in the Development of Hyperuricemia","volume":"13","author":"Yin","year":"2022","journal-title":"Front Immunol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1835819","article-title":"Targets and Mechanisms of Dietary Anthocyanins to Combat Hyperglycemia and Hyperuricemia: A Comprehensive Review","volume":"62","author":"Yang","year":"2022","journal-title":"Crit Rev Food Sci Nutr"},{"key":"B111","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s13075-019-1974-z","article-title":"Curcumin Attenuates MSU Crystal-Induced Inflammation by Inhibiting the Degradation of I\u03bab\u03b1 and Blocking Mitochondrial Damage","volume":"21","author":"Chen","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/15.8.1717","article-title":"Inhibitory Effect of Curcumin on Xanthine Dehydrogenase\/Oxidase Induced by Phorbol-12-Myristate-13-Acetate in NIH3T3 Cells","volume":"15","author":"Lin","year":"1994","journal-title":"Carcinogenesis"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1021\/np8007123","article-title":"Inhibition Studies of Bovine Xanthine Oxidase by Luteolin, Silibinin, Quercetin, and Curcumin","volume":"72","author":"Pauff","year":"2009","journal-title":"J Nat Prod"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.09.076","article-title":"Insights Into the Inhibition of Xanthine Oxidase by Curcumin","volume":"19","author":"Shen","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.10.022","article-title":"Discovery of Novel Curcumin Derivatives Targeting Xanthine Oxidase and Urate Transporter 1 as Anti-Hyperuricemic Agents","volume":"25","author":"Ao","year":"2017","journal-title":"Bioorg Med Chem"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.09.013","article-title":"Reduction of Atherogenic Risk in Patients With Type 2 Diabetes by Curcuminoid Extract: A Randomized Controlled Trial","volume":"25","author":"Chuengsamarn","year":"2014","journal-title":"J Nutr Biochem"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000406","article-title":"Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial","volume":"68","author":"Panahi","year":"2016","journal-title":"J Cardiovasc Pharmacol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.2174\/187152012803529736","article-title":"Anti-Cancer Effects of Curcumin on Head and Neck Cancers","volume":"12","author":"Gao","year":"2012","journal-title":"Anticancer Agents Med Chem"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27229","article-title":"Potential Therapeutic Effects of Curcumin in Gastric Cancer","volume":"234","author":"Barati","year":"2019","journal-title":"J Cell Physiol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The Essential Medicinal Chemistry of Curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J Med Chem"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1080\/15376510903200766","article-title":"Safety and Toxicological Evaluation of Demethylatedcurcuminoids;a Novel Standardized Curcumin Product","volume":"19","author":"Krishnaraju","year":"2009","journal-title":"Toxicology Mechanisms and Methods"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.05.008","article-title":"Toxicological Evaluation of pH-Sensitive Nanoparticles of Curcumin:Acute, Sub-Acute and Genotoxicity Studies","volume":"48","author":"Dandekar","year":"2010","journal-title":"Food Chem Toxicol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.891822\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T06:32:44Z","timestamp":1658471564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.891822\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":122,"alternative-id":["10.3389\/fimmu.2022.891822"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.891822","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"article-number":"891822"}}