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Although asymptomatic in the vast majority of cases, <jats:italic>H pylori<\/jats:italic> infection can lead to the development of peptic ulcers gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. Using a variety of mechanisms, <jats:italic>H pylori<\/jats:italic> locally suppresses the function of the host immune system to establish chronic infection. Systemic immunomodulation has been observed in both clinical and pre-clinical studies, which have demonstrated that <jats:italic>H pylori<\/jats:italic> infection is associated with reduced incidence of inflammatory diseases, such as asthma and Crohn\u2019s disease. The introduction of immunotherapies in the arsenal of anti-cancer drugs has revealed a new facet of <jats:italic>H pylori<\/jats:italic>-induced immune suppression. In this review, we will describe the intimate interactions between <jats:italic>H pylori<\/jats:italic> and its host, and formulate hypothtyeses describing the detrimental impact of <jats:italic>H pylori<\/jats:italic> infection on the efficacy of cancer immunotherapies.<\/jats:p>","DOI":"10.3389\/fimmu.2022.899161","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T05:15:30Z","timestamp":1653282930000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["The Efficacy of Cancer Immunotherapies Is Compromised by Helicobacter pylori 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