{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:29:15Z","timestamp":1787938155814,"version":"build-2784847793"},"reference-count":10,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Mucous membrane pemphigoid (MMP) and anti-laminin (LM) \u03b31 pemphigoid, two subtypes of subepidermal autoimmune bullous diseases characterized by autoantibodies against epidermal basement membrane zone proteins, mainly show mucosal and skin lesions, respectively. The known autoantigens of MMP includes BP180, BP230, LM332, integrin \u03b16\u03b24 and type VII collagen, and anti-LM\u03b31 pemphigoid targets LM\u03b31. In this study, we present an unique MMP case with oral mucosal lesions, which showed positive IgA signals on basement membrane zone in indirect immunofluorescence using normal human skin and on dermal side in indirect immunofluorescence using salt-split skin, positive IgA autoantibodies against LM\u03b31 by immunoblotting of epidermal extracts, positive IgA autoantibodies against LM\u03b15 by immunoblotting of LM521 recombinant protein (rLM521) and positive IgG autoantibodies against LM\u03b31 by immunoblotting of rLM111 and rLM521 at first visit (Day 0). After therapy, further serological analyses of serum samples collected at Day 30 and Day 50 indicated that IgA autoantibodies against LM\u03b31 were likely to be pathogenic. These results suggest that LM\u03b31 is another autoantigen of MMP, and our patient might be the first reported case of anti-LM\u03b31 MMP.<\/jats:p>","DOI":"10.3389\/fimmu.2022.903174","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T12:16:45Z","timestamp":1654085805000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Case Report: Mucous Membrane Pemphigoid With IgG and IgA Anti-Laminin \u03b31 Antibodies and IgA Anti-Laminin \u03b15 Antibodies"],"prefix":"10.3389","volume":"13","author":[{"given":"Wenjing","family":"Kuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jaad.2020.05.161","article-title":"Subepithelial 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