{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:18:37Z","timestamp":1793215117100,"version":"4.5.0"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>In recent years, studies of macrophage polarization in atherosclerosis have become an intense area of research. However, there are few bibliometric analyses regarding this area. In this review, we used CiteSpace 5.8.R3 and VOSviewer 1.6.16 software to perform text mining and knowledge-map analysis. We explored the development process, knowledge structure, research hotspots, and potential trends using a bibliometric and knowledge-map analysis to provide researchers with a macroscopic view of this field. The studies concerning macrophage polarization in atherosclerosis were downloaded from the Web of Science Core Collection. A total of 781 studies were identified and published by 954 institutions from 51 countries\/regions. The number of studies of macrophage polarization in atherosclerosis increased over time. <jats:italic>Arteriosclerosis Thrombosis and Vascular Biology<\/jats:italic> published the highest number of articles and was the top co-cited journal. De Winther was the most prolific researcher, and Moore had the most co-citations. The author co-occurrence map illustrated that there was active cooperation among researchers. The most productive countries were the United States and China. Amsterdam University, Harvard University, and Maastricht University were the top three productive institutions in the research field. Keyword Co-occurrence, Clusters, and Burst analysis showed that \u201cinflammation,\u201d \u201cmonocyte,\u201d \u201cNF kappa B,\u201d \u201cmechanism,\u201d and \u201cfoam cell\u201d appeared with the highest frequency in studies. \u201cOxidative stress,\u201d \u201ccoronary heart disease,\u201d and \u201cprevention\u201d were the strongest citation burst keywords from 2019 to 2021.<\/jats:p>","DOI":"10.3389\/fimmu.2022.910444","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T04:31:47Z","timestamp":1655699507000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":77,"title":["A Bibliometric and Knowledge-Map Analysis of Macrophage Polarization in Atherosclerosis From 2001 to 2021"],"prefix":"10.3389","volume":"13","author":[{"given":"Luxia","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runmin","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wende","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-021-02881-1","article-title":"Inflammation Drives Stiffness Mediated Uptake of Lipoproteins in Primary Human Macrophages and Foam Cell Proliferation","volume":"49","author":"Ammanamanchi","year":"2021","journal-title":"Ann BioMed Eng"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S316816","article-title":"Monomeric CRP Aggravates Myocardial Injury After Myocardial Infarction by Polarizing the Macrophage to Pro-Inflammatory Phenotype Through JNK Signaling Pathway","volume":"14","author":"Zha","year":"2021","journal-title":"J Inflammation Res"},{"key":"B3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12865-021-00410-2","article-title":"Differential Polarization and the Expression of Efferocytosis Receptor MerTK on M1 and M2 Macrophages Isolated From Coronary Artery Disease Patients","volume":"22","author":"Idrus","year":"2021","journal-title":"BMC Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1159\/000430106","article-title":"Enhanced M1 and Impaired M2 Macrophage Polarization and Reduced Mitochondria! 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