{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:20:08Z","timestamp":1792790408391,"version":"4.5.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Neutrophil extracellular trap formation (NETosis) has been rarely reported in psoriatic arthritis (PsA). We aimed to explore the involvement of NETosis in the inflammation of PsA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum myeloperoxidase\u2013DNA (MPO-DNA) complex was detected by a modified enzyme-linked immunosorbent assay and compared among 74 patients with PsA, 58 patients with psoriasis (PsO), and 20 healthy controls. The association of MPO\u2013DNA level with disease activity index at baseline and follow-up was analyzed in patients with PsA. Receiver operating characteristic curve was used to evaluate the predictive value of MPO\u2013DNA for treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MPO\u2013DNA complex level in serum was significantly increased in patients with PsA\/PsO compared to healthy controls (<jats:italic>p<\/jats:italic> &amp;lt; 0.001). The level of MPO\u2013DNA was positively associated with DAPSA score and its components (including TJC, SJC, PGA, VAS-pain and CRP, r = 0.25\u20130.409, all <jats:italic>p<\/jats:italic>-values &amp;lt; 0.05). Serum MPO\u2013DNA level was downregualted at 12 weeks after treatment compared to baseline (<jats:italic>p<\/jats:italic> = 0.022). The decrease of MPO\u2013DNA level was more dramatic in patients with PsA who achieved both ACR50 and PASI50 response than those achieving neither of them at 12 weeks (<jats:italic>p<\/jats:italic> = 0.023). ROC analysis revealed that the serum MPO\u2013DNA level predicted both ACR50 and PASI50 achievement at week 12 (<jats:italic>p<\/jats:italic> = 0.04; 95% CIs, 0.56\u20130.94). Moreover, the baseline MPO\u2013DNA level (<jats:italic>p<\/jats:italic> = 0.009; 95% CIs, 0.748\u20131) and change of MPO\u2013DNA at week 12 from baseline (<jats:italic>p<\/jats:italic> = 0.004; 95% CIs, 0.802\u20131) were associated with the achievement of both ACR70 and PASI75 response at week 24.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NETosis plays an important role in psoriatic diseases. The level of MPO\u2013DNA complex in serum reflects disease activity. Serum MPO\u2013DNA complex may be a useful biomarker to predict the therapeutic response in PsA.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2022.911347","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T15:10:40Z","timestamp":1655219440000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["NETosis in Psoriatic Arthritis: Serum MPO\u2013DNA Complex Level Correlates With Its Disease 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