{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T22:30:32Z","timestamp":1772490632891,"version":"3.50.1"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41806153"],"award-info":[{"award-number":["41806153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The effects of <jats:italic>Laminaria japonica<\/jats:italic> fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work. Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum. Moreover, LF could regulate intestinal flora composition, increasing the abundance of <jats:italic>Lactobacillaceae<\/jats:italic> and <jats:italic>Alistipes<\/jats:italic>, and inhibiting <jats:italic>Erysipelotrichia<\/jats:italic>, <jats:italic>Turicibacter<\/jats:italic>, <jats:italic>Romboutsia<\/jats:italic>, <jats:italic>Peptostreptococcaceae<\/jats:italic>, and <jats:italic>Faecalibaculum<\/jats:italic>. These results were positively correlated with immune characteristics. Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders.<\/jats:p>","DOI":"10.3389\/fimmu.2022.916618","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T05:34:20Z","timestamp":1652938460000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated 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