{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:22:22Z","timestamp":1793658142398,"version":"4.5.1"},"reference-count":173,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009580","name":"General Hospital of People\u2019s Liberation Army","doi-asserted-by":"publisher","award":["18CXZ026"],"award-info":[{"award-number":["18CXZ026"]}],"id":[{"id":"10.13039\/501100009580","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Acute lung injury (ALI)\/acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with high morbidity and mortality that poses a major challenge in critical care medicine. The development of ALI\/ARDS involves excessive inflammatory response, and macrophage autophagy plays an important role in regulating the inflammatory response in ALI\/ARDS. In this paper, we review the effects of autophagy in regulating macrophage function, discuss the roles of macrophage autophagy in ALI\/ARDS, and highlight drugs and other interventions that can modulate macrophage autophagy in ALI\/ARDS to improve the understanding of the mechanism of macrophage autophagy in ALI\/ARDS and provide new ideas and further research directions for the treatment of ALI\/ARDS.<\/jats:p>","DOI":"10.3389\/fimmu.2022.922702","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T02:21:06Z","timestamp":1660789266000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":51,"title":["Progress in preclinical studies of macrophage autophagy in the regulation of 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