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A mouse model of sterile inflammation that involves bone resorption was used to examine endogenous RvD1 kinetics during inflammation. Application of exogenous RvD1 significantly inhibited bone remodeling <jats:italic>via<\/jats:italic> osteoclast reduction, alongside an anti-inflammatory secretome shift, increased macrophages recruitment and reduction of T-cytotoxic cells. <jats:italic>In vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>, RvD1 led to significant reduction in RANK expression which reduce osteoclastogenesis in a dose-dependent manner. 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