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Immunol."],"abstract":"<jats:p>\n                    The targeted inhibition of effector cytokines such as interleukin 17 (IL-17) in psoriasis and IL-13 in atopic dermatitis offers impressive efficacy with a favorable side effect profile. In contrast, the downregulation of interferon gamma (IFN-\u03b3) in T helper (Th) 1-dominant skin disorders may lead to more adverse events, given the crucial role of IFN-\u03b3 in antiviral and antitumoral immunity. Modulating Th17 and Th2 cell differentiation is performed by blocking IL-23 and IL-4, respectively, whereas anti-IL-12 antibodies are only moderately effective in downregulating Th1 lymphocyte differentiation. Therefore, a targeted approach of IFN-\u03b3-driven disorders remains challenging. Recent literature suggests that certain pathogenic Th17 cell subsets with Th1 characteristics, such as CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD161\n                    <jats:sup>+<\/jats:sup>\n                    CCR6\n                    <jats:sup>+<\/jats:sup>\n                    CXCR3\n                    <jats:sup>+<\/jats:sup>\n                    IL-17\n                    <jats:sup>+<\/jats:sup>\n                    IFN-y\n                    <jats:sup>+<\/jats:sup>\n                    (Th17.1) and CD4\n                    <jats:sup>+<\/jats:sup>\n                    CD161\n                    <jats:sup>+<\/jats:sup>\n                    CCR6\n                    <jats:sup>+<\/jats:sup>\n                    CXCR3\n                    <jats:sup>+<\/jats:sup>\n                    IL-17\n                    <jats:sup>-<\/jats:sup>\n                    IFN-y\n                    <jats:sup>+<\/jats:sup>\n                    (exTh17), are important contributors in Th1-mediated autoimmunity. Differentiation to a Th17.1 or exTh17 profile results in the upregulation of IFN-y. Remarkably, these pathogenic Th17 cell subsets are resistant to glucocorticoid therapy and the dampening effect of regulatory T cells (Treg). The identification of Th17.1\/exTh17 cells in auto-immune disorders may explain the frequent treatment failure of conventional immunosuppressants. In this review, we summarize the current evidence regarding the cellular plasticity of Th17 cells in inflammatory skin disorders. A deeper understanding of this phenomenon may lead to better insights into the pathogenesis of various skin diseases and the discovery of a potential new treatment target.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2022.932265","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T07:31:52Z","timestamp":1658993512000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":43,"title":["From IL-17 to IFN-\u03b3 in inflammatory skin disorders: Is transdifferentiation a potential treatment target?"],"prefix":"10.3389","volume":"13","author":[{"given":"Arno","family":"Belpaire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanja","family":"van 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