{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:56:20Z","timestamp":1781708180618,"version":"3.54.5"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Control of tuberculosis depends on the rapid expression of protective CD4<jats:sup>+<\/jats:sup> T-cell responses in the <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (Mtb)-infected lungs. We have recently shown that the immunomodulatory cytokine IL-10 acts intrinsically in CD4<jats:sup>+<\/jats:sup> T cells and impairs their parenchymal migratory capacity, thereby preventing control of Mtb infection. Herein, we show that IL-10 overexpression does not impact the protection conferred by the established memory CD4<jats:sup>+<\/jats:sup> T-cell response, as BCG-vaccinated mice overexpressing IL-10 only during Mtb infection display an accelerated, BCG-induced, Ag85b-specific CD4<jats:sup>+<\/jats:sup> T-cell response and control Mtb infection. However, IL-10 inhibits the migration of recently activated ESAT-6-specific CD4<jats:sup>+<\/jats:sup> T cells into the lung parenchyma and impairs the development of ectopic lymphoid structures associated with reduced expression of the chemokine receptors CXCR5 and CCR7. Together, our data support a role for BCG vaccination in preventing the immunosuppressive effects of IL-10 in the fast progression of Mtb infection and may provide valuable insights on the mechanisms contributing to the variable efficacy of BCG vaccination.<\/jats:p>","DOI":"10.3389\/fimmu.2022.946181","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T05:55:30Z","timestamp":1658469330000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["IL-10 Overexpression After BCG Vaccination Does Not Impair Control of Mycobacterium tuberculosis Infection"],"prefix":"10.3389","volume":"13","author":[{"given":"Catarina M.","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Micheli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palmira","family":"Barreira-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Margarida","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Resende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Vilanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Silvestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostinho","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Correia-Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio Gil","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eg\u00eddio","family":"Torrado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"B1","volume-title":"Global Tuberculosis Report","year":"2021"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68507-3","article-title":"Effect of BCG Vaccination on Childhood Tuberculous Meningitis and Miliary Tuberculosis Worldwide: A Meta-Analysis and Assessment of Cost-Effectiveness","volume":"367","author":"Trunz","year":"2006","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2016.1170599","article-title":"Why Don\u2019t We Have an Effective Tuberculosis Vaccine Yet","volume":"15","author":"Davenne","year":"2016","journal-title":"Expert Rev Vaccines"},{"key":"B4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1542\/peds.96.1.29","article-title":"The Efficacy of Bacillus Calmette-Gu\u00e9rin Vaccination of Newborns and Infants in the Prevention of Tuberculosis: Meta-Analyses of the Published Literature","volume":"96","author":"Colditz","year":"1995","journal-title":"Pediatrics"},{"key":"B5","article-title":"Does the Efficacy of BCG Decline With Time Since Vaccination","volume":"2","author":"Sterne","year":"1998","journal-title":"Int J Tuberc Lung Dis"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714021","article-title":"Prevention of M. 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