{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:52:11Z","timestamp":1793904731547,"version":"4.8.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The intestine is the largest digestive and immune organ in the human body, with an intact intestinal mucosal barrier. <jats:italic>Bifidobacterium longum<\/jats:italic> is the specific gut commensals colonized in the human gut for boosting intestinal immunity to defend against intestinal mucosal immune injury. In the LPS-induced intestinal injury model, the <jats:italic>Bifidobacterium longum<\/jats:italic> BL-10 was suggested to boost the intestinal immune. Detailly, compared with the LPS-induced mice, the BL10 group significantly reduced intestine (jejunum, ileum, and colon) tissue injury, pro-inflammatory cytokines (TNF-\u03b1, IFN-\u03b3, IL-2, IL-6, IL-17, IL-22, and IL-12) levels and myeloperoxidase activities. Moreover, the <jats:italic>B. longum<\/jats:italic> BL-10 significantly increased the number of immunocytes (CD4+ T cells, IgA plasma cells) and the expression of tight junction protein (Claudin1 and Occludin). <jats:italic>B. longum<\/jats:italic> BL-10 regulated the body\u2019s immune function by regulating the Th1\/Th2 and Th17\/Treg balance, which showed a greater impact on the Th1\/Th2 balance. Moreover, the results also showed that <jats:italic>B. longum<\/jats:italic> BL-10 significantly down-regulated the intestinal protein expression of TLR4, <jats:italic>p<\/jats:italic>-I\u03baB, and NF-\u03baB p65. The <jats:italic>B. longum<\/jats:italic> BL-10 increased the relative abundance of the genera, including <jats:italic>Lachnospiraceae_<\/jats:italic>NK4A136_group and <jats:italic>Clostridia_<\/jats:italic>UCG-014, which were related to declining the levels of intestinal injury. Overall, these results indicated that the <jats:italic>B. longum<\/jats:italic> BL-10 had great functionality in reducing LPS-induced intestinal mucosal immune injury.<\/jats:p>","DOI":"10.3389\/fimmu.2022.947755","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T10:41:51Z","timestamp":1661337711000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":61,"title":["Immunomodulatory effects of the Bifidobacterium longum BL-10 on lipopolysaccharide-induced intestinal mucosal immune 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