{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T06:16:20Z","timestamp":1793513780767,"version":"4.5.0"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Hexavalent chromium [Cr(VI)] is a dangerous heavy metal which can impair the gastrointestinal system in various species; however, the processes behind Cr(VI)-induced intestinal barrier damage are unknown. Forty-eight healthy 1-day-old ducks were stochastically assigned to four groups and fed a basal ration containing various Cr(VI) dosages for 49 days. Results of the study suggested that Cr(VI) exposure could significantly increase the content of Cr(VI) in the jejunum, increase the level of diamine oxidase (DAO) in serum, affect the production performance, cause histological abnormalities (shortening of the intestinal villi, deepening of the crypt depth, reduction and fragmentation of microvilli) and significantly reduced the mRNA levels of intestinal barrier-related genes (ZO-1, occludin, claudin-1, and MUC2) and protein levels of ZO-1, occludin, cand laudin-1, resulting in intestinal barrier damage. Furthermore, Cr(VI) intake could increase the contents of hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ) and malondialdehyde (MDA), tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukin-1\u03b2 (IL-1\u03b2), and interleukin-18 (IL-18) but decrease the activities of total superoxide dismutase (T-SOD), catalase (CAT), and glutathione reductase (GR), as well as up-regulate the mRNA levels of TLR4, MyD88, NF-\u03baB, TNF\u03b1, IL-6, NLRP3, caspase-1, ASC, IL-1\u03b2, and IL-18 and protein levels of TLR4, MyD88, NF-\u03baB, NLRP3, caspase-1, ASC, IL-1\u03b2, and IL-18 in the jejunum. In conclusion, Cr(VI) could cause intestinal oxidative damage and inflammation in duck jejunum by activating the NF-\u03baB signaling pathway and the NLRP3 inflammasome.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2022.952639","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T05:37:23Z","timestamp":1658468243000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["Hexavalent Chromium Exposure Induces Intestinal Barrier Damage via Activation of the NF-\u03baB Signaling Pathway and NLRP3 Inflammasome in Ducks"],"prefix":"10.3389","volume":"13","author":[{"given":"Chenghong","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyi","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2017.09.010","article-title":"Intestinal Epithelial Cell Injury Induced by Copper Containing Nanoparticles in Piglets","volume":"56","author":"Zhang","year":"2017","journal-title":"Environ Toxicol Pharmacol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-018-1653-7","article-title":"Transcriptome Analysis Reveals the Molecular Mechanism of Hepatic Metabolism Disorder Caused by Chromium Poisoning in Chickens","volume":"25","author":"Tian","year":"2018","journal-title":"Environ Sci pollut Res Int"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2007.11.005","article-title":"Lack of Genotoxic Effects in Hematopoietic and Gastrointestinal Cells of Mice Receiving Chromium(VI) With the Drinking Water","volume":"659","author":"De Flora","year":"2008","journal-title":"Mutat Res"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-05075-4","article-title":"Metabonomic Analysis of the Hepatic Injury Suffer From Hexavalent Chromium Poisoning in Broilers","volume":"26","author":"Zhao","year":"2019","journal-title":"Environ Sci pollut Res Int"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167503","article-title":"Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium","volume":"11","author":"Tian","year":"2016","journal-title":"PLoS One"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.03.074","article-title":"Chromium Speciation, Bioavailability, Uptake, Toxicity and Detoxification in Soil-Plant System: A Review","volume":"178","author":"Shahid","year":"2017","journal-title":"Chemosphere"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2020.111547","article-title":"Biomanagement of Hexavalent Chromium: Current Trends and Promising Perspectives","volume":"279","author":"Singh","year":"2021","journal-title":"J Environ Manage"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.109504","article-title":"Co-Occurrence Patterns of Microbial Communities Affected by Inoculants of Plant Growth-Promoting Bacteria During Phytoremediation of Heavy Metal-Contaminated Soils","volume":"183","author":"Kong","year":"2019","journal-title":"Ecotoxicol Environ Saf"},{"key":"B9","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.jhazmat.2006.06.060","article-title":"Activated Carbons and Low Cost Adsorbents for Remediation of Tri- and Hexavalent Chromium From Water","volume":"137","author":"Mohan","year":"2006","journal-title":"J Hazard Mater"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2014.06.080","article-title":"Distribution of Chromium Species in a Cr-Polluted Soil: Presence of Cr(III) in Glomalin Related Protein Fraction","volume":"493","author":"Gil-Cardeza","year":"2014","journal-title":"Sci Total Environ"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2020.111809","article-title":"Effect of Hexavalent Chromium on the Environment and Removal Techniques: A Review","volume":"280","author":"Ukhurebor","year":"2021","journal-title":"J Environ Manage"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1515\/intox-2017-0003","article-title":"Melatonin Protects Against Chromium (VI) Induced Hepatic Oxidative Stress and Toxicity: Duration Dependent Study With Realistic Dosage","volume":"10","author":"Banerjee","year":"2017","journal-title":"Interdiscip Toxicol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112220","article-title":"Exposure to Intranasal Chromium Triggers Dose and Time-Dependent Behavioral and Neurotoxicological Defects in Rats","volume":"216","author":"Hegazy","year":"2021","journal-title":"Ecotoxicol Environ Saf"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.envpol.2016.11.045","article-title":"Effects of Environmental Pollutants on Gut Microbiota","volume":"222","author":"Jin","year":"2017","journal-title":"Environ pollut"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.04.088","article-title":"Gut Microbiota: An Underestimated and Unintended Recipient for Pesticide-Induced Toxicity","volume":"227","author":"Yuan","year":"2019","journal-title":"Chemosphere"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03032.x","article-title":"Intestinal Barrier: An Interface Between Health and Disease","volume":"18","author":"Farhadi","year":"2003","journal-title":"J Gastroenterol Hepatol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0822-3","article-title":"Composition and Functional Role of the Mucus Layers in the Intestine","volume":"68","author":"Johansson","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.58","article-title":"The Resilience of the Intestinal Microbiota Influences Health and Disease","volume":"15","author":"Sommer","year":"2017","journal-title":"Nat Rev Microbiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.toxlet.2015.06.002","article-title":"Toxicity of Oral Cadmium Intake: Impact on Gut Immunity","volume":"237","author":"Ninkov","year":"2015","journal-title":"Toxicol Lett"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.126704","article-title":"Cadmium Exposure Triggers Oxidative Stress, Necroptosis, Th1\/Th2 Imbalance and Promotes Inflammation Through the TNF-Alpha\/NF-kappaB Pathway in Swine Small Intestine","volume":"421","author":"Chen","year":"2022","journal-title":"J Hazard Mater"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2020.108877","article-title":"Exposure of Lead on Intestinal Structural Integrity and the Diversity of Gut Microbiota of Common Carp","volume":"239","author":"Zhang","year":"2021","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.147780","article-title":"Arsenic Exposure Induces Intestinal Barrier Damage and Consequent Activation of Gut-Liver Axis Leading to Inflammation and Pyroptosis of Liver in Ducks","volume":"788","author":"Zhong","year":"2021","journal-title":"Sci Total Environ"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.109920","article-title":"Effects of Subchronic Exposure of Mercuric Chloride on Intestinal Histology and Microbiota in the Cecum of Chicken","volume":"188","author":"Zhou","year":"2020","journal-title":"Ecotoxicol Environ Saf"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112871","article-title":"Environmental Hexavalent Chromium Exposure Induces Gut Microbial Dysbiosis in Chickens","volume":"227","author":"Li","year":"2021","journal-title":"Ecotoxicol Environ Saf"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2021.103725","article-title":"Toxic Effects of Hexavalent Chromium (Cr(6+)) on Bioaccumulation, Apoptosis, Oxidative Damage and Inflammatory Response in Channa Asiatica","volume":"87","author":"Yu","year":"2021","journal-title":"Environ Toxicol Pharmacol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-016-0915-9","article-title":"Selenium Administration Alleviates Toxicity of Chromium(VI) in the Chicken Brain","volume":"178","author":"Hao","year":"2017","journal-title":"Biol Trace Elem Res"},{"key":"B27","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.taap.2016.07.016","article-title":"Different Roles of ROS and Nrf2 in Cr(VI)-Induced Inflammatory Responses in Normal and Cr(VI)-Transformed Cells","volume":"307","author":"Roy","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.01.015","article-title":"Cadmium-Induced Inflammatory Responses in Cells Relevant for Lung Toxicity: Expression and Release of Cytokines in Fibroblasts, Epithelial Cells and Macrophages","volume":"193","author":"Lag","year":"2010","journal-title":"Toxicol Lett"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/tox.20642","article-title":"Subchronic Effects of Perfluorooctanesulfonate Exposure on Inflammation in Adult Male C57BL\/6 Mice","volume":"27","author":"Dong","year":"2012","journal-title":"Environ Toxicol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.toxlet.2008.10.012","article-title":"Oxidative Stress and Pro-Inflammatory Responses Induced by Silica Nanoparticles In Vivo and In Vitro","volume":"184","author":"Park","year":"2009","journal-title":"Toxicol Lett"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731117003342","article-title":"Leucine Alters Immunoglobulin a Secretion and Inflammatory Cytokine Expression Induced by Lipopolysaccharide via the Nuclear factor-kappaB Pathway in Intestine Of Chicken Embryos","volume":"12","author":"Liu","year":"2018","journal-title":"Animal"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23446","article-title":"Lithium Intoxication Induced Pyroptosis via ROS\/NF-Kappab\/NLRP3 Inflammasome Regulatory Networks in Kidney of Mice","volume":"37","author":"Jing","year":"2022","journal-title":"Environ Toxicol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.09.145","article-title":"Zearalenone (ZEA)-Induced Intestinal Inflammation Is Mediated by the NLRP3 Inflammasome","volume":"190","author":"Fan","year":"2018","journal-title":"Chemosphere"},{"key":"B34","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.intimp.2019.04.052","article-title":"Regulating Effect of Baicalin on IKK\/IKB\/NF-kB Signaling Pathway and Apoptosis-Related Proteins in Rats With Ulcerative Colitis","volume":"73","author":"Shen","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pex402","article-title":"Effects of Maternal Dietary Canthaxanthin and 25-Hydroxycholecalciferol Supplementation on Antioxidant Status and Calcium-Phosphate Metabolism of Progeny Ducks","volume":"97","author":"Ren","year":"2018","journal-title":"Poult Sci"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111584","article-title":"In Vivo Assessment of Molybdenum and Cadmium Co-Induce Nephrotoxicity via NLRP3\/Caspase-1-Mediated Pyroptosis in Ducks","volume":"224","author":"Zhang","year":"2021","journal-title":"J Inorg Biochem"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1547-0","article-title":"Mitochondrial Permeability Transition and its Regulatory Components are Implicated in Apoptosis of Primary Cultures of Rat Proximal Tubular Cells Exposed to Lead","volume":"90","author":"Liu","year":"2016","journal-title":"Arch Toxicol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1795","article-title":"Ammonia Induces Autophagy via Circ-IFNLR1\/miR-2188-5p\/RNF182 Axis in Tracheas of Chickens","volume":"48","author":"Zhang","year":"2022","journal-title":"Biofactors"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-022-03288-2","article-title":"Selenium Deficiency Leads to Reduced Skeletal Muscle Cell Differentiation by Oxidative Stress in Mice","author":"Bao","year":"2022","journal-title":"Biol Trace Elem Res"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.110158","article-title":"Long-Term Exposure to Copper Induces Autophagy and Apoptosis Through Oxidative Stress in Rat Kidneys","volume":"190","author":"Wan","year":"2020","journal-title":"Ecotoxicol Environ Saf"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10590501.2015.1096883","article-title":"Toxic and Genotoxic Effects of Hexavalent Chromium in Environment and its Bioremediation Strategies","volume":"34","author":"Mishra","year":"2016","journal-title":"J Environ Sci Health C Environ Carcinog Ecotoxicol Rev"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.05.050","article-title":"Biosorption and Biotransformation of Hexavalent Chromium [Cr(VI)]: A Comprehensive Review","volume":"207","author":"Jobby","year":"2018","journal-title":"Chemosphere"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.124607","article-title":"The Role of ATF6 in Cr(VI)-Induced Apoptosis in DF-1 Cells","volume":"410","author":"Zhang","year":"2021","journal-title":"J Hazard Mater"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2019.102115","article-title":"Characterization of the Microbial Community Structure in Intestinal Segments of Yak (Bos Grunniens)","volume":"61","author":"Zhang","year":"2020","journal-title":"Anaerobe"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111237","article-title":"Long-Term Hexavalent Chromium Exposure Facilitates Colorectal Cancer in Mice Associated With Changes in Gut Microbiota Composition","volume":"138","author":"Zhang","year":"2020","journal-title":"Food Chem Toxicol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2200","article-title":"Biopharmaceutics Classification and Intestinal Absorption of Chikusetsusaponin IVa","volume":"40","author":"Zhang","year":"2019","journal-title":"Biopharm Drug Dispos"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.07.004","article-title":"The Intestinal Crypt, a Prototype Stem Cell Compartment","volume":"154","author":"Clevers","year":"2013","journal-title":"Cell"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-020-02300-x","article-title":"Exposed to Mercury-Induced Oxidative Stress, Changes of Intestinal Microflora, and Association Between Them in Mice","volume":"199","author":"Zhao","year":"2021","journal-title":"Biol Trace Elem Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.140533","article-title":"Self-Recovery Study of the Adverse Effects of Fluoride on Small Intestine: Involvement of Pyroptosis Induced Inflammation","volume":"742","author":"Li","year":"2020","journal-title":"Sci Total Environ"},{"key":"B50","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10208","article-title":"Intestinal Homeostasis and its Breakdown in Inflammatory Bowel Disease","volume":"474","author":"Maloy","year":"2011","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030972","article-title":"The Integral Role of Tight Junction Proteins in the Repair of Injured Intestinal Epithelium","volume":"21","author":"Slifer","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5490743","article-title":"Selenium-Enriched Yeast Alleviates Oxidative Stress-Induced Intestinal Mucosa Disruption in Weaned Pigs","volume":"2020","author":"Liu","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.17235\/reed.2015.3846\/2015","article-title":"The Intestinal Barrier Function and its Involvement in Digestive Disease","volume":"107","author":"Salvo","year":"2015","journal-title":"Rev Esp Enferm Dig"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2021.103640","article-title":"Cr(VI) Promotes Tight Joint and Oxidative Damage by Activating the Nrf2\/ROS\/Notch1 Axis","volume":"85","author":"Zhu","year":"2021","journal-title":"Environ Toxicol Pharmacol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00280","article-title":"Central Role of the Gut Epithelial Barrier in the Pathogenesis of Chronic Intestinal Inflammation: Lessons Learned From Animal Models and Human Genetics","volume":"4","author":"Pastorelli","year":"2013","journal-title":"Front Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.05.006","article-title":"Claudin-Related Intestinal Diseases","volume":"42","author":"Barmeyer","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2289-8","article-title":"Cytokine Responses and Epithelial Function in the Intestinal Mucosa","volume":"73","author":"Onyiah","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113846","article-title":"Impact of Chronic Exposure to Trichlorfon on Intestinal Barrier, Oxidative Stress, Inflammatory Response and Intestinal Microbiome in Common Carp (Cyprinus Carpio L.)","volume":"259","author":"Chang","year":"2020","journal-title":"Environ pollut"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.09.016","article-title":"Trivalent Arsenic Species Induce Changes in Expression and Levels of Proinflammatory Cytokines in Intestinal Epithelial Cells","volume":"224","author":"Calatayud","year":"2014","journal-title":"Toxicol Lett"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4145-y","article-title":"Interleukin-1beta Mediates Beta-Catenin-Driven Downregulation of Claudin-3 and Barrier Dysfunction in Caco2 Cells","volume":"61","author":"Haines","year":"2016","journal-title":"Dig Dis Sci"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.072","article-title":"Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis","volume":"163","author":"Nowarski","year":"2015","journal-title":"Cell"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2020.44948.10482","article-title":"Soluble Uric Acid Induces Inflammation via TLR4\/NLRP3 Pathway in Intestinal Epithelial Cells","volume":"23","author":"Ma","year":"2020","journal-title":"Iran J Basic Med Sci"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.143753","article-title":"Activation of the ROS\/HO-1\/NQO1 Signaling Pathway Contributes to the Copper-Induced Oxidative Stress and Autophagy in Duck Renal Tubular Epithelial Cells","volume":"757","author":"Fang","year":"2021","journal-title":"Sci Total Environ"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-021-02882-0","article-title":"Selenium Deficiency Promotes Oxidative Stress-Induced Mastitis via Activating the NF-kappaB and MAPK Pathways in Dairy Cow","volume":"200","author":"Zhang","year":"2022","journal-title":"Biol Trace Elem Res"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2017.09.035","article-title":"Glutamate Attenuates Lipopolysaccharide-Induced Oxidative Damage and mRNA Expression Changes of Tight Junction and Defensin Proteins, Inflammatory and Apoptosis Response Signaling Molecules in the Intestine of Fish","volume":"70","author":"Jiang","year":"2017","journal-title":"Fish Shellfish Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1080\/01926230290166724","article-title":"Oxidation of Biological Systems: Oxidative Stress Phenomena, Antioxidants, Redox Reactions, and Methods for Their Quantification","volume":"30","author":"Kohen","year":"2002","journal-title":"Toxicol Pathol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/nri2725","article-title":"NLRP3 Inflammasome Activation: The Convergence of Multiple Signalling Pathways on ROS Production","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.149","article-title":"From NAFLD to NASH to Cirrhosis-new Insights into Disease Mechanisms","volume":"10","author":"Wree","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1038\/s41598-017-03161-6","article-title":"Early Gut Microbiota Intervention Suppresses DSS-Induced Inflammatory Responses by Deactivating TLR\/NLR Signalling in Pigs","volume":"7","author":"Xiao","year":"2017","journal-title":"Sci Rep"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4510628","article-title":"High Glucose Induces the Loss of Retinal Pericytes Partly via NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis","volume":"2020","author":"Gan","year":"2020","journal-title":"BioMed Res Int"},{"key":"B71","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1038\/s41467-020-16043-9","article-title":"N-GSDMD Trafficking to Neutrophil Organelles Facilitates IL-1beta Release Independently of Plasma Membrane Pores and Pyroptosis","volume":"11","author":"Karmakar","year":"2020","journal-title":"Nat Commun"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.952639\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T05:37:28Z","timestamp":1658468248000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.952639\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":71,"alternative-id":["10.3389\/fimmu.2022.952639"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.952639","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"article-number":"952639"}}