{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:21:38Z","timestamp":1787235698242,"version":"build-2736575974"},"reference-count":541,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Most B cells produced in the bone marrow have some level of autoreactivity. Despite efforts of central tolerance to eliminate these cells, many escape to periphery, where in healthy individuals, they are rendered functionally non-responsive to restimulation through their antigen receptor\n                    <jats:italic>via<\/jats:italic>\n                    a process termed anergy. Broad repertoire autoreactivity may reflect the chances of generating autoreactivity by stochastic use of germline immunoglobulin gene segments or active mechanisms may select autoreactive cells during egress to the na\u00efve peripheral B cell pool. Likewise, it is unclear why in some individuals autoreactive B cell clones become activated and drive pathophysiologic changes in autoimmune diseases. Both of these remain central questions in the study of the immune system(s). In most individuals, autoimmune diseases arise from complex interplay of genetic risk factors and environmental influences. Advances in genome sequencing and increased statistical power from large autoimmune disease cohorts has led to identification of more than 200 autoimmune disease risk loci. It has been observed that autoantibodies are detectable in the serum years to decades prior to the diagnosis of autoimmune disease. Thus, current models hold that genetic defects in the pathways that control autoreactive B cell tolerance set genetic liability thresholds across multiple autoimmune diseases. Despite the fact these seminal concepts were developed in animal (especially murine) models of autoimmune disease, some perceive a disconnect between human risk alleles and those identified in murine models of autoimmune disease. Here, we synthesize the current state of the art in our understanding of human risk alleles in two prototypical autoimmune diseases \u2013\u00a0systemic lupus erythematosus (SLE) and type 1 diabetes (T1D) along with spontaneous murine disease models. We compare these risk networks to those reported in murine models of these diseases, focusing on pathways relevant to anergy and central tolerance. We highlight some differences between murine and human environmental and genetic factors that may impact autoimmune disease development and expression and may, in turn, explain some of this discrepancy. Finally, we show that there is substantial overlap between the molecular networks that define these disease states across species. Our synthesis and analysis of the current state of the field are consistent with the idea that the same molecular networks are perturbed in murine and human autoimmune disease. Based on these analyses, we anticipate that murine autoimmune disease models will continue to yield novel insights into how best to diagnose, prognose, prevent and treat human autoimmune diseases.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2022.953439","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T09:07:50Z","timestamp":1661332070000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans"],"prefix":"10.3389","volume":"13","author":[{"given":"Isaac T. W.","family":"Harley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Allison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Hal","family":"Scofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human b cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830240616","article-title":"Negative selection of multireactive b cell clones in normal adult mice","volume":"24","author":"Grandien","year":"1994","journal-title":"Eur J Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nri2133","article-title":"B-cell anergy: from transgenic models to naturally occurring anergic b cells","volume":"7","author":"Cambier","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.imlet.2009.09.006","article-title":"B cell activation versus anergy; the antigen receptor as a molecular switch","volume":"128","author":"Cambier","year":"2010","journal-title":"Immunol Lett"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/ni1256","article-title":"Maintenance of b cell anergy requires constant antigen receptor occupancy and signaling","volume":"6","author":"Gauld","year":"2005","journal-title":"Nat Immunol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.03.015","article-title":"Silencing of autoreactive b cells by anergy: a fresh perspective","volume":"18","author":"Gauld","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nri1939","article-title":"Receptor editing in lymphocyte development and central tolerance","volume":"6","author":"Nemazee","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0765-7","article-title":"NR4A nuclear receptors restrain b cell responses to antigen when second signals are absent or limiting","volume":"21","author":"Tan","year":"2020","journal-title":"Nat Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi4742","article-title":"Preventing type 1 diabetes in childhood","volume":"373","author":"Dayan","year":"2021","journal-title":"Science"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021933","article-title":"Development of autoantibodies before the clinical onset of systemic lupus erythematosus","volume":"349","author":"Arbuckle","year":"2003","journal-title":"N Engl J Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0233-2","article-title":"B cells in autoimmune and neurodegenerative central nervous system diseases","volume":"20","author":"Sabatino","year":"2019","journal-title":"Nat Rev Neurosci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/art.41417","article-title":"Rheumatoid arthritis pathogenesis, prediction, and prevention: An emerging paradigm shift","volume":"73","author":"Deane","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.000000000000563","article-title":"B cells in multiple sclerosis","volume":"31","author":"Sospedra","year":"2018","journal-title":"Curr Opin Neurol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/art.40049","article-title":"Efficacy and safety of subcutaneous belimumab in systemic lupus erythematosus: A fifty-Two-Week randomized, double-blind, placebo-controlled study","volume":"69","author":"Stohl","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/art.30613","article-title":"A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits b lymphocyte stimulator, in patients with systemic lupus erythematosus","volume":"63","author":"Furie","year":"2011","journal-title":"Arthritis Rheum"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61354-2","article-title":"Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial","volume":"377","author":"Navarra","year":"2011","journal-title":"Lancet"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0884","article-title":"Combined immunosuppressive therapy induces remission in patients with severe type b insulin resistance: A prospective cohort study","volume":"41","author":"Klubo-Gwiezdzinska","year":"2018","journal-title":"Diabetes Care"},{"key":"B18","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41435-018-0032-1","article-title":"Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes","volume":"20","author":"Linsley","year":"2019","journal-title":"Genes Immun"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0626","article-title":"B-lymphocyte depletion with rituximab and beta-cell function: two-year results","volume":"37","author":"Pescovitz","year":"2014","journal-title":"Diabetes Care"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0674","article-title":"Rituximab selectively suppresses specific islet antibodies","volume":"60","author":"Yu","year":"2011","journal-title":"Diabetes"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904452","article-title":"Rituximab, b-lymphocyte depletion, and preservation of beta-cell function","volume":"361","author":"Pescovitz","year":"2009","journal-title":"N Engl J Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.4049\/jimmunol.1100539","article-title":"Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes","volume":"187","author":"Herold","year":"2011","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212763","article-title":"Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study","volume":"78","author":"Gerlag","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/art.10467","article-title":"Efficacy of selective b cell blockade in the treatment of rheumatoid arthritis: evidence for a pathogenetic role of b cells","volume":"46","author":"De Vita","year":"2002","journal-title":"Arthritis Rheum"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032534","article-title":"Efficacy of b-cell-targeted therapy with rituximab in patients with rheumatoid arthritis","volume":"350","author":"Edwards","year":"2004","journal-title":"N Engl J Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/art.22025","article-title":"Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks","volume":"54","author":"Cohen","year":"2006","journal-title":"Arthritis Rheum"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.085787","article-title":"Rituximab inhibits structural joint damage in patients with rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitor therapies","volume":"68","author":"Keystone","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204544","article-title":"An extra dose of rituximab improves clinical response in rheumatoid arthritis patients with initial incomplete b cell depletion: a randomised controlled trial","volume":"74","author":"Vital","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2977-z","article-title":"Updated systematic review and meta-analysis of randomized controlled trials comparing low- versus high-dose rituximab for rheumatoid arthritis","volume":"34","author":"Bredemeier","year":"2015","journal-title":"Clin Rheumatol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/imr.12821","article-title":"Impaired b-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies","volume":"292","author":"Meffre","year":"2019","journal-title":"Immunol Rev"},{"key":"B31","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/imr.12820","article-title":"Understanding and measuring human b-cell tolerance and its breakdown in autoimmune disease","volume":"292","author":"Cashman","year":"2019","journal-title":"Immunol Rev"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.09.001","article-title":"B-cell tolerance checkpoints in health and autoimmunity","volume":"20","author":"Meffre","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/imr.13062","article-title":"B-cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human b cells","volume":"307","author":"Pelanda","year":"2022","journal-title":"Immunol Rev"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042251","article-title":"Defective b cell tolerance checkpoints in systemic lupus erythematosus","volume":"201","author":"Yurasov","year":"2005","journal-title":"J Exp Med"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1172\/jci118985","article-title":"Characterization of a germline vk gene encoding cationic anti-DNA antibody and role of receptor editing for development of the autoantibody in patients with systemic lupus erythematosus","volume":"98","author":"Suzuki","year":"1996","journal-title":"J Clin Invest"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1172\/jci3113","article-title":"Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus","volume":"102","author":"D\u00f6rner","year":"1998","journal-title":"J Clin Invest"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082053","article-title":"RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes","volume":"205","author":"Panigrahi","year":"2008","journal-title":"J Exp Med"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042321","article-title":"Impaired early b cell tolerance in patients with rheumatoid arthritis","volume":"201","author":"Samuels","year":"2005","journal-title":"J Exp Med"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/art.30164","article-title":"Inflammation-independent defective early b cell tolerance checkpoints in rheumatoid arthritis","volume":"63","author":"Menard","year":"2011","journal-title":"Arthritis Rheum"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/art.40215","article-title":"Defective early b cell tolerance checkpoints in sj\u00f6gren's syndrome patients","volume":"69","author":"Glauzy","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1798","article-title":"Loss of anergic b cells in prediabetic and new-onset type 1 diabetic patients","volume":"64","author":"Smith","year":"2015","journal-title":"Diabetes"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.12.001","article-title":"Activation of thyroid antigen-reactive b cells in recent onset autoimmune thyroid disease patients","volume":"89","author":"Smith","year":"2018","journal-title":"J Autoimmun"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/art.39710","article-title":"Checkpoints for autoreactive b cells in the peripheral blood of lupus patients assessed by flow cytometry","volume":"68","author":"Malkiel","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1172\/jci24179","article-title":"Germinal center exclusion of autoreactive b cells is defective in human systemic lupus erythematosus","volume":"115","author":"Cappione","year":"2005","journal-title":"J Clin Invest"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3175","article-title":"Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus","volume":"16","author":"Tipton","year":"2015","journal-title":"Nat Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122551","article-title":"Self-tolerance curtails the b cell repertoire to microbial epitopes","volume":"4","author":"Watanabe","year":"2019","journal-title":"JCI Insight"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.09.001","article-title":"Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive b-lymphocytes","volume":"40","author":"Liubchenko","year":"2013","journal-title":"J Autoimmun"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e12792","DOI":"10.1111\/sji.12792","article-title":"CD21(-\/low) b cells associate with joint damage in rheumatoid arthritis patients","volume":"90","author":"Thorarinsdottir","year":"2019","journal-title":"Scand J Immunol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-243071","article-title":"Complement receptor 2\/CD21- human naive b cells contain mostly autoreactive unresponsive clones","volume":"115","author":"Isnardi","year":"2010","journal-title":"Blood"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.150999","article-title":"Circulating autoreactive proteinase 3+ b cells and tolerance checkpoints in ANCA-associated vasculitis","volume":"6","author":"Berti","year":"2021","journal-title":"JCI Insight"},{"key":"B51","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nrmicro732","article-title":"The damage-response framework of microbial pathogenesis","volume":"1","author":"Casadevall","year":"2003","journal-title":"Nat Rev Microbiol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-09550-9_11","article-title":"The damage-response framework of microbial pathogenesis and infectious diseases","volume":"635","author":"Pirofski","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1093\/infdis\/jiy083","article-title":"The damage-response framework as a tool for the physician-scientist to understand the pathogenesis of infectious diseases","volume":"218","author":"Pirofski","year":"2018","journal-title":"J Infect Dis"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0243","article-title":"Inferring processes underlying b-cell repertoire diversity","volume":"370","author":"Elhanati","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.12.003","article-title":"A prescription for human immunology","volume":"29","author":"Davis","year":"2008","journal-title":"Immunity"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00665","article-title":"Putting on the brakes: Regulatory kinases and phosphatases maintaining B cell anergy","volume":"9","author":"Franks","year":"2018","journal-title":"Front Immunol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000547","article-title":"Endotypes in T1D: B lymphocytes and early onset","volume":"27","author":"Smith","year":"2020","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2014.01.010","article-title":"B cells and type 1 diabetes in mice and men","volume":"160","author":"Hinman","year":"2014","journal-title":"Immunol Lett"},{"key":"B59","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/nm.2635","article-title":"Autoimmunity's next top models","volume":"18","author":"Wekerle","year":"2012","journal-title":"Nat Med"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020241","article-title":"Mouse models of human autoimmune diseases: essential tools that require the proper controls","volume":"2","author":"Morel","year":"2004","journal-title":"PloS Biol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.63","article-title":"Genetics of SLE: evidence from mouse models","volume":"6","author":"Morel","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.2174\/1389202921999201020203249","article-title":"Single-cell RNA sequencing in immunology","volume":"21","author":"Cao","year":"2020","journal-title":"Curr Genomics"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0214-4","article-title":"Revolutionizing immunology with single-cell RNA sequencing","volume":"16","author":"Chen","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4049\/jimmunol.1701494","article-title":"A beginner's guide to analyzing and visualizing mass cytometry data","volume":"200","author":"Kimball","year":"2018","journal-title":"J Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.768113","article-title":"How to prepare spectral flow cytometry datasets for high dimensional data analysis: A practical workflow","volume":"12","author":"den Braanker","year":"2021","journal-title":"Front Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.612801","article-title":"Full spectrum flow cytometry as a powerful technology for cancer immunotherapy research","volume":"7","author":"Bonilla","year":"2020","journal-title":"Front Mol Biosci"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051224","article-title":"Lost in translation: barriers to implementing clinical immunotherapeutics for autoimmunity","volume":"202","author":"von Herrath","year":"2005","journal-title":"J Exp Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000344417.42972.54","article-title":"Multiple sclerosis therapeutics: unexpected outcomes clouding undisputed successes","volume":"72","author":"Wiendl","year":"2009","journal-title":"Neurology"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012350","article-title":"Effects of insulin in relatives of patients with type 1 diabetes mellitus","volume":"346","year":"2002","journal-title":"N Engl J Med"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/80516","article-title":"Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand","volume":"6","author":"Bielekova","year":"2000","journal-title":"Nat Med"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/80525","article-title":"Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. the altered peptide ligand in relapsing MS study group","volume":"6","author":"Kappos","year":"2000","journal-title":"Nat Med"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/80424","article-title":"Specific immunotherapy: one size does not fit all","volume":"6","author":"Genain","year":"2000","journal-title":"Nat Med"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(87)92863-7","article-title":"Exacerbations of multiple sclerosis in patients treated with gamma interferon","volume":"1","author":"Panitch","year":"1987","journal-title":"Lancet"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.3.457","article-title":"TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. the lenercept multiple sclerosis study group and the university of British Columbia MS\/MRI analysis group","volume":"53","year":"1999","journal-title":"Neurology"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.47.6.1531","article-title":"Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2","volume":"47","author":"van Oosten","year":"1996","journal-title":"Neurology"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00387","article-title":"Systemic lupus erythematosus: Definitions, contexts, conflicts, enigmas","volume":"9","author":"Rekvig","year":"2018","journal-title":"Front Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01104","article-title":"The dsDNA, anti-dsDNA antibody, and lupus nephritis: What we agree on, what must be done, and what the best strategy forward could be","volume":"10","author":"Rekvig","year":"2019","journal-title":"Front Immunol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.569234","article-title":"Autoimmunity and SLE: Factual and semantic evidence-based critical analyses of definitions, etiology, and pathogenesis","volume":"11","author":"Rekvig","year":"2020","journal-title":"Front Immunol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2015.33","article-title":"Autoimmune diseases - connecting risk alleles with molecular traits of the immune system","volume":"17","author":"Gutierrez-Arcelus","year":"2016","journal-title":"Nat Rev Genet"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.3528","article-title":"Familial aggregation of systemic lupus erythematosus and coaggregation of autoimmune diseases in affected families","volume":"175","author":"Kuo","year":"2015","journal-title":"JAMA Internal Med"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S172207","article-title":"Familial aggregation and heritability of type 1 diabetes mellitus and coaggregation of chronic diseases in affected families","volume":"10","author":"Kuo","year":"2018","journal-title":"Clin Epidemiol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00668-1","article-title":"Global epidemiology of systemic lupus erythematosus","volume":"17","author":"Barber","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/art.40512","article-title":"Brief report: Lupus-an unrecognized leading cause of death in young females: A population-based study using nationwide death certificates, 2000-2015","volume":"70","author":"Yen","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1002\/art.39504","article-title":"Genome-wide association study in an Amerindian ancestry population reveals novel systemic lupus erythematosus risk loci and the role of European admixture","volume":"68","author":"Alarcon-Riquelme","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/art.30563","article-title":"Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study","volume":"63","author":"Sanchez","year":"2011","journal-title":"Arthritis Rheum"},{"key":"B86","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1146\/annurev.genom.4.070802.110226","article-title":"Patterns of human genetic diversity: implications for human evolutionary history and disease","volume":"4","author":"Tishkoff","year":"2003","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1002\/art.41632","article-title":"Prevalence of systemic lupus erythematosus in the united states: Estimates from a meta-analysis of the centers for disease control and prevention national lupus registries","volume":"73","author":"Izmirly","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"B88","article-title":"Prevalence and incidence of type 1 diabetes among children and adults in the United States and comparison with non-U.S. Countries","volume-title":"Diabetes in America 3rd Edition","author":"Imperatore","year":"2018"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05276-4","article-title":"Type 1 diabetes can present before the age of 6 months and is characterised by autoimmunity and rapid loss of beta cells","volume":"63","author":"Johnson","year":"2020","journal-title":"Diabetologia"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0767","article-title":"Increasing incidence of type 1 diabetes in youth: twenty years of the Philadelphia pediatric diabetes registry","volume":"36","author":"Lipman","year":"2013","journal-title":"Diabetes Care"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1837","article-title":"Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth","volume":"30","author":"Vehik","year":"2007","journal-title":"Diabetes Care"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1891","article-title":"Trends in incidence of type 1 diabetes among non-Hispanic white youth in the U.S., 2002-2009","volume":"63","author":"Lawrence","year":"2014","journal-title":"Diabetes"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020100","article-title":"The effect of infections on susceptibility to autoimmune and allergic diseases","volume":"347","author":"Bach","year":"2002","journal-title":"N Engl J Med"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2010.02.004","article-title":"The worldwide gradient of autoimmune conditions","volume":"9","author":"Selmi","year":"2010","journal-title":"Autoimmun Rev"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1002\/art.41214","article-title":"Increasing prevalence of antinuclear antibodies in the united states","volume":"72","author":"Dinse","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.11.005","article-title":"The study of interactions between genome and exposome in the development of systemic lupus erythematosus","volume":"18","author":"Leffers","year":"2019","journal-title":"Autoimmun Rev"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2017.09.005","article-title":"Understanding the role of environmental factors in the development of systemic lupus erythematosus","volume":"31","author":"Parks","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.737964","article-title":"Environmental determinants of type 1 diabetes: From association to proving causality","volume":"12","author":"Quinn","year":"2021","journal-title":"Front Immunol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002033420501","article-title":"A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM study group","volume":"342","author":"Imagawa","year":"2000","journal-title":"N Engl J Med"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-S067","article-title":"Diagnosis and classification of diabetes mellitus","year":"2013","journal-title":"Diabetes Care"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.7.1183","article-title":"Report of the expert committee on the diagnosis and classification of diabetes mellitus","volume":"20","year":"1997","journal-title":"Diabetes Care"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1172\/JCI142244","article-title":"Monogenic diabetes: a gateway to precision medicine in diabetes","volume":"131","author":"Zhang","year":"2021","journal-title":"J Clin Invest"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-2324","article-title":"Etiological approach to characterization of diabetes type: the SEARCH for diabetes in youth study","volume":"34","author":"Dabelea","year":"2011","journal-title":"Diabetes Care"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05211-7","article-title":"The clinical consequences of heterogeneity within and between different diabetes types","volume":"63","author":"Redondo","year":"2020","journal-title":"Diabetologia"},{"key":"B105","volume-title":"Maturity Onset Diabetes in the Young. Statpearls","author":"Hoffman","year":"2022"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1172\/JCI127397","article-title":"Residual beta cell function and monogenic variants in long-duration type 1 diabetes patients","volume":"129","author":"Yu","year":"2019","journal-title":"J Clin Invest"},{"key":"B107","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s11892-019-1140-7","article-title":"Economics of genetic testing for diabetes","volume":"19","author":"Naylor","year":"2019","journal-title":"Curr Diabetes Rep"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154418","article-title":"Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score","volume":"114","author":"Qu","year":"2021","journal-title":"Metabolism"},{"key":"B109","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s42003-021-02368-8","article-title":"Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci","volume":"4","author":"Qu","year":"2021","journal-title":"Commun Biol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"16013","DOI":"10.1038\/s41598-021-94994-9","article-title":"Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients","volume":"11","author":"Qu","year":"2021","journal-title":"Sci Rep"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780150512","article-title":"Criteria for the classification of systemic lupus erythematosus\u2013status 1972","volume":"15","author":"Cohen","year":"1972","journal-title":"Arthritis Rheum"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan","year":"1982","journal-title":"Arthritis Rheum"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheum"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473","article-title":"Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus","volume":"64","author":"Petri","year":"2012","journal-title":"Arthritis Rheum"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1002\/art.40930","article-title":"European League against Rheumatism\/American college of rheumatology classification criteria for systemic lupus erythematosus","author":"Aringer","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214819","article-title":"European League against Rheumatism\/American college of rheumatology classification criteria for systemic lupus erythematosus","volume":"78","author":"Aringer","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"B117","doi-asserted-by":"publisher","first-page":"108953","DOI":"10.1016\/j.clim.2022.108953","article-title":"Systemic lupus erythematosus as a genetic disease","volume":"236","author":"Harley","year":"2022","journal-title":"Clin Immunol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00424","article-title":"From GWAS to function: Using functional genomics to identify the mechanisms underlying complex diseases","volume":"11","author":"Cano-Gamez","year":"2020","journal-title":"Front Genet"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1038\/nature09266","article-title":"From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus","volume":"466","author":"Musunuru","year":"2010","journal-title":"Nature"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222794","article-title":"Systematic localization of common disease-associated variation in regulatory DNA","volume":"337","author":"Maurano","year":"2012","journal-title":"Science"},{"key":"B121","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/ng.3353","article-title":"Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk","volume":"47","author":"Hu","year":"2015","journal-title":"Nat Genet"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1076","article-title":"Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis","volume":"44","author":"Raychaudhuri","year":"2012","journal-title":"Nat Genet"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2277-x","article-title":"Complement genes contribute sex-biased vulnerability in diverse disorders","volume":"582","author":"Kamitaki","year":"2020","journal-title":"Nature"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030712","article-title":"New horizons in the genetic etiology of systemic lupus erythematosus and lupus-like disease: Monogenic lupus and beyond","volume":"9","author":"Demirkaya","year":"2020","journal-title":"J Clin Med"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02496","article-title":"Monogenic lupus: A developing paradigm of disease","volume":"9","author":"Alperin","year":"2018","journal-title":"Front Immunol"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.102361","article-title":"Monogenic lupus: Dissecting heterogeneity","volume":"18","author":"Omarjee","year":"2019","journal-title":"Autoimmun Rev"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/ng.748","article-title":"Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature","volume":"43","author":"Briggs","year":"2011","journal-title":"Nat Genet"},{"key":"B128","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12969-017-0193-x","article-title":"Autoimmune phenotype with type I interferon signature in two brothers with ADA2 deficiency carrying a novel CECR1 mutation","volume":"15","author":"Skrabl-Baumgartner","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-016-0245-x","article-title":"Deficiency of adenosine deaminase 2 causes antibody deficiency","volume":"36","author":"Schepp","year":"2016","journal-title":"J Clin Immunol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2414","article-title":"Mutations in ADAR1 cause aicardi-gouti\u00e8res syndrome associated with a type I interferon signature","volume":"44","author":"Rice","year":"2012","journal-title":"Nat Genet"},{"key":"B131","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/ajmg.a.36887","article-title":"Characterization of human disease phenotypes associated with mutations in trex1, rnaseh2a, rnaseh2b, rnaseh2c, samhd1, adar, and ifih1","author":"Crow","year":"2015","journal-title":"Am J Med Genet A"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1002\/art.24852","article-title":"C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis","volume":"60","author":"Lood","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1002\/art.40158","article-title":"Brief report: Deficiency of complement 1r subcomponent in early-onset systemic lupus erythematosus: The role of disease-modifying alleles in a monogenic disease","volume":"69","author":"Demirkaya","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20163","article-title":"Lupus nephritis associated with complete C1s deficiency efficiently treated with rituximab: a case report","volume":"62","author":"Bienaim\u00e9","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.07.005","article-title":"Overcoming C2 deficiency","volume":"144","author":"Miller","year":"2012","journal-title":"Clin Immunol"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/s1567-5769(01)00019-4","article-title":"Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, slp and C4","volume":"1","author":"Blanchong","year":"2001","journal-title":"Int Immunopharmacol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(82)90118-0","article-title":"Identification of the alpha-gamma subunit of the eighth component of complement (C8) in a patient with systemic lupus erythematosus and absent C8 activity: patients and family studies","volume":"23","author":"Pickering","year":"1982","journal-title":"Clin Immunol Immunopathol"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1172\/jci108823","article-title":"Absence of the eighth component of complement in association with systemic lupus erythematosus-like disease","volume":"60","author":"Jasin","year":"1977","journal-title":"J Clin Invest"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-021-01140-1","article-title":"Late onset of chronic granulomatous disease revealed by paecilomyces lilacinus cutaneous infection","volume":"42","author":"Lemaigre","year":"2022","journal-title":"J Clin Immunol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.11.019","article-title":"Mutations in DDX58, which encodes RIG-I, cause atypical singleton-merten syndrome","volume":"96","author":"Jang","year":"2015","journal-title":"Am J Hum Genet"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1038\/91070","article-title":"Mutation of DNASE1 in people with systemic lupus erythematosus","volume":"28","author":"Yasutomo","year":"2001","journal-title":"Nat Genet"},{"key":"B142","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1038\/s41467-017-01932-3","article-title":"Type I interferon-mediated autoinflammation due to DNase II deficiency","volume":"8","author":"Rodero","year":"2017","journal-title":"Nat Commun"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1126\/science.292.5521.1546","article-title":"Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver","volume":"292","author":"Kawane","year":"2001","journal-title":"Science"},{"key":"B144","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.clim.2017.06.009","article-title":"Rare splicing defects of FAS underly severe recessive autoimmune lymphoproliferative syndrome","volume":"183","author":"Agrebi","year":"2017","journal-title":"Clin Immunol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1172\/jci118892","article-title":"Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease","volume":"98","author":"Wu","year":"1996","journal-title":"J Clin Invest"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2933","article-title":"Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling","volume":"46","author":"Rice","year":"2014","journal-title":"Nat Genet"},{"key":"B147","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.jaci.2018.04.008","article-title":"A kindred with mutant IKAROS and autoimmunity","volume":"142","author":"Van Nieuwenhove","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.029","article-title":"Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations","volume":"140","author":"Hoshino","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B149","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.it.2016.11.001","article-title":"ISG15: In sickness and in health","volume":"38","author":"Hermann","year":"2017","journal-title":"Trends Immunol"},{"key":"B150","article-title":"Noonan syndrome and systemic lupus erythematosus in a patient with a novel KRAS mutation","volume":"28","author":"Leventopoulos","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35290","article-title":"Autoimmune disease and multiple autoantibodies in 42 patients with RASopathies","author":"Quaio","year":"2012","journal-title":"Am J Med Genet A"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.04.009","article-title":"Are RASopathies new monogenic predisposing conditions to the development of systemic lupus erythematosus? case report and systematic review of the literature","volume":"43","author":"Bader-Meunier","year":"2013","journal-title":"Semin Arthritis Rheum"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-004-1404-2","article-title":"Sisters with alpha-mannosidosis and systemic lupus erythematosus","volume":"163","author":"Urushihara","year":"2004","journal-title":"Eur J Pediatr"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.07.019","article-title":"Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders","volume":"94","author":"Lu","year":"2018","journal-title":"J Autoimmun"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211004","article-title":"P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance","volume":"219","author":"He","year":"2022","journal-title":"J Exp Med"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-1102-1","article-title":"Prolidase deficiency: it looks like systemic lupus erythematosus but it is not","volume":"169","author":"Klar","year":"2010","journal-title":"Eur J Pediatr"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.12254","article-title":"Prolidase deficiency breaks tolerance to lupus-associated antigens","volume":"16","author":"Kurien","year":"2013","journal-title":"Int J Rheum Dis"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.5.441","article-title":"Prolidase deficiency and systemic lupus erythematosus","volume":"76","author":"Shrinath","year":"1997","journal-title":"Arch Dis Child"},{"key":"B159","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1007\/s10545-007-0496-z","article-title":"Systemic lupus erythematosus-like disease in a 6-year-old boy with prolidase deficiency","volume":"30","author":"Di Rocco","year":"","journal-title":"J Inherit Metab Dis"},{"key":"B160","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/ajmg.b.30945","article-title":"A broad spectrum of developmental delay in a large cohort of prolidase deficiency patients demonstrates marked interfamilial and intrafamilial phenotypic variability","author":"Falik-Zaccai","year":"2010","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1186\/1546-0096-10-18","article-title":"Prolidase deficiency associated with systemic lupus erythematosus (SLE): single site experience and literature review","volume":"10","author":"Butbul Aviel","year":"2012","journal-title":"Pediatr Rheumatol Online J"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1002\/art.38008","article-title":"Protein kinase c\u03b4 deficiency causes mendelian systemic lupus erythematosus with b cell-defective apoptosis and hyperproliferation","volume":"65","author":"Belot","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.13228","article-title":"Monogenic interferonopathies: Phenotypic and genotypic findings of CANDLE syndrome and its overlap with C1q deficient SLE","volume":"21","author":"Al-Mayouf","year":"2018","journal-title":"Int J Rheum Dis"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05205-1","article-title":"Systemic lupus erythematosus in a girl with PTEN variant and transaldolase deficiency: a novel phenotype","volume":"39","author":"Al-Mayouf","year":"2020","journal-title":"Clin Rheumatol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12969-019-0349-y","article-title":"Whole exome sequencing in childhood-onset lupus frequently detects single gene etiologies","volume":"17","author":"Tirosh","year":"2019","journal-title":"Pediatr Rheumatol Online J"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12767","article-title":"Systemic lupus erythematosus in a patient with PTEN hamartoma tumour syndrome","volume":"170","author":"Lee","year":"2014","journal-title":"Br J Dermatol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1053\/j.gastro.2012.01.011","article-title":"Autoimmunity, intestinal lymphoid hyperplasia, and defects in mucosal b-cell homeostasis in patients with PTEN hamartoma tumor syndrome","volume":"142","author":"Heindl","year":"2012","journal-title":"Gastroenterology"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22616","article-title":"A 50-Year-Old woman with cowden syndrome and joint pains","volume":"67","author":"Sagar","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2018.11.003","article-title":"PTEN hamartoma tumor syndrome and immune dysregulation","volume":"12","author":"Eissing","year":"2019","journal-title":"Transl Oncol"},{"key":"B170","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/j.jaci.2013.11.038","article-title":"Autoimmunity due to RAG deficiency and estimated disease incidence in RAG1\/2 mutations","volume":"133","author":"Chen","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1172\/jci80477","article-title":"Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency","volume":"125","author":"Walter","year":"2015","journal-title":"J Clin Invest"},{"key":"B172","doi-asserted-by":"publisher","first-page":"148","DOI":"10.12688\/f1000research.17056.1","article-title":"Recent advances in understanding RAG deficiencies","volume":"8","author":"Gennery","year":"2019","journal-title":"F1000Res"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.063","article-title":"Impaired receptor editing and heterozygous RAG2 mutation in a patient with systemic lupus erythematosus and erosive arthritis","volume":"135","author":"Walter","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"B174","author":"Laura Barnabei","year":"2020"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593339","article-title":"Ribonuclease H2 mutations induce a cGAS\/STING-dependent innate immune response","volume":"35","author":"Mackenzie","year":"2016","journal-title":"EMBO J"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33778","article-title":"Autosomal dominant inheritance of a heterozygous mutation in SAMHD1 causing familial chilblain lupus","author":"Ravenscroft","year":"2011","journal-title":"Am J Med Genet A"},{"key":"B177","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1055\/s-0030-1255059","article-title":"Chilblains as a diagnostic sign of aicardi-gouti\u00e8res syndrome","volume":"41","author":"Abdel-Salam","year":"2010","journal-title":"Neuropediatrics"},{"key":"B178","first-page":"2810","article-title":"Does loss-of-function variants in Sat1 cause x-linked pediatric lupus","volume":"71","author":"Xu L","year":"","journal-title":"Arthritis Rheumatol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.12.021","article-title":"Renal involvement in lysinuric protein intolerance: contribution of pathology to assessment of heterogeneity of renal lesions","volume":"62","author":"Est\u00e8ve","year":"2017","journal-title":"Hum Pathol"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1007\/bf01799838","article-title":"Immune complex disease consistent with systemic lupus erythematosus in a patient with lysinuric protein intolerance","volume":"19","author":"Parsons","year":"1996","journal-title":"J Inherit Metab Dis"},{"key":"B181","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/s0140-6736(04)15839-x","article-title":"Neonatal lupus and a seronegative mother","volume":"363","author":"Gattorno","year":"2004","journal-title":"Lancet"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050784","article-title":"Lysinuric protein intolerance and systemic lupus erythematosus","volume":"157","author":"Kamoda","year":"1998","journal-title":"Eur J Pediatr"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1007\/pl00008455","article-title":"Lysinuric protein intolerance in siblings: complication of systemic lupus erythematosus in the elder sister","volume":"160","author":"Aoki","year":"2001","journal-title":"Eur J Pediatr"},{"key":"B184","doi-asserted-by":"publisher","first-page":"5341","DOI":"10.1038\/s41467-020-18925-4","article-title":"Early-onset autoimmunity associated with SOCS1 haploinsufficiency","volume":"11","author":"Hadjadj","year":"2020","journal-title":"Nat Commun"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2265-1","article-title":"Whole-genome sequencing of a sporadic primary immunodeficiency cohort","volume":"583","author":"Thaventhiran","year":"2020","journal-title":"Nature"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312625","article-title":"Activated STING in a vascular and pulmonary syndrome","volume":"371","author":"Liu","year":"2014","journal-title":"N Engl J Med"},{"key":"B187","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s10875-019-00695-4","article-title":"A De novo frameshift mutation in TNFAIP3 impairs A20 deubiquitination function to cause neuropsychiatric systemic lupus erythematosus","volume":"39","author":"Duan","year":"2019","journal-title":"J Clin Immunol"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-021-01479-6","article-title":"Analysis of five cases of monogenic lupus related to primary immunodeficiency diseases","volume":"70","author":"Su","year":"2021","journal-title":"Inflammation Res"},{"key":"B189","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12969-021-00558-6","article-title":"Clinical characteristics and genetic analysis of A20 haploinsufficiency","volume":"19","author":"Zhang","year":"2021","journal-title":"Pediatr Rheumatol Online J"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.629457","article-title":"Case report: A novel TNFAIP3 mutation causing haploinsufficiency of A20 with a lupus-like phenotype","volume":"12","author":"Shaheen","year":"2021","journal-title":"Front Immunol"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212403","article-title":"A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease","volume":"77","author":"Aeschlimann","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1097\/rhu.0000000000000118","article-title":"Immune complex-mediated autoimmunity in a patient with smith-magenis syndrome (del 17p11.2)","volume":"20","author":"Yang","year":"2014","journal-title":"J Clin Rheumatol"},{"key":"B193","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jaut.2018.05.002","article-title":"B-cell activating factor and related genetic variants in lupus related atherosclerosis","volume":"92","author":"Theodorou","year":"2018","journal-title":"J Autoimmun"},{"key":"B194","doi-asserted-by":"publisher","first-page":"8195","DOI":"10.1038\/s41598-018-26573-4","article-title":"Association of a rare variant of the TNFSF13B gene with susceptibility to rheumatoid arthritis and systemic lupus erythematosus","volume":"8","author":"Gonz\u00e1lez-Serna","year":"2018","journal-title":"Sci Rep"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-015-0147-3","article-title":"Human disease phenotypes associated with mutations in TREX1","volume":"35","author":"Rice","year":"2015","journal-title":"J Clin Immunol"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151529","article-title":"Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome","volume":"213","author":"Meuwissen","year":"2016","journal-title":"J Exp Med"},{"key":"B197","doi-asserted-by":"publisher","first-page":"e99","DOI":"10.1016\/S2665-9913(19)30142-0","article-title":"Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts","volume":"2","author":"Belot","year":"2020","journal-title":"Lancet Rheumatol"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-018-01966-7","article-title":"Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus","volume":"138","author":"Alml\u00f6f","year":"2019","journal-title":"Hum Genet"},{"key":"B199","doi-asserted-by":"publisher","first-page":"8775","DOI":"10.1038\/s41598-018-26274-y","article-title":"Whole exome sequencing of patients from multicase families with systemic lupus erythematosus identifies multiple rare variants","volume":"8","author":"Delgado-Vega","year":"2018","journal-title":"Sci Rep"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1120","article-title":"The NHGRI-EBI GWAS catalog of published genome-wide association studies, targeted arrays and summary statistics 2019","volume":"47","author":"Buniello","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa840","article-title":"Open targets genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics","volume":"49","author":"Ghoussaini","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00945-5","article-title":"An open approach to systematically prioritize causal variants and genes at all published human GWAS trait-associated loci","volume":"53","author":"Mountjoy","year":"2021","journal-title":"Nat Genet"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30095-X","article-title":"Monogenic autoimmune diseases of the endocrine system","volume":"4","author":"Johnson","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210759","article-title":"A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance","volume":"218","author":"Warshauer","year":"2021","journal-title":"J Exp Med"},{"key":"B205","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cmet.2019.11.017","article-title":"New frontiers in the treatment of type 1 diabetes","volume":"31","author":"Warshauer","year":"2020","journal-title":"Cell Metab"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.108798","article-title":"Novel compound heterozygous LRBA deletions in a 6-month-old with neonatal diabetes","volume":"175","author":"Sanyoura","year":"2021","journal-title":"Diabetes Res Clin Pract"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025174","article-title":"A delayed diagnosis of atypical immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: A case report","volume":"100","author":"Zhang","year":"2021","journal-title":"Med (Baltimore)"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2019-0261","article-title":"Screening of monogenic autoimmune diabetes among children with type 1 diabetes and multiple autoimmune diseases: is it worth doing","volume":"32","author":"Strakova","year":"2019","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12612","article-title":"FOXP3 mutations causing early-onset insulin-requiring diabetes but without other features of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome","volume":"19","author":"Hwang","year":"2018","journal-title":"Pediatr Diabetes"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0040","article-title":"Recessively inherited LRBA mutations cause autoimmunity presenting as neonatal diabetes","volume":"66","author":"Johnson","year":"2017","journal-title":"Diabetes"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3040","article-title":"Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease","volume":"46","author":"Flanagan","year":"2014","journal-title":"Nat Genet"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.02.001","article-title":"Identification of a SIRT1 mutation in a family with type 1 diabetes","volume":"17","author":"Biason-Lauber","year":"2013","journal-title":"Cell Metab"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3194","article-title":"The deacetylase Sirt1 is an essential regulator of aire-mediated induction of central immunological tolerance","volume":"16","author":"Chuprin","year":"2015","journal-title":"Nat Immunol"},{"key":"B214","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5152\/eurjrheum.2020.21225","article-title":"Clinical subgroup clustering analysis in a systemic lupus erythematosus cohort from Western Pennsylvania","volume":"9","author":"Coit","year":"2022","journal-title":"Eur J Rheumatol"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1038\/nature12170","article-title":"Negligible impact of rare autoimmune-locus coding-region variants on missing heritability","volume":"498","author":"Hunt","year":"2013","journal-title":"Nature"},{"key":"B216","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s11892-019-1141-6","article-title":"Genetic mechanisms highlight shared pathways for the pathogenesis of polygenic type 1 diabetes and monogenic autoimmune diabetes","volume":"19","author":"Johnson","year":"2019","journal-title":"Curr Diabetes Rep"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.177","article-title":"Sporadic cases are the norm for complex disease","volume":"18","author":"Yang","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.038","article-title":"An expanded view of complex traits: From polygenic to omnigenic","volume":"169","author":"Boyle","year":"2017","journal-title":"Cell"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1038\/ng.608","article-title":"Common SNPs explain a large proportion of the heritability for human height","volume":"42","author":"Yang","year":"2010","journal-title":"Nat Genet"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00901-3","article-title":"The distribution of common-variant effect sizes","volume":"53","author":"O'Connor","year":"2021","journal-title":"Nat Genet"},{"key":"B221","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1186\/s13063-018-3076-7","article-title":"Study of anti-malarials in incomplete lupus erythematosus (SMILE): study protocol for a randomized controlled trial","volume":"19","author":"Olsen","year":"2018","journal-title":"Trials"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa237","article-title":"In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","volume":"71","author":"Yao","year":"2020","journal-title":"Clin Infect Dis"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022926","article-title":"Effect of hydroxychloroquine in hospitalized patients with covid-19","volume":"383","author":"Horby","year":"2020","journal-title":"N Engl J Med"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2019014","article-title":"Hydroxychloroquine with or without azithromycin in mild-to-Moderate covid-19","volume":"383","author":"Cavalcanti","year":"2020","journal-title":"N Engl J Med"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021801","article-title":"A cluster-randomized trial of hydroxychloroquine for prevention of covid-19","volume":"384","author":"Mitja","year":"2021","journal-title":"N Engl J Med"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2016638","article-title":"A randomized trial of hydroxychloroquine as postexposure prophylaxis for covid-19","volume":"383","author":"Boulware","year":"2020","journal-title":"N Engl J Med"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1093\/emph\/eow014","article-title":"Mouse models of human disease: An evolutionary perspective","volume":"2016","author":"Perlman","year":"2016","journal-title":"Evol Med Public Health"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1038\/454682a","article-title":"Neuroscience: Standard model","volume":"454","author":"Schnabel","year":"2008","journal-title":"Nature"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.6.2271","article-title":"Experimental autoimmune encephalomyelitis induction in genetically b cell-deficient mice","volume":"184","author":"Wolf","year":"1996","journal-title":"J Exp Med"},{"key":"B230","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0165-5728(00)00409-4","article-title":"B cells and antibodies in CNS demyelinating disease","volume":"112","author":"Cross","year":"2001","journal-title":"J Neuroimmunol"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.6.3105","article-title":"Increased severity of experimental allergic encephalomyelitis in lyn-\/- mice in the absence of elevated proinflammatory cytokine response in the central nervous system","volume":"168","author":"Du","year":"2002","journal-title":"J Immunol"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1038\/ni833","article-title":"B cells regulate autoimmunity by provision of IL-10","volume":"3","author":"Fillatreau","year":"2002","journal-title":"Nat Immunol"},{"key":"B233","article-title":"Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin\/oligodendrocyte glycoprotein","volume":"130","author":"Linington","year":"1988","journal-title":"Am J Pathol"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3432::AID-IMMU3432>3.0.CO;2-2","article-title":"B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide","volume":"29","author":"Lyons","year":"1999","journal-title":"Eur J Immunol"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36030","article-title":"Regulatory b cells inhibit EAE initiation in mice while other b cells promote disease progression","volume":"118","author":"Matsushita","year":"2008","journal-title":"J Clin Invest"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr2032177","article-title":"Antigen presentation by b cells in multiple sclerosis","volume":"384","author":"Zamvil","year":"2021","journal-title":"N Engl J Med"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2101056","article-title":"Preclinical analysis of candidate anti-human CD79 therapeutic antibodies using a humanized CD79 mouse model","volume":"208","author":"Wemlinger","year":"2022","journal-title":"J Immunol"},{"key":"B238","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1126\/science.abj8222","article-title":"Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis","volume":"375","author":"Bjornevik","year":"2022","journal-title":"Science"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm7930","article-title":"Epstein-Barr Virus and multiple sclerosis","volume":"375","author":"Robinson","year":"2022","journal-title":"Science"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04432-7","article-title":"Clonally expanded b cells in multiple sclerosis bind EBV EBNA1 and GlialCAM","volume":"603","author":"Lanz","year":"2022","journal-title":"Nature"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2016-000199","article-title":"Mouse models of lupus: what they tell us and what they don't","volume":"5","author":"Richard","year":"2018","journal-title":"Lupus Sci Med"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1080\/08830185.2020.1742712","article-title":"Contribution of mouse models in our understanding of lupus","volume":"39","author":"Halkom","year":"2020","journal-title":"Int Rev Immunol"},{"key":"B243","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00281-010-0204-1","article-title":"Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease","volume":"33","author":"Driver","year":"2011","journal-title":"Semin Immunopathol"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)00806-7","article-title":"Gene-gene interactions in the NOD mouse model of type 1 diabetes","volume":"100","author":"Ridgway","year":"2008","journal-title":"Adv Immunol"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4730-z","article-title":"Silencing of high-affinity insulin-reactive b lymphocytes by anergy and impact of the NOD genetic background in mice","volume":"61","author":"Smith","year":"2018","journal-title":"Diabetologia"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69289","article-title":"Autoimmunity risk alleles: hotspots in b cell regulatory signaling pathways","volume":"123","author":"Cambier","year":"2013","journal-title":"J Clin Invest"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95882","article-title":"Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice","volume":"3","author":"Tan","year":"2018","journal-title":"JCI Insight"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2004.01860.x","article-title":"Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid p component gene: SAP deficiency or strain combination","volume":"112","author":"Gillmore","year":"2004","journal-title":"Immunology"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.05.010","article-title":"Excess BAFF rescues self-reactive b cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches","volume":"20","author":"Thien","year":"2004","journal-title":"Immunity"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.10.1453","article-title":"BAFF mediates survival of peripheral immature b lymphocytes","volume":"192","author":"Batten","year":"2000","journal-title":"J Exp Med"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.27","article-title":"Bcl-2-regulated cell death signalling in the prevention of autoimmunity","volume":"1","author":"Tischner","year":"2010","journal-title":"Cell Death Dis"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1002\/art.39744","article-title":"Bcl-2 as a therapeutic target in human tubulointerstitial inflammation","volume":"68","author":"Ko","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"B253","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/art.38966","article-title":"Bcl-2 antagonists kill plasmacytoid dendritic cells from lupus-prone mice and dampen interferon-\u03b1 production","volume":"67","author":"Zhan","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1080\/17402520600877786","article-title":"Increased fas and bcl-2 expression on peripheral blood T and b lymphocytes from juvenile-onset systemic lupus erythematosus, but not from juvenile rheumatoid arthritis and juvenile dermatomyositis","volume":"13","author":"Liphaus","year":"2006","journal-title":"Clin Dev Immunol"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1038\/ni721","article-title":"Defective T cell activation and autoimmune disorder in Stra13-deficient mice","volume":"2","author":"Sun","year":"2001","journal-title":"Nat Immunol"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051407","article-title":"Loss of the proapoptotic protein, bim, breaks b cell anergy","volume":"203","author":"Oliver","year":"2006","journal-title":"J Exp Med"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5445.1735","article-title":"Proapoptotic bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity","volume":"286","author":"Bouillet","year":"1999","journal-title":"Science"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.705307","article-title":"Impaired b cell apoptosis results in autoimmunity that is alleviated by ablation of btk","volume":"12","author":"Wright","year":"2021","journal-title":"Front Immunol"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092054","article-title":"Reduced b lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL\/6-lpr\/lpr mice","volume":"9","author":"Samuelson","year":"2014","journal-title":"PloS One"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.76","article-title":"Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ b cells","volume":"90","author":"Samuelson","year":"2012","journal-title":"Immunol Cell Biol"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303022","article-title":"Cutting edge: The transcription factor Bob1 counteracts b cell activation and regulates miR-146a in b cells","volume":"192","author":"Lindner","year":"2014","journal-title":"J Immunol"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.7.4277","article-title":"Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease","volume":"173","author":"Haywood","year":"2004","journal-title":"J Immunol"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1016\/s0171-2985(98)80032-6","article-title":"C1q and systemic lupus erythematosus","volume":"199","author":"Walport","year":"1998","journal-title":"Immunobiology"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1159\/000019076","article-title":"C1q knock-out mice for the study of complement deficiency in autoimmune disease","volume":"15","author":"Botto","year":"1998","journal-title":"Exp Clin Immunogenet"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1038\/35003228","article-title":"Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor cbl-b","volume":"403","author":"Bachmaier","year":"2000","journal-title":"Nature"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6627","article-title":"Regulatory defects in cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells","volume":"165","author":"Yi","year":"2000","journal-title":"J Immunol"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008178","article-title":"Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice","volume":"15","author":"Mattner","year":"2019","journal-title":"PloS Genet"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1038\/376352a0","article-title":"Impairment of T-cell-dependent b-cell responses and b-1 cell development in CD19-deficient mice","volume":"376","author":"Rickert","year":"1995","journal-title":"Nature"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.6.3884-3894.1994","article-title":"Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent b-lymphocyte development","volume":"14","author":"Zhou","year":"1994","journal-title":"Mol Cell Biol"},{"key":"B270","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1126\/science.274.5288.798","article-title":"Hyperresponsive b cells in CD22-deficient mice","volume":"274","author":"O'Keefe","year":"1996","journal-title":"Science"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02235","article-title":"CD22: A regulator of innate and adaptive b cell responses and autoimmunity","volume":"9","author":"Clark","year":"2018","journal-title":"Front Immunol"},{"key":"B272","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/s1074-7613(00)80554-3","article-title":"Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection","volume":"8","author":"Cornall","year":"1998","journal-title":"Immunity"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02180","article-title":"CD226 deletion reduces type 1 diabetes in the NOD mouse by impairing thymocyte development and peripheral T cell activation","volume":"11","author":"Shapiro","year":"2020","journal-title":"Front Immunol"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.10.009","article-title":"Association of extensive polymorphisms in the SLAM\/CD2 gene cluster with murine lupus","volume":"21","author":"Wandstrat","year":"2004","journal-title":"Immunity"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00225","article-title":"Ly9 (CD229) cell-surface receptor is crucial for the development of spontaneous autoantibody production to nuclear antigens","volume":"4","author":"de Salort","year":"2013","journal-title":"Front Immunol"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.4590","article-title":"Targeted disruption of CD38 accelerates autoimmune diabetes in NOD\/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion","volume":"176","author":"Chen","year":"2006","journal-title":"J Immunol"},{"key":"B277","doi-asserted-by":"publisher","first-page":"9","DOI":"10.4049\/jimmunol.168.1.9","article-title":"Cutting edge: Ectopic expression of CD40 ligand on b cells induces lupus-like autoimmune disease","volume":"168","author":"Higuchi","year":"2002","journal-title":"J Immunol"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0933-4","article-title":"Increased expression of CD154 and FAS in SLE patients' lymphocytes","volume":"30","author":"Manea","year":"2009","journal-title":"Rheumatol Int"},{"key":"B279","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.159.9.4580","article-title":"CD40 ligand expressed on b cells in the BXSB mouse model of systemic lupus erythematosus","volume":"159","author":"Blossom","year":"1997","journal-title":"J Immunol"},{"key":"B280","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.clim.2016.01.008","article-title":"Roles of CD48 in regulating immunity and tolerance","volume":"164","author":"McArdel","year":"2016","journal-title":"Clin Immunol"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxq465","article-title":"Auto-antibody production and glomerulonephritis in congenic Slamf1-\/- and Slamf2-\/- [B6.129] but not in Slamf1-\/- and Slamf2-\/- [BALB\/c.129] mice","volume":"23","author":"Keszei","year":"2011","journal-title":"Int Immunol"},{"key":"B282","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.jaut.2011.03.004","article-title":"The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis","volume":"37","author":"Koh","year":"2011","journal-title":"J Autoimmun"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0185","article-title":"Requirement of homotypic NK-cell interactions through 2B4(CD244)\/CD48 in the generation of NK effector functions","volume":"107","author":"Lee","year":"2006","journal-title":"Blood"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.1787","article-title":"The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes","volume":"98","author":"Morel","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000148","article-title":"CD70 inversely regulates regulatory T cells and invariant NKT cells and modulates type 1 diabetes in NOD mice","volume":"205","author":"Ye","year":"2020","journal-title":"J Immunol"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203576","article-title":"Cd72(c) is a modifier gene that regulates fas(lpr)-induced autoimmune disease","volume":"190","author":"Xu","year":"2013","journal-title":"J Immunol"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1080\/0891693031000141059","article-title":"Structure and function of CD72 in the non-obese diabetic (NOD) mouse","volume":"36","author":"Rojas","year":"2003","journal-title":"Autoimmunity"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.10.014","article-title":"The role of SLAM\/CD2 polymorphisms in systemic autoimmunity","volume":"22","author":"Wang","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403023","article-title":"B cell-intrinsic CD84 and Ly108 maintain germinal center b cell tolerance","volume":"194","author":"Wong","year":"2015","journal-title":"J Immunol"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1038\/72272","article-title":"The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development","volume":"6","author":"Balomenos","year":"2000","journal-title":"Nat Med"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002544","article-title":"Cyclin-dependent kinase inhibitor Cdkn2c regulates b cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1","volume":"186","author":"Xu","year":"2011","journal-title":"J Immunol"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200556","article-title":"Cyclin-dependent kinase inhibitor Cdkn2c deficiency promotes B1a cell expansion and autoimmunity in a mouse model of lupus","volume":"189","author":"Potula","year":"2012","journal-title":"J Immunol"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.143","article-title":"Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB\/c but not C57BL\/6 strain","volume":"17","author":"Qiao","year":"2010","journal-title":"Cell Death Differ"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2001.5017","article-title":"Defective apoptosis in lymphocytes and the role of IL-2 in autoimmune hematologic cytopenias","volume":"99","author":"Shenoy","year":"2001","journal-title":"Clin Immunol"},{"key":"B295","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.immuni.2007.11.023","article-title":"The lupus-related Lmb3 locus contains a disease-suppressing coronin-1A gene mutation","volume":"28","author":"Haraldsson","year":"2008","journal-title":"Immunity"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1084\/jem.161.6.1344","article-title":"C-reactive protein mediates the solubilization of nuclear DNA by complement","volume":"161","author":"Robey","year":"1985","journal-title":"vitro J Exp Med"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1002\/art.11026","article-title":"Delayed lupus onset in (NZB x NZW)F1 mice expressing a human c-reactive protein transgene","volume":"48","author":"Szalai","year":"2003","journal-title":"Arthritis Rheum"},{"key":"B298","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021258","article-title":"Deficiencies of GM-CSF and interferon gamma link inflammation and cancer","volume":"197","author":"Enzler","year":"2003","journal-title":"J Exp Med"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1126\/science.8171324","article-title":"Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis","volume":"264","author":"Dranoff","year":"1994","journal-title":"Science"},{"key":"B300","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.202.Supp.50.11","article-title":"Evaluating the role of candidate gene, csf3r, for sex-linked susceptibility to lupus-like disease in mice","volume":"202","author":"Gubbels Bupp","year":"2019","journal-title":"J Immunol"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2108957118","article-title":"Acute csk inhibition hinders b cell activation by constraining the PI3 kinase pathway","volume":"118","author":"Lu","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90125-6","article-title":"Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4","volume":"3","author":"Tivol","year":"1995","journal-title":"Immunity"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2021570118","article-title":"Central human b cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice","volume":"118","author":"Alves da Costa","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"B304","doi-asserted-by":"publisher","first-page":"157ra141","DOI":"10.1126\/scitranslmed.3004801","article-title":"NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus","volume":"4","author":"Campbell","year":"2012","journal-title":"Sci Transl Med"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1172\/jci24096","article-title":"Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity","volume":"116","author":"Fanzo","year":"2006","journal-title":"J Clin Invest"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1042\/bj20040046","article-title":"Expression pattern of the deoxyribonuclease 1 gene: lessons from the Dnase1 knockout mouse","volume":"380","author":"Napirei","year":"2004","journal-title":"Biochem J"},{"key":"B307","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1073\/pnas.2112032118","article-title":"De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes","author":"Foray","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(01)00254-0","article-title":"Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity","volume":"15","author":"Murga","year":"2001","journal-title":"Immunity"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.6941","article-title":"p300 protein acetyltransferase activity suppresses systemic lupus erythematosus-like autoimmune disease in mice","volume":"178","author":"Forster","year":"2007","journal-title":"J Immunol"},{"key":"B310","doi-asserted-by":"publisher","first-page":"793","DOI":"10.4049\/jimmunol.1200411","article-title":"Murine lupus susceptibility locus Sle1c2 mediates CD4+ T cell activation and maps to estrogen-related receptor \u03b3","volume":"189","author":"Perry","year":"2012","journal-title":"J Immunol"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500165","article-title":"Genetic interaction between Lyn, Ets1, and btk in the control of antibody levels","volume":"195","author":"Mayeux","year":"2015","journal-title":"J Immunol"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400666","article-title":"A balance between b cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels","volume":"193","author":"Luo","year":"2014","journal-title":"J Immunol"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0915133107","article-title":"A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus","volume":"107","author":"Willcocks","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B314","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/ni1151","article-title":"The inhibitory fcgamma receptor modulates autoimmunity by limiting the accumulation of immunoglobulin g+ anti-DNA plasma cells","volume":"6","author":"Fukuyama","year":"2005","journal-title":"Nat Immunol"},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.15.12.6961","article-title":"An immunological renal disease in transgenic mice that overexpress fli-1, a member of the ets family of transcription factor genes","volume":"15","author":"Zhang","year":"1995","journal-title":"Mol Cell Biol"},{"key":"B316","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1612","article-title":"Foxo1 directly regulates the transcription of recombination-activating genes during b cell development","volume":"9","author":"Amin","year":"2008","journal-title":"Nat Immunol"},{"key":"B317","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/s1074-7613(02)00302-3","article-title":"Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome","volume":"16","author":"Salvador","year":"2002","journal-title":"Immunity"},{"key":"B318","doi-asserted-by":"publisher","DOI":"10.1002\/art.27363","article-title":"Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells","volume":"62","author":"Li","year":"2010","journal-title":"Arthritis Rheum"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.1038\/13802","article-title":"Genomic instability in Gadd45a-deficient mice","volume":"23","author":"Hollander","year":"1999","journal-title":"Nat Genet"},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64557","article-title":"Galectin-9 regulates the threshold of b cell activation and autoimmunity","volume":"10","author":"Smith","year":"2021","journal-title":"Elife"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(01)00145-5","article-title":"Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome","volume":"14","author":"Le","year":"2001","journal-title":"Immunity"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.1038\/ng0693-124","article-title":"Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene","volume":"4","author":"Tsui","year":"1993","journal-title":"Nat Genet"},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90369-2","article-title":"Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene","volume":"73","author":"Shultz","year":"1993","journal-title":"Cell"},{"key":"B324","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.6.2840","article-title":"A failure to repair self-proteins leads to T cell hyperproliferation and autoantibody production","volume":"171","author":"Doyle","year":"2003","journal-title":"J Immunol"},{"key":"B325","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.5863","article-title":"Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis","volume":"176","author":"Xin","year":"2006","journal-title":"J Immunol"},{"key":"B326","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.5927","article-title":"Disruption of mutually negative regulatory feedback loop between interferon-inducible p202 protein and the E2F family of transcription factors in lupus-prone mice","volume":"180","author":"Panchanathan","year":"2008","journal-title":"J Immunol"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2003.10.002","article-title":"The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation","volume":"32","author":"Asefa","year":"2004","journal-title":"Blood Cells Mol Dis"},{"key":"B328","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1196\/annals.1423.006","article-title":"Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders","volume":"1110","author":"Mondini","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"B329","doi-asserted-by":"publisher","DOI":"10.1002\/art.21307","article-title":"Deficiency of type I interferon contributes to Sle2-associated component lupus phenotypes","volume":"52","author":"Li","year":"2005","journal-title":"Arthritis Rheum"},{"key":"B330","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.9.1451","article-title":"Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis","volume":"186","author":"Seery","year":"1997","journal-title":"J Exp Med"},{"key":"B331","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.10089","article-title":"Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response","volume":"95","author":"Ehrenstein","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"B332","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.7.1253","article-title":"Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies","volume":"191","author":"Ehrenstein","year":"2000","journal-title":"J Exp Med"},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0490-2","article-title":"Ikaros prevents autoimmunity by controlling anergy and toll-like receptor signaling in b cells","volume":"20","author":"Schwickert","year":"2019","journal-title":"Nat Immunol"},{"key":"B334","doi-asserted-by":"publisher","DOI":"10.1038\/352621a0","article-title":"Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting","volume":"352","author":"Schorle","year":"1991","journal-title":"Nature"},{"key":"B335","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.07.042","article-title":"Transcriptional regulation of IL-2 in health and autoimmunity","volume":"8","author":"Crisp\u00edn","year":"2009","journal-title":"Autoimmun Rev"},{"key":"B336","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1016\/j.celrep.2019.11.010","article-title":"Interleukin-27 is essential for type 1 diabetes development and sj\u00f6gren syndrome-like inflammation","volume":"29","author":"Ciecko","year":"2019","journal-title":"Cell Rep"},{"key":"B337","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90180-9","article-title":"Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment","volume":"3","author":"Willerford","year":"1995","journal-title":"Immunity"},{"key":"B338","doi-asserted-by":"publisher","DOI":"10.1126\/science.7770771","article-title":"Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta","volume":"268","author":"Suzuki","year":"1995","journal-title":"Science"},{"key":"B339","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jaut.2015.06.007","article-title":"B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens","volume":"62","author":"Akerlund","year":"2015","journal-title":"J Autoimmun"},{"key":"B340","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301169","article-title":"A role for IRF8 in b cell anergy","volume":"191","author":"Pathak","year":"2013","journal-title":"J Immunol"},{"key":"B341","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1038\/ncomms3813","article-title":"Integrin CD11b negatively regulates BCR signalling to maintain autoreactive b cell tolerance","volume":"4","author":"Ding","year":"2013","journal-title":"Nat Commun"},{"key":"B342","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910371106","article-title":"Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling","volume":"106","author":"Pflegerl","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B343","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1761","article-title":"Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation","volume":"10","author":"Meixner","year":"2008","journal-title":"Nat Cell Biol"},{"key":"B344","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.7","article-title":"The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulonephritis","volume":"10","author":"Li","year":"2009","journal-title":"Genes Immun"},{"key":"B345","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107213","article-title":"Autoimmune diabetes is suppressed by treatment with recombinant human tissue kallikrein-1","volume":"9","author":"Maneva-Radicheva","year":"2014","journal-title":"PloS One"},{"key":"B346","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.693911","article-title":"Deregulation of the kallikrein protease family in the salivary glands of the sj\u00f6gren's syndrome ERdj5 knockout mouse model","volume":"12","author":"Moustardas","year":"2021","journal-title":"Front Immunol"},{"key":"B347","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01674.x","article-title":"Treatment of MRL\/lpr mice, a genetic autoimmune model, with the ras inhibitor, farnesylthiosalicylate (FTS)","volume":"126","author":"Katzav","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"B348","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.09.003","article-title":"Amelioration of SLE-like manifestations in (NZBxNZW)F1 mice following treatment with a peptide based on the complementarity determining region 1 of an autoantibody is associated with a down-regulation of apoptosis and of the pro-apoptotic factor JNK kinase","volume":"117","author":"Rapoport","year":"2005","journal-title":"Clin Immunol"},{"key":"B349","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069066","article-title":"A LAT mutation that inhibits T cell development yet induces lymphoproliferation","volume":"296","author":"Sommers","year":"2002","journal-title":"Science"},{"key":"B350","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069057","article-title":"Induction of T helper type 2 immunity by a point mutation in the LAT adaptor","volume":"296","author":"Aguado","year":"2002","journal-title":"Science"},{"key":"B351","doi-asserted-by":"publisher","DOI":"10.1007\/s003359900098","article-title":"Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain","volume":"7","author":"Morel","year":"1996","journal-title":"Mamm Genome"},{"key":"B352","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.6.1645","article-title":"Genetic analysis of MRL-lpr mice: relationship of the fas apoptosis gene to disease manifestations and renal disease-modifying loci","volume":"176","author":"Watson","year":"1992","journal-title":"J Exp Med"},{"key":"B353","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.clim.2016.06.009","article-title":"Slamf6 negatively regulates autoimmunity","volume":"173","author":"Wang","year":"2016","journal-title":"Clin Immunol"},{"key":"B354","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101653","article-title":"A novel isoform of the Ly108 gene ameliorates murine lupus","volume":"208","author":"Keszei","year":"2011","journal-title":"J Exp Med"},{"key":"B355","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125893","article-title":"Regulation of b cell tolerance by the lupus susceptibility gene Ly108","volume":"312","author":"Kumar","year":"2006","journal-title":"Science"},{"key":"B356","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90171-x","article-title":"Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease","volume":"83","author":"Hibbs","year":"1995","journal-title":"Cell"},{"key":"B357","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90126-4","article-title":"Impaired proliferation of peripheral b cells and indication of autoimmune disease in lyn-deficient mice","volume":"3","author":"Nishizumi","year":"1995","journal-title":"Immunity"},{"key":"B358","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.4.1850","article-title":"Reduced dosage of bruton's tyrosine kinase uncouples b cell hyperresponsiveness from autoimmunity in lyn-\/- mice","volume":"171","author":"Whyburn","year":"2003","journal-title":"J Immunol"},{"key":"B359","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.06.008","article-title":"Mammalian n-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis","volume":"27","author":"Green","year":"2007","journal-title":"Immunity"},{"key":"B360","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)80322-0","article-title":"Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis","volume":"90","author":"Chui","year":"1997","journal-title":"Cell"},{"key":"B361","doi-asserted-by":"publisher","DOI":"10.1002\/art.23382","article-title":"MEK\/ERK pathway inhibitors as a treatment for inflammatory arthritis might result in the development of lupus: comment on the article by thiel et al","volume":"58","author":"Sawalha","year":"2008","journal-title":"Arthritis Rheum"},{"key":"B362","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801320","article-title":"A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells","volume":"182","author":"Rogers","year":"2009","journal-title":"J Immunol"},{"key":"B363","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.21.9.3206-3219.2001","article-title":"Immune system dysfunction and autoimmune disease in mice lacking emk (Par-1) protein kinase","volume":"21","author":"Hurov","year":"2001","journal-title":"Mol Cell Biol"},{"key":"B364","doi-asserted-by":"publisher","first-page":"10997","DOI":"10.1038\/s41598-021-90517-8","article-title":"MeCP2 deficiency exacerbates the neuroinflammatory setting and autoreactive response during an autoimmune challenge","volume":"11","author":"Zalosnik","year":"2021","journal-title":"Sci Rep"},{"key":"B365","doi-asserted-by":"publisher","DOI":"10.1002\/art.24360","article-title":"Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus","volume":"60","author":"Webb","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B366","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.trsl.2008.10.007","article-title":"Epigenetic regulation and the pathogenesis of systemic lupus erythematosus","volume":"153","author":"Pan","year":"2009","journal-title":"Transl Res"},{"key":"B367","doi-asserted-by":"publisher","DOI":"10.1038\/35075603","article-title":"Phagocytosis and clearance of apoptotic cells is mediated by MER","volume":"411","author":"Scott","year":"2001","journal-title":"Nature"},{"key":"B368","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094359","article-title":"Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice","volume":"304","author":"Hanayama","year":"2004","journal-title":"Science"},{"key":"B369","doi-asserted-by":"publisher","first-page":"18565","DOI":"10.1038\/s41598-019-55061-6","article-title":"Polymorphisms of MFGE8 are associated with susceptibility and clinical manifestations through gene expression modulation in koreans with systemic lupus erythematosus","volume":"9","author":"Baek","year":"2019","journal-title":"Sci Rep"},{"key":"B370","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3385","article-title":"The microRNA miR-148a functions as a critical regulator of b cell tolerance and autoimmunity","volume":"17","author":"Gonzalez-Martin","year":"2016","journal-title":"Nat Immunol"},{"key":"B371","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801275200","article-title":"Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice","volume":"283","author":"Lu","year":"2008","journal-title":"J Biol Chem"},{"key":"B372","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.01.050","article-title":"BCR and endosomal TLR signals synergize to increase AID expression and establish central b cell tolerance","volume":"18","author":"Kuraoka","year":"2017","journal-title":"Cell Rep"},{"key":"B373","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00637","article-title":"A variant of the histone-binding protein sNASP contributes to mouse lupus","volume":"10","author":"Ju","year":"2019","journal-title":"Front Immunol"},{"key":"B374","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001472","article-title":"NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity","volume":"185","author":"Tse","year":"2010","journal-title":"J Immunol"},{"key":"B375","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00209.2003","article-title":"Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice","volume":"18","author":"Li","year":"2004","journal-title":"Physiol Genomics"},{"key":"B376","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00939.x","article-title":"Nrf2-deficient female mice develop lupus-like autoimmune nephritis","volume":"60","author":"Yoh","year":"2001","journal-title":"Kidney Int"},{"key":"B377","doi-asserted-by":"publisher","DOI":"10.1186\/ar1699","article-title":"The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products","volume":"7","author":"Elliott","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"B378","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.02.016","article-title":"The PBX1 lupus susceptibility gene regulates CD44 expression","volume":"85","author":"Niu","year":"2017","journal-title":"Mol Immunol"},{"key":"B379","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(00)80089-8","article-title":"Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor","volume":"11","author":"Nishimura","year":"1999","journal-title":"Immunity"},{"key":"B380","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2018.10.025","article-title":"PD-1 immunobiology in systemic lupus erythematosus","volume":"97","author":"Curran","year":"2019","journal-title":"J Autoimmun"},{"key":"B381","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0027","article-title":"Platelet endothelial cell adhesion molecule-1 (PECAM-1\/CD31) acts as a regulator of b-cell development, b-cell antigen receptor (BCR)-mediated activation, and autoimmune disease","volume":"100","author":"Wilkinson","year":"2002","journal-title":"Blood"},{"key":"B382","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181652","article-title":"Active PI3K abrogates central tolerance in high-avidity autoreactive b cells","volume":"216","author":"Greaves","year":"2019","journal-title":"J Exp Med"},{"key":"B383","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2048","article-title":"PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance","volume":"15","author":"Mukundan","year":"2009","journal-title":"Nat Med"},{"key":"B384","doi-asserted-by":"publisher","DOI":"10.1038\/srep26646","article-title":"Quantitative PPAR\u03b3 expression affects the balance between tolerance and immunity","volume":"6","author":"Liu","year":"2016","journal-title":"Sci Rep"},{"key":"B385","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002230","article-title":"Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency","volume":"186","author":"Roszer","year":"2011","journal-title":"J Immunol"},{"key":"B386","doi-asserted-by":"publisher","DOI":"10.1172\/jci13202","article-title":"Peroxisome proliferator-activated receptor-gamma haploinsufficiency enhances b cell proliferative responses and exacerbates experimentally induced arthritis","volume":"108","author":"Setoguchi","year":"2001","journal-title":"J Clin Invest"},{"key":"B387","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.08.026","article-title":"Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of b cell anergy","volume":"31","author":"Browne","year":"2009","journal-title":"Immunity"},{"key":"B388","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5436.2122","article-title":"Impaired fas response and autoimmunity in pten+\/- mice","volume":"285","author":"Di Cristofano","year":"1999","journal-title":"Science"},{"key":"B389","doi-asserted-by":"publisher","DOI":"10.1038\/1235","article-title":"Pten is essential for embryonic development and tumour suppression","volume":"19","author":"Di Cristofano","year":"1998","journal-title":"Nat Genet"},{"key":"B390","doi-asserted-by":"publisher","DOI":"10.1172\/jci45790","article-title":"The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive b cells in humans","volume":"121","author":"Menard","year":"2011","journal-title":"J Clin Invest"},{"key":"B391","doi-asserted-by":"publisher","DOI":"10.1038\/ng.904","article-title":"The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp\/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness","volume":"43","author":"Zhang","year":"2011","journal-title":"Nat Genet"},{"key":"B392","doi-asserted-by":"publisher","DOI":"10.1172\/jci66963","article-title":"A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models","volume":"123","author":"Dai","year":"2013","journal-title":"J Clin Invest"},{"key":"B393","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803317","article-title":"PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background","volume":"182","author":"Zikherman","year":"2009","journal-title":"J Immunol"},{"key":"B394","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20150537","article-title":"Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic b cells","volume":"213","author":"Getahun","year":"2016","journal-title":"J Exp Med"},{"key":"B395","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.immuni.2007.04.016","article-title":"B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes b-1a cell development and causes systemic autoimmunity","volume":"27","author":"Pao","year":"2007","journal-title":"Immunity"},{"key":"B396","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a108625","article-title":"Motheaten, an immunodeficient mutant of the mouse. i. genetics and pathology","volume":"66","author":"Green","year":"1975","journal-title":"J Hered"},{"key":"B397","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)00209-9","article-title":"An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity","volume":"103","author":"Majeti","year":"2000","journal-title":"Cell"},{"key":"B398","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121258","article-title":"Attenuating homologous recombination stimulates an AID-induced antileukemic effect","volume":"210","author":"Lamont","year":"2013","journal-title":"J Exp Med"},{"key":"B399","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700024","article-title":"Genetic and small molecule disruption of the AID\/RAD51 axis similarly protects nonobese diabetic mice from type 1 diabetes through expansion of regulatory b lymphocytes","volume":"198","author":"Ratiu","year":"2017","journal-title":"J Immunol"},{"key":"B400","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502132","article-title":"RasGRP1 is an essential signaling molecule for development of B1a cells with autoantigen receptors","volume":"196","author":"Guo","year":"2016","journal-title":"J Immunol"},{"key":"B401","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2143","article-title":"Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion","volume":"179","author":"Priatel","year":"2007","journal-title":"J Immunol"},{"key":"B402","doi-asserted-by":"publisher","DOI":"10.1038\/ni950","article-title":"RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1","volume":"4","author":"Katagiri","year":"2003","journal-title":"Nat Immunol"},{"key":"B403","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2004.02.008","article-title":"Regulation of lymphocyte adhesion and migration by the small GTPase Rap1 and its effector molecule, RAPL","volume":"93","author":"Kinashi","year":"2004","journal-title":"Immunol Lett"},{"key":"B404","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.immuni.2010.12.010","article-title":"Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1","volume":"34","author":"Katagiri","year":"2011","journal-title":"Immunity"},{"key":"B405","doi-asserted-by":"publisher","DOI":"10.1038\/nature03555","article-title":"A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity","volume":"435","author":"Vinuesa","year":"2005","journal-title":"Nature"},{"key":"B406","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.02.010","article-title":"Latest update on the Ro\/SS-a autoantibody system","volume":"8","author":"Schulte-Pelkum","year":"2009","journal-title":"Autoimmun Rev"},{"key":"B407","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/cei.12094","article-title":"Immunization with 60 kD ro peptide produces different stages of preclinical autoimmunity in a sj\u00f6gren's syndrome model among multiple strains of inbred mice","volume":"173","author":"Kurien","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"B408","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.10.687","article-title":"Degree of modification of Ro60 by the lipid peroxidation by-product 4-hydroxy-2-nonenal may differentially induce sj\u00f6gren syndrome or systemic lupus erythematosus in BALB\/c mice","volume":"50","author":"Kurien","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"B409","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199905)42:5<1017::Aid-anr22>3.0.Co;2-7","article-title":"Immunization of mice with human 60-kd ro peptides results in epitope spreading if the peptides are highly homologous between human and mouse","volume":"42","author":"Scofield","year":"1999","journal-title":"Arthritis Rheum"},{"key":"B410","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/cei.12480","article-title":"Passive transfer of antibodies to the linear epitope 60\u2009kD ro 273-289 induces features of sj\u00f6gren's syndrome in naive mice","volume":"180","author":"Maier-Moore","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"B411","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0913545107","article-title":"Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression","volume":"107","author":"N\u00fa\u00f1ez","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B412","doi-asserted-by":"publisher","DOI":"10.1038\/11272","article-title":"Serum amyloid p component (not serum amyloid protein)","volume":"5","author":"Pepys","year":"1999","journal-title":"Nat Med"},{"key":"B413","doi-asserted-by":"publisher","DOI":"10.1038\/9544","article-title":"Serum amyloid p component controls chromatin degradation and prevents antinuclear autoimmunity","volume":"5","author":"Bickerstaff","year":"1999","journal-title":"Nat Med"},{"key":"B414","doi-asserted-by":"publisher","DOI":"10.1038\/9450","article-title":"SAP-less chromatin triggers systemic lupus erythematosus","volume":"5","author":"Paul","year":"1999","journal-title":"Nat Med"},{"key":"B415","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021358","article-title":"Impaired T cell death and lupus-like autoimmunity in T cell-specific adapter protein-deficient mice","volume":"198","author":"Drappa","year":"2003","journal-title":"J Exp Med"},{"key":"B416","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2017.8","article-title":"A Skint6 allele potentially contributes to mouse lupus","volume":"18","author":"Xu","year":"2017","journal-title":"Genes Immun"},{"key":"B417","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(01)00228-x","article-title":"Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein","volume":"15","author":"Boackle","year":"2001","journal-title":"Immunity"},{"key":"B418","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2010.23","article-title":"Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells","volume":"11","author":"Cuda","year":"2010","journal-title":"Genes Immun"},{"key":"B419","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002362","article-title":"Pre-b cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans","volume":"188","author":"Cuda","year":"2012","journal-title":"J Immunol"},{"key":"B420","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.2.1080","article-title":"Several genes contribute to the production of autoreactive b and T cells in the murine lupus susceptibility locus Sle1c","volume":"175","author":"Chen","year":"2005","journal-title":"J Immunol"},{"key":"B421","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/gene.2010.69","article-title":"Murine lupus susceptibility locus Sle2 activates DNA-reactive b cells through two sub-loci with distinct phenotypes","volume":"12","author":"Zeumer","year":"2011","journal-title":"Genes Immun"},{"key":"B422","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.159.1.454","article-title":"Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to b cell hyperactivity","volume":"159","author":"Mohan","year":"1997","journal-title":"J Immunol"},{"key":"B423","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.2.936","article-title":"Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal b-1a cells and lupus nephritis map to different loci","volume":"175","author":"Xu","year":"2005","journal-title":"J Immunol"},{"key":"B424","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.162.11.6492","article-title":"Genetic dissection of sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death","volume":"162","author":"Mohan","year":"1999","journal-title":"J Immunol"},{"key":"B425","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.03.009","article-title":"STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus","volume":"120","author":"Xu","year":"2006","journal-title":"Clin Immunol"},{"key":"B426","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.155.6.3205","article-title":"SLE-like autoantibodies and sj\u00f6gren's syndrome-like lymphoproliferation in TGF-beta knockout mice","volume":"155","author":"Dang","year":"1995","journal-title":"J Immunol"},{"key":"B427","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.21.9944","article-title":"Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype","volume":"90","author":"Geiser","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"B428","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249478","article-title":"Toll-like receptor 7 is required for lacrimal gland autoimmunity and type 1 diabetes development in Male nonobese diabetic mice","volume":"21","author":"Debreceni","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B429","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603912103","article-title":"A Tlr7 translocation accelerates systemic autoimmunity in murine lupus","volume":"103","author":"Subramanian","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B430","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838138","article-title":"Yaa autoimmune phenotypes are conferred by overexpression of TLR7","volume":"38","author":"Fairhurst","year":"2008","journal-title":"Eur J Immunol"},{"key":"B431","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124978","article-title":"Autoreactive b cell responses to RNA-related antigens due to TLR7 gene duplication","volume":"312","author":"Pisitkun","year":"2006","journal-title":"Science"},{"key":"B432","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050338","article-title":"Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus","volume":"202","author":"Christensen","year":"2005","journal-title":"J Exp Med"},{"key":"B433","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200517","article-title":"Pathological RANK signaling in b cells drives autoimmunity and chronic lymphocytic leukemia","volume":"218","author":"Alankus","year":"2021","journal-title":"J Exp Med"},{"key":"B434","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(03)00025-6","article-title":"Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor","volume":"18","author":"Seshasayee","year":"2003","journal-title":"Immunity"},{"key":"B435","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2016.00022","article-title":"The effect of BAFF inhibition on autoreactive b-cell selection in murine systemic lupus erythematosus","volume":"22","author":"Boneparth","year":"2016","journal-title":"Mol Med"},{"key":"B436","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101784","article-title":"BAFF\/APRIL inhibition decreases selection of naive but not antigen-induced autoreactive b cells in murine systemic lupus erythematosus","volume":"187","author":"Huang","year":"2011","journal-title":"J Immunol"},{"key":"B437","doi-asserted-by":"publisher","first-page":"4316","DOI":"10.1038\/s41598-019-40898-8","article-title":"Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus","volume":"9","author":"Forsberg","year":"2019","journal-title":"Sci Rep"},{"key":"B438","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.11.1697","article-title":"Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations","volume":"190","author":"Mackay","year":"1999","journal-title":"J Exp Med"},{"key":"B439","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.11.1747","article-title":"BAFF, a novel ligand of the tumor necrosis factor family, stimulates b cell growth","volume":"189","author":"Schneider","year":"1999","journal-title":"J Exp Med"},{"key":"B440","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030789","article-title":"Normal b cell homeostasis requires b cell activation factor production by radiation-resistant cells","volume":"198","author":"Gorelik","year":"2003","journal-title":"J Exp Med"},{"key":"B441","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900485","article-title":"The CD137 ligand is important for type 1 diabetes development but dispensable for the homeostasis of disease-suppressive CD137(+) FOXP3(+) regulatory CD4 T cells","volume":"204","author":"Foda","year":"2020","journal-title":"J Immunol"},{"key":"B442","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000322","article-title":"TRAF3 acts as a checkpoint of b cell receptor signaling to control antibody class switch recombination and anergy","volume":"205","author":"Chen","year":"2020","journal-title":"J Immunol"},{"key":"B443","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2007.09.015","article-title":"Act1 modulates autoimmunity through its dual functions in CD40L\/BAFF and IL-17 signaling","volume":"41","author":"Li","year":"2008","journal-title":"Cytokine"},{"key":"B444","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200738113","article-title":"Deficiency of Act1, a critical modulator of b cell function, leads to development of sj\u00f6gren's syndrome","volume":"38","author":"Qian","year":"2008","journal-title":"Eur J Immunol"},{"key":"B445","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142238","article-title":"Lack of T cells in Act1-deficient mice results in elevated IgM-specific autoantibodies but reduced lupus-like disease","volume":"42","author":"Johnson","year":"2012","journal-title":"Eur J Immunol"},{"key":"B446","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1038\/s41467-018-04974-3","article-title":"Act1 is a negative regulator in T and b cells via direct inhibition of STAT3","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat Commun"},{"key":"B447","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.014","article-title":"Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis","volume":"37","author":"Pisitkun","year":"2012","journal-title":"Immunity"},{"key":"B448","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090585","article-title":"Loss of the lupus autoantigen Ro52\/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway","volume":"206","author":"Espinosa","year":"2009","journal-title":"J Exp Med"},{"key":"B449","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101623","article-title":"The immunoreceptor adapter protein DAP12 suppresses b lymphocyte-driven adaptive immune responses","volume":"208","author":"Nakano-Yokomizo","year":"2011","journal-title":"J Exp Med"},{"key":"B450","doi-asserted-by":"publisher","first-page":"12019","DOI":"10.1038\/s41598-020-68956-6","article-title":"UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice","volume":"10","author":"Chen","year":"2020","journal-title":"Sci Rep"},{"key":"B451","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B452","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0327-1","article-title":"Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK biobank data","volume":"51","author":"Tachmazidou","year":"2019","journal-title":"Nat Genet"},{"key":"B453","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0637-y","article-title":"Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis","volume":"52","author":"Vujkovic","year":"2020","journal-title":"Nat Genet"},{"key":"B454","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41467-020-20460-1","article-title":"SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression","volume":"12","author":"Hou","year":"2021","journal-title":"Nat Commun"},{"key":"B455","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218810","article-title":"Arg206Cys substitution in DNASE1L3 causes a defect in DNASE1L3 protein secretion that confers risk of systemic lupus erythematosus","volume":"80","author":"Coke","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"B456","doi-asserted-by":"publisher","DOI":"10.1038\/ng.975","article-title":"Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus","volume":"43","author":"Al-Mayouf","year":"2011","journal-title":"Nat Genet"},{"key":"B457","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316676382","article-title":"An autosomal recessive DNASE1L3-related autoimmune disease with unusual clinical presentation mimicking systemic lupus erythematosus","volume":"26","author":"Carbonella","year":"2017","journal-title":"Lupus"},{"key":"B458","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171358","article-title":"Whole exome sequencing in early-onset systemic lupus erythematosus","volume":"45","author":"Batu","year":"2018","journal-title":"J Rheumatol"},{"key":"B459","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201138","article-title":"Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus","volume":"218","author":"Hartl","year":"2021","journal-title":"J Exp Med"},{"key":"B460","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.immuni.2020.04.015","article-title":"Plasmacytoid dendritic cells and type I interferon promote extrafollicular b cell responses to extracellular self-DNA","volume":"52","author":"Soni","year":"2020","journal-title":"Immunity"},{"key":"B461","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210322","article-title":"Breaching self-tolerance by targeting the gatekeeper","volume":"218","author":"Wan","year":"2021","journal-title":"J Exp Med"},{"key":"B462","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cell.2016.05.034","article-title":"Digestion of chromatin in apoptotic cell microparticles prevents autoimmunity","volume":"166","author":"Sisirak","year":"2016","journal-title":"Cell"},{"key":"B463","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00450","article-title":"Lupus risk variants in the PXK locus alter b-cell receptor internalization","volume":"5","author":"Vaughn","year":"2014","journal-title":"Front Genet"},{"key":"B464","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/s41586-021-03552-w","article-title":"Interpreting type 1 diabetes risk with genetics and single-cell epigenomics","volume":"594","author":"Chiou","year":"2021","journal-title":"Nature"},{"key":"B465","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu106","article-title":"Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM","volume":"23","author":"Maiti","year":"2014","journal-title":"Hum Mol Genet"},{"key":"B466","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403034","article-title":"The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human","volume":"194","author":"Rawlings","year":"2015","journal-title":"J Immunol"},{"key":"B467","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-010-8243-x","article-title":"Hydroxychloroquine: from malaria to autoimmunity","volume":"42","author":"Ben-Zvi","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"key":"B468","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1038\/s41467-021-23084-1","article-title":"A BAFF\/APRIL axis regulates obesogenic diet-driven weight gain","volume":"12","author":"Chan","year":"2021","journal-title":"Nat Commun"},{"key":"B469","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2159","article-title":"Basophils and the T helper 2 environment can promote the development of lupus nephritis","volume":"16","author":"Charles","year":"2010","journal-title":"Nat Med"},{"key":"B470","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1104","article-title":"BioGPS: building your own mash-up of gene annotations and expression profiles","volume":"44","author":"Wu","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"B471","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-632","article-title":"An expression atlas of human primary cells: inference of gene function from coexpression networks","volume":"14","author":"Mabbott","year":"2013","journal-title":"BMC Genomics"},{"key":"B472","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.886736","article-title":"Roep and tatjana nikolic. functional impact of risk gene variants on the autoimmune responses in type 1 diabetes","volume":"13","author":"Chelsea Gootjes","year":"2022","journal-title":"Front Immunol"},{"key":"B473","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2013.04.004","article-title":"Differential colonization with segmented filamentous bacteria and lactobacillus murinus do not drive divergent development of diet-induced obesity in C57BL\/6 mice","volume":"2","author":"Harley","year":"2013","journal-title":"Mol Metab"},{"key":"B474","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2299","article-title":"Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency","volume":"44","author":"Meimaridou","year":"2012","journal-title":"Nat Genet"},{"key":"B475","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MR0516-224R","article-title":"Caspase-1 as a multifunctional inflammatory mediator: noncytokine maturation roles","volume":"100","author":"Sun","year":"2016","journal-title":"J Leukoc Biol"},{"key":"B476","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J Immunol"},{"key":"B477","doi-asserted-by":"publisher","DOI":"10.1126\/science.1158298","article-title":"Pyogenic bacterial infections in humans with MyD88 deficiency","volume":"321","author":"von Bernuth","year":"2008","journal-title":"Science"},{"key":"B478","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.5.2770","article-title":"Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency","volume":"177","author":"Cohen","year":"2006","journal-title":"J Immunol"},{"key":"B479","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.695859","article-title":"Enhancing effects of environmental enrichment on the functions of natural killer cells in mice","volume":"12","author":"Xiao","year":"2021","journal-title":"Front Immunol"},{"key":"B480","doi-asserted-by":"publisher","first-page":"5725","DOI":"10.1038\/s41467-021-25967-9","article-title":"Environmental eustress modulates beta-ARs\/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice","volume":"12","author":"Liu","year":"2021","journal-title":"Nat Commun"},{"key":"B481","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120988","article-title":"Unstressing intemperate models: how cold stress undermines mouse modeling","volume":"209","author":"Karp","year":"2012","journal-title":"J Exp Med"},{"key":"B482","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.636198","article-title":"Thermoneutrality alters gastrointestinal antigen passage patterning and predisposes to oral antigen sensitization in mice","volume":"12","author":"Noah","year":"2021","journal-title":"Front Immunol"},{"key":"B483","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4346","article-title":"Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling","volume":"23","author":"Giles","year":"2017","journal-title":"Nat Med"},{"key":"B484","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.187","article-title":"Thermoneutral housing is a critical factor for immune function and diet-induced obesity in C57BL\/6 nude mice","volume":"39","author":"Stemmer","year":"2015","journal-title":"Int J Obes (Lond)"},{"key":"B485","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.09.008","article-title":"Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL\/6 mice","volume":"5","author":"Giles","year":"2016","journal-title":"Mol Metab"},{"key":"B486","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00044","article-title":"Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders","volume":"9","author":"Breit","year":"2018","journal-title":"Front Psychiatry"},{"key":"B487","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605635113","article-title":"Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis","volume":"113","author":"Koopman","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B488","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2020.1764617","article-title":"Short-term transcutaneous non-invasive vagus nerve stimulation may reduce disease activity and pro-inflammatory cytokines in rheumatoid arthritis: results of a pilot study","volume":"50","author":"Drewes","year":"2021","journal-title":"Scand J Rheumatol"},{"key":"B489","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000215","article-title":"Autoimmune rheumatic disease and sleep: a review","volume":"21","author":"Sangle","year":"2015","journal-title":"Curr Opin Pulm Med"},{"key":"B490","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318778368","article-title":"Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus","volume":"27","author":"Young","year":"2018","journal-title":"Lupus"},{"key":"B491","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.9.1244","article-title":"Increased disease activity is associated with altered sleep architecture in an experimental model of systemic lupus erythematosus","volume":"33","author":"Palma","year":"2010","journal-title":"Sleep"},{"key":"B492","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1590\/s0100-879x2009000300012","article-title":"Effects on prolactin secretion and binding to dopaminergic receptors in sleep-deprived lupus-prone mice","volume":"42","author":"Palma","year":"2009","journal-title":"Braz J Med Biol Res"},{"key":"B493","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9051062","article-title":"Consideration of gut microbiome in murine models of diseases","volume":"9","author":"Zhang","year":"2021","journal-title":"Microorganisms"},{"key":"B494","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9102064","article-title":"Characterization of the eukaryotic virome of mice from different sources","volume":"9","author":"Zhang","year":"2021","journal-title":"Microorganisms"},{"key":"B495","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100484","article-title":"Caught in a trap: How pre-clinical studies in laboratory mice exaggerate vaccine responses","volume":"2","author":"Coughlan","year":"2021","journal-title":"Cell Rep Med"},{"key":"B496","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211220","article-title":"Natural rodent model of viral transmission reveals biological features of virus population dynamics","volume":"219","author":"Fay","year":"2022","journal-title":"J Exp Med"},{"key":"B497","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1016\/j.celrep.2019.07.028","article-title":"Microbial exposure enhances immunity to pathogens recognized by TLR2 but increases susceptibility to cytokine storm through TLR4 sensitization","volume":"28","author":"Huggins","year":"2019","journal-title":"Cell Rep"},{"key":"B498","doi-asserted-by":"publisher","DOI":"10.1038\/nature17655","article-title":"Normalizing the environment recapitulates adult human immune traits in laboratory mice","volume":"532","author":"Beura","year":"2016","journal-title":"Nature"},{"key":"B499","unstructured":"Standard diets2022"},{"key":"B500","unstructured":"Laboratory rodent diet2021"},{"key":"B501","doi-asserted-by":"publisher","DOI":"10.1126\/science.7071589","article-title":"Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid","volume":"216","author":"Malinow","year":"1982","journal-title":"Science"},{"key":"B502","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.12.004","article-title":"Role of non-protein amino acid l-canavanine in autoimmunity","volume":"5","author":"Akaogi","year":"2006","journal-title":"Autoimmun Rev"},{"key":"B503","unstructured":"5 things to avoid if you have lupus"},{"key":"B504","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102612","article-title":"Rhupus: a systematic literature review","volume":"19","author":"Antonini","year":"2020","journal-title":"Autoimmun Rev"},{"key":"B505","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad2791","article-title":"Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion","volume":"351","author":"Delong","year":"2016","journal-title":"Science"},{"key":"B506","doi-asserted-by":"publisher","DOI":"10.1215\/03616878-9716698","article-title":"Hydroxychloroquine for COVID-19: Variation in regional political preferences predicted new prescriptions after President trump's endorsement","volume":"47","author":"Madanay","year":"2022","journal-title":"J Health Polit Policy Law"},{"key":"B507","doi-asserted-by":"publisher","first-page":"102291","DOI":"10.1016\/j.jaut.2019.06.002","article-title":"Ultraviolet light induces increased T cell activation in lupus-prone mice via type I IFN-dependent inhibition of T regulatory cells","volume":"103","author":"Wolf","year":"2019","journal-title":"J Autoimmun"},{"key":"B508","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.616483","article-title":"Exploring the evidence for an immunomodulatory role of vitamin d in juvenile and adult rheumatic disease","volume":"11","author":"Zou","year":"2020","journal-title":"Front Immunol"},{"key":"B509","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-066452","article-title":"Vitamin d and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial","volume":"376","author":"Hahn","year":"2022","journal-title":"Bmj"},{"key":"B510","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.148494","article-title":"Vitamin d deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus","volume":"70","author":"Ritterhouse","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"B511","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094500","article-title":"Vitamin d deficiency in a multiethnic healthy control cohort and altered immune response in vitamin d deficient European-American healthy controls","volume":"9","author":"Ritterhouse","year":"2014","journal-title":"PloS One"},{"key":"B512","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jdermsci.2017.12.009","article-title":"Skin wound healing in humans and mice: Challenges in translational research","volume":"90","author":"Zomer","year":"2018","journal-title":"J Dermatol Sci"},{"key":"B513","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.06.019","article-title":"Mouse models of psoriasis: A comprehensive review","volume":"142","author":"Gangwar","year":"2022","journal-title":"J Invest Dermatol"},{"key":"B514","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700807","article-title":"Mouse models of psoriasis","volume":"127","author":"Gudjonsson","year":"2007","journal-title":"J Invest Dermatol"},{"key":"B515","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2013-0279","article-title":"The top skin-associated genes: a comparative analysis of human and mouse skin transcriptomes","volume":"395","author":"Gerber","year":"2014","journal-title":"Biol Chem"},{"key":"B516","doi-asserted-by":"publisher","DOI":"10.1177\/0961203306070009","article-title":"The curiously suspicious: a role for Epstein-Barr virus in lupus","volume":"15","author":"Harley","year":"2006","journal-title":"Lupus"},{"key":"B517","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01952-18","article-title":"Comparative analysis of gammaherpesvirus circular RNA repertoires: Conserved and unique viral circular RNAs","volume":"93","author":"Ungerleider","year":"2019","journal-title":"J Virol"},{"key":"B518","unstructured":"LoweD The latest on drug failure and approval rates2019"},{"key":"B519","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-019-00074-z","article-title":"Trends in clinical success rates and therapeutic focus","volume":"18","author":"Dowden","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"B520","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.85","article-title":"Trends in clinical success rates","volume":"15","author":"Smietana","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"B521","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202104","article-title":"Tolerant anti-insulin b cells are effective APCs","volume":"190","author":"Kendall","year":"2013","journal-title":"J Immunol"},{"key":"B522","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701717","article-title":"Anti-insulin b cells are poised for antigen presentation in type 1 diabetes","volume":"201","author":"Felton","year":"2018","journal-title":"J Immunol"},{"key":"B523","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3390\/jcm5110098","article-title":"B cell receptor affinity for insulin dictates autoantigen acquisition and b cell functionality in autoimmune diabetes","volume":"5","author":"Packard","year":"2016","journal-title":"J Clin Med"},{"key":"B524","doi-asserted-by":"publisher","DOI":"10.1159\/000066863","article-title":"The role of b lymphocytes as key antigen-presenting cells in the development of T cell-mediated autoimmune type 1 diabetes","volume":"6","author":"Serreze","year":"2003","journal-title":"Curr Dir Autoimmun"},{"key":"B525","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0006","article-title":"B-cell cross-presentation of autologous antigen precipitates diabetes","volume":"61","author":"Mari\u00f1o","year":"2012","journal-title":"Diabetes"},{"key":"B526","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700822","article-title":"Transient BAFF blockade inhibits type 1 diabetes development in nonobese diabetic mice by enriching immunoregulatory b lymphocytes sensitive to deletion by anti-CD20 cotherapy","volume":"199","author":"Wang","year":"2017","journal-title":"J Immunol"},{"key":"B527","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1606","article-title":"B-lymphocytes expressing an ig specificity recognizing the pancreatic ss-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice","volume":"65","author":"Leeth","year":"2016","journal-title":"Diabetes"},{"key":"B528","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32405","article-title":"Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice","volume":"117","author":"Hu","year":"2007","journal-title":"J Clin Invest"},{"key":"B529","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1081","article-title":"Dynamic immune phenotypes of b and T helper cells mark distinct stages of T1D progression","volume":"68","author":"Habib","year":"2019","journal-title":"Diabetes"},{"key":"B530","doi-asserted-by":"publisher","DOI":"10.1126\/science.abh1654","article-title":"Immunotherapy: Building a bridge to a cure for type 1 diabetes","volume":"373","author":"Bluestone","year":"2021","journal-title":"Science"},{"key":"B531","doi-asserted-by":"publisher","first-page":"697","DOI":"10.2337\/db17-0937","article-title":"Loss of b-cell anergy in type 1 diabetes is associated with high-risk HLA and non-HLA disease susceptibility alleles","volume":"67","author":"Smith","year":"2018","journal-title":"Diabetes"},{"key":"B532","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00842","article-title":"HLA allele-specific quantitative profiling of type 1 diabetic b lymphocyte immunopeptidome","volume":"21","author":"Sudhir","year":"2022","journal-title":"J Proteome Res"},{"key":"B533","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.123384","article-title":"Elevated PTEN expression maintains anergy in human b cells and reveals unexpectedly high repertoire autoreactivity","volume":"4","author":"Smith","year":"2019","journal-title":"JCI Insight"},{"key":"B534","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009382","article-title":"Biomedical data commons (BMDC) prioritizes b-lymphocyte non-coding genetic variants in type 1 diabetes","volume":"17","author":"Piekos","year":"2021","journal-title":"PloS Comput Biol"},{"key":"B535","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2021.102780","article-title":"New insights into the taxonomy of autoimmune diseases based on polyautoimmunity","volume":"126","author":"Rojas","year":"2022","journal-title":"J Autoimmun"},{"key":"B536","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.jaut.2018.11.002","article-title":"Cluster analysis of autoimmune rheumatic diseases based on autoantibodies. new insights for polyautoimmunity","volume":"98","author":"Molano-Gonz\u00e1lez","year":"2019","journal-title":"J Autoimmun"},{"key":"B537","doi-asserted-by":"publisher","DOI":"10.1002\/art.41610","article-title":"Integrative analysis reveals a molecular stratification of systemic autoimmune diseases","volume":"73","author":"Barturen","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"B538","doi-asserted-by":"publisher","first-page":"3523","DOI":"10.1038\/s41467-021-23472-7","article-title":"A new molecular classification to drive precision treatment strategies in primary sj\u00f6gren's syndrome","volume":"12","author":"Soret","year":"2021","journal-title":"Nat Commun"},{"key":"B539","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nrrheum.2017.220","article-title":"Moving towards a molecular taxonomy of autoimmune rheumatic diseases","volume":"14","author":"Barturen","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"B540","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214127","article-title":"Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases","volume":"78","author":"Acosta-Herrera","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"B541","doi-asserted-by":"publisher","DOI":"10.1038\/nature13835","article-title":"Genetic and epigenetic fine mapping of causal autoimmune disease variants","volume":"518","author":"Farh","year":"2015","journal-title":"Nature"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.953439\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T15:13:11Z","timestamp":1676473991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.953439\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":541,"alternative-id":["10.3389\/fimmu.2022.953439"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.953439","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]},"article-number":"953439"}}