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Mutations occurring within the viral genome, characterized by these new emerging VOCs, confer on them the ability to efficiently resist and escape natural and vaccine-induced humoral and cellular immune responses. Consequently, these VOCs have enhanced infectivity, increasing their stable spread in a given population with an important fatality rate. While the humoral immune escape process is well documented, the evasion mechanisms of VOCs from cellular immunity are not well elaborated. In this review, we discussed how SARS-CoV-2 VOCs adapt inside host cells and escape anti-COVID-19 cellular immunity, focusing on the effect of specific SARS-CoV-2 mutations in hampering the activation of CD8<jats:sup>+<\/jats:sup>T-cell immunity.<\/jats:p>","DOI":"10.3389\/fimmu.2022.962079","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T05:44:20Z","timestamp":1666849460000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["CD8+ T-cell immune escape by SARS-CoV-2 variants of concern"],"prefix":"10.3389","volume":"13","author":[{"given":"Arnaud John","family":"Kombe Kombe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleury Augustin Nsole","family":"Biteghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00e9lia 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