{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:08:08Z","timestamp":1791493688251,"version":"4.3.4"},"reference-count":116,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874408"],"award-info":[{"award-number":["81874408"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014472","name":"Scientific Research Foundation of Hunan Provincial Education Department","doi-asserted-by":"publisher","award":["21B0359"],"award-info":[{"award-number":["21B0359"]}],"id":[{"id":"10.13039\/100014472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["202207015643"],"award-info":[{"award-number":["202207015643"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014978","name":"Hunan University of Chinese Medicine","doi-asserted-by":"publisher","award":["2022ZYX03"],"award-info":[{"award-number":["2022ZYX03"]}],"id":[{"id":"10.13039\/501100014978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>According to the difference in temperature, thermotherapy can be divided into thermal ablation and mild hyperthermia. The main advantage of thermal ablation is that it can efficiently target tumors in situ, while mild hyperthermia has a good inhibitory effect on distant metastasis. There are some similarities and differences between the two therapies with respect to inducing anti-tumor immune responses, but neither of them results in sustained systemic immunity. Malignant tumors (such as breast cancer, pancreatic cancer, nasopharyngeal carcinoma, and brain cancer) are recurrent, highly metastatic, and highly invasive even after treatment, hence a single therapy rarely resolves the clinical issues. A more effective and comprehensive treatment strategy using a combination of hyperthermia and immune checkpoint inhibitor (ICI) therapies has gained attention. This paper summarizes the relevant preclinical and clinical studies on hyperthermia combined with ICI therapies and compares the efficacy of two types of hyperthermia combined with ICIs, in order to provide a better treatment for the recurrence and metastasis of clinically malignant tumors.<\/jats:p>","DOI":"10.3389\/fimmu.2022.969447","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T07:10:25Z","timestamp":1660288225000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Hyperthermia combined with immune checkpoint inhibitor therapy in the treatment of primary and metastatic tumors"],"prefix":"10.3389","volume":"13","author":[{"given":"Ximing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaozhi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runshi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-21-0041","article-title":"Innate immune checkpoint inhibitors: The next breakthrough in medical oncology","volume":"20","author":"Lentz","year":"2021","journal-title":"Mol Cancer Ther"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00784","article-title":"The tumor microenvironment in the response to immune checkpoint blockade therapies","volume":"11","author":"Petitprez","year":"2020","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.715234","article-title":"CD8(+) T cell exhaustion in cancer","volume":"12","author":"Dolina","year":"2021","journal-title":"Front Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.672356","article-title":"Neoantigen: A new breakthrough in tumor immunotherapy","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13045-020-01014-w","article-title":"NK cell-based cancer immunotherapy: from basic biology to clinical development","volume":"14","author":"Liu","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00167","article-title":"NK cell-based immune checkpoint inhibition","volume":"11","author":"Khan","year":"2020","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01869","article-title":"Natural killer cells: Development, maturation, and clinical utilization","volume":"9","author":"Abel","year":"2018","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1922-8","article-title":"B cells and tertiary lymphoid structures promote immunotherapy response","volume":"577","author":"Helmink","year":"2020","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1623679","DOI":"10.1155\/2017\/1623679","article-title":"Clinical applications of immunotherapy combination methods and new opportunities for the future","volume":"2017","author":"Esin","year":"2017","journal-title":"BioMed Res Int"},{"key":"B10","doi-asserted-by":"publisher","first-page":"5245034","DOI":"10.1155\/2019\/5245034","article-title":"Combinatorial approach to improve cancer immunotherapy: Rational drug design strategy to simultaneously hit multiple targets to kill tumor cells and to activate the immune system","volume":"2019","author":"Joshi","year":"2019","journal-title":"J Oncol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s13046-019-1266-0","article-title":"Advances in cancer immunotherapy 2019 - latest trends","volume":"38","author":"Kruger","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/026765919601100602","article-title":"Therapeutic hyperthermia","volume":"11","author":"Alpard","year":"1996","journal-title":"Perfusion"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e1638","DOI":"10.1002\/wnan.1638","article-title":"Direct treatment versus indirect: Thermo-ablative and mild hyperthermia effects","volume":"12","author":"Payne","year":"2020","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64074-1.00053-7","article-title":"Therapeutic hyperthermia","volume":"157","author":"Habash","year":"2018","journal-title":"Handb Clin Neurol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.addr.2020.07.007","article-title":"Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy","author":"Dunne","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3779\/j.issn.1009-3419.2020.02.06","article-title":"Advances and challenges of local thermal ablation in non-small cell lung cancer","volume":"23","author":"Gou","year":"2020","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0377","article-title":"Thermal ablation for small papillary thyroid cancer: A systematic review","volume":"29","author":"Cho","year":"2019","journal-title":"Thyroid"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.751213","article-title":"Clinical effects of microwave ablation in the treatment of low-risk papillary thyroid microcarcinomas and related histopathological changes","volume":"12","author":"Lu","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2021.1887942","article-title":"Incomplete thermal ablation of tumors promotes increased tumorigenesis","volume":"38","author":"Markezana","year":"2021","journal-title":"Int J Hyperthermia"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000200","article-title":"Non-thermal histotripsy tumor ablation promotes abscopal immune responses that enhance cancer immunotherapy","volume":"8","author":"Qu","year":"2020","journal-title":"J Immunother Cancer"},{"key":"B21","doi-asserted-by":"publisher","first-page":"4398","DOI":"10.3390\/ijms21124398","article-title":"Percutaneous ablation-induced immunomodulation in hepatocellular carcinoma","volume":"21","author":"Dumolard","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c02537","article-title":"Mild magnetic hyperthermia-activated innate immunity for liver cancer therapy","volume":"143","author":"Pan","year":"2021","journal-title":"J Am Chem Soc"},{"key":"B23","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1158\/2643-3230.BCD-20-0188","article-title":"Hyperthermia selectively destabilizes oncogenic fusion proteins","volume":"2","author":"Maimaitiyiming","year":"2021","journal-title":"Blood Cancer Discovery"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR03201A","article-title":"Two step promotion of a hot tumor immune environment by gold decorated iron oxide nanoflowers and light-triggered mild hyperthermia","volume":"13","author":"Nicolas-Boluda","year":"2021","journal-title":"Nanoscale"},{"key":"B25","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1080\/02656736.2020.1778800","article-title":"Exosomes released by breast cancer cells under mild hyperthermic stress possess immunogenic potential and modulate polarization in vitro in macrophages","volume":"37","author":"Sen","year":"2020","journal-title":"Int J Hyperthermia"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1039\/D1BM01888D","article-title":"Autophagy-inhibiting biomimetic nanodrugs enhance photothermal therapy and boost antitumor immunity","volume":"10","author":"Huang","year":"2022","journal-title":"Biomater Sci"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.617365","article-title":"Immune modulation plus tumor ablation: Adjuvants and antibodies to prime and boost anti-tumor immunity in situ","volume":"12","author":"van den Bijgaart","year":"2021","journal-title":"Front Immunol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2019-000337corr1","article-title":"Consensus guidelines for the definition, detection and interpretation of immunogenic cell death","volume":"8","author":"Galluzzi","year":"2020","journal-title":"J Immunother Cancer"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21959","article-title":"Pattern of carcinoembryonic antigen drop after laparoscopic radiofrequency ablation of liver metastasis from colorectal carcinoma","volume":"107","author":"Ghanamah","year":"2006","journal-title":"Cancer"},{"key":"B30","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.urolonc.2004.06.005","article-title":"PSA elevation during prostate cryosurgery and subsequent decline","volume":"23","author":"Leibovici","year":"2005","journal-title":"Urol Oncol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b01107","article-title":"Surface-functionalized modified copper sulfide nanoparticles enhance checkpoint blockade tumor immunotherapy by photothermal therapy and antigen capturing","volume":"11","author":"Wang","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1177\/1534735419876345","article-title":"The role of hyperthermia in the multidisciplinary treatment of malignant tumors","volume":"18","author":"Cheng","year":"2019","journal-title":"Integr Cancer Ther"},{"key":"B33","doi-asserted-by":"publisher","first-page":"102615","DOI":"10.1016\/j.jtherbio.2020.102615","article-title":"Hyperthermia and protein homeostasis: Cytoprotection and cell death","volume":"91","author":"Ahmed","year":"2020","journal-title":"J Therm Biol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14356","article-title":"Immunogenic cell death in cancer therapy: Present and emerging inducers","volume":"23","author":"Zhou","year":"2019","journal-title":"J Cell Mol Med"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151017380","article-title":"Hyperthermia induces apoptosis through endoplasmic reticulum and reactive oxygen species in human osteosarcoma cells","volume":"15","author":"Hou","year":"2014","journal-title":"Int J Mol Sci"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-017-0044-9","article-title":"eIF2alpha phosphorylation is pathognomonic for immunogenic cell death","volume":"25","author":"Bezu","year":"2018","journal-title":"Cell Death Differ"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2017.04.008","article-title":"Thermal ablation and immunomodulation: From preclinical experiments to clinical trials","volume":"98","author":"Takaki","year":"2017","journal-title":"Diagn Interv Imaging"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12836","article-title":"Immunomodulation characteristics by thermal ablation therapy in cancer patients","volume":"14","author":"Yang","year":"2018","journal-title":"Asia Pac J Clin Oncol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0449-0","article-title":"Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells","volume":"18","author":"Yu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12967-017-1124-9","article-title":"Microwave ablation combined with OK-432 induces Th1-type response and specific antitumor immunity in a murine model of breast cancer","volume":"15","author":"Li","year":"2017","journal-title":"J Transl Med"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2017.12.011","article-title":"Enhanced antitumor efficacy through microwave ablation in combination with immune checkpoints blockade in breast cancer: A pre-clinical study in a murine model","volume":"99","author":"Zhu","year":"2018","journal-title":"Diagn Interv Imaging"},{"key":"B42","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.addr.2020.01.003","article-title":"Molecular and biological rationale of hyperthermia as radio- and chemosensitizer","author":"Oei","year":"2020","journal-title":"Adv Drug Delivery Rev"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.10.016","article-title":"Emerging hyperthermia applications for pediatric oncology","author":"Tydings","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.7150\/thno.57511","article-title":"Magnetism-mediated targeting hyperthermia-immunotherapy in \"cold\" tumor with CSF1R inhibitor","volume":"11","author":"Fang","year":"2021","journal-title":"Theranostics"},{"key":"B45","doi-asserted-by":"publisher","first-page":"10278","DOI":"10.1038\/s41598-021-89740-0","article-title":"Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor","volume":"11","author":"Wan Mohd Zawawi","year":"2021","journal-title":"Sci Rep"},{"key":"B46","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s40820-021-00622-6","article-title":"Recent advancements in nanomedicine for 'Cold' tumor immunotherapy","volume":"13","author":"Chen","year":"2021","journal-title":"Nanomicro Lett"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1226","article-title":"Therapeutic strategies to remodel immunologically cold tumors","volume":"9","author":"Wang","year":"2020","journal-title":"Clin Transl Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0255","article-title":"Classifying cancers based on T-cell infiltration and PD-L1","volume":"75","author":"Teng","year":"2015","journal-title":"Cancer Res"},{"key":"B49","doi-asserted-by":"publisher","first-page":"4871","DOI":"10.1038\/s41467-019-12771-9","article-title":"Mild photothermal therapy potentiates anti-PD-L1 treatment for immunologically cold tumors via an all-in-one and all-in-control strategy","volume":"10","author":"Huang","year":"2019","journal-title":"Nat Commun"},{"key":"B50","doi-asserted-by":"publisher","first-page":"100720","DOI":"10.1016\/j.xpro.2021.100720","article-title":"Protocol for fever-range whole-body hyperthermia (WBH) in mice to study febrile effect on T-cell adhesion and migration","volume":"2","author":"Lin","year":"2021","journal-title":"STAR Protoc"},{"key":"B51","first-page":"53","article-title":"Combined thermotherapy and heat shock protein modulation for tumor treatment","volume-title":"Heat shock proteins in human diseases","author":"Hoter","year":"2021"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S261638","article-title":"Preparation and evaluation of doxorubicin-loaded PLA-PEG-FA copolymer containing superparamagnetic iron oxide nanoparticles (SPIONs) for cancer treatment: Combination therapy with hyperthermia and chemotherapy","volume":"15","author":"Khaledian","year":"2020","journal-title":"Int J Nanomed"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2021.1915604","article-title":"Immuno-hyperthermia effected by antibody-conjugated nanoparticles selectively targets and eradicates individual cancer cells","volume":"20","author":"Kagawa","year":"2021","journal-title":"Cell Cycle"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01932A","article-title":"Multifunctional l-arginine-based magnetic nanoparticles for multiple-synergistic tumor therapy","volume":"9","author":"Yang","year":"2021","journal-title":"Biomater Sci"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202004788","article-title":"Recent advances in hyperthermia therapy-based synergistic immunotherapy","volume":"33","author":"Chang","year":"2021","journal-title":"Adv Mater"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2016.1157216","article-title":"Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms","volume":"32","author":"van den Tempel","year":"2016","journal-title":"Int J Hyperthermia"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e2001415","DOI":"10.1002\/adhm.202001415","article-title":"Recent progress in the synergistic combination of nanoparticle-mediated hyperthermia and immunotherapy for treatment of cancer","volume":"10","author":"Stephen","year":"2021","journal-title":"Adv Healthc Mater"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210893","article-title":"Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53\/ATM status in chronic lymphocytic leukaemia cells","volume":"27","author":"Lin","year":"2008","journal-title":"Oncogene"},{"key":"B59","article-title":"Heat shock proteins mediate anastasis and plasticity of thermotolerant cells","volume-title":"Heat shock proteins in human diseases","author":"Saadeldin","year":"2021"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.595207","article-title":"Hyperthermia targeting the tumor microenvironment facilitates immune checkpoint inhibitors","volume":"11","author":"Li","year":"2020","journal-title":"Front Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12874","article-title":"Exosomes from heat-stressed tumour cells inhibit tumour growth by converting regulatory T cells to Th17 cells via IL-6","volume":"154","author":"Guo","year":"2018","journal-title":"Immunology"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3109\/02656736.2011.564598","article-title":"Induction of a tumour-specific CTL response by exosomes isolated from heat-treated malignant ascites of gastric cancer patients","volume":"27","author":"Zhong","year":"2011","journal-title":"Int J Hyperthermia"},{"key":"B63","doi-asserted-by":"publisher","first-page":"9912281","DOI":"10.1155\/2021\/9912281","article-title":"Role of extracellular vesicles in compromising cellular resilience to environmental stressors","volume":"2021","author":"Alharbi","year":"2021","journal-title":"BioMed Res Int"},{"key":"B64","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.cell.2019.02.016","article-title":"Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory","volume":"177","author":"Poggio","year":"2019","journal-title":"Cell"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1080\/19336918.2016.1250999","article-title":"Exosomes in cancer theranostic: Diamonds in the rough","volume":"11","author":"Cordonnier","year":"2017","journal-title":"Cell Adh Migr"},{"key":"B66","doi-asserted-by":"publisher","first-page":"100870","DOI":"10.1016\/j.mam.2020.100870","article-title":"NK cells and ILCs in tumor immunotherapy","volume":"80","author":"Sivori","year":"2021","journal-title":"Mol Aspects Med"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S287473","article-title":"Thermal ablation for papillary thyroid microcarcinoma: How far we have come","volume":"12","author":"Min","year":"2020","journal-title":"Cancer Manag Res"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_558_19","article-title":"Expert consensus workshop report: Guidelines for thermal ablation of thyroid tumors (2019 edition)","volume":"16","author":"Xu","year":"2020","journal-title":"J Cancer Res Ther"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202100656","article-title":"Enhancement of CD8(+) T-Cell-Mediated tumor immunotherapy via magnetic hyperthermia","volume":"17","author":"Zhang","year":"2022","journal-title":"ChemMedChem"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2018-0029","article-title":"Gold nanoparticles-mediated photothermal therapy and immunotherapy","volume":"10","author":"Liu","year":"2018","journal-title":"Immunotherapy"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S116583","article-title":"Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation","volume":"12","author":"Cantu","year":"2017","journal-title":"Int J Nanomed"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1149\/MA2010-01\/19\/1044","article-title":"Single-wall carbon nanotubes assisted photothermal cancer therapy: animal study with a murine model of squamous cell carcinoma","volume":"42","author":"Huang","year":"2010","journal-title":"Lasers Surg Med"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1039\/C3NR06160D","article-title":"Cu(2)-xSe@mSiO(2)-PEG core-shell nanoparticles: a low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density","volume":"6","author":"Liu","year":"2014","journal-title":"Nanoscale"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1021\/nl100996u","article-title":"Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy","volume":"10","author":"Yang","year":"2010","journal-title":"Nano Lett"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b00579","article-title":"Iron nanoparticles for low-power local magnetic hyperthermia in combination with immune checkpoint blockade for systemic antitumor therapy","volume":"19","author":"Chao","year":"2019","journal-title":"Nano Lett"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b08550","article-title":"Combined magnetic hyperthermia and immune therapy for primary and metastatic tumor treatments","volume":"14","author":"Pan","year":"2020","journal-title":"ACS Nano"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042020-042741","article-title":"Immune checkpoint inhibitors for the treatment of cancer: Clinical impact and mechanisms of response and resistance","volume":"16","author":"Bagchi","year":"2021","journal-title":"Annu Rev Pathol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ctrv.2016.11.007","article-title":"Resistance to PD1\/PDL1 checkpoint inhibition","volume":"52","author":"O'Donnell","year":"2017","journal-title":"Cancer Treat Rev"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02212","article-title":"Nivolumab and ipilimumab as maintenance therapy in extensive-disease small-cell lung cancer: CheckMate 451","volume":"39","author":"Owonikoko","year":"2021","journal-title":"J Clin Oncol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-021-00843-0","article-title":"Durvalumab: A review in extensive-stage SCLC","volume":"16","author":"Al-Salama","year":"2021","journal-title":"Target Oncol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32381-3","article-title":"Breast cancer","volume":"397","author":"Loibl","year":"2021","journal-title":"Lancet"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202007051","article-title":"M2-like TAMs function reversal contributes to breast cancer eradication by combination dual immune checkpoint blockade and photothermal therapy","volume":"17","author":"Zhao","year":"2021","journal-title":"Small"},{"key":"B83","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/02656736.2019.1685686","article-title":"Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer","volume":"36","author":"Oei","year":"2019","journal-title":"Int J Hyperthermia"},{"key":"B84","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/s41598-020-80135-1","article-title":"Immune modulation resulting from MR-guided high intensity focused ultrasound in a model of murine breast cancer","volume":"11","author":"Fite","year":"2021","journal-title":"Sci Rep"},{"key":"B85","doi-asserted-by":"publisher","first-page":"114639","DOI":"10.1016\/j.bcp.2021.114639","article-title":"Gold nanostructures as mediators of hyperthermia therapies in breast cancer","volume":"190","author":"Granja","year":"2021","journal-title":"Biochem Pharmacol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"77","DOI":"10.2217\/nnm-2019-0190","article-title":"Depleting tumor-associated tregs via nanoparticle-mediated hyperthermia to enhance anti-CTLA-4 immunotherapy","volume":"15","author":"Chen","year":"2020","journal-title":"Nanomed (Lond)"},{"key":"B87","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13045-020-01030-w","article-title":"Targeting hypoxic tumor microenvironment in pancreatic cancer","volume":"14","author":"Tao","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01114-4","article-title":"Pancreatic adenocarcinoma presenting with cushing's syndrome","volume":"398","author":"Karniadakis","year":"2021","journal-title":"Lancet"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: A review","volume":"326","author":"Park","year":"2021","journal-title":"JAMA"},{"key":"B90","doi-asserted-by":"publisher","first-page":"20210266","DOI":"10.1098\/rsif.2021.0266","article-title":"Pulsed focused ultrasound can improve the anti-cancer effects of immune checkpoint inhibitors in murine pancreatic cancer","volume":"18","author":"Mouratidis","year":"2021","journal-title":"J R Soc Interface"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2017-0101","article-title":"Complex effects of tumor microenvironment on the tumor disposition of carrier-mediated agents","volume":"12","author":"Lucas","year":"2017","journal-title":"Nanomed (Lond)"},{"key":"B92","doi-asserted-by":"publisher","first-page":"13193","DOI":"10.1038\/ncomms13193","article-title":"Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy","volume":"7","author":"Chen","year":"2016","journal-title":"Nat Commun"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.05.002","article-title":"Mild hyperthermia promotes immune checkpoint blockade-based immunotherapy against metastatic pancreatic cancer using size-adjustable nanoparticles","volume":"133","author":"Yu","year":"2021","journal-title":"Acta Biomater"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01123-5","article-title":"Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial","volume":"398","author":"Chen","year":"2021","journal-title":"Lancet"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01240-X","article-title":"Adjuvant metronomic chemotherapy for locoregionally advanced nasopharyngeal carcinoma","volume":"398","author":"Kerbel","year":"2021","journal-title":"Lancet"},{"key":"B96","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.clon.2019.02.004","article-title":"Overcoming radioresistance: Small molecule radiosensitisers and hypoxia-activated prodrugs","volume":"31","author":"Jackson","year":"2019","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-3018","article-title":"Long-term efficacy and adverse reactions of IMRT combined with endostar versus IMRT combined with chemotherapy for locally advanced nasopharyngeal carcinoma: a retrospective study","volume":"10","author":"Chen","year":"2021","journal-title":"Ann Palliat Med"},{"key":"B98","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s12951-021-00918-0","article-title":"Polyethylene glycol-coated ultrasmall superparamagnetic iron oxide nanoparticles-coupled sialyl Lewis X nanotheranostic platform for nasopharyngeal carcinoma imaging and photothermal therapy","volume":"19","author":"Liu","year":"2021","journal-title":"J Nanobiotechnol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.03.168","article-title":"Surface charge transition nano-theranostics based on ultra-small Fe3O4 nanoparticles for enhanced photodynamic and photothermal therapy against nasopharyngeal carcinoma","volume":"557","author":"Bejjanki","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2021.1971778","article-title":"Whole-body hyperthermia combined with chemotherapy and intensity-modulated radiotherapy for treatment of advanced nasopharyngeal carcinoma: a retrospective study with propensity score matching","volume":"38","author":"Zheng","year":"2021","journal-title":"Int J Hyperthermia"},{"key":"B101","article-title":"Apoptosis-inducing effects of cetuximab combined with radiotherapy and hypothermia on human nasopharyngeal carcinoma CNE cells","volume":"8","author":"Liu","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.7150\/thno.40298","article-title":"Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.3390\/pharmaceutics13101668","article-title":"Elucidating the innate immunological effects of mild magnetic hyperthermia on U87 human glioblastoma cells: An in vitro study","volume":"13","author":"Persano","year":"2021","journal-title":"Pharmaceutics"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2019-0023","article-title":"Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory","volume":"11","author":"Liu","year":"2019","journal-title":"Immunotherapy"},{"key":"B105","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1208\/s12249-021-01928-9","article-title":"Enhancement of therapies for glioblastoma (GBM) using nanoparticle-based delivery systems","volume":"22","author":"Wiwatchaitawee","year":"2021","journal-title":"AAPS PharmSciTech"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.10.015","article-title":"Prussian Blue nanoparticle-based photothermal therapy combined with checkpoint inhibition for photothermal immunotherapy of neuroblastoma","volume":"13","author":"Cano-Mejia","year":"2017","journal-title":"Nanomedicine"},{"key":"B107","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1186\/s40425-019-0805-8","article-title":"Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors","volume":"7","author":"Das","year":"2019","journal-title":"J Immunother Cancer"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02526","article-title":"A non-interventional clinical trial assessing immune responses after radiofrequency ablation of liver metastases from colorectal cancer","volume":"10","author":"Loffler","year":"2019","journal-title":"Front Immunol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.07.051","article-title":"Photothermal therapy mediated by gold nanocages composed of anti-PDL1 and galunisertib for improved synergistic immunotherapy in colorectal cancer","volume":"134","author":"Wang","year":"2021","journal-title":"Acta Biomater"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-020-02751-0","article-title":"Low-dose ipilimumab plus nivolumab combined with IL-2 and hyperthermia in cancer patients with advanced disease: exploratory findings of a case series of 131 stage IV cancers - a retrospective study of a single institution","volume":"70","author":"Kleef","year":"2021","journal-title":"Cancer Immunol Immunother"},{"key":"B111","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1080\/02656736.2019.1647350","article-title":"Immune correlates of clinical benefit in a phase I study of hyperthermia with adoptive T cell immunotherapy in patients with solid tumors","volume":"36","author":"Qiao","year":"2019","journal-title":"Int J Hyperthermia"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b17137","article-title":"Photothermal-chemotherapy integrated nanoparticles with tumor microenvironment response enhanced the induction of immunogenic cell death for colorectal cancer efficient treatment","volume":"11","author":"Wen","year":"2019","journal-title":"ACS Appl Mater Interfaces"},{"key":"B113","doi-asserted-by":"publisher","first-page":"e1311433","DOI":"10.1080\/2162402X.2017.1311433","article-title":"Severe, but not mild heat-shock treatment induces immunogenic cell death in cancer cells","volume":"6","author":"Adkins","year":"2017","journal-title":"Oncoimmunology"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0190","article-title":"A pilot study of preoperative single-dose ipilimumab and\/or cryoablation in women with early-stage breast cancer with comprehensive immune profiling","volume":"22","author":"McArthur","year":"2016","journal-title":"Clin Cancer Res"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.125","article-title":"The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4(+) T-cell-mediated antitumor memory immune response","volume":"8","author":"He","year":"2017","journal-title":"Cell Death Dis"},{"key":"B116","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3109\/02656736.2011.616182","article-title":"Effector CD8+ T cell IFN-gamma production and cytotoxicity are enhanced by mild hyperthermia","volume":"28","author":"Mace","year":"2012","journal-title":"Int J Hyperthermia"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.969447\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T07:10:33Z","timestamp":1660288233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.969447\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,12]]},"references-count":116,"alternative-id":["10.3389\/fimmu.2022.969447"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.969447","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,12]]},"article-number":"969447"}}