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Immunol."],"abstract":"<jats:p>The immunopathology associated with Leishmaniasis is a consequence of inflammation. Upon infection with <jats:italic>Leishmania<\/jats:italic>, the type of host-immune response is determinant for the clinical manifestations that can lead to either self-healing or chronic disease. Multiple pathways may determine disease severity. A comparison of systemic immune profiles in patients with cutaneous leishmaniasis caused by <jats:italic>L. guyanensis<\/jats:italic> and healthy individuals with the same socio-epidemiological characteristics coming from the same endemic areas as the patients is performed to identify particular immune profile and pathways associated with the progression of disease development. Twenty-seven plasma soluble circulating factors were evaluated between the groups by univariate and multivariate analysis. The following biomarkers pairs IL-17\/IL-9 (\u03c1=0,829), IL-17\/IL-12 (\u03c1=0,786), IL-6\/IL-1ra (\u03c1=0,785), IL-6\/IL-12 (\u03c1=0,780), IL-1\u03b2\/G-CSF (\u03c1=0,758) and IL-17\/MIP-1\u03b2 (\u03c1=0,754) showed the highest correlation mean among the patient while only INF-\u03b3\/IL-4 (\u03c1=0.740), 17\/MIP-1\u03b2 (\u03c1=0,712) and IL-17\/IL-9 (\u03c1=0,707) exhibited positive correlation among the control group. The cytokine IL-17 and IL1\u03b2 presented the greater number of positive pair correlation among the patients. The linear combinations of biomarkers displayed IP-10, IL-2 and RANTES as the variables with the higher discriminatory activity in the patient group compared to PDGF, IL-1ra and eotaxin among the control subjects. IP-10, IL-2, IL-1\u03b2, RANTES and IL-17 seem to be predictive value of progression to the development of disease among the <jats:italic>Lg<\/jats:italic>-infected individuals.<\/jats:p>","DOI":"10.3389\/fimmu.2022.974051","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T08:10:42Z","timestamp":1661415042000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasis"],"prefix":"10.3389","volume":"13","author":[{"given":"Tirza Gabrielle Ramos de","family":"Mesquita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 do Esp\u00edrito Santo","family":"Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan Diego Oliveira 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