{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:35:26Z","timestamp":1790199326946,"version":"4.1.0"},"reference-count":158,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      HLA-G plays a central role in immune tolerance at the maternal-fetal interface. The HLA-G gene is characterized by low allelic polymorphism and restricted tissue expression compared with classical HLA genes. HLA-G polymorphism is associated with HLA-G expression and linked to pregnancy complications. However, the association of parental HLA-G polymorphisms with soluble HLA-G (sHLA-G) expression and their roles in recurrent implantation failure (RIF) is unclear. The study aims to systematically review the association of HLA-G polymorphisms with RIF, the association of sHLA-G expression with RIF, and the association of HLA-G polymorphisms with sHLA-G expressions in patients attending\n                      <jats:italic>in-vitro<\/jats:italic>\n                      fertilization (IVF) treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Studies that evaluated the association of HLA-G polymorphisms with RIF, the association between sHLA-G expression with RIF, and the association between HLA-G polymorphisms with sHLA-G expressions in patients attending IVF treatment were included. Meta-analysis was performed by random-effect models. Sensitivity analysis was performed by excluding one study each time. Subgroup analysis was performed based on ethnicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HLA-G 14bp ins variant is associated with a lower expression of sHLA-G in seminal or blood plasma of couples attending IVF treatment. The maternal HLA-G*010101 and paternal HLA-G*010102 alleles are associated with RIF risk compared to other alleles. However, single maternal HLA-G 14bp ins\/del polymorphism, HLA-G -725 C&amp;gt;G\/T polymorphism, or circulating sHLA-G concentration was not significantly associated with RIF in the general population. HLA-G 14bp ins\/ins homozygous genotype or ins variant was associated with a higher risk of RIF in the Caucasian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Specific HLA-G alleles or HLA-G polymorphisms are associated with sHLA-G expression in couples attending IVF treatment. Several HLA-G polymorphisms may be related to RIF, considering different ethnic backgrounds. A combined genetic effect should be considered in future studies to confirm the association of HLA-G polymorphisms and sHLA-G expressions in relation to RIF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2022.988370","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:16:40Z","timestamp":1669853800000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of parental HLA-G polymorphisms with soluble HLA-G expressions and their roles on recurrent implantation failure: A systematic review and meta-analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Lian","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12513","article-title":"HLA-G: Function, polymorphisms and pathology","volume":"48","author":"Arnaiz-Villena","year":"2021","journal-title":"Int J Immunogenet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.153","article-title":"Soluble HLA-G generated by proteolytic shedding inhibits NK-mediated cell lysis","volume":"313","author":"Park","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1708-5","article-title":"Matrix metalloproteinase-2 (MMP-2) generates soluble HLA-G1 by cell surface proteolytic shedding","volume":"381","author":"Rizzo","year":"2013","journal-title":"Mol Cell Biochem"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02623.x","article-title":"Synthesis of beta(2)-microglobulin-free, disulphide-linked HLA-G5 homodimers in human placental villous cytotrophoblast cells","volume":"122","author":"Morales","year":"2007","journal-title":"Immunology"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.3.1376","article-title":"Protein expression and peptide binding suggest unique and interacting functional roles for HLA-e, f, and G in maternal-placental immune recognition","volume":"171","author":"Ishitani","year":"2003","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008941","article-title":"Inhibitory NK receptor recognition of HLA-G: regulation by contact residues and by cell specific expression at the fetal-maternal interface","volume":"5","author":"Gonen-Gross","year":"2010","journal-title":"PloS One"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13259","article-title":"Is there a role for HLA-G in the induction of regulatory T cells during the maintenance of a healthy pregnancy","volume":"84","author":"Al-Khunaizi","year":"2020","journal-title":"Am J Reprod Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02982","article-title":"Association of soluble HLA-G plasma level and HLA-G genetic polymorphism with pregnancy outcome of patients undergoing in vitro fertilization embryo transfer","volume":"10","author":"Nowak","year":"2019","journal-title":"Front Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-017-0994-3","article-title":"The HLA-G 14-bp polymorphism and recurrent implantation failure: a meta-analysis","volume":"34","author":"Fan","year":"2017","journal-title":"J Assist Reprod Genet"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.06.020","article-title":"Association of genetic variants in the 3'UTR of HLA-G with recurrent pregnancy loss","volume":"77","author":"Amodio","year":"2016","journal-title":"Hum Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.fertnstert.2019.05.003","article-title":"Association of human leukocyte antigen-G 14 bp polymorphism with recurrent pregnancy loss in European countries: a meta-analysis of literature studies","volume":"112","author":"Monti","year":"2019","journal-title":"Fertil Steril"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah035","article-title":"Association between HLA-G genotype and risk of pre-eclampsia: A case-control study using family triads","volume":"10","author":"Hylenius","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01435.x","article-title":"The 3'-untranslated region of the HLA-G gene in relation to pre-eclampsia: revisited","volume":"75","author":"Larsen","year":"2010","journal-title":"Tissue Antigens"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1023\/a:1024592901663","article-title":"Placental abruption is associated with decreased maternal plasma levels of soluble HLA-G","volume":"23","author":"Steinborn","year":"2003","journal-title":"J Clin Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00251-003-0547-z","article-title":"HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels","volume":"55","author":"Hviid","year":"2003","journal-title":"Immunogenetics"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2003.08.347","article-title":"The 14 bp deletion-insertion polymorphism in the 3' UT region of the HLA-G gene influences HLA-G mRNA stability","volume":"64","author":"Rousseau","year":"2003","journal-title":"Hum Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1086\/375501","article-title":"Variation in the HLA-G promoter region influences miscarriage rates","volume":"72","author":"Ober","year":"2003","journal-title":"Am J Hum Genet"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.06.002","article-title":"HLA-G regulatory haplotypes and implantation outcome in couples who underwent assisted reproduction treatment","volume":"73","author":"Costa","year":"2012","journal-title":"Hum Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12001","article-title":"Analysis of HLA-G polymorphisms in couples with implantation failure","volume":"68","author":"Nardi Fda","year":"2012","journal-title":"Am J Reprod Immunol"},{"key":"B20","article-title":"The relationship between HLA-G gene polymorphisms and repeated implantation failure in infertile couples undergoing assisted reproductive technique","volume":"14","author":"Kuroshli","year":"2015","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2016.09.002","article-title":"HLA-G profile of infertile couples who underwent assisted reproduction treatment","volume":"77","author":"Costa","year":"2016","journal-title":"Hum Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.rbmo.2013.08.011","article-title":"Recurrent implantation failure: definition and management","volume":"28","author":"Coughlan","year":"2014","journal-title":"Reprod BioMed Online"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1205-6","article-title":"Prevalent genotypes of methylenetetrahydrofolate reductase (MTHFR) in recurrent miscarriage and recurrent implantation failure","volume":"35","author":"Zhu","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"B24","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s40246-019-0246-y","article-title":"Associations between microRNA (miR-25, miR-32, miR-125, and miR-222) polymorphisms and recurrent implantation failure in Korean women","volume":"13","author":"Lee","year":"2019","journal-title":"Hum Genomics"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-021-00623-1","article-title":"PAI-1 4G\/4G genotype is associated with recurrent implantation failure: A systematic review and meta-analysis","volume":"28","author":"Zeng","year":"2021","journal-title":"Reprod Sci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s00404-021-06072-0","article-title":"Polymorphisms of vascular endothelial growth factor and recurrent implantation failure: a systematic review and meta-analysis","volume":"304","author":"Zeng","year":"2021","journal-title":"Arch Gynecol Obstet"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.06.048","article-title":"Is there a role for human leukocyte antigen-G typing in infertility treatment","volume":"114","author":"Alecsandru","year":"2020","journal-title":"Fertil Steril"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn007","article-title":"Accuracy of soluble human leukocyte antigen-G for predicting pregnancy among women undergoing infertility treatment: meta-analysis","volume":"14","author":"Vercammen","year":"2008","journal-title":"Hum Reprod Update"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq120","article-title":"Soluble HLA-G is an independent factor for the prediction of pregnancy outcome after ART: A German multi-centre study","volume":"25","author":"Rebmann","year":"2010","journal-title":"Hum Reprod"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.07.1977","article-title":"The effect of the biochemical marker soluble human leukocyte antigen G on pregnancy outcome in assisted reproductive technology\u2013a multicenter study","volume":"100","author":"Kotze","year":"2013","journal-title":"Fertil Steril"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.03.002","article-title":"A meta-analysis of the impact of human leukocyte antigen-G on the outcomes of IVF\/ICSI","volume":"34","author":"Niu","year":"2017","journal-title":"Reprod BioMed Online"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13499","article-title":"Soluble human leukocyte antigen-G is a potential embryo viability biomarker and a positive predictor of live-births in humans","volume":"86","author":"Vani","year":"2021","journal-title":"Am J Reprod Immunol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"Bmj"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1497","article-title":"HLA-g\u221701:03 and HLA-G\u221701:04:01 higher frequencies in couples who conceived naturally compared to couples undergoing assisted reproduction treatment","volume":"85","author":"Costa","year":"2015","journal-title":"Tissue Antigens"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12507","article-title":"High amounts of total and extracellular vesicle-derived soluble HLA-G are associated with HLA-G 14-bp deletion variant in women with embryo implantation failure","volume":"75","author":"Nardi Fda","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1399-0039.2012.01899.x","article-title":"Haplotypes and genotypes of HLA-G alleles and 14-bp Del\/Ins in the 3'UTR region in implantation failure couples","volume":"80","author":"Da Silva-Nardi","year":"2012","journal-title":"Tissue Antigens"},{"key":"B37","article-title":"Association of the maternal 14-bp insertion\/deletion polymorphism in the histocompatibility leukocyte antigen G gene with recurrent implantation failure","volume":"12","author":"Enghelabifar","year":"2014","journal-title":"Iran J Reprod Med"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi048","article-title":"HLA-G in human reproduction: Aspects of genetics, function and pregnancy complications","volume":"12","author":"Hviid","year":"2006","journal-title":"Hum Reprod Update"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2004.00239.x","article-title":"Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcome","volume":"64","author":"Hviid","year":"2004","journal-title":"Tissue Antigens"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-017-0474-6","article-title":"KIR, LILRB and their ligands' genes as potential biomarkers in recurrent implantation failure","volume":"65","author":"Nowak","year":"2017","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac118","article-title":"Endometrial HLA-f expression is influenced by genotypes and correlates differently with immune cell infiltration in IVF and recurrent implantation failure patients","volume":"37","author":"Pap\u00fachov\u00e1","year":"2022","journal-title":"Hum Reprod"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01205.x","article-title":"HLA-G polymorphism and in vitro fertilization failure in a polish population","volume":"73","author":"Sipak-Szmigiel","year":"2009","journal-title":"Tissue Antigens"},{"key":"B43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jri.2017.07.018","article-title":"The study of genetic polymorphisms for KIR2DL4, LILRB1, LILRB2 receptors and their ligand\u2013HLA-G in recurrent implantation failure","volume":"122","author":"Wilczy\u0144ska","year":"2017","journal-title":"J Reprod Immunol"},{"key":"B44","article-title":"Parental contribution of HLA-G\u22170106 and G\u22170105N to repeated implantation failure","volume":"7","author":"Kuroshli","year":"2013","journal-title":"Int J Fertility Sterility"},{"key":"B45","first-page":"52","article-title":"Association between HLA-G genotypes and repeated implantation failure in Iranian couples","volume":"11","author":"Kuroshli","year":"2013","journal-title":"Iranian J Reprod Med"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12108","article-title":"Comparative analysis of allele frequencies of HLA-G gene in embryo implantation failure, assisted reproduction treatment, spontaneous recurrent miscarriage and fertile control couples","volume":"81","author":"Da Silva Nardi","year":"2013","journal-title":"Tissue Antigens"},{"key":"B47","article-title":"Investigating association of HLA-G gene polymorphisms and failed implantation in human embryos","volume":"6","author":"Kuroshli","year":"2012","journal-title":"Int J Fertility Sterility"},{"key":"B48","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1111\/j.1399-0039.2011.01671.x","article-title":"Comparative analysis of ins\/del 14 bp at the 3UTR region of HLA-G gene in couples under assisted reproduction","volume":"77","author":"Costa","year":"2011","journal-title":"Tissue Antigens"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2011.01671.x","article-title":"SNPs in the HLA-G 5UTR region in couples submitted to assisted reproduction","volume":"77","author":"Costa","year":"2011","journal-title":"Tissue Antigens"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12452","article-title":"Maternal HLA-C2 and 14 bp insertion in HLA-G is associated with recurrent implantation failure after in vitro fertilization treatment","volume":"84","author":"Lashley","year":"2014","journal-title":"Tissue Antigens"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-017-0988-4","article-title":"HLA class ib in pregnancy and pregnancy-related disorders","volume":"69","author":"Persson","year":"2017","journal-title":"Immunogenetics"},{"key":"B52","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3109\/10408363.2012.677947","article-title":"The immunosuppressive molecule HLA-G and its clinical implications","volume":"49","author":"Gonz\u00e1lez","year":"2012","journal-title":"Crit Rev Clin Lab Sci"},{"key":"B53","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jri.2011.06.015","article-title":"HLA-G polymorphism, soluble HLA-G and early and late pregnancy complications","volume":"90","author":"Hviid","year":"2011","journal-title":"J Reprod Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.11.002","article-title":"Implication of HLA-G in human embryo implantation","volume":"68","author":"Fanchin","year":"2007","journal-title":"Hum Immunol"},{"key":"B55","article-title":"Non-classical HLA genes: From implantation to transplantation","volume":"168","author":"Hviid","year":"2006","journal-title":"Ugeskrift Laeger"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.5681\/apb.2013.072","article-title":"HLA-G expression pattern: Reliable assessment for pregnancy outcome prediction","volume":"3","author":"Mosaferi","year":"2013","journal-title":"Adv Pharm Bull"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00198","article-title":"Controlling the immunological crosstalk during conception and pregnancy: HLA-G in reproduction","volume":"5","author":"Lynge Nilsson","year":"2014","journal-title":"Front Immunol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac007","article-title":"HLA class ib-receptor interactions during embryo implantation and early pregnancy","volume":"28","author":"Nilsson","year":"2022","journal-title":"Hum Reprod Update"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.3390\/ijerph16091546","article-title":"The relationship between the HLA-G polymorphism and sHLA-G levels in parental pairs with high-risk pregnancy","volume":"16","author":"Sipak","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2009.00742.x","article-title":"Soluble human leukocyte antigen-G isoforms in maternal plasma in early and late pregnancy","volume":"62","author":"Rizzo","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/s0198-8859(00)00123-3","article-title":"Soluble HLA levels in early pregnancy after in vitro fertilization","volume":"61","author":"Pfeiffer","year":"2000","journal-title":"Hum Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jri.2015.10.001","article-title":"sHLA-G and sHLA-I levels in follicular fluid are not associated with successful implantation","volume":"113","author":"Ouji-Sageshima","year":"2016","journal-title":"J Reprod Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12684","article-title":"Endometrial immune markers are potential predictors of normal fertility and pregnancy after in vitro fertilization","volume":"78","author":"Kofod","year":"2017","journal-title":"Am J Reprod Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.08.853","article-title":"Hla-G levels in follicular fluid are not associated with follicular G-CSF concen-trations in women undergoing in vitro fertilization","volume":"114","author":"Parvanov","year":"2020","journal-title":"Fertility Sterility"},{"key":"B65","doi-asserted-by":"publisher","first-page":"i183","DOI":"10.1093\/humrep\/30.Supplement-1.1","article-title":"Soluble HLA-G as a non-invasive biomarker from ovulation to early pregnancy in assisted reproduction","volume":"30","author":"Filippini-Cattaneo","year":"2015","journal-title":"Hum Reprod"},{"key":"B66","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.immbio.2012.10.004","article-title":"Soluble human leukocyte antigen-G (sHLA-G) in follicular fluid and embryo culture medium and its impact on pregnancy prediction in IVF-ICSI treatment","volume":"28","author":"Wunder","year":"2013","journal-title":"Immuno-Analyse Biologie Specialisee"},{"key":"B67","article-title":"The relationship between soluble serum HLA-G and ICSI success rates","volume":"12","author":"Alinejad","year":"2011","journal-title":"J Reprod Infertility"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2017.07.028","article-title":"Recurrent implantation failure and soluble HLA-G plasma levels","volume":"122","author":"Wilczy\u0144ska","year":"2017","journal-title":"J Reprod Immunol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jri.2018.05.043","article-title":"Impaired peripheral blood HLA-g+ T cells are associated with recurrent miscarriage and recurrent implantation failure: Biomarkers in pregnancy complications\u2013present knowledge and future direction","volume":"128","author":"Liu","year":"2018","journal-title":"J Reprod Immunol"},{"key":"B70","article-title":"Antigens HLA-G, sHLA- G and sHLA- class I in reproductive failure","author":"Sipak-Szmigiel","year":"2007","journal-title":"Folia Histochem Cytobiol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev-genom-083118-014943","article-title":"Pregnancy immunogenetics and genomics: Implications for pregnancy-related complications and autoimmune disease","volume":"20","author":"Yeung","year":"2019","journal-title":"Annual review of genomics and human genetics"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081830","article-title":"European Patent in immunoncology: From immunological principles of implantation to cancer treatment","volume":"20","author":"W\u00fcrfel","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/157339510790231806","article-title":"HLA-G - from fetal tolerance to a regulatory molecule in inflammatory diseases","volume":"6","author":"Veit","year":"2010","journal-title":"Curr Immunol Rev"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2011.06.077","article-title":"Soluble human leukocyte antigen (HLA)-G and HLA-G genotype in couples undergoing treatment for infertility","volume":"90","author":"Dahl","year":"2011","journal-title":"J Reprod Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-004-0673-2","article-title":"HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms","volume":"56","author":"Hviid","year":"2004","journal-title":"Immunogenetics"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.791399","article-title":"The association of HLA-G gene polymorphism and its soluble form with Male infertility","volume":"12","author":"Piekarska","year":"2021","journal-title":"Front Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1111\/tan.13628","article-title":"Soluble HLA-G levels in seminal plasma are associated with HLA-G 3'UTR genotypes and haplotypes","volume":"94","author":"Craenmehr","year":"2019","journal-title":"Hla"},{"key":"B78","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/aji.12251","article-title":"Soluble human leukocyte antigen-G in seminal plasma is associated with HLA-G genotype: possible implications for fertility success","volume":"72","author":"Dahl","year":"2014","journal-title":"Am J Reprod Immunol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2019.102857","article-title":"Soluble HLA-G and TGF-\u03b2 in couples attending assisted reproduction - a possible role of TGF-\u03b2 isoforms in semen","volume":"137","author":"Nilsson","year":"2020","journal-title":"J Reprod Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124362","article-title":"NKG2A\/CD94 is a new immune receptor for HLA-G and distinguishes amino acid differences in the HLA-G heavy chain","volume":"21","author":"H\u00f2","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076023","article-title":"Soluble human leukocyte antigen-g5 activates extracellular signal-regulated protein kinase signaling and stimulates trophoblast invasion","volume":"8","author":"Guo","year":"2013","journal-title":"PloS One"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.53","article-title":"HLA-g-mediated NK cell senescence promotes vascular remodeling: implications for reproduction","volume":"11","author":"Rajagopalan","year":"2014","journal-title":"Cell Mol Immunol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev196","article-title":"Soluble human leukocyte antigen G5 polarizes differentiation of macrophages toward a decidual macrophage-like phenotype","volume":"30","author":"Lee","year":"2015","journal-title":"Hum Reprod"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.immuni.2017.11.018","article-title":"Natural killer cells promote fetal development through the secretion of growth-promoting factors","volume":"47","author":"Fu","year":"2017","journal-title":"Immunity"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.592010","article-title":"Roles of HLA-G in the maternal-fetal immune microenvironment","volume":"11","author":"Xu","year":"2020","journal-title":"Front Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.8379","article-title":"Differential expression of alternatively spliced transcripts of HLA-G in human preimplantation embryos and inner cell masses","volume":"175","author":"Yao","year":"2005","journal-title":"J Immunol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2007.04.007","article-title":"Maternal antigen presenting cells are a source of plasmatic HLA-G during pregnancy: longitudinal study during pregnancy","volume":"68","author":"Alegre","year":"2007","journal-title":"Hum Immunol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem326","article-title":"Human decidual stromal cells express HLA-G: Effects of cytokines and decidualization","volume":"23","author":"Blanco","year":"2008","journal-title":"Hum Reprod"},{"key":"B89","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.fertnstert.2018.11.011","article-title":"Relationship between unexplained recurrent pregnancy loss and 5,10-methylenetetrahydrofolate reductase) polymorphisms","volume":"111","author":"Xu","year":"2019","journal-title":"Fertil Steril"},{"key":"B90","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14767058.2019.1569618","article-title":"Effect of multiple thrombophilic gene mutations on uterine artery blood flow in nonpregnant recurrent pregnancy loss patients: are we searching enough","volume":"33","author":"Akdemir","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12627","article-title":"Meta-analysis of the human leukocyte antigen-G (HLA-G) 14 bp insertion\/deletion polymorphism as a risk factor for preeclampsia","volume":"86","author":"Pabalan","year":"2015","journal-title":"Tissue Antigens"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2018.08.003","article-title":"Genetic association between HLA-G 14-bp polymorphism and diseases: A systematic review and meta-analysis","volume":"79","author":"de Almeida","year":"2018","journal-title":"Hum Immunol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12910","article-title":"Maternal genetic polymorphisms and unexplained recurrent miscarriage: a systematic review and meta-analysis","volume":"91","author":"Shi","year":"2017","journal-title":"Clin Genet"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2022.146804","article-title":"Role of polymorphisms on the recurrent pregnancy loss: A systematic review, meta-analysis and bioinformatic analysis","volume":"844","author":"Jalilvand","year":"2022","journal-title":"Gene"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1697657","article-title":"HLA-G polymorphisms associated with HIV infection and preeclampsia in south africans of African ancestry","author":"Phoswa","year":"2020","journal-title":"BioMed Res Int"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4254750","article-title":"The immunosignature of Mother\/Fetus couples in gestational diabetes mellitus: Role of HLA-G 14\u2009bp ins\/del and PAPP-a A\/C polymorphisms in the uterine inflammatory milieu","volume":"2017","author":"Martinetti","year":"2017","journal-title":"Dis Markers"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.600202.x","article-title":"HLA-G polymorphisms in couples with recurrent spontaneous abortions","volume":"60","author":"Hviid","year":"2002","journal-title":"Tissue Antigens"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01584.x","article-title":"Role of 14-bp insertion\/deletion polymorphism in HLA-G among Indian women with recurrent spontaneous abortions","volume":"77","author":"Aruna","year":"2011","journal-title":"Tissue Antigens"},{"key":"B99","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.humimm.2012.04.014","article-title":"Maternal homozygocity for a 14 base pair insertion in exon 8 of the HLA-G gene and carriage of HLA class II alleles restricting HY immunity predispose to unexplained secondary recurrent miscarriage and low birth weight in children born to these patients","volume":"73","author":"Christiansen","year":"2012","journal-title":"Hum Immunol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12768","article-title":"Association between 14 bp insertion\/deletion HLA-G functional polymorphism and insulin resistance in a cohort of Italian children with obesity","volume":"19","author":"Marzuillo","year":"2018","journal-title":"Pediatr Diabetes"},{"key":"B101","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jri.2017.02.002","article-title":"Associations between fetal HLA-G genotype and birth weight and placental weight in a large cohort of pregnant women - possible implications for HLA diversity","volume":"120","author":"Emmery","year":"2017","journal-title":"J Reprod Immunol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1052398","article-title":"Maternal and fetal HLA-G 14\u2009bp gene polymorphism in pregnancy-induced hypertension, preeclampsia, intrauterine growth restricted and normal pregnancies","volume":"29","author":"Mand\u00f2","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2008.03.001","article-title":"The HLA-G 14bp gene polymorphism and decidual HLA-G 14bp gene expression in pre-eclamptic and normal pregnancies","volume":"78","author":"Iversen","year":"2008","journal-title":"J Reprod Immunol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1111\/tan.13198","article-title":"The HLA-G 14 bp insertion\/deletion polymorphism and its association with soluble HLA-G levels in women with recurrent miscarriages","volume":"91","author":"Kalotra","year":"2018","journal-title":"Hla"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-017-1404-3","article-title":"The impact of HLA-G, LILRB1 and LILRB2 gene polymorphisms on susceptibility to and severity of endometriosis","volume":"293","author":"Byli\u0144ska","year":"2018","journal-title":"Mol Genet Genomics"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16060982","article-title":"Molecular analysis of HLA-G in women with high-risk pregnancy and their partners with regard to possible complications","volume":"16","author":"Sipak","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-016-0389-7","article-title":"Possible role of HLA-G, LILRB1 and KIR2DL4 gene polymorphisms in spontaneous miscarriage","volume":"64","author":"Nowak","year":"2016","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2017.04.002","article-title":"Evaluation of HLA-G 14-bp ins\/del and +3142G>C polymorphisms with susceptibility to recurrent spontaneous abortion","volume":"56","author":"Hashemi","year":"2017","journal-title":"Taiwan J Obstet Gynecol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/s1472-6483(10)61930-x","article-title":"Genotyping: the HLA system and embryo development","volume":"4","author":"Warner","year":"2002","journal-title":"Reprod BioMed Online"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/s0143-4004(98)90000-5","article-title":"HLA-G1 protein expression is not essential for fetal survival","volume":"19","author":"Ober","year":"1998","journal-title":"Placenta"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.01.013","article-title":"Human leukocyte antigen (HLA)-G during pregnancy part I: correlations between maternal soluble HLA-G at midterm, at term, and umbilical cord blood soluble HLA-G at term","volume":"76","author":"Klitkou","year":"2015","journal-title":"Hum Immunol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2007.00475.x","article-title":"Early detection of decreased soluble HLA-G levels in the maternal circulation predicts the occurrence of preeclampsia and intrauterine growth retardation during further course of pregnancy","volume":"57","author":"Steinborn","year":"2007","journal-title":"Am J Reprod Immunol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.11.062","article-title":"Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia later in pregnancy","volume":"193","author":"Yie","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12919","article-title":"Establishment of optimized ELISA system specific for HLA-G in body fluids","volume":"88","author":"Ouji-Sageshima","year":"2016","journal-title":"Hla"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.6.4330","article-title":"Analysis of HLA-G in maternal plasma, follicular fluid, and preimplantation embryos reveal an asymmetric pattern of expression","volume":"180","author":"Shaikly","year":"2008","journal-title":"J Immunol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxv002","article-title":"Association between sHLA-G and HLA-G 14-bp deletion\/insertion polymorphism in crohn's disease","volume":"27","author":"Zidi","year":"2015","journal-title":"Int Immunol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.10.016","article-title":"HLA-G 14 bp insertion\/deletion polymorphism and its association with sHLA-G levels in beh\u00e7et's disease Tunisian patients","volume":"77","author":"Sakly","year":"2016","journal-title":"Hum Immunol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2021.145712","article-title":"New markers for predictions of acute and chronic rejection and graft outcomes in kidney transplant recipients; HLA-G gene 3'UTR 14 bp polymorphism and sHLA-G","volume":"790","author":"Darbas","year":"2021","journal-title":"Gene"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.08.005","article-title":"Role of HLA-G 14bp deletion\/insertion and +3142C>G polymorphisms in the production of sHLA-G molecules in relapsing-remitting multiple sclerosis","volume":"73","author":"Rizzo","year":"2012","journal-title":"Hum Immunol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1530\/eje-19-0379","article-title":"Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia","volume":"181","author":"Nguyen","year":"2019","journal-title":"Eur J Endocrinol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2011.52.6.967","article-title":"Soluble human leukocyte antigen G level in fluid from single dominant follicle and the association with oocyte competence","volume":"52","author":"Jee","year":"2011","journal-title":"Yonsei Med J"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2007.02.005","article-title":"Soluble HLA-G molecules in follicular fluid: a tool for oocyte selection in IVF","volume":"74","author":"Rizzo","year":"2007","journal-title":"J Reprod Immunol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13296","article-title":"Soluble immune checkpoints CTLA-4, HLA-G, PD-1, and PD-L1 are associated with endometriosis-related infertility","volume":"84","author":"Santoso","year":"2020","journal-title":"Am J Reprod Immunol"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13504","article-title":"Longitudinal profile of sHLA-G during pregnancy and its association with small for gestational age births in north Indian pregnant females: A nested case-control study","volume":"87","author":"Sehgal","year":"2021","journal-title":"Am J Reprod Immunol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12270","article-title":"Temporal variation in soluble human leukocyte antigen-G (sHLA-G) and pregnancy-associated plasma protein a (PAPP-a) in pregnancies complicated by gestational diabetes mellitus and in controls","volume":"72","author":"Beneventi","year":"2014","journal-title":"Am J Reprod Immunol"},{"key":"B126","first-page":"67","article-title":"Soluble HLA-G changes in maternal blood serum during the progression of labor","volume":"30","author":"Knafel","year":"2009","journal-title":"Neuro Endocrinol Lett"},{"key":"B127","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jri.2016.05.004","article-title":"Soluble HLA-G concentrations in maternal blood and cervical vaginal fluid of pregnant women with preterm premature rupture of membranes","volume":"116","author":"Beneventi","year":"2016","journal-title":"J Reprod Immunol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.01.033","article-title":"HLA-G protein concentrations in maternal serum and placental tissue are decreased in preeclampsia","volume":"191","author":"Yie","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2015-0062","article-title":"Association between decreased plasma levels of soluble human leukocyte antigen-G and severe pre-eclampsia","volume":"44","author":"He","year":"2016","journal-title":"J Perinat Med"},{"key":"B130","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/10641955.2017.1385794","article-title":"Circulating fetal and total cell-free DNA, and sHLA-G in black south African women with gestational hypertension and pre-eclampsia","volume":"36","author":"Eche","year":"2017","journal-title":"Hypertens Pregnancy"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.497264","article-title":"Evaluation of maternal serum sHLA-G levels for trisomy 18 fetuses screening at second trimester","volume":"11","author":"Xu","year":"2020","journal-title":"Front Genet"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01685","article-title":"Soluble HLA-G expression inversely correlates with fetal microchimerism levels in peripheral blood from women with scleroderma","volume":"9","author":"Di Cristofaro","year":"2018","journal-title":"Front Immunol"},{"key":"B133","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.medre.2015.09.001","article-title":"Gene polymorphisms and HLA-G expression in spontaneous abortions","volume":"2","author":"Garc\u00eda-L\u00e1ez","year":"2015","journal-title":"Medicina Reproductiva y Embriol Clinica"},{"key":"B134","doi-asserted-by":"publisher","first-page":"i145","DOI":"10.1111\/aji.13152","article-title":"Quantitative analysis of the sHLA-G protein in seminal plasma","volume":"35","author":"Schallmoser","year":"2020","journal-title":"Hum Reprod"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2018.1467925","article-title":"Association between HLA-G 14bp gene polymorphism and serum sHLA-G protein concentrations in preeclamptic patients and normal pregnant women","volume":"47","author":"Rokhafrooz","year":"2018","journal-title":"Immunol Invest"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.657217","article-title":"Maternal HLA ib polymorphisms in pregnancy allo-immunization","volume":"12","author":"Persson","year":"2021","journal-title":"Front Immunol"},{"key":"B137","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jri.2015.04.005","article-title":"Soluble HLA-G in pregnancies complicated by autoimmune rheumatic diseases","volume":"110","author":"Beneventi","year":"2015","journal-title":"J Reprod Immunol"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01107.x","article-title":"The 14 bp deletion polymorphisms in HLA-G gene play an important role in the expression of soluble HLA-G in plasma","volume":"72","author":"Chen","year":"2008","journal-title":"Tissue Antigens"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071742","article-title":"Polymorphic sites at the 3' untranslated region of the HLA-G gene are associated with differential hla-g soluble levels in the Brazilian and French population","volume":"8","author":"Martelli-Palomino","year":"2013","journal-title":"PloS One"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.2450\/2012.0144-12","article-title":"The plasma levels of soluble HLA-G molecules correlate directly with CD34+ cell concentration and HLA-G 14bp insertion\/insertion polymorphism in cord blood donors","author":"Capittini","year":"2014","journal-title":"Blood Transfus"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00855.x","article-title":"Evaluation of HLA-G5 plasmatic levels during pregnancy and relationship with the 14-bp polymorphism","volume":"64","author":"Gonzalez","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del036","article-title":"The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells","volume":"21","author":"Ober","year":"2006","journal-title":"Hum Reprod"},{"key":"B143","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00393-020-00783-6","article-title":"Association of soluble HLA-G plasma levels with HLA-G alleles","volume":"57","author":"Rebmann","year":"2001","journal-title":"Tissue Antigens"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gas041","article-title":"The maternal HLA-G 1597\u0394C null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women","volume":"19","author":"Loisel","year":"2013","journal-title":"Mol Hum Reprod"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.74","article-title":"The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes","volume":"11","author":"Castelli","year":"2010","journal-title":"Genes Immun"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033395","article-title":"MiRNA-mediated control of HLA-G expression and function","volume":"7","author":"Manaster","year":"2012","journal-title":"PloS One"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00476","article-title":"Insights into HLA-G genetics provided by worldwide haplotype diversity","volume":"5","author":"Castelli","year":"2014","journal-title":"Front Immunol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2017.01.005","article-title":"The role of methylation, DNA polymorphisms and microRNAs on HLA-G expression in human embryonic stem cells","volume":"19","author":"Verloes","year":"2017","journal-title":"Stem Cell Res"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.755624","article-title":"ERAP, KIR, and HLA-c profile in recurrent implantation failure","volume":"12","author":"Piekarska","year":"2021","journal-title":"Front Immunol"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.05.008","article-title":"Parental human leukocyte antigen-c allotypes are predictive of live birth rate and risk of poor placentation in assisted reproductive treatment","volume":"114","author":"Alecsandru","year":"2020","journal-title":"Fertil Steril"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu251","article-title":"Maternal KIR haplotype influences live birth rate after double embryo transfer in IVF cycles in patients with recurrent miscarriages and implantation failure","volume":"29","author":"Alecsandru","year":"2014","journal-title":"Hum Reprod"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.04.052","article-title":"Examining extended human leukocyte antigen-G and HLA-f haplotypes: the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers","volume":"114","author":"Nilsson","year":"2020","journal-title":"Fertil Steril"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.10.6849","article-title":"Leukemia inhibitory factor (LIF) stimulates the human HLA-G promoter in JEG3 choriocarcinoma cells","volume":"85","author":"Bamberger","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1159\/000484378","article-title":"Preimplantation factor (PIF) promotes HLA-G, -e, -f, -c expression in JEG-3 choriocarcinoma cells and endogenous progesterone activity","volume":"43","author":"Hakam","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"B155","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/molehr\/gas043","article-title":"Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy","volume":"19","author":"Tirado-Gonz\u00e1lez","year":"2013","journal-title":"Mol Hum Reprod"},{"key":"B156","doi-asserted-by":"publisher","first-page":"17683","DOI":"10.1038\/s41598-018-36146-0","article-title":"Human herpesvirus 6A and 6B inhibit in vitro angiogenesis by induction of human leukocyte antigen G","volume":"8","author":"Rizzo","year":"2018","journal-title":"Sci Rep"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.11.060","article-title":"The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis","volume":"74","author":"Kuroki","year":"2013","journal-title":"Hum Immunol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-228247","article-title":"Synthetic HLA-G proteins for therapeutic use in transplantation","volume":"27","author":"LeMaoult","year":"2013","journal-title":"FASEB J"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.988370\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:16:51Z","timestamp":1669853811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.988370\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":158,"alternative-id":["10.3389\/fimmu.2022.988370"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.988370","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,1]]},"article-number":"988370"}}