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Immunol."],"abstract":"<jats:p>Immunoglobulin G (IgG) antibodies play an important role in the immune response against viruses such as SARS-CoV-2. As the effector functions of IgG are modulated by <jats:italic>N<\/jats:italic>-glycosylation of the Fc region, the structure and possible function of the IgG <jats:italic>N<\/jats:italic>-glycome has been under investigation in relation to divergent COVID-19 disease courses. Through LC-MS analysis we studied both total IgG1 and spike protein-specific IgG1 Fc glycosylation of 129 German and 163 Brazilian COVID-19 patients representing diverse patient populations. We found that hospitalized COVID-19 patients displayed decreased levels of total IgG1 bisection and galactosylation and lowered anti-S IgG1 fucosylation and bisection as compared to mild outpatients. Anti-S IgG1 glycosylation was dynamic over the disease course and both anti-S and total IgG1 glycosylation were correlated to inflammatory markers. Further research is needed to dissect the possible role of altered IgG glycosylation profiles in (dys)regulating the immune response in COVID-19.<\/jats:p>","DOI":"10.3389\/fimmu.2022.993354","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T08:15:58Z","timestamp":1666080958000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["The IgG glycome of SARS-CoV-2 infected individuals reflects disease course and severity"],"prefix":"10.3389","volume":"13","author":[{"given":"Sterre 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