{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T17:36:55Z","timestamp":1767202615243,"version":"build-2238731810"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atopy is a genetic condition predisposing individuals to develop immunoglobulin E (IgE) against common allergens through T-helper 2 (Th2) polarization mechanisms. The impact of atopy on graft survival in solid organ transplantation is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>We analyzed 268 renal allograft recipients from the Swiss Transplant Cohort Study, a prospective multicenter cohort studying patients after solid organ transplantation, with a 9-year median follow-up (IQR 3.0). We used the Phadiatop assay to measure IgE antibodies against a mixture of common inhaled allergens (grass, tree, herbs, spores, animals, and mites) to identify pre-transplantation atopic patients (&amp;gt;0.35 KU\/L).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 268 kidney transplant recipients, 66 individuals were atopic (24.6%). Atopic patients were significantly younger than non-atopic patients (49.6 vs 58.0 years old, P = 0.002). No significant difference was found for gender, cold\/warm ischemia time, preformed donor-specific antibodies (DSA), HLA mismatches, induction and maintenance immunosuppressive therapy, CMV serostatus, or cause of kidney failure. Patient and graft survival at ten years of follow-up were significantly better in the atopic group, 95.2% versus 69.2% patient survival (P &amp;lt; 0.001), and 87.9% versus 60.8% graft survival (P &amp;lt; 0.001), respectively. A multivariate Cox analysis revealed that atopy predicted recipient and graft survival independently of age and living donor donation. Finally, we found similar rates of biopsy-proven acute cellular and antibody-mediated rejections between atopic and non-atopic recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Atopy was associated with better long-term patient and graft survival, independently of age and living donor donation after kidney transplantation. Yet, atopy should not be used as a predictor for acute rejection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2022.997364","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T06:40:30Z","timestamp":1664779230000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Atopy as an independent predictor for long-term patient and graft survival after kidney transplantation"],"prefix":"10.3389","volume":"13","author":[{"given":"Rapha\u00ebl","family":"Porret","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00ebl P. H.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josip","family":"Mikulic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Pascual","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Aubert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Harr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9la","family":"Golshayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick D.","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxw006","article-title":"CD4 + T-cell subsets in inflammatory diseases: beyond the T h 1\/T h 2 paradigm","volume":"28","author":"Hirahara","year":"2016","journal-title":"Int Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12106","article-title":"T Helper subsets & regulatory T cells: rethinking the paradigm in the clinical context of solid organ transplantation","volume":"41","author":"Askar","year":"2014","journal-title":"Int J Immunogenet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/362245a0","article-title":"Disruption of the murine IL-4 gene blocks Th2 cytokine responses","volume":"362","author":"Kopf","year":"1993","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.296.5567.490","article-title":"Allergy, parasites, and the hygiene hypothesis","volume":"296","author":"Yazdanbakhsh","year":"2002","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.t01-1-00001.x","article-title":"A revised nomenclature for allergy. an EAACI position statement from the EAACI nomenclature task force","volume":"56","author":"Johansson","year":"2001","journal-title":"Allergy"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-011-0178-7","article-title":"T-Cell subset regulation in atopy","volume":"11","author":"Jutel","year":"2011","journal-title":"Curr Allergy Asthma Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1159\/000351416","article-title":"Prevalence of atopy and respiratory allergic diseases in the elderly SAPALDIA population","volume":"162","author":"W\u00fcthrich","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1990.tb00497.x","article-title":"Allergy screening with phadiatop and CAP phadiatop in combination with a questionnaire in adults with asthma and rhinitis","volume":"45","author":"Eriksson","year":"1990","journal-title":"Allergy"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-012-9754-y","article-title":"Design and methodology of the Swiss transplant cohort study (STCS): A comprehensive prospective nationwide long-term follow-up cohort","volume":"28","author":"Koller","year":"2013","journal-title":"Eur J Epidemiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e051176","DOI":"10.1136\/bmjopen-2021-051176","article-title":"Cohort profile: The Swiss transplant cohort study (STCS): A nationwide longitudinal cohort study of all solid organ recipients in Switzerland","volume":"11","author":"Stampf","year":"2021","journal-title":"BMJ Open"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.11.025","article-title":"Polymorphisms in the lectin pathway of complement activation influence the incidence of acute rejection and graft outcome after kidney transplantation","volume":"89","author":"Golshayan","year":"2016","journal-title":"Kidney Int"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002366","article-title":"A 2018 reference guide to the banff classification of renal allograft pathology","volume":"102","author":"Roufosse","year":"2018","journal-title":"Transplantation"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15601","article-title":"Management of allergy transfer upon solid organ transplantation","volume":"20","author":"Muller","year":"2020","journal-title":"Am J Transplant"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2013.5.3.170","article-title":"The age impact on serum total and allergen-specific IgE","volume":"5","author":"De Amici","year":"2013","journal-title":"Allergy Asthma Immunol Res"},{"key":"B15","first-page":"18331","volume-title":"Potential of T regulatory cells to protect pancreatic islets grafts","author":"Muller","year":"2011"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.6.2081","article-title":"Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones","volume":"170","author":"Fiorentino","year":"1989","journal-title":"J Exp Med"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/383787a0","article-title":"Functional diversity of helper T lymphocytes","volume":"383","author":"Abbas","year":"1996","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S1074-7613(02)00332-1","article-title":"IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13","volume":"17","author":"Fallon","year":"2002","journal-title":"Immunity"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/ni1084","article-title":"Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice","volume":"5","author":"Dillon","year":"2004","journal-title":"Nat Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.4161\/isl.24698","article-title":"Murine animal models for preclinical islet transplantation: No model fits all (research purposes)","volume":"5","author":"Cantarelli","year":"2013","journal-title":"Islets"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3727\/096368908787648146","article-title":"Intrahepatic islet transplant in the mouse: Functional and morphological characterization","volume":"17","author":"Melzi","year":"2008","journal-title":"Cell Transplant"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13111","article-title":"Rituximab as monotherapy for the treatment of chronic active antibody-mediated rejection after kidney transplantation","volume":"31","author":"Muller","year":"2018","journal-title":"Transpl Int"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1775","article-title":"Long-term acquisition of allergen-specific IgE and asthma following allogeneic bone marrow transplantation from allergic donors","volume":"104","author":"Hallstrand","year":"2004","journal-title":"Blood"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709183371204","article-title":"Transfer of symptomatic peanut allergy to the recipient of a combined liver-and-kidney transplant","volume":"337","author":"Legendre","year":"1997","journal-title":"N Engl J Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.07.015","article-title":"Transfer of peanut allergy from the donor to a lung transplant recipient","volume":"27","author":"Khalid","year":"2008","journal-title":"J Heart Lung Transplant"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0370","article-title":"Immunosuppressive therapy does not prevent the occurrence of immunoglobulin e-mediated allergies in children and adolescents with organ transplants","volume":"118","author":"Dehlink","year":"2006","journal-title":"Pediatrics"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12342","article-title":"Increase in de novo food allergies after pediatric liver transplantation: tacrolimus vs. cyclosporine immunosuppression","volume":"18","author":"Lebel","year":"2014","journal-title":"Pediatr Transplant"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.116571","article-title":"Food allergy after pediatric organ transplantation with tacrolimus immunosuppression","volume":"108","author":"Nowak-Wegrzyn","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90941-9","article-title":"Aetiology of asthma: lessons from lung transplantation","volume":"341","author":"Corris","year":"1993","journal-title":"Lancet"}],"updated-by":[{"DOI":"10.3389\/fimmu.2023.1175484","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000}}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.997364\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T08:31:47Z","timestamp":1680597107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.997364\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,3]]},"references-count":29,"alternative-id":["10.3389\/fimmu.2022.997364"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.997364","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,3]]},"article-number":"997364"}}