{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:07:35Z","timestamp":1788314855290,"version":"build-2803163510"},"reference-count":217,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>In recent years, diagnostic and therapeutic approaches for rheumatoid arthritis (RA) have continued to improve. However, in the advanced stages of the disease, patients are unable to achieve long-term clinical remission and often suffer from systemic multi-organ damage and severe complications. Patients with RA usually have no overt clinical manifestations in the early stages, and by the time a definitive diagnosis is made, the disease is already at an advanced stage. RA is diagnosed clinically and with laboratory tests, including the blood markers C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) and the autoantibodies rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA). However, the presence of RF and ACPA autoantibodies is associated with aggravated disease, joint damage, and increased mortality, and these autoantibodies have low specificity and sensitivity. The etiology of RA is unknown, with the pathogenesis involving multiple factors and clinical heterogeneity. The early diagnosis, subtype classification, and prognosis of RA remain challenging, and studies to develop minimally invasive or non-invasive biomarkers in the form of biofluid biopsies are becoming more common. Non-coding RNA (ncRNA) molecules are composed of long non-coding RNAs, small nucleolar RNAs, microRNAs, and circular RNAs, which play an essential role in disease onset and progression and can be used in the early diagnosis and prognosis of RA. In this review of the diagnostic and prognostic approaches to RA disease, we provide an overview of the current knowledge on the subject, focusing on recent advances in mRNA\u2013ncRNA as diagnostic and prognostic biomarkers from the biofluid to the tissue level.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1087925","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T01:52:26Z","timestamp":1675216346000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Biomarkers (mRNAs and non-coding RNAs) for the diagnosis and prognosis of rheumatoid arthritis"],"prefix":"10.3389","volume":"14","author":[{"given":"Yong","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanling","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet (London England)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.04.018","article-title":"Extra-articular manifestations and comorbidity in rheumatoid arthritis: Potential impact of pre-rheumatoid arthritis prevention","volume":"41","author":"Giles","year":"2019","journal-title":"Clin Ther"},{"key":"B3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: A review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102797","article-title":"The pre-clinical phase of rheumatoid arthritis: From risk factors to prevention of arthritis","volume":"20","author":"Petrovsk\u00e1","year":"2021","journal-title":"Autoimmun Rev"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0275-1","article-title":"Treatment strategies in early rheumatoid arthritis and prevention of rheumatoid arthritis","volume":"14","author":"Demoruelle","year":"2012","journal-title":"Curr Rheumatol Rep"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102400","article-title":"The etiology of rheumatoid arthritis","volume":"110","author":"Scherer","year":"2020","journal-title":"J Autoimmun"},{"key":"B8","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/ng1010-814","article-title":"Gene-environment interaction influences the reactivity of autoantibodies to citrullinated antigens in rheumatoid arthritis","volume":"42","author":"van der Woude","year":"2010","journal-title":"Nat Genet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.3390\/cells10112857","article-title":"Management of Rheumatoid Arthritis: An Overview","volume":"10","author":"Radu","year":"2021","journal-title":"Cells"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-021-00993-0","article-title":"Etiologies of rheumatoid arthritis: Update on mucosal, genetic, and cellular pathogenesis","volume":"23","author":"Kronzer","year":"2021","journal-title":"Curr Rheumatol Rep"},{"key":"B11","doi-asserted-by":"publisher","first-page":"800","DOI":"10.3390\/cells9040880","article-title":"Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102392","article-title":"An overview of autoantibodies in rheumatoid arthritis","volume":"110","author":"van Delft","year":"2020","journal-title":"J Autoimmun"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.790122","article-title":"Molecular and cellular heterogeneity in rheumatoid arthritis: Mechanisms and clinical implications","volume":"12","author":"Zhao","year":"2021","journal-title":"Front Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048952","article-title":"Towards prevention of autoimmune diseases: The example of rheumatoid arthritis","volume":"51","author":"Hensvold","year":"2021","journal-title":"Eur J Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes279","article-title":"ACR\/EULAR 2010 rheumatoid arthritis classification criteria","author":"Kay","year":"2012","journal-title":"Rheumatol (Oxford)"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12980","article-title":"Individuals at risk of seropositive rheumatoid arthritis: the evolving story","volume":"286","author":"Rantap\u00e4\u00e4 Dahlqvist","year":"2019","journal-title":"J Intern Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/rheumatology\/kex036","article-title":"Diagnostic test accuracy of ultrasound for synovitis in rheumatoid arthritis: systematic review and meta-analysis","volume":"57","author":"Takase-Minegishi","year":"2018","journal-title":"Rheumatol (Oxford)"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.12659\/pjr.899317","article-title":"Rheumatoid arthritis revisited - advanced imaging review","volume":"81","author":"Vyas","year":"2016","journal-title":"Pol J Radiol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20413","article-title":"Extremity magnetic resonance imaging in rheumatoid arthritis: Updated literature review","volume":"63","author":"Cohen","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1080\/10408363.2020.1775545","article-title":"Multiple biomarker approach for the diagnosis and therapy of rheumatoid arthritis","volume":"58","author":"Savvateeva","year":"2021","journal-title":"Crit Rev Clin Lab Sci"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203284","article-title":"Performance of the 2010 ACR\/EULAR classification criteria for rheumatoid arthritis: a systematic literature review","volume":"73","author":"Radner","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203641","article-title":"Analysis of gut microbiota and metabolites in patients with rheumatoid arthritis and identification of potential biomarkers","volume":"13","author":"Chen","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204050","article-title":"Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis","volume":"73","author":"Knevel","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00570","article-title":"Epigenetic changes in the pathogenesis of rheumatoid arthritis","volume":"10","author":"Nemtsova","year":"2019","journal-title":"Front Genet"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.237","article-title":"Genetics and epigenetics of rheumatoid arthritis","volume":"9","author":"Viatte","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.clim.2017.07.019","article-title":"Biomarkers as a treatment guide in rheumatoid arthritis","volume":"186","author":"Takeuchi","year":"2018","journal-title":"Clin Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2017.1321481","article-title":"Defining the proteomic landscape of rheumatoid arthritis: progress and prospective clinical applications","volume":"14","author":"Lourido","year":"2017","journal-title":"Expert Rev Proteomics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1186\/s12967-021-03169-7","article-title":"Serum metabolomic and lipidomic profiling identifies diagnostic biomarkers for seropositive and seronegative rheumatoid arthritis patients","volume":"19","author":"Luan","year":"2021","journal-title":"J Transl Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s12916-022-02416-y","article-title":"A positive faecal immunochemical test result and its association with the incidence of rheumatoid arthritis, systemic lupus erythematosus, and psoriatic arthritis: an analysis of one-million national colorectal cancer screening programme results","volume":"20","author":"Noh","year":"2022","journal-title":"BMC Med"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2462","article-title":"High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis","volume":"44","author":"Eyre","year":"2012","journal-title":"Nat Genet"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nature12873","article-title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery","volume":"506","author":"Okada","year":"2014","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy395","article-title":"Genetic influences on susceptibility to rheumatoid arthritis in African-americans","volume":"28","author":"Laufer","year":"2019","journal-title":"Hum Mol Genet"},{"key":"B33","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13073-018-0604-8","article-title":"Meta-analysis of immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations","volume":"10","author":"M\u00e1rquez","year":"2018","journal-title":"Genome Med"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/art.21309","article-title":"Association between PADI4 and rheumatoid arthritis: a replication study","volume":"52","author":"Ikari","year":"2005","journal-title":"Arthritis Rheumatol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/ng.233","article-title":"Common variants at CD40 and other loci confer risk of rheumatoid arthritis","volume":"40","author":"Raychaudhuri","year":"2008","journal-title":"Nat Genet"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140741","article-title":"Genetic factors for the severity of ACPA-negative rheumatoid arthritis in 2 cohorts of early disease: A genome-wide study","volume":"42","author":"de Rooy","year":"2015","journal-title":"J Rheumatol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1097\/fpc.0000000000000036","article-title":"Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation","volume":"24","author":"Senapati","year":"2014","journal-title":"Pharmacogenet Genomics"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003394","article-title":"Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis","volume":"9","author":"Cui","year":"2013","journal-title":"PLoS Genet"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41397-018-0040-6","article-title":"Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis","volume":"18","author":"Massey","year":"2018","journal-title":"Pharmacogenomics J"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/art.33381","article-title":"Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort","volume":"64","author":"Plant","year":"2012","journal-title":"Arthritis Rheumatol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2017-0385","article-title":"14-3-3\u03b7 protein: a promising biomarker for rheumatoid arthritis","volume":"12","author":"Zeng","year":"2018","journal-title":"biomark Med"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4202-3","article-title":"Serum-soluble folate receptor \u03b2 as a biomarker for the activity of rheumatoid arthritis synovitis and the response to anti-TNF agents","volume":"37","author":"Otsubo","year":"2018","journal-title":"Clin Rheumatol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/ar3280","article-title":"Biochemical markers of ongoing joint damage in rheumatoid arthritis\u2013current and future applications, limitations and opportunities","volume":"13","author":"Karsdal","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"B44","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s13075-020-02190-3","article-title":"Serum calprotectin: a promising biomarker in rheumatoid arthritis and axial spondyloarthritis","volume":"22","author":"Jarlborg","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1038\/s41467-020-15700-3","article-title":"Scavenger receptor-a is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study","volume":"11","author":"Hu","year":"2020","journal-title":"Nat Commun"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.579228","article-title":"Fibrinogen-like protein 1 is a novel biomarker for predicting disease activity and prognosis of rheumatoid arthritis","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/vlvlqu","article-title":"Antibody to peptidoglycan recognition protein (PGLYRP)-2 as a novel biomarker in rheumatoid arthritis","volume":"39","author":"Huang","year":"2021","journal-title":"Clin Exp Rheumatol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13075-020-02405-7","article-title":"Serum biomarker panel for the diagnosis of rheumatoid arthritis","volume":"23","author":"Mun","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"B49","article-title":"Lipopolysaccharide-binding protein is a sensitive disease activity biomarker for rheumatoid arthritis","volume":"36","author":"Wen","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/art.41056","article-title":"Machine learning to predict anti-tumor necrosis factor drug responses of rheumatoid arthritis patients by integrating clinical and genetic markers","volume":"71","author":"Guan","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s13075-020-02240-w","article-title":"A multi-biomarker disease activity score can predict sustained remission in rheumatoid arthritis","volume":"22","author":"Ma","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"B52","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3390\/cells8090953","article-title":"DNA Methylation as a Future Therapeutic and Diagnostic Target in Rheumatoid Arthritis","volume":"8","author":"Ciechomska","year":"2019","journal-title":"Cells"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03129","article-title":"Non-coding RNAs in rheumatoid arthritis: From bench to bedside","volume":"10","author":"Wang","year":"2019","journal-title":"Front Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.112.146704","article-title":"Long noncoding RNAs: past, present, and future","volume":"193","author":"Kung","year":"2013","journal-title":"Genetics"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058040","article-title":"The sequence of the human genome","volume":"291","author":"Venter","year":"2001","journal-title":"Science"},{"key":"B56","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"B57","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/s41584-021-00687-y","article-title":"The non-coding RNA interactome in joint health and disease","volume":"17","author":"Ali","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110617","article-title":"Dysregulation of non-coding RNAs in rheumatoid arthritis","volume":"130","author":"Taheri","year":"2020","journal-title":"BioMed Pharmacother"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072249","article-title":"An expanding universe of noncoding RNAs","volume":"296","author":"Storz","year":"2002","journal-title":"Science"},{"key":"B60","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cell.2014.03.008","article-title":"The noncoding RNA revolution-trashing old rules to forge new ones","volume":"157","author":"Cech","year":"2014","journal-title":"Cell"},{"key":"B61","doi-asserted-by":"publisher","first-page":"20190027","DOI":"10.1515\/jib-2019-0027","article-title":"Non-Coding RNAs and their Integrated Networks","volume":"16","author":"Zhang","year":"2019","journal-title":"J Integr Bioinform"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/genes6020163","article-title":"Nuclear export of messenger RNA","volume":"6","author":"Katahira","year":"2015","journal-title":"Genes (Basel)"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4070-x","article-title":"Expression of circulating Semaphorin3A and its association with inflammation and bone destruction in rheumatoid arthritis","volume":"37","author":"Gao","year":"2018","journal-title":"Clin Rheumatol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2021.146059","article-title":"Epigenetically-regulated RPN2 gene influences lymphocyte activation and is involved in pathogenesis of rheumatoid arthritis","volume":"810","author":"He","year":"2022","journal-title":"Gene"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.13539","article-title":"Elevated expression of interleukin-37 in patients with rheumatoid arthritis","volume":"22","author":"Yuan","year":"2019","journal-title":"Int J Rheum Dis"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01336","article-title":"Identification of a human SOCS1 polymorphism that predicts rheumatoid arthritis severity","volume":"11","author":"Lamana","year":"2020","journal-title":"Front Immunol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000026504","article-title":"Increased hexokinase-2 as a novel biomarker for the diagnosis and correlating with disease severity in rheumatoid arthritis","volume":"100","author":"Zhou","year":"2021","journal-title":"Medicine"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7313515","article-title":"Reduced activity of HDAC3 and increased acetylation of histones H3 in peripheral blood mononuclear cells of patients with rheumatoid arthritis","volume":"2018","author":"Li","year":"2018","journal-title":"J Immunol Res"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6683148","article-title":"Single immunoglobulin IL-1-Related receptor (SIGIRR) gene rs7396562 polymorphism and expression level in rheumatoid arthritis","volume":"2021","author":"Yang","year":"2021","journal-title":"BioMed Res Int"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02901-9","article-title":"SLAMF6 is associated with the susceptibility and severity of rheumatoid arthritis in the Chinese population","volume":"17","author":"Xia","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-017-1119-2","article-title":"Polymorphisms and expression of inflammasome genes are associated with the development and severity of rheumatoid arthritis in Brazilian patients","volume":"67","author":"Addobbati","year":"2018","journal-title":"Inflammation Res"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5735279","article-title":"Decreased ALKBH5, FTO, and YTHDF2 in peripheral blood are as risk factors for rheumatoid arthritis","volume":"2020","author":"Luo","year":"2020","journal-title":"BioMed Res Int"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/ixdaek","article-title":"Identification of RRM2 in peripheral blood mononuclear cells as a novel biomarker for the diagnosis of rheumatoid arthritis","volume":"40","author":"Wu","year":"2022","journal-title":"Clin Exp Rheumatol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/ck1ksi","article-title":"The mRNA levels of TGF-\u03b2 type II receptor splice variants in monocytes are associated with disease activity in patients with rheumatoid arthritis","volume":"39","author":"Carrea","year":"2021","journal-title":"Clin Exp Rheumatol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-019-00568-5","article-title":"Assessment of CD40 and CD40L expression in rheumatoid arthritis patients, association with clinical features and DAS28","volume":"19","author":"Rom\u00e1n-Fern\u00e1ndez","year":"2019","journal-title":"Clin Exp Med"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.intimp.2018.09.028","article-title":"Plasma interleukin-38 in patients with rheumatoid arthritis","volume":"65","author":"Xu","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4268-y","article-title":"Association of CD26\/dipeptidyl peptidase IV mRNA level in peripheral blood mononuclear cells with disease activity and bone erosion in rheumatoid arthritis","volume":"37","author":"Yeganeh","year":"2018","journal-title":"Clin Rheumatol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23530","article-title":"Increased FURIN expression in rheumatoid arthritis patients and its anti-inflammatory effect","volume":"34","author":"Cao","year":"2020","journal-title":"J Clin Lab Anal"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.03.024","article-title":"Interleukin10-1082 A\/G polymorphism: Allele frequency, correlation with disease markers, messenger RNA and serum levels in north Indian rheumatoid arthritis patients","volume":"55","author":"Jahid","year":"2018","journal-title":"Clin Biochem"},{"key":"B80","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/1547691x.2022.2067916","article-title":"Expression and clinical significance of the m6A reader YTHDF2 in peripheral blood mononuclear cells from rheumatoid arthritis patients","volume":"19","author":"Yao","year":"2022","journal-title":"J Immunotoxicol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10711","article-title":"Activation of TGR5 alleviates inflammation in rheumatoid arthritis peripheral blood mononuclear cells and in mice with collagen II\u2212induced arthritis","volume":"20","author":"Li","year":"2019","journal-title":"Mol Med Rep"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6885","article-title":"Decreased regulatory T-cell frequency and interleukin-35 levels in patients with rheumatoid arthritis","volume":"16","author":"Zhang","year":"2018","journal-title":"Exp Ther Med"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/art.41701","article-title":"Semaphorins: From angiogenesis to inflammation in rheumatoid arthritis","volume":"73","author":"Avouac","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1038\/s41598-018-37907-7","article-title":"Differential expression and regulation of the non-integrin 37\/67-kDa laminin receptor on peripheral blood leukocytes of healthy individuals and patients with rheumatoid arthritis","volume":"9","author":"Kane","year":"2019","journal-title":"Sci Rep"},{"key":"B85","doi-asserted-by":"publisher","first-page":"14050","DOI":"10.1038\/s41598-018-32485-0","article-title":"Genetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients","volume":"8","author":"Damen","year":"2018","journal-title":"Sci Rep"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa428","article-title":"Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis","volume":"60","author":"Muller","year":"2021","journal-title":"Rheumatol (Oxford)"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-019-04344-2","article-title":"Baseline adenosine receptor mRNA expression in blood as predictor of response to methotrexate therapy in patients with rheumatoid arthritis","volume":"39","author":"Singh","year":"2019","journal-title":"Rheumatol Int"},{"key":"B88","doi-asserted-by":"publisher","first-page":"keac553","DOI":"10.1093\/rheumatology\/keac553","article-title":"A Novel Long Noncoding RNA, lnc-RNU12, Influences the T-Cell Cycle via c-JUN and CCNL2 in Rheumatoid Arthritis","volume":"27","author":"Mo","year":"2022","journal-title":"Rheumatol (Oxford)"},{"key":"B89","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3892\/etm.2020.9601","article-title":"Network analysis and transcriptome profiling in peripheral blood mononuclear cells of patients with rheumatoid arthritis","volume":"21","author":"Long","year":"2021","journal-title":"Exp Ther Med"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roab128","article-title":"The implication of long non-coding RNA expression profile in rheumatoid arthritis: Correlation with treatment response to tumor necrosis factor inhibitor","volume":"33","author":"Wang","year":"2022","journal-title":"Mod Rheumatol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00702","article-title":"Long non-coding RNA GAPLINC promotes tumor-like biologic behaviors of fibroblast-like synoviocytes as MicroRNA sponging in rheumatoid arthritis patients","volume":"9","author":"Mo","year":"2018","journal-title":"Front Immunol"},{"key":"B92","article-title":"Role of RP11-83J16.1, a novel long non-coding RNA, in rheumatoid arthritis","volume":"12","author":"Piao","year":"2020","journal-title":"Am J Trans Res"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.11.024","article-title":"LncRNA PICSAR promotes cell proliferation, migration and invasion of fibroblast-like synoviocytes by sponging miRNA-4701-5p in rheumatoid arthritis","volume":"50","author":"Bi","year":"2019","journal-title":"EBioMedicine"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2020.36.270.21827","article-title":"A new tool for early diagnosis of rheumatoid arthritis using combined biomarkers; synovial MAGE-1 mRNA and serum anti-CCP and RF","volume":"36","author":"Aiman","year":"2020","journal-title":"Pan Afr Med J"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4030-5","article-title":"Genetic polymorphism of rs9277535 in HLA-DP associated with rheumatoid arthritis and anti-CCP production in a Chinese population","volume":"37","author":"Huang","year":"2018","journal-title":"Clin Rheumatol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.3892\/etm.2021.10544","article-title":"NLRP3 gene polymorphisms and expression in rheumatoid arthritis","volume":"22","author":"Cheng","year":"2021","journal-title":"Exp Ther Med"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2021.1879429","article-title":"Good response to methotrexate is associated with a decrease in the gene expression of ABCG2, a drug transporter, in patients with rheumatoid arthritis","volume":"31","author":"Muto","year":"2021","journal-title":"Mod Rheumatol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.728015","article-title":"Tristetraprolin gene single-nucleotide polymorphisms and mRNA level in patients with rheumatoid arthritis","volume":"12","author":"Yang","year":"2021","journal-title":"Front Pharmacol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.2147\/ijgm.S309436","article-title":"Correlation between level of interleukin-37 and rheumatoid arthritis progression","volume":"14","author":"Zhu","year":"2021","journal-title":"Int J Gen Med"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.162","article-title":"Deregulation and therapeutic potential of microRNAs in arthritic diseases","volume":"12","author":"Vicente","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.3390\/ijms17101712","article-title":"MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions","volume":"17","author":"Catalanotto","year":"2016","journal-title":"Int J Mol Sci"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.09.003","article-title":"The role of microRNAs in the pathogenesis of autoimmune diseases","volume":"15","author":"Chen","year":"2016","journal-title":"Autoimmun Rev"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.3390\/ijms21051723","article-title":"Regulatory Mechanism of MicroRNA Expression in Cancer","volume":"21","author":"Ali Syeda","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.633201","article-title":"Serum miRNA signature in rheumatoid arthritis and \"At-risk individuals\"","volume":"12","author":"Cunningham","year":"2021","journal-title":"Front Immunol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s10020-020-00199-7","article-title":"Serum a proliferation-inducing ligand and MicroRNA-223 are associated with rheumatoid arthritis: diagnostic and prognostic implications","volume":"26","author":"Taha","year":"2020","journal-title":"Mol Med"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13156","article-title":"Circulating serum miR-223-3p and miR-16-5p as possible biomarkers of early rheumatoid arthritis","volume":"193","author":"Dunaeva","year":"2018","journal-title":"Clin Exp Immunol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"e14651","DOI":"10.1111\/ijcp.14651","article-title":"Serum miR-224, miR-760, miR-483-5p, miR-378 and miR-375 as potential novel biomarkers in rheumatoid arthritis","volume":"75","author":"Abdelaleem","year":"2021","journal-title":"Int J Clin Pract"},{"key":"B108","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1159\/000525112","article-title":"Upregulated miR-146a expression in peripheral blood relates to Th17 and treg imbalance in elder rheumatoid arthritis patients","volume":"15","author":"Liu","year":"2022","journal-title":"Lifestyle Genom"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.144081","article-title":"Identification of putative miRNA biomarkers in early rheumatoid arthritis by genome-wide microarray profiling: A pilot study","volume":"720","author":"Romo-Garc\u00eda","year":"2019","journal-title":"Gene"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233897","article-title":"Hypermethylation of the miR-155 gene in the whole blood and decreased plasma level of miR-155 in rheumatoid arthritis","volume":"15","author":"Kolarz","year":"2020","journal-title":"PLoS One"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.18502\/ijaai.v20i3.6334","article-title":"Plasma levels of MicroRNA-146a-5p, MicroRNA-24-3p, and MicroRNA-125a-5p as potential diagnostic biomarkers for rheumatoid arthris","volume":"20","author":"Safari","year":"2021","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"69","DOI":"10.55563\/clinexprheumatol\/4me6tg","article-title":"Identification of circulating miR-22-3p and let-7a-5p as novel diagnostic biomarkers for rheumatoid arthritis","volume":"40","author":"Tang","year":"2022","journal-title":"Clin Exp Rheumatol"},{"key":"B113","doi-asserted-by":"publisher","first-page":"143911","DOI":"10.1016\/j.gene.2019.06.001","article-title":"Circulating microRNA-23b as a new biomarker for rheumatoid arthritis","volume":"712","author":"Liu","year":"2019","journal-title":"Gene"},{"key":"B114","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3892\/etm.2021.9890","article-title":"microRNA-23 inhibits inflammation to alleviate rheumatoid arthritis via regulating CXCL12","volume":"21","author":"Gao","year":"2021","journal-title":"Exp Ther Med"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-04417-w","article-title":"MiR-5571-3p and miR-135b-5p, derived from analyses of microRNA profile sequencing, correlate with increased disease risk and activity of rheumatoid arthritis","volume":"38","author":"Liu","year":"2019","journal-title":"Clin Rheumatol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27014","article-title":"Exosome-encapsulated miR-6089 regulates inflammatory response via targeting TLR4","volume":"234","author":"Xu","year":"2019","journal-title":"J Cell Physiol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00751-x","article-title":"Identification of novel rheumatoid arthritis-associated MiRNA-204-5p from plasma exosomes","volume":"54","author":"Wu","year":"2022","journal-title":"Exp Mol Med"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.790880","article-title":"A serum biomarker panel of exomiR-451a, exomiR-25-3p and soluble TWEAK for early diagnosis of rheumatoid arthritis","volume":"12","author":"Rodr\u00edguez-Muguruza","year":"2021","journal-title":"Front Immunol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26659","article-title":"MiR-548a-3p regulates inflammatory response via TLR4\/NF-\u03baB signaling pathway in rheumatoid arthritis","volume":"6","author":"Wang","year":"2018","journal-title":"J Cell Biochem"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12124","article-title":"Serum exosomal miRNA-1915-3p is correlated with disease activity of Korean rheumatoid arthritis","volume":"34","author":"Lim","year":"2020","journal-title":"In Vivo"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0319-9","article-title":"Exosomal microRNA in autoimmunity","volume":"16","author":"Duan","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s13577-017-0179-5","article-title":"LncRNA ZFAS1 promotes cell migration and invasion of fibroblast-like synoviocytes by suppression of miR-27a in rheumatoid arthritis","volume":"31","author":"Ye","year":"2018","journal-title":"Hum Cell"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-020-00461-4","article-title":"LncRNA NEAT1 regulates the proliferation and production of the inflammatory cytokines in rheumatoid arthritis fibroblast-like synoviocytes by targeting miR-204-5p","volume":"34","author":"Xiao","year":"2021","journal-title":"Hum Cell"},{"key":"B124","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1186\/s13018-022-03295-y","article-title":"Inhibition of lncRNA NEAT1 induces dysfunction of fibroblast-like synoviocytes in rheumatoid arthritis via miRNA-338-3p-mediated regulation of glutamine metabolism","volume":"17","author":"Zhang","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3390\/life11121382","article-title":"Long non-coding RNA PVT1 and its target miRNA-146a as potential prognostic biomarkers in rheumatoid arthritis patients","volume":"11","author":"Erfan","year":"2021","journal-title":"Life (Basel)"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-020-00419-6","article-title":"Long non-coding RNA PVT1 can regulate the proliferation and inflammatory responses of rheumatoid arthritis fibroblast-like synoviocytes by targeting microRNA-145-5p","volume":"33","author":"Tang","year":"2020","journal-title":"Hum Cell"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2021.1919879","article-title":"LncRNA FOXD2-AS1 promotes cell proliferation and invasion of fibroblast-like synoviocytes by regulation of miR-331-3p\/PIAS3 pathway in rheumatoid arthritis","volume":"54","author":"Zhao","year":"2021","journal-title":"Autoimmunity"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.2022075","article-title":"Long non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p\/B-cell translocation gene 3 signaling axis in rheumatoid arthritis","volume":"13","author":"Ye","year":"2022","journal-title":"Bioengineered"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2022.2126460","article-title":"LncRNA HOTAIR inhibits the progression of fibroblast-like synoviocytes by sponging miRNA-106b-5p in rheumatoid arthritis","volume":"55","author":"Qiu","year":"2022","journal-title":"Autoimmunity"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20036","article-title":"Long noncoding RNAs expression profile and functional networks in rheumatoid arthritis","volume":"8","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"key":"B131","volume-title":"Long non-coding RNA THRIL mediates cell growth and inflammatory response of fibroblast-like synoviocytes by activating PI3","author":"Liang","year":""},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20182374","article-title":"LncRNA DILC participates in rheumatoid arthritis by inducing apoptosis of fibroblast-like synoviocytes and down-regulating IL-6","volume":"39","author":"Wang","year":"2019","journal-title":"Biosci Rep"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11018","article-title":"lncRNA CASC2 downregulation participates in rheumatoid arthritis, and CASC2 overexpression promotes the apoptosis of fibroblast-like synoviocytes by downregulating IL-17","volume":"21","author":"Liu","year":"2020","journal-title":"Mol Med Rep"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080816","article-title":"Long non-coding RNAs target pathogenetically relevant genes and pathways in rheumatoid arthritis","volume":"8","author":"Dolcino","year":"2019","journal-title":"Cells"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.325","article-title":"Integrative lncRNA-mRNA co-expression network analysis identifies novel lncRNA E2F3-IT1 for rheumatoid arthritis","volume":"11","author":"Wu","year":"2021","journal-title":"Clin Transl Med"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6401978","article-title":"Elevated expression of the long noncoding RNA IFNG-AS1 in the peripheral blood from patients with rheumatoid arthritis","volume":"2020","author":"Peng","year":"2020","journal-title":"J Immunol Res"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.8681","article-title":"Differential long non-coding RNA expression profiles in the peripheral blood and CD4(+) T cells of patients with active rheumatoid arthritis","volume":"20","author":"Li","year":"2020","journal-title":"Exp Ther Med"},{"key":"B138","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/s41419-019-1744-5","article-title":"Roles of circular RNAs in immune regulation and autoimmune diseases","volume":"10","author":"Zhou","year":"2019","journal-title":"Cell Death Dis"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00639","article-title":"Roles of CircRNAs in autoimmune diseases","volume":"10","author":"Xia","year":"2019","journal-title":"Front Immunol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2073139","article-title":"Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in peripheral blood are novel potential biomarkers for new-onset rheumatoid arthritis","volume":"2019","author":"Luo","year":"2019","journal-title":"Dis Markers"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2021.104617","article-title":"Circ_AFF2 facilitates proliferation and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-375\/TAB2 axis","volume":"119","author":"Zhi","year":"2021","journal-title":"Exp Mol Pathol"},{"key":"B142","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s13018-021-02306-8","article-title":"Circ-AFF2\/miR-650\/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts","volume":"16","author":"Qu","year":"2021","journal-title":"J Orthop Surg Res"},{"key":"B143","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.gpb.2015.02.001","article-title":"Exosome and exosomal microRNA: trafficking, sorting, and function","volume":"13","author":"Zhang","year":"2015","journal-title":"Genomics Proteomics Bioinf"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577640","article-title":"The pathogenic, therapeutic and diagnostic role of exosomal microRNA in the autoimmune diseases","volume":"358","author":"Mirzaei","year":"2021","journal-title":"J Neuroimmunol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4380-z","article-title":"MicroRNA-132, miR-146a, and miR-155 as potential biomarkers of methotrexate response in patients with rheumatoid arthritis","volume":"38","author":"Singh","year":"2019","journal-title":"Clin Rheumatol"},{"key":"B146","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3390\/jpm10040205","article-title":"Analysis of miRNA Expression in Patients with Rheumatoid Arthritis during Olokizumab Treatment","volume":"10","author":"Bure","year":"2020","journal-title":"J Pers Med"},{"key":"B147","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.intimp.2018.07.028","article-title":"Analysis of miRNA expression in patients with rheumatoid arthritis during remission and relapse after a 5-year trial of tofacitinib treatment","volume":"63","author":"Fern\u00e1ndez-Ruiz","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23329","article-title":"The potential of circulating microRNA-125a and microRNA-125b as markers for inflammation and clinical response to infliximab in rheumatoid arthritis patients","volume":"34","author":"Cheng","year":"2020","journal-title":"J Clin Lab Anal"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.5907","article-title":"miR-143-3p regulates cell proliferation and apoptosis by targeting IGF1R and IGFBP5 and regulating the Ras\/p38 MAPK signaling pathway in rheumatoid arthritis","volume":"15","author":"Yang","year":"2018","journal-title":"Exp Ther Med"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-017-3003-3","article-title":"MicroRNA-192 suppresses cell proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes by downregulating caveolin 1","volume":"432","author":"Li","year":"2017","journal-title":"Mol Cell Biochem"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5665","article-title":"Roles of microRNA-539 and osteopontin in rheumatoid arthritis","volume":"15","author":"Liu","year":"2018","journal-title":"Exp Ther Med"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106404","article-title":"Altered expression of microRNAs may predict therapeutic response in rheumatoid arthritis patients","volume":"83","author":"Rezaeepoor","year":"2020","journal-title":"Int Immunopharmacol."},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3390\/life11121382","article-title":"Long non-coding RNA PVT1 and its target miRNA-146a as potential prognostic biomarkers in rheumatoid arthritis patients","volume":"11","author":"Erfan","year":"2021","journal-title":"Life (Basel)"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-018-3351-7","article-title":"Possible use of miRNAs-146a and -499 expression and their polymorphisms as diagnostic markers for rheumatoid arthritis","volume":"449","author":"Ayeldeen","year":"2018","journal-title":"Mol Cell Biochem"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-018-0513-y","article-title":"Changes in MiRNA-5196 expression as a potential biomarker of anti-TNF-\u03b1 therapy in rheumatoid arthritis and ankylosing spondylitis patients","volume":"66","author":"Ciechomska","year":"2018","journal-title":"Arch Immunol Ther Exp (Warsz)."},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.9124","article-title":"Expression of miR-495 and miR-326 in peripheral blood of rheumatoid arthritis patients and its significance","volume":"20","author":"Sui","year":"2020","journal-title":"Exp Ther Med"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2017.1343545","article-title":"Serum miR-210 and miR-155 expression levels as novel biomarkers for rheumatoid arthritis diagnosis","volume":"74","author":"Abdul-Maksoud","year":"2017","journal-title":"Br J BioMed Sci"},{"key":"B158","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2174\/1389201019666180417155140","article-title":"Circulating miR-10a as predictor of therapy response in rheumatoid arthritis patients treated with methotrexate","volume":"19","author":"Hong","year":"2018","journal-title":"Curr Pharm Biotechnol"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.55563\/clinexprheumatol\/zdhkrp","article-title":"Plasma micro-RNA-22 is associated with disease activity in well-established rheumatoid arthritis","volume":"40","author":"Cie\u015bla","year":"2022","journal-title":"Clin Exp Rheumatol"},{"key":"B160","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3899\/jrheum.170266","article-title":"Plasma MicroRNA profiles in patients with early rheumatoid arthritis responding to adalimumab plus methotrexate vs methotrexate alone: A placebo-controlled clinical trial","volume":"45","author":"Sode","year":"2018","journal-title":"J Rheumatol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.13644","article-title":"Circulating miR-99b-5p as a novel predictor of erosion progression on high-resolution peripheral quantitative computed tomography in early rheumatoid arthritis: A prospective cohort study","volume":"22","author":"Yue","year":"2019","journal-title":"Int J Rheum Dis"},{"key":"B162","doi-asserted-by":"publisher","first-page":"4719","DOI":"10.1038\/s41598-021-84004-3","article-title":"High miR-451 expression in peripheral blood mononuclear cells from subjects at risk of developing rheumatoid arthritis","volume":"11","author":"Prajzlerov\u00e1","year":"2021","journal-title":"Sci Rep"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2019.1676613","article-title":"Identification of PBMC-expressed miRNAs for rheumatoid arthritis","volume":"15","author":"Zhu","year":"2020","journal-title":"Epigenetics"},{"key":"B164","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10238-018-0524-3","article-title":"Upregulation of miR-221\/222 expression in rheumatoid arthritis (RA) patients: correlation with disease activity","volume":"19","author":"Abo ElAtta","year":"2019","journal-title":"Clin Exp Med"},{"key":"B165","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s13075-017-1459-x","article-title":"Whole blood microRNA expression pattern differentiates patients with rheumatoid arthritis, their seropositive first-degree relatives, and healthy unrelated control subjects","volume":"19","author":"Anaparti","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22953","article-title":"Correlation of microRNA expression profile with clinical response to tumor necrosis factor inhibitor in treating rheumatoid arthritis patients: A prospective cohort study","volume":"33","author":"Liu","year":"2019","journal-title":"J Clin Lab Anal"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13181","article-title":"Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for rheumatoid arthritis","volume":"194","author":"Luo","year":"2018","journal-title":"Clin Exp Immunol"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2021.1916272","article-title":"Hsa_circ_0044235 regulates the pyroptosis of rheumatoid arthritis via MiR-135b-5p-SIRT1 axis","volume":"20","author":"Chen","year":"2021","journal-title":"Cell Cycle"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.722017","article-title":"Identification of circular RNAs Circ_0005008 and Circ_0005198 in plasma as novel biomarkers for new-onset rheumatoid arthritis","volume":"12","author":"Ouyang","year":"2021","journal-title":"Front Pharmacol"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.52547\/rbmb.10.4.527","article-title":"Potential role of circRNA-HIPK3\/microRNA-124a crosstalk in the pathogenesis of rheumatoid arthritis","volume":"10","author":"Saad El-Din","year":"2022","journal-title":"Rep Biochem Mol Biol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3892\/mmr.2021.12256","article-title":"circPTPN22 as a novel biomarker and ceRNA in peripheral blood mononuclear cells of rheumatoid arthritis","volume":"24","author":"Jiang","year":"2021","journal-title":"Mol Med Rep"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0783-7","article-title":"Elevated expression of ciRS-7 in peripheral blood mononuclear cells from rheumatoid arthritis patients","volume":"14","author":"Tang","year":"2019","journal-title":"Diagn Pathol"},{"key":"B173","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1186\/s13018-021-02794-8","article-title":"Identification of circular RNAs hsa_circ_0140271 in peripheral blood mononuclear cells as a novel diagnostic biomarker for female rheumatoid arthritis","volume":"16","author":"Chen","year":"2021","journal-title":"J Orthop Surg Res"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.885896","article-title":"Circular RNA circNUP214 modulates the T helper 17 cell response in patients with rheumatoid arthritis","volume":"13","author":"Peng","year":"2022","journal-title":"Front Immunol"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2019.1674004","article-title":"Aberrant dysregulated circular RNAs in the peripheral blood mononuclear cells of patients with rheumatoid arthritis revealed by RNA sequencing: novel diagnostic markers for RA","volume":"79","author":"Yang","year":"2019","journal-title":"Scand J Clin Lab Invest"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4498","article-title":"Expression and clinical significance of circular RNAs hsa_circ_0000175 and hsa_circ_0008410 in peripheral blood mononuclear cells from patients with rheumatoid arthritis","volume":"45","author":"Luo","year":"2020","journal-title":"Int J Mol Med"},{"key":"B177","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12920-022-01225-9","article-title":"Expression profile of circRNA in peripheral blood mononuclear cells of patients with rheumatoid arthritis","volume":"15","author":"Lu","year":"2022","journal-title":"BMC Med Genomics"},{"key":"B178","doi-asserted-by":"publisher","first-page":"BSR20193160","DOI":"10.1042\/bsr20193160","article-title":"RNA-Seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis","volume":"40","author":"Wen","year":"2020","journal-title":"Biosci Rep"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.628654","article-title":"Circ_0088194 promotes the invasion and migration of rheumatoid arthritis fibroblast-like synoviocytes via the miR-766-3p\/MMP2 axis","volume":"12","author":"Cai","year":"2021","journal-title":"Front Immunol"},{"key":"B180","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1186\/s13018-021-02550-y","article-title":"CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p\/PPM1A axis","volume":"16","author":"Luo","year":"2021","journal-title":"J Orthop Surg Res"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2022.2102164","article-title":"Knockdown of circ_0025908 inhibits proliferation, migration, invasion, and inflammation while stimulates apoptosis in fibroblast-like synoviocytes by regulating miR-650-dependent SCUBE2","volume":"55","author":"Wang","year":"2022","journal-title":"Autoimmunity"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2021.1958837","article-title":"Circ_0003972 promotes the proliferation and inflammation of fibroblast-like synovial cells in rheumatoid arthritis through regulation of the miR-654-5p\/FZD4 axis","volume":"51","author":"Li","year":"2022","journal-title":"Immunol Invest."},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1186\/s40709-020-00131-4","article-title":"Circ_0000396 inhibits rheumatoid arthritis synovial fibroblast growth and inflammatory response via miR-203\/HBP1 axis","volume":"28","author":"Wang","year":"2021","journal-title":"J Biol Res (Thessalon)."},{"key":"B184","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1007\/s10753-021-01538-4","article-title":"Circular RNA circ_0008360 inhibits the proliferation, migration, and inflammation and promotes apoptosis of fibroblast-like synoviocytes by regulating miR-135b-5p\/HDAC4 axis in rheumatoid arthritis","volume":"45","author":"Hao","year":"2022","journal-title":"Inflammation"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107366","article-title":"Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis","volume":"92","author":"Wen","year":"2021","journal-title":"Int Immunopharmacol."},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab407","article-title":"Comprehensive microRNA and transcriptomic profiling of rheumatoid arthritis monocytes: role of microRNA-146b in pro-inflammatory progression","volume":"60","author":"Ciechomska","year":"2021","journal-title":"Rheumatol (Oxford)."},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26659","article-title":"MiR-548a-3p regulates inflammatory response via TLR4\/NF-\u03baB signaling pathway in rheumatoid arthritis","author":"Wang","year":"2018","journal-title":"J Cell Biochem"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2924935","article-title":"Exploring the extracellular vesicle MicroRNA expression repertoire in patients with rheumatoid arthritis and ankylosing spondylitis treated with TNF inhibitors","volume":"2021","author":"Wieli\u0144ska","year":"2021","journal-title":"Dis Markers."},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.006","article-title":"Evolution and functions of long noncoding RNAs","volume":"136","author":"Ponting","year":"2009","journal-title":"Cell"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.2021347","article-title":"Long non-coding RNA TSPEAR antisense RNA 2 is downregulated in rheumatoid arthritis and inhibits the apoptosis of fibroblast-like synoviocytes by downregulating microRNA-212-3p (miR-212-3p)","volume":"13","author":"Lv","year":"2022","journal-title":"Bioengineered"},{"key":"B191","article-title":"Circulating lnc-ITSN1-2 expression presents a high value in diagnosis of rheumatoid arthritis and correlates with disease activity","volume":"10","author":"Gong","year":"2017","journal-title":"Int J Clin Exp pathol"},{"key":"B192","article-title":"Downregulation of lncRNA ITSN1-2 correlates with decreased disease risk and activity of rheumatoid arthritis (RA), and reduces RA fibroblast-like synoviocytes proliferation and inflammation via inhibiting NOD2\/RIP2 signaling pathway","volume":"11","author":"Yue","year":"2019","journal-title":"Am J Trans Res"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2018.0117","article-title":"Expression profile of long noncoding RNAs, lnc-Cox2, and HOTAIR in rheumatoid arthritis patients","volume":"39","author":"Shaker","year":"2019","journal-title":"J Interferon Cytokine Res"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2020.1744942","article-title":"Serum LINC00305 expression and its genetic variant rs2850711 are associated with clinical and laboratory features of rheumatoid arthritis","volume":"77","author":"Wahba","year":"2020","journal-title":"Br J BioMed Sci"},{"key":"B195","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/08916934.2020.1750010","article-title":"LncRNA PlncRNA-1 participates in rheumatoid arthritis by regulating transforming growth factor \u03b21","volume":"53","author":"Wang","year":"2020","journal-title":"Autoimmunity"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2037854","article-title":"LncRNA OSER1-AS1 regulates the inflammation and apoptosis of rheumatoid arthritis fibroblast like synoviocytes via regulating miR-1298-5p\/E2F1 axis","volume":"13","author":"Fu","year":"2022","journal-title":"Bioengineered"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-019-00666-6","article-title":"Analysis of lncRNA expression profiles by sequencing reveals that lnc-AL928768.3 and lnc-AC091493.1 are novel biomarkers for disease risk and activity of rheumatoid arthritis","volume":"28","author":"Sun","year":"2020","journal-title":"Inflammopharmacology"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.146757","article-title":"Increased Long Noncoding RNA LINK-a Contributes to Rheumatoid Synovial Inflammation and Aggression","volume":"6","author":"Wang","year":"2021","journal-title":"JCI Insight"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.13930","article-title":"LncRNA GAS5 activates the AMPK pathway in peripheral blood mononuclear cells derived from rheumatoid arthritis patients","volume":"23","author":"Cao","year":"2020","journal-title":"Int J Rheum Dis"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-021-04098-1","article-title":"Long non-coding RNA GAS5 suppresses rheumatoid arthritis progression via miR-128-3p\/HDAC4 axis","volume":"476","author":"Peng","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"B201","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3892\/br.2021.1469","article-title":"Diagnostic role of lncRNA GAS5 and its genetic polymorphisms rs2067079, rs6790 and rs17359906 in rheumatoid arthritis","volume":"15","author":"Elamir","year":"2021","journal-title":"BioMed Rep"},{"key":"B202","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/08916934.2020.1846183","article-title":"LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p\/Sirt1 signalling axis","volume":"54","author":"Yang","year":"2021","journal-title":"Autoimmunity"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1159\/000477883","article-title":"Microarray expression profile of circular RNAs in peripheral blood mononuclear cells from rheumatoid arthritis patients","volume":"42","author":"Ouyang","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-022-00501-9","article-title":"tRNA dysregulation and disease","volume":"23","author":"Orellana","year":"2022","journal-title":"Nat Rev Genet"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12977","article-title":"tsRNAs: Novel small molecules from cell function and regulatory mechanism to therapeutic targets","volume":"54","author":"Zong","year":"2021","journal-title":"Cell Prolif"},{"key":"B206","doi-asserted-by":"publisher","first-page":"10193","DOI":"10.3390\/ijms221910193","article-title":"Emerging Functions for snoRNAs and snoRNA-Derived Fragments","volume":"22","author":"Wajahat","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B207","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.3390\/ijms22052373","article-title":"piRNAs as Modulators of Disease Pathogenesis","volume":"22","author":"Rayford","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.191012","article-title":"Circulating small noncoding RNA biomarkers of response to triple disease-modifying antirheumatic drug therapy in white women with early rheumatoid arthritis","volume":"47","author":"Foers","year":"2020","journal-title":"J Rheumatol"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.05.010409","article-title":"Prevalence of rheumatoid arthritis in low- and middle-income countries: A systematic review and analysis","volume":"5","author":"Rudan","year":"2015","journal-title":"J Glob Health"},{"key":"B210","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/art.30100","article-title":"Classification of rheumatoid arthritis: comparison of the 1987 American college of rheumatology criteria and the 2010 American college of Rheumatology\/European league against rheumatism criteria","volume":"63","author":"van der Linden","year":"2011","journal-title":"Arthritis Rheumatol"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04694-z","article-title":"The expression of GAS5, THRIL, and RMRP lncRNAs is increased in T cells of patients with rheumatoid arthritis","volume":"38","author":"Moharamoghli","year":"2019","journal-title":"Clin Rheumatol"},{"key":"B212","article-title":"Role of RP11-83J16.1, a novel long non-coding RNA, in rheumatoid arthritis","volume":"12","author":"Piao","year":"2020","journal-title":"Am J Trans Res"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.2217\/pme-2020-0009","article-title":"Increase in MEG3, MALAT1, NEAT1 significantly predicts the clinical parameters in patients with rheumatoid arthritis","volume":"17","author":"Chatterjee","year":"2020","journal-title":"Per Med"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2021-0070","article-title":"Multiple time-point assessment of lncRNA MEG3 shows potential to monitor treatment efficacy in rheumatoid arthritis patients","volume":"15","author":"Wang","year":"2021","journal-title":"biomark Med"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12913","article-title":"lncRNA expression profiles related to apoptosis and autophagy in peripheral blood mononuclear cells of patients with rheumatoid arthritis","volume":"10","author":"Wen","year":"2020","journal-title":"FEBS Open Bio"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.663","article-title":"Overexpression of long noncoding RNA LINC00638 inhibits inflammation and oxidative stress in rheumatoid arthritis fibroblast-like synoviocytes by regulating the Nrf2\/HO-1 pathway","volume":"10","author":"Sun","year":"2022","journal-title":"Immun Inflammation Dis"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24076","article-title":"Long non-coding RNA NEAT1 and its targets (microRNA-21 and microRNA-125a) in rheumatoid arthritis: Altered expression and potential to monitor disease activity and treatment outcome","volume":"35","author":"Yang","year":"2021","journal-title":"J Clin Lab Anal"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1087925\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T01:52:35Z","timestamp":1675216355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1087925\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":217,"alternative-id":["10.3389\/fimmu.2023.1087925"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1087925","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,1]]},"article-number":"1087925"}}