{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:09Z","timestamp":1787771949140,"version":"build-2784847793"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\u03b2-glucan is the most abundant polysaccharide in the cell wall of <jats:italic>Pneumocystis jirovecii<\/jats:italic>, which has attracted extensive attention because of its unique immunobiological characteristics. \u03b2-glucan binds to various cell surface receptors, which produces an inflammatory response and accounts for its immune effects. A deeper comprehension of the processes by <jats:italic>Pneumocystis<\/jats:italic> \u03b2-glucan recognizes its receptors, activates related signaling pathways, and regulates immunity as required. Such understanding will provide a basis for developing new therapies against <jats:italic>Pneumocystis<\/jats:italic>. Herein, we briefly review the structural composition of \u03b2-glucans as a vital component of the <jats:italic>Pneumocystis<\/jats:italic> cell wall, the host immunity mediated by \u03b2-glucans after their recognition, and discuss opportunities for the development of new strategies to combat <jats:italic>Pneumocystis<\/jats:italic>.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1094464","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T10:27:11Z","timestamp":1675938431000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Targeting \u03b2-glucans, vital components of the Pneumocystis cell 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