{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:20:53Z","timestamp":1792452053419,"version":"4.5.0"},"reference-count":238,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100936"],"award-info":[{"award-number":["82100936"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272485"],"award-info":[{"award-number":["82272485"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012620","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["No.tsqnz20221170"],"award-info":[{"award-number":["No.tsqnz20221170"]}],"id":[{"id":"10.13039\/100012620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Aseptic loosening (AL) is the most common complication of total joint arthroplasty (TJA). Both local inflammatory response and subsequent osteolysis around the prosthesis are the fundamental causes of disease pathology. As the earliest change of cell behavior, polarizations of macrophages play an essential role in the pathogenesis of AL, including regulating inflammatory responses and related pathological bone remodeling. The direction of macrophage polarization is closely dependent on the microenvironment of the periprosthetic tissue. When the classically activated macrophages (M1) are characterized by the augmented ability to produce proinflammatory cytokines, the primary functions of alternatively activated macrophages (M2) are related to inflammatory relief and tissue repair. Yet, both M1 macrophages and M2 macrophages are involved in the occurrence and development of AL, and a comprehensive understanding of polarized behaviors and inducing factors would help in identifying specific therapies. In recent years, studies have witnessed novel discoveries regarding the role of macrophages in AL pathology, the shifts between polarized phenotype during disease progression, as well as local mediators and signaling pathways responsible for regulations in macrophages and subsequent osteoclasts (OCs). In this review, we summarize recent progress on macrophage polarization and related mechanisms during the development of AL and discuss new findings and concepts in the context of existing work.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1122057","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T04:33:21Z","timestamp":1678250001000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":47,"title":["Macrophages in aseptic loosening: Characteristics, functions, and mechanisms"],"prefix":"10.3389","volume":"14","author":[{"given":"Yehao","family":"Cong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxun","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32344-4","article-title":"Knee replacement","volume":"392","author":"Price","year":"2018","journal-title":"Lancet (London England)."},{"key":"B2","first-page":"1","article-title":"Current research in the pathogenesis of aseptic implant loosening associated with particulate wear debris","volume":"79","author":"Jiang","year":"2013","journal-title":"Acta orthopaedica Belgica."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00352","article-title":"The effects of biomaterial implant Wear debris on osteoblasts","volume":"8","author":"Zhang","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1186\/ar2170","article-title":"Aseptic loosening of total joint replacements: Mechanisms underlying osteolysis and potential therapies","volume":"9","author":"Abu-Amer","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"B5","doi-asserted-by":"publisher","first-page":"121127","DOI":"10.1016\/j.biomaterials.2021.121127","article-title":"Aseptic and septic prosthetic joint loosening: Impact of biomaterial wear on immune cell function, inflammation, and infection","volume":"278","author":"Hodges","year":"2021","journal-title":"Biomaterials"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122091","article-title":"Periprosthetic osteolysis: Mechanisms, prevention and treatment","volume":"8","author":"Goodman","year":"2019","journal-title":"J Clin Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010092","article-title":"The phagocytic function of macrophage-enforcing innate immunity and tissue homeostasis","volume":"19","author":"Hirayama","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"496","DOI":"10.5604\/17322693.1150133","article-title":"Different pathways of macrophage activation and polarization","volume":"69","author":"Juhas","year":"2015","journal-title":"Postepy higieny i medycyny doswiadczalnej"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12910","article-title":"Implications of macrophage polarization in autoimmunity","volume":"154","author":"Funes","year":"2018","journal-title":"Immunology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/nu12102999","article-title":"Macrophage polarization and osteoporosis: A review","volume":"12","author":"Mu\u00f1oz","year":"2020","journal-title":"Nutrients"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01462","article-title":"The metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1800749","DOI":"10.1002\/advs.201800749","article-title":"Zinc-modified sulfonated polyetheretherketone surface with immunomodulatory function for guiding cell fate and bone regeneration","volume":"5","author":"Liu","year":"2018","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00147C","article-title":"ZBTB20-mediated titanium particle-induced peri-implant osteolysis by promoting macrophage inflammatory responses","volume":"8","author":"Qiu","year":"2020","journal-title":"Biomaterials science."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197658050-00005","article-title":"Extensive localized bone resorption in the femur following total hip replacement","volume":"58","author":"Harris","year":"1976","journal-title":"J Bone Joint Surg Am volume."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2022.02.060","article-title":"Diagnosis and detection of subtle aseptic loosening in total hip arthroplasty","volume":"37","author":"Anil","year":"2022","journal-title":"J arthroplasty."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2017.03.066","article-title":"Current epidemiology of revision total knee arthroplasty in the united states","volume":"32","author":"Delanois","year":"2017","journal-title":"J arthroplasty."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1735282","article-title":"The epidemiology of revision total knee arthroplasty","volume":"34","author":"Tarazi","year":"2021","journal-title":"J knee surgery."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.02.030","article-title":"Projections and Epidemiology of Revision Hip and Knee Arthroplasty in the United States to 2030","volume":"35","author":"Schwartz","year":"2020","journal-title":"J Arthroplasty"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1080\/17453670610045902","article-title":"Aseptic loosening, not only a question of wear: A review of different theories","volume":"77","author":"Sundfeldt","year":"2006","journal-title":"Acta orthopaedica."},{"key":"B22","first-page":"296","article-title":"[Mechanisms, prevention, and treatments of prosthetic aseptic loosening]","volume":"24","author":"Wei","year":"2010","journal-title":"Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chin J reparative reconstructive Surg"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.6b00006","article-title":"Macrophage polarization by titanium dioxide (TiO(2)) particles: Size matters","volume":"2","author":"Schoenenberger","year":"2016","journal-title":"ACS biomaterials Sci engineering."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00055","article-title":"Curcumin attenuates titanium particle-induced inflammation by regulating macrophage polarization In vitro and in vivo","volume":"8","author":"Li","year":"2017","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA12677H","article-title":"Proinflammatory and osteolysis-inducing effects of 3D printing Ti6Al4V particles in vitro and in vivo","volume":"8","author":"Li","year":"2018","journal-title":"RSC Adv"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR00696G","article-title":"The TiO(2)-\u03bc implant residual is more toxic than the Al(2)O(3)-n implant residual via blocking LAP and inducing macrophage polarization","volume":"13","author":"Hu","year":"2021","journal-title":"Nanoscale"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA12325F","article-title":"In vivo analysis of the effects of CoCrMo and Ti particles on inflammatory responses and osteolysis","volume":"8","author":"Li","year":"2018","journal-title":"RSC advances."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.12200\/j.issn.1003-0034.2020.12.012","article-title":"[Role and mechanism of endoplasmic reticulum stress response induced by wear particles in osteolysis]","volume":"33","author":"Liu","year":"2020","journal-title":"Zhongguo gu shang = China J orthopaedics traumatology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.jot.2016.06.026","article-title":"Specific material effects of wear-particle-induced inflammation and osteolysis at the bone-implant interface: A rat model","volume":"8","author":"Longhofer","year":"2017","journal-title":"J orthopaedic translation."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.O.00736","article-title":"Particle-induced osteolysis is mediated by TIRAP\/Mal in vitro and in vivo: Dependence on adherent pathogen-associated molecular patterns","volume":"98","author":"Bechtel","year":"2016","journal-title":"J Bone Joint Surg Am volume"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.11.2082","article-title":"Adherent endotoxin on orthopedic wear particles stimulates cytokine production and osteoclast differentiation","volume":"16","author":"Bi","year":"2001","journal-title":"J Bone mineral research: Off J Am Soc Bone Mineral Res"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.136895","article-title":"Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate toll-like receptors","volume":"285","author":"Greenfield","year":"2010","journal-title":"J Biol Chem"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.04.010","article-title":"Results of cemented posterior-stabilized total knee arthroplasty in obese patients with an average 10-year follow-up","volume":"35","author":"Hagman","year":"2020","journal-title":"J arthroplasty."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2019.11.004","article-title":"The genetic variations associated with time to aseptic loosening after total joint arthroplasty","volume":"35","author":"Koks","year":"2020","journal-title":"J arthroplasty."},{"key":"B35","doi-asserted-by":"publisher","first-page":"53","DOI":"10.5371\/hp.2021.33.2.53","article-title":"Factors affecting periprosthetic bone loss after hip arthroplasty","volume":"33","author":"Lee","year":"2021","journal-title":"Hip pelvis."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.20.00788","article-title":"Risk factors for aseptic loosening after total knee arthroplasty with a rotating-hinge implant: A case-control study","volume":"103","author":"Levent","year":"2021","journal-title":"J Bone Joint Surg Am volume."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/jor.24474","article-title":"Association of NLRP3 and CARD8 inflammasome polymorphisms with aseptic loosening after primary total hip arthroplasty","volume":"38","author":"Mav\u010di\u010d","year":"2020","journal-title":"J orthopaedic research: Off Publ Orthopaedic Res Soc"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2019.03.018","article-title":"Aseptic loosening after THA and TKA - do gender, tobacco use and BMI have an impact on implant survival time","volume":"16","author":"Schiffner","year":"2019","journal-title":"J orthopaedics"},{"key":"B39","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.arth.2021.10.015","article-title":"Total knee arthroplasty in hemophilia: Survivorship and outcomes-a systematic review and meta-analysis","volume":"37","author":"Fenelon","year":"2022","journal-title":"J arthroplasty."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2019.07.011","article-title":"Rheumatoid arthritis disease activity and the risk of aseptic arthroplasty loosening","volume":"50","author":"B\u00f6hler","year":"2020","journal-title":"Semin Arthritis rheumatism."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081259","article-title":"Cytokine profile in patients with aseptic loosening of total hip replacements and its relation to metal release and metal allergy","volume":"8","author":"Christiansen","year":"2019","journal-title":"J Clin Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1002\/jbm.a.32674","article-title":"Profile of toll-like receptor-positive cells in septic and aseptic loosening of total hip arthroplasty implants","volume":"94","author":"Pajarinen","year":"2010","journal-title":"J BioMed Mater Res A."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35581","article-title":"Lipoteichoic acid modulates inflammatory response in macrophages after phagocytosis of titanium particles through toll-like receptor 2 cascade and inflammasomes","volume":"104","author":"Naganuma","year":"2016","journal-title":"J BioMed Mater Res A."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000224050.94248.38","article-title":"Lipopolysaccharide found in aseptic loosening of patients with inflammatory arthritis","volume":"451","author":"Nalepka","year":"2006","journal-title":"Clin orthopaedics related Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23292","article-title":"Emperor's new clothes: Is particle disease really infected particle disease","volume":"34","author":"Wasko","year":"2016","journal-title":"J orthopaedic research: Off Publ Orthopaedic Res Soc"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02963","article-title":"Mechanism and prevention of titanium particle-induced inflammation and osteolysis","volume":"9","author":"Eger","year":"2018","journal-title":"Front Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1146\/annurev-physiol-022516-034356","article-title":"Mechanisms of organ injury and repair by macrophages","volume":"79","author":"Vannella","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255354","article-title":"Macrophages: Master regulators of inflammation and fibrosis","volume":"30","author":"Wynn","year":"2010","journal-title":"Semin liver disease."},{"key":"B49","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair","volume":"115","author":"Duffield","year":"2005","journal-title":"J Clin Invest"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121999","article-title":"IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1","volume":"210","author":"Jenkins","year":"2013","journal-title":"J Exp Med"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204351","article-title":"Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation","volume":"332","author":"Jenkins","year":"2011","journal-title":"Sci (New York NY)."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35076","article-title":"Mixed material wear particle isolation from periprosthetic tissue surrounding total joint replacements","volume":"110","author":"Stratton-Powell","year":"2022","journal-title":"J Biomed materials Res Part B Appl biomaterials"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1515549","article-title":"NF-\u03baB\/let-7f-5p\/IL-10 pathway involves in wear particle-induced osteolysis by inducing M1 macrophage polarization","volume":"17","author":"Gao","year":"2018","journal-title":"Cell Cycle (Georgetown Tex)."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.03.042","article-title":"Revision joint replacement, wear particles, and macrophage polarization","volume":"8","author":"Rao","year":"2012","journal-title":"Acta biomaterialia."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.10.041","article-title":"Orthopaedic implant materials drive M1 macrophage polarization in a spleen tyrosine kinase- and mitogen-activated protein kinase-dependent manner","volume":"65","author":"Mahon","year":"2018","journal-title":"Acta biomaterialia."},{"key":"B57","doi-asserted-by":"publisher","first-page":"10","DOI":"10.12659\/MSM.914197","article-title":"Protection effect of curcumin for macrophage-involved polyethylene Wear particle-induced inflammatory osteolysis by increasing the cholesterol efflux","volume":"25","author":"Liu","year":"2019","journal-title":"Med Sci monitor: Int Med J Exp Clin Res"},{"key":"B58","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s10020-018-0013-x","article-title":"Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype","volume":"24","author":"Yan","year":"2018","journal-title":"Mol Med (Cambridge Mass)."},{"key":"B59","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1146\/annurev-micro-091213-112949","article-title":"Lipoteichoic acid synthesis and function in gram-positive bacteria","volume":"68","author":"Percy","year":"2014","journal-title":"Annu Rev Microbiol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"152128","DOI":"10.1016\/j.imbio.2021.152128","article-title":"Bacterial lipoproteins in sepsis","volume":"226","author":"Venkataranganayaka Abhilasha","year":"2021","journal-title":"Immunobiology"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.02.015","article-title":"Gamma-irradiated resveratrol negatively regulates LPS-induced MAPK and NF-\u03baB signaling through TLR4 in macrophages","volume":"25","author":"Byun","year":"2015","journal-title":"Int immunopharmacol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072404","article-title":"GATA-2 transduces LPS-induced il-1\u03b2 gene expression in macrophages via a toll-like receptor 4\/MD88\/MAPK-dependent mechanism","volume":"8","author":"Wu","year":"2013","journal-title":"PloS One"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.02.003","article-title":"4-methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to toll-like receptor of macrophages and M1 macrophage polarization","volume":"45","author":"Jang","year":"2017","journal-title":"Int immunopharmacol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000073345.50837.84","article-title":"Detection of biomaterial-associated infections in orthopaedic joint implants","author":"Neut","year":"2003","journal-title":"Clin orthopaedics related Res"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1086\/653003","article-title":"Oral cavity staphylococci are a potential source of prosthetic joint infection","volume":"50","author":"Friedlander","year":"2010","journal-title":"Clin Infect diseases: an Off Publ Infect Dis Soc America"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-014-3786-4","article-title":"Do genetic susceptibility, toll-like receptors, and pathogen-associated molecular patterns modulate the effects of wear","volume":"472","author":"Greenfield","year":"2014","journal-title":"Clin orthopaedics related Res"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.910039","article-title":"Endotoxin contributes to artificial loosening of prostheses induced by titanium particles","volume":"24","author":"Wang","year":"2018","journal-title":"Med Sci monitor: Int Med J Exp Clin Res"},{"key":"B68","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1600-065X.2010.00989.x","article-title":"Innate immunity to intracellular pathogens: Macrophage receptors and responses to microbial entry","volume":"240","author":"Pl\u00fcddemann","year":"2011","journal-title":"Immunol Rev"},{"key":"B69","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nrd3810","article-title":"Targeting the TGF\u03b2 signalling pathway in disease","volume":"11","author":"Akhurst","year":"2012","journal-title":"Nat Rev Drug discovery."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1550057","article-title":"Resolution of liver fibrosis: basic mechanisms and clinical relevance","volume":"35","author":"Ramachandran","year":"2015","journal-title":"Semin liver disease."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.03.012","article-title":"Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis","volume":"40","author":"Zigmond","year":"2014","journal-title":"Immunity"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.03.011","article-title":"Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function","volume":"40","author":"Shouval","year":"2014","journal-title":"Immunity"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202002054","article-title":"Engineering macrophages for cancer immunotherapy and drug delivery","volume":"32","author":"Xia","year":"2020","journal-title":"Advanced materials (Deerfield Beach Fla)."},{"key":"B74","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41419-021-04486-x","article-title":"Targeting prooxidant MnSOD effect inhibits triple-negative breast cancer (TNBC) progression and M2 macrophage functions under the oncogenic stress","volume":"13","author":"Al Haq","year":"2022","journal-title":"Cell Death Dis"},{"key":"B75","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s13075-022-02938-z","article-title":"Macrophage polarization toward M1 phenotype through NF-\u03baB signaling in patients with beh\u00e7et's disease","volume":"24","author":"Wu","year":"2022","journal-title":"Arthritis Res Ther"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1MR0114-021R","article-title":"Phagosome maturation in polarized macrophages","volume":"96","author":"Canton","year":"2014","journal-title":"J leukocyte Biol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1038\/s41598-018-38127-9","article-title":"In-depth characterization of monocyte-derived macrophages using a mass cytometry-based phagocytosis assay","volume":"9","author":"Schulz","year":"2019","journal-title":"Sci Rep"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0012OC","article-title":"Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages","volume":"53","author":"Tarique","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X19666210407150632","article-title":"Autophagy & phagocytosis in neurological disorders and their possible cross-talk","volume":"19","author":"Li","year":"2021","journal-title":"Curr neuropharmacol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(01)00307-7","article-title":"Scavenger receptors in innate immunity","volume":"14","author":"Peiser","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.026","article-title":"Phagocytosis: An immunobiologic process","volume":"44","author":"Gordon","year":"2016","journal-title":"Immunity"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12453","article-title":"Clearance of apoptotic neutrophils and resolution of inflammation","volume":"273","author":"Greenlee-Wacker","year":"2016","journal-title":"Immunol Rev"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1556946","article-title":"TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia","volume":"15","author":"Lee","year":"2019","journal-title":"Autophagy"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16463","article-title":"Autophagy promotes phagocytosis and clearance of treponema pallidum via the NLRP3 inflammasome in macrophages","volume":"34","author":"Xu","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2017.08.012","article-title":"LC3-associated phagocytosis and inflammation","volume":"429","author":"Heckmann","year":"2017","journal-title":"J Mol Biol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.222984","article-title":"LC3-associated phagocytosis at a glance","volume":"132","author":"Heckmann","year":"2019","journal-title":"J Cell Sci"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.026","article-title":"Autophagy regulates phagocytosis by modulating the expression of scavenger receptors","volume":"39","author":"Bonilla","year":"2013","journal-title":"Immunity"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1569298","article-title":"Vitamin d improves sunburns by increasing autophagy in M2 macrophages","volume":"15","author":"Das","year":"2019","journal-title":"Autophagy"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00567-7","article-title":"USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy","volume":"18","author":"Liu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.4161\/auto.23546","article-title":"Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation","volume":"9","author":"Chang","year":"2013","journal-title":"Autophagy"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11137","article-title":"Cell death: A review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D'Arcy","year":"2019","journal-title":"Cell Biol Int"},{"key":"B92","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: A review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol pathol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-020-01615-3","article-title":"The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation","volume":"25","author":"Maimon","year":"2020","journal-title":"Apoptosis: an Int J programmed Cell Death"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200662","article-title":"Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction","volume":"189","author":"Zizzo","year":"2012","journal-title":"J Immunol (Baltimore Md: 1950)."},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.09.020","article-title":"Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells","volume":"1853","author":"Nadella","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(98)00214-2","article-title":"Induction of macrophage apoptosis by ceramic and polyethylene particles in vitro","volume":"20","author":"Catelas","year":"1999","journal-title":"Biomaterials"},{"key":"B97","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.intimp.2019.04.027","article-title":"Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects","volume":"72","author":"Wang","year":"2019","journal-title":"Int immunopharmacol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.42","article-title":"ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation","volume":"8","author":"Schumacher","year":"2017","journal-title":"Cell Death Dis"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.08.031","article-title":"Adiponectin attenuates osteolysis in aseptic loosening of total hip replacements","volume":"10","author":"Landgraeber","year":"2014","journal-title":"Acta biomaterialia."},{"key":"B100","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.intimp.2013.03.013","article-title":"Cucurbitacin IIa induces caspase-3-dependent apoptosis and enhances autophagy in lipopolysaccharide-stimulated RAW 264.7 macrophages","volume":"16","author":"He","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311266","article-title":"Transcription factor Zhx2 deficiency reduces atherosclerosis and promotes macrophage apoptosis in mice","volume":"38","author":"Erbilgin","year":"2018","journal-title":"Arteriosclerosis thrombosis Vasc Biol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12964-017-0214-x","article-title":"Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis","volume":"16","author":"Pagie","year":"2018","journal-title":"Cell communication Signaling"},{"key":"B103","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41418-018-0212-6","article-title":"Pyroptosis versus necroptosis: Similarities, differences, and crosstalk","volume":"26","author":"Frank","year":"2019","journal-title":"Cell Death differentiation."},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: Gasdermin-mediated programmed necrotic cell death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem Sci"},{"key":"B105","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12876-022-02146-8","article-title":"Excess fatty acids induce pancreatic acinar cell pyroptosis through macrophage M1 polarization","volume":"22","author":"Xia","year":"2022","journal-title":"BMC Gastroenterol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1186\/s13054-021-03775-3","article-title":"Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury","volume":"25","author":"Jiao","year":"2021","journal-title":"Crit Care (London England)."},{"key":"B107","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/s41420-022-00894-w","article-title":"Myoglobin promotes macrophage polarization to M1 type and pyroptosis via the RIG-I\/Caspase1\/GSDMD signaling pathway in CS-AKI","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death discovery."},{"key":"B108","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/s41420-021-00756-x","article-title":"The METTL3\/MALAT1\/PTBP1\/USP8\/TAK1 axis promotes pyroptosis and M1 polarization of macrophages and contributes to liver fibrosis","volume":"7","author":"Shu","year":"2021","journal-title":"Cell Death discovery."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c12440","article-title":"Dual-targeted nanodiscs revealing the cross-talk between osteogenic differentiation of mesenchymal stem cells and macrophages","volume":"17","author":"Chen","year":"2023","journal-title":"ACS nano"},{"key":"B110","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s40779-022-00404-0","article-title":"Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles","volume":"9","author":"Wu","year":"2022","journal-title":"Military Med Res"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062851","article-title":"Regulation of osteoblast differentiation by cytokine networks","volume":"22","author":"Amarasekara","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1122","article-title":"Genetic regulation of osteoclast development and function","volume":"4","author":"Teitelbaum","year":"2003","journal-title":"Nat Rev Genet"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2017.0225","article-title":"Current understanding of RANK signaling in osteoclast differentiation and maturation","volume":"40","author":"Park","year":"2017","journal-title":"Molecules Cells"},{"key":"B115","doi-asserted-by":"publisher","first-page":"4913534","DOI":"10.1155\/2022\/4913534","article-title":"Network pharmacology deciphers the action of bioactive polypeptide in attenuating inflammatory osteolysis via the suppression of oxidative stress and restoration of bone remodeling balance","volume":"2022","author":"Cui","year":"2022","journal-title":"Oxid Med Cell longevity."},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-031521-040919","article-title":"Osteoclasts, master sculptors of bone","volume":"24","author":"Veis","year":"2022","journal-title":"Annu Rev Pathol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00264-13","article-title":"Macrophage M1\/M2 polarization dynamically adapts to changes in cytokine microenvironments in cryptococcus neoformans infection","volume":"4","author":"Davis","year":"2013","journal-title":"mBio"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.666449","article-title":"Huang-Lian-Jie-Du decoction attenuates atherosclerosis and increases plaque stability in high-fat diet-induced ApoE(-\/-) mice by inhibiting M1 macrophage polarization and promoting M2 macrophage polarization","volume":"12","author":"Cai","year":"2021","journal-title":"Front Physiol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.01.006","article-title":"Transcriptome-based network analysis reveals a spectrum model of human macrophage activation","volume":"40","author":"Xue","year":"2014","journal-title":"Immunity"},{"key":"B120","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: Nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"B121","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2172-14-6","article-title":"Characterization of murine macrophages from bone marrow, spleen and peritoneum","volume":"14","author":"Wang","year":"2013","journal-title":"BMC Immunol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.10.003","article-title":"Molecular and epigenetic basis of macrophage polarized activation","volume":"27","author":"Porta","year":"2015","journal-title":"Semin Immunol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular mechanisms that influence the macrophage m1-m2 polarization balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front Immunol"},{"key":"B124","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3892\/ijmm.2019.4402","article-title":"HMGB1 participates in LPS\u2212induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE\/NF\u2212\u03baB signaling pathways","volume":"45","author":"Wang","year":"2020","journal-title":"Int J Mol Med"},{"key":"B125","doi-asserted-by":"publisher","first-page":"16014","DOI":"10.1038\/boneres.2016.14","article-title":"A review of UHMWPE wear-induced osteolysis: The role for early detection of the immune response","volume":"4","author":"Kandahari","year":"2016","journal-title":"Bone Res"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10163489","article-title":"The expression levels of toll-like receptors after metallic particle and ion exposition in the synovium of a murine model","volume":"10","author":"Cheng","year":"2021","journal-title":"J Clin Med"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2018.2533","article-title":"Small heterodimer partner negatively regulates TLR4 signaling pathway of titanium particles-induced osteolysis in mice","volume":"14","author":"Zhang","year":"2018","journal-title":"J Biomed nanotechnol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"104146","DOI":"10.1016\/j.cellimm.2020.104146","article-title":"THP-1 cells increase TNF-\u03b1 production upon LPS + soluble human IgG co-stimulation supporting evidence for TLR4 and fc\u03b3 receptors crosstalk","volume":"355","author":"Vargas-Hern\u00e1ndez","year":"2020","journal-title":"Cell Immunol"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-00942-y","article-title":"Lipoxin A4 regulates M1\/M2 macrophage polarization via FPR2-IRF pathway","volume":"30","author":"Yuan","year":"2022","journal-title":"Inflammopharmacology"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14494","article-title":"Age-dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages","volume":"23","author":"Yamada","year":"2019","journal-title":"J Cell Mol Med"},{"key":"B131","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.4110\/in.2018.18.e27","article-title":"Damage-associated molecular patterns in inflammatory diseases","volume":"18","author":"Roh","year":"2018","journal-title":"Immune network."},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.3390\/cells11091438","article-title":"Fas\/CD95 signaling pathway in damage-associated molecular pattern (DAMP)-sensing receptors","volume":"11","author":"Galli","year":"2022","journal-title":"Cells"},{"key":"B133","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1146\/annurev-pathmechdis-012419-032847","article-title":"DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation","volume":"15","author":"Zindel","year":"2020","journal-title":"Annu Rev pathol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160141","article-title":"Cobalt alloy implant debris induces inflammation and bone loss primarily through danger signaling, not TLR4 activation: Implications for DAMP-ening implant related inflammation","volume":"11","author":"Samelko","year":"2016","journal-title":"PloS One"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"B136","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature08512","article-title":"HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses","volume":"462","author":"Yanai","year":"2009","journal-title":"Nature"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00484.2014","article-title":"HMGB1 exacerbates renal tubulointerstitial fibrosis through facilitating M1 macrophage phenotype at the early stage of obstructive injury","volume":"308","author":"Tian","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.01.013","article-title":"HMGB1 silencing in macrophages prevented their functional skewing and ameliorated EAM development: Nuclear HMGB1 may be a checkpoint molecule of macrophage reprogramming","volume":"56","author":"Jiang","year":"2018","journal-title":"Int immunopharmacol"},{"key":"B139","doi-asserted-by":"publisher","first-page":"13582","DOI":"10.1038\/s41598-020-70137-4","article-title":"Hepatocellular carcinoma-derived high mobility group box 1 triggers M2 macrophage polarization via a TLR2\/NOX2\/autophagy axis","volume":"10","author":"Shiau","year":"2020","journal-title":"Sci Rep"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.04.053","article-title":"HMGB1 in macrophage nucleus protects against pressure overload induced cardiac remodeling via regulation of macrophage differentiation and inflammatory response","volume":"611","author":"Yang","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3390\/biom12060779","article-title":"Transcriptomic profiling reveals that HMGB1 induces macrophage polarization different from classical M1","volume":"12","author":"Qu","year":"2022","journal-title":"Biomolecules"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-012-0506-y","article-title":"Modulation of heat shock proteins during macrophage differentiation","volume":"61","author":"Fagone","year":"2012","journal-title":"Inflammation research: Off J Eur Histamine Res Soc [et al]."},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.8292","article-title":"Strontium ranelate reduces the progression of titanium particle-induced osteolysis by increasing the ratio of osteoprotegerin to receptor activator of nuclear factor-\u03baB ligand in vivo","volume":"17","author":"Geng","year":"2018","journal-title":"Mol Med Rep"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1039\/D1BM00563D","article-title":"Irisin recouples osteogenesis and osteoclastogenesis to protect wear-particle-induced osteolysis by suppressing oxidative stress and RANKL production","volume":"9","author":"Hu","year":"2021","journal-title":"Biomaterials science."},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.07.115","article-title":"Cepharanthine ameliorates titanium particle-induced osteolysis by inhibiting osteoclastogenesis and modulating OPG\/RANKL ratio in a murine model","volume":"517","author":"Liao","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00718H","article-title":"Punicalagin ameliorates wear-particle-induced inflammatory bone destruction by bi-directional regulation of osteoblastic formation and osteoclastic resorption","volume":"8","author":"Wang","year":"2020","journal-title":"Biomaterials science."},{"key":"B147","doi-asserted-by":"publisher","first-page":"555","DOI":"10.3109\/08820139.2013.822766","article-title":"The role of cytokines in inflammatory bone loss","volume":"42","author":"Souza","year":"2013","journal-title":"Immunol investigations."},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.8698","article-title":"TNF\u2212\u03b1 and RANKL promote osteoclastogenesis by upregulating RANK via the NF\u2212\u03baB pathway","volume":"17","author":"Luo","year":"2018","journal-title":"Mol Med Rep"},{"key":"B149","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12865-021-00409-9","article-title":"Lipopolysaccharide- TLR-4 axis regulates osteoclastogenesis independent of RANKL\/RANK signaling","volume":"22","author":"AlQranei","year":"2021","journal-title":"BMC Immunol"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.657687","article-title":"Harmine alleviates titanium particle-induced inflammatory bone destruction by immunomodulatory effect on the macrophage polarization and subsequent osteogenic differentiation","volume":"12","author":"Wang","year":"2021","journal-title":"Front Immunol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"105865","DOI":"10.1016\/j.intimp.2019.105865","article-title":"Crocin inhibits titanium particle-induced inflammation and promotes osteogenesis by regulating macrophage polarization","volume":"76","author":"Zhu","year":"2019","journal-title":"Int immunopharmacol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36504","article-title":"NF\u03baB sensing IL-4 secreting mesenchymal stem cells mitigate the proinflammatory response of macrophages exposed to polyethylene wear particles","volume":"106","author":"Lin","year":"2018","journal-title":"J BioMed Mater Res A."},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7837-3_12","article-title":"Polarizing macrophages in vitro","volume":"1784","author":"Huang","year":"2018","journal-title":"Methods Mol Biol (Clifton NJ)"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.06.001","article-title":"Monocyte and macrophage plasticity in tissue repair and regeneration","volume":"185","author":"Das","year":"2015","journal-title":"Am J pathol"},{"key":"B156","doi-asserted-by":"publisher","first-page":"100138","DOI":"10.1016\/j.xjidi.2022.100138","article-title":"Restoring Prohealing\/Remodeling-Associated M2a\/c Macrophages Using ON101 Accelerates Diabetic Wound Healing","volume":"2","author":"Lin","year":"2020","journal-title":"JID Innov"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.07.085","article-title":"M2b macrophages reduce early reperfusion injury after myocardial ischemia in mice: A predominant role of inhibiting apoptosis via A20","volume":"245","author":"Yue","year":"2017","journal-title":"Int J Cardiol"},{"key":"B158","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s13075-017-1447-1","article-title":"TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1\/M2 phenotype","volume":"19","author":"Quero","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"B159","doi-asserted-by":"publisher","first-page":"174715","DOI":"10.1016\/j.ejphar.2021.174715","article-title":"Dapagliflozin exerts anti-inflammatory effects via inhibition of LPS-induced TLR-4 overexpression and NF-\u03baB activation in human endothelial cells and differentiated macrophages","volume":"918","author":"Abdollahi","year":"2022","journal-title":"Eur J Pharmacol"},{"key":"B160","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0092-8674(02)00827-9","article-title":"IRAK-m is a negative regulator of toll-like receptor signaling","volume":"110","author":"Kobayashi","year":"2002","journal-title":"Cell"},{"key":"B161","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12866-017-1095-2","article-title":"IRAK-m alters the polarity of macrophages to facilitate the survival of mycobacterium tuberculosis","volume":"17","author":"Shen","year":"2017","journal-title":"BMC Microbiol"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34375","article-title":"Wear Particles promote endotoxin tolerance in macrophages by inducing interleukin-1 receptor-associated kinase-m expression","volume":"101","author":"Zhang","year":"2013","journal-title":"J BioMed Mater Res A."},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190418","article-title":"Biology and therapeutic potential of interleukin-10","volume":"217","author":"Saraiva","year":"2020","journal-title":"J Exp Med"},{"key":"B164","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ajpath.2015.09.006","article-title":"Macrophage polarization in IL-10 treatment of particle-induced inflammation and osteolysis","volume":"186","author":"Jiang","year":"2016","journal-title":"Am J pathol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/jbm.a.10279","article-title":"Modulation of bone ingrowth and tissue differentiation by local infusion of interleukin-10 in the presence of ultra-high molecular weight polyethylene (UHMWPE) wear particles","volume":"65","author":"Goodman","year":"2003","journal-title":"J BioMed Mater Res A."},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2013.39","article-title":"Macrophage polarization in response to wear particles in vitro","volume":"10","author":"Antonios","year":"2013","journal-title":"Cell Mol Immunol"},{"key":"B167","first-page":"65","article-title":"The macrophage polarization regulates MSC osteoblast differentiation in vitro","volume":"46","author":"Gong","year":"2016","journal-title":"Ann Clin Lab Sci"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2598-8","article-title":"Macrophage type modulates osteogenic differentiation of adipose tissue MSCs","volume":"369","author":"Zhang","year":"2017","journal-title":"Cell Tissue Res"},{"key":"B169","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1186\/s13287-018-1039-2","article-title":"Preconditioning of bone marrow-derived mesenchymal stem cells highly strengthens their potential to promote IL-6-dependent M2b polarization","volume":"9","author":"Philipp","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202462","article-title":"PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase a-SIK-CRTC3 pathway","volume":"190","author":"MacKenzie","year":"2013","journal-title":"J Immunol (Baltimore Md: 1950)."},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23084104","article-title":"The secretome of preconditioned mesenchymal stem cells drives polarization and reprogramming of M2a macrophages toward an IL-10-Producing phenotype","volume":"23","author":"Holthaus","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B172","doi-asserted-by":"publisher","first-page":"816460","DOI":"10.1155\/2015\/816460","article-title":"Understanding the mysterious M2 macrophage through activation markers and effector mechanisms","volume":"2015","author":"R\u0151szer","year":"2015","journal-title":"Mediators inflammation."},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b05719","article-title":"Attenuation of atherosclerosis by protocatechuic acid via inhibition of M1 and promotion of M2 macrophage polarization","volume":"67","author":"Liu","year":"2019","journal-title":"J Agric Food Chem"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00599","article-title":"Deacylcynaropicrin inhibits RANKL-induced osteoclastogenesis by inhibiting NF-\u03baB and MAPK and promoting M2 polarization of macrophages","volume":"10","author":"Li","year":"2019","journal-title":"Front Pharmacol"},{"key":"B175","article-title":"Metformin induces the M2 macrophage polarization to accelerate the wound healing via regulating AMPK\/mTOR\/NLRP3 inflammasome singling pathway","volume":"11","author":"Qing","year":"2019","journal-title":"Am J Trans Res"},{"key":"B176","doi-asserted-by":"publisher","first-page":"119422","DOI":"10.1016\/j.lfs.2021.119422","article-title":"Minocycline alleviates peripheral nerve adhesion by promoting regulatory macrophage polarization via the TAK1 and its downstream pathway","volume":"276","author":"Li","year":"2021","journal-title":"Life Sci"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15376","article-title":"MiR-106b inhibition suppresses inflammatory bone destruction of wear debris-induced periprosthetic osteolysis in rats","volume":"24","author":"Yu","year":"2020","journal-title":"J Cell Mol Med"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01744","article-title":"Notch signaling modulates macrophage polarization and phagocytosis through direct suppression of signal regulatory protein \u03b1 expression","volume":"9","author":"Lin","year":"2018","journal-title":"Front Immunol"},{"key":"B179","doi-asserted-by":"publisher","first-page":"3182368","DOI":"10.1155\/2022\/3182368","article-title":"Cyclic polypeptide D7 protects bone marrow mesenchymal cells and promotes chondrogenesis during osteonecrosis of the femoral head via growth differentiation factor 15-mediated redox signaling","volume":"2022","author":"Chen","year":"2022","journal-title":"Oxid Med Cell longevity."},{"key":"B180","doi-asserted-by":"publisher","first-page":"22469","DOI":"10.1038\/s41598-021-01866-3","article-title":"S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R\/STAT3 signaling","volume":"11","author":"Miki","year":"2021","journal-title":"Sci Rep"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12162","article-title":"An optimized protocol for human M2 macrophages using m-CSF and IL-4\/IL-10\/TGF-\u03b2 yields a dominant immunosuppressive phenotype","volume":"79","author":"Mia","year":"2014","journal-title":"Scand J Immunol"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: Guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.12.005","article-title":"What the myddosome structure tells us about the initiation of innate immunity","volume":"32","author":"Gay","year":"2011","journal-title":"Trends Immunol"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.01.033","article-title":"Isotrifoliol inhibits pro-inflammatory mediators by suppression of TLR\/NF-\u03baB and TLR\/MAPK signaling in LPS-induced RAW264.7 cells","volume":"45","author":"Li","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23115889","article-title":"Anti-inflammatory mechanism of an alkaloid rutaecarpine in LTA-stimulated RAW 264.7 cells: Pivotal role on NF-\u03baB and ERK\/p38 signaling molecules","volume":"23","author":"Jayakumar","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00276","article-title":"NLRP3 inflammasome and inflammatory bowel disease","volume":"10","author":"Zhen","year":"2019","journal-title":"Front Immunol"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.016","article-title":"K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter","volume":"38","author":"Mu\u00f1oz-Planillo","year":"2013","journal-title":"Immunity"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500509","article-title":"Multiple cathepsins promote pro-IL-1\u03b2 synthesis and NLRP3-mediated IL-1\u03b2 activation","volume":"195","author":"Orlowski","year":"2015","journal-title":"J Immunol (Baltimore Md 1950)."},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: An overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B190","article-title":"Luteolin alleviates NLRP3 inflammasome activation and directs macrophage polarization in lipopolysaccharide-stimulated RAW264.7 cells","volume":"10","author":"Zhang","year":"2018","journal-title":"Am J Trans Res"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13258","article-title":"NLRP3 inflammasome mediates M1 macrophage polarization and IL-1\u03b2 production in inflammatory root resorption","volume":"47","author":"Zhang","year":"2020","journal-title":"J Clin periodontol"},{"key":"B192","doi-asserted-by":"publisher","first-page":"7360","DOI":"10.1038\/ncomms8360","article-title":"Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury","volume":"6","author":"Ito","year":"2015","journal-title":"Nat Commun"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.02.007","article-title":"LncRNA Neat1 promotes the macrophage inflammatory response and acts as a therapeutic target in titanium particle-induced osteolysis","volume":"142","author":"Lin","year":"2022","journal-title":"Acta biomaterialia."},{"key":"B194","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1002\/jbm.a.37088","article-title":"miR-34a carried by adipocyte exosomes inhibits the polarization of M1 macrophages in mouse osteolysis model","volume":"109","author":"Gao","year":"2021","journal-title":"J BioMed Mater Res A."},{"key":"B195","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nri2765","article-title":"The SYK tyrosine kinase: a crucial player in diverse biological functions","volume":"10","author":"M\u00f3csai","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14893","article-title":"Chondroprotective and anti-inflammatory effects of amurensin h by regulating TLR4\/Syk\/NF-\u03baB signals","volume":"24","author":"Ma","year":"2020","journal-title":"J Cell Mol Med"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0430-4","article-title":"Helicobacter pylori LPS-induced gastric mucosal spleen tyrosine kinase (Syk) recruitment to TLR4 and activation occurs with the involvement of protein kinase c\u03b4","volume":"26","author":"Slomiany","year":"2018","journal-title":"Inflammopharmacology"},{"key":"B198","doi-asserted-by":"publisher","first-page":"101857","DOI":"10.1016\/j.jbc.2022.101857","article-title":"The transmembrane adapter SCIMP recruits tyrosine kinase syk to phosphorylate toll-like receptors to mediate selective inflammatory outputs","volume":"298","author":"Liu","year":"2022","journal-title":"J Biol Chem"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb7100030","article-title":"Tyrosine kinase syk associates with toll-like receptor 4 and regulates signaling in human monocytic cells","volume":"85","author":"Chaudhary","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00325","article-title":"Omics and transgenic analyses reveal that salvianolic acid b exhibits its anti-inflammatory effects through inhibiting the mincle-Syk-Related pathway in macrophages","volume":"20","author":"Li","year":"2021","journal-title":"J Proteome Res"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105152108","article-title":"Inflammasome components asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response","volume":"108","author":"Malik","year":"2011","journal-title":"Proc Natl Acad Sci United States America."},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1038\/nature07965","article-title":"Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence","volume":"459","author":"Gross","year":"2009","journal-title":"Nature"},{"key":"B203","doi-asserted-by":"publisher","first-page":"158654","DOI":"10.1016\/j.bbalip.2020.158654","article-title":"Contribution of FP receptors in M1 macrophage polarization via IL-10-regulated nuclear translocation of NF-\u03baB p65","volume":"1865","author":"Maehara","year":"2020","journal-title":"Biochim Biophys Acta Mol Cell Biol lipids."},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.3109\/1547691X.2012.700652","article-title":"Inhibitors of TLR-4, NF-\u03baB, and SAPK\/JNK signaling reduce the toxic effect of lipopolysaccharide on RAW 264.7 cells","volume":"10","author":"Glushkova","year":"2013","journal-title":"J immunotoxicol"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.746391","article-title":"Icariin alleviates Wear particle-induced periprosthetic osteolysis via down-regulation of the estrogen receptor \u03b1-mediated NF-\u03baB signaling pathway in macrophages","volume":"12","author":"Guangtao","year":"2021","journal-title":"Front Pharmacol"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28063","article-title":"Vaccarin prevents titanium particle-induced osteolysis and inhibits RANKL-induced osteoclastogenesis by blocking NF-\u03baB and MAPK signaling pathways","volume":"234","author":"Liu","year":"2019","journal-title":"J Cell Physiol"},{"key":"B207","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13020-021-00555-7","article-title":"\u03b1-mangostin inhibits LPS-induced bone resorption by restricting osteoclastogenesis via NF-\u03baB and MAPK signaling","volume":"17","author":"Zhang","year":"2022","journal-title":"Chin Med"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1159\/000494537","article-title":"Curcumin inhibits polyethylene-induced osteolysis via repressing NF-\u03baB signaling pathway activation","volume":"50","author":"An","year":"2018","journal-title":"Cell Physiol Biochem Int J Exp Cell physiol biochem Pharmacol"},{"key":"B209","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1186\/s12951-022-01498-3","article-title":"Photoluminescent carbon dots (PCDs) from sour apple: A biocompatible nanomaterial for preventing UHMWPE wear-particle induced osteolysis via modulating Chemerin\/ChemR23 and SIRT1 signaling pathway and its bioimaging application","volume":"20","author":"Li","year":"2022","journal-title":"J nanobiotechnol"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103004","article-title":"Roles of mitogen-activated protein kinases in osteoclast biology","volume":"19","author":"Lee","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.807","article-title":"Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation","volume":"81","author":"Kyriakis","year":"2001","journal-title":"Physiol Rev"},{"key":"B212","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12865-020-00355-y","article-title":"Progranulin inhibits LPS-induced macrophage M1 polarization via NF-\u043aB and MAPK pathways","volume":"21","author":"Liu","year":"2020","journal-title":"BMC Immunol"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.01.015","article-title":"Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-\u03baB\/MAPK signaling and protecting chondrocytes","volume":"9","author":"Zhou","year":"2019","journal-title":"Acta Pharm Sin B"},{"key":"B214","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13075-021-02512-z","article-title":"Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-\u03baB pathways","volume":"23","author":"Lu","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-013-2084-3","article-title":"NF-\u03baB and STAT3 signaling pathways collaboratively link inflammation to cancer","volume":"4","author":"Fan","year":"2013","journal-title":"Protein Cell"},{"key":"B217","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal transduction targeted Ther"},{"key":"B218","doi-asserted-by":"publisher","first-page":"106432","DOI":"10.1016\/j.intimp.2020.106432","article-title":"RBM4 regulates M1 macrophages polarization through targeting STAT1-mediated glycolysis","volume":"83","author":"Huangfu","year":"2020","journal-title":"Int immunopharmacol"},{"key":"B219","doi-asserted-by":"publisher","first-page":"12849","DOI":"10.1038\/ncomms12849","article-title":"PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation","volume":"7","author":"Iwata","year":"2016","journal-title":"Nat Commun"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27537","article-title":"Physalin d regulates macrophage M1\/M2 polarization via the STAT1\/6 pathway","volume":"234","author":"Ding","year":"2019","journal-title":"J Cell Physiol"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14885","article-title":"The protective effect of WKYMVm peptide on inflammatory osteolysis through regulating NF-\u03baB and CD9\/gp130\/STAT3 signalling pathway","volume":"24","author":"Hu","year":"2020","journal-title":"J Cell Mol Med"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01256D","article-title":"STAT3\/IL-6 dependent induction of inflammatory response in osteoblast and osteoclast formation in nanoscale wear particle-induced aseptic prosthesis loosening","volume":"9","author":"Deng","year":"2021","journal-title":"Biomaterials science."},{"key":"B223","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-12457-1_1","article-title":"Calcium signaling: From basic to bedside","volume":"1131","author":"Islam","year":"2020","journal-title":"Adv Exp Med Biol"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004226","article-title":"Calcium oscillations","volume":"3","author":"Dupont","year":"2011","journal-title":"Cold Spring Harbor Perspect Biol"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3645","article-title":"Regulator of G protein signaling protein 12 (Rgs12) controls mouse osteoblast differentiation via calcium Channel\/Oscillation and g\u03b1i-ERK signaling","volume":"34","author":"Li","year":"2019","journal-title":"J Bone mineral research: Off J Am Soc Bone Mineral Res"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001103","article-title":"Defective interaction of mutant calreticulin and SOCE in megakaryocytes from patients with myeloproliferative neoplasms","volume":"135","author":"Di Buduo","year":"2020","journal-title":"Blood"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194966","article-title":"Mitochondrial calcium uptake is instrumental to alternative macrophage polarization and phagocytic activity","volume":"20","author":"Tedesco","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B228","doi-asserted-by":"publisher","first-page":"103339","DOI":"10.1016\/j.isci.2021.103339","article-title":"Resolving macrophage polarization through distinct Ca(2+) entry channel that maintains intracellular signaling and mitochondrial bioenergetics","volume":"24","author":"Nascimento Da Conceicao","year":"2021","journal-title":"iScience"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061603","article-title":"A novel peptide oligomer of bacitracin induces M1 macrophage polarization by facilitating Ca(2+) influx","volume":"12","author":"Ji","year":"2020","journal-title":"Nutrients"},{"key":"B230","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.isci.2018.09.014","article-title":"M1 macrophage polarization is dependent on TRPC1-mediated calcium entry","volume":"8","author":"Chauhan","year":"2018","journal-title":"iScience"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.259544","article-title":"Kir2.1 channel regulates macrophage polarization via the Ca2+\/CaMK II\/ERK\/NF-\u03baB signaling pathway","volume":"135","author":"Chen","year":"2022","journal-title":"J Cell Sci"},{"key":"B232","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/s41419-021-03792-8","article-title":"TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca(2+)\/CaMKII\/Nrf2 signaling pathway","volume":"12","author":"Lv","year":"2021","journal-title":"Cell Death Dis"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7229","article-title":"Morin attenuates osteoclast formation and function by suppressing the NF-\u03baB, MAPK and calcium signalling pathways","volume":"35","author":"Shi","year":"2021","journal-title":"Phytother Res"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010180","article-title":"Finely-tuned calcium oscillations in osteoclast differentiation and bone resorption","volume":"22","author":"Okada","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103646","article-title":"The role of Ca(2+)-NFATc1 signaling and its modulation on osteoclastogenesis","volume":"21","author":"Kang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30496","article-title":"Flunarizine inhibits osteoclastogenesis by regulating calcium signaling and promotes osteogenesis","volume":"236","author":"Kim","year":"2021","journal-title":"J Cell Physiol"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3754","article-title":"CTLA4-ig directly inhibits osteoclastogenesis by interfering with intracellular calcium oscillations in bone marrow macrophages","volume":"34","author":"Okada","year":"2019","journal-title":"J Bone mineral research: Off J Am Soc Bone Mineral Res"},{"key":"B238","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s40779-020-00292-2","article-title":"CRISPR\/Cas9 from bench to bedside: what clinicians need to know before application","volume":"7","author":"Li","year":"2020","journal-title":"Military Med Res"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1122057\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T04:33:31Z","timestamp":1678250011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1122057\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":238,"alternative-id":["10.3389\/fimmu.2023.1122057"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1122057","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,8]]},"article-number":"1122057"}}