{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:50:38Z","timestamp":1792788638708,"version":"4.5.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is the leading cause of dementia in the United States. Sporadic or late-onset AD remains incompletely understood, with age as the current greatest risk factor. Inflammation in general and neutrophils, a potent mediator of inflammation, have been shown to exacerbate AD associated dementia. This review explores the latest research on neutrophils in AD mouse models and in human cohort studies and discusses current gaps in research and needs for future studies. AD mouse models have shown neutrophil chemotactic migration towards amyloid beta plaques in the brain. Capillary blood flow stalling decreases blood perfusion to associated brain regions and mouse studies have demonstrated that anti-Ly6G antibodies lead to a decrease in capillary blood flow stalling and memory improvement. Several recent transcriptomic studies of blood and brain tissue from persons with AD have shown an upregulation in neutrophil-related genes, and studies have demonstrated neutrophil involvement in brain capillary adhesion, blood brain barrier breaching, myeloperoxidase release, and the propensity for neutrophil extracellular trap release in AD. Neutrophil-derived inflammation and regulation are a potential potent novel therapeutic target for AD progression. Future studies should further investigate neutrophil functionality in AD. In addition, other aspects of AD that may impact neutrophils including the microbiome and the\n                    <jats:italic>APOE4<\/jats:italic>\n                    allele should be studied.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2023.1123149","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:48:31Z","timestamp":1677804511000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":61,"title":["Neutrophils as a potential therapeutic target in Alzheimer\u2019s disease"],"prefix":"10.3389","volume":"14","author":[{"given":"Michelle L.","family":"Aries","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Hensley-McBain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/alz.12328","article-title":"2021 alzheimer\u2019s disease facts and figures","volume":"17","year":"2021","journal-title":"Alzheimers Dement"},{"key":"B2","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41583-021-00533-w","article-title":"The probabilistic model of Alzheimer disease: the amyloid hypothesis revised","volume":"23","author":"Frisoni","year":"2022","journal-title":"Nat Rev Neurosci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00391-w","article-title":"The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics","volume":"21","author":"Karran","year":"2022","journal-title":"Nat Rev Drug Discov"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.796867","article-title":"The impact of systemic inflammation on alzheimer\u2019s disease pathology","volume":"12","author":"Xie","year":"2022","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in alzheimer\u2019s disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement Transl Res Clin Interv"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv404","article-title":"Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant alzheimer\u2019s disease","volume":"139","author":"Rodriguez-Vieitez","year":"2016","journal-title":"Brain"},{"key":"B7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.nbd.2016.07.007","article-title":"The blood-brain barrier in alzheimer\u2019s disease","volume":"107","author":"Zenaro","year":"2017","journal-title":"Neurobiol Dis"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12295","article-title":"Alzheimer\u2019s disease drug development pipeline: 2022","volume":"8","author":"Cummings","year":"2022","journal-title":"Alzheimers Dement Transl Res Clin Interv"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.01.003","article-title":"Migration of neutrophils targeting amyloid plaques in alzheimer\u2019s disease mouse model","volume":"35","author":"Baik","year":"2014","journal-title":"Neurobiol Aging"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0329-4","article-title":"Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in alzheimer\u2019s disease mouse models","volume":"22","author":"Cruz Hern\u00e1ndez","year":"2019","journal-title":"Nat Neurosci"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3913","article-title":"Neutrophils promote alzheimer\u2019s disease\u2013like pathology and cognitive decline via LFA-1 integrin","volume":"21","author":"Zenaro","year":"2015","journal-title":"Nat Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40478-022-01347-2","article-title":"Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in alzheimer\u2019s disease","volume":"10","author":"Smyth","year":"2022","journal-title":"Acta Neuropathol Commun"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.523798","article-title":"PET imaging of neutrophils infiltration in alzheimer\u2019s disease transgenic mice","volume":"11","author":"Kong","year":"2020","journal-title":"Front Neurol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1186\/1742-2094-8-26","article-title":"Novel alzheimer\u2019s disease risk variants identified based on whole-genome sequencing of APOE \u03f54 carriers","volume":"11","author":"Park","year":"2021","journal-title":"Transl Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S1389-0344(01)00067-3","article-title":"Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of alzheimer\u2019s disease","volume":"8","author":"Grammas","year":"2011","journal-title":"J Neuroinflamma"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/s1389-0344(01)00067-3","article-title":"Co-Expression of multiple transgenes in mouse CNS: a comparison of strategies","volume":"17","author":"Jankowsky","year":"2001","journal-title":"Biomol Eng"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Triple-transgenic model of alzheimer\u2019s disease with plaques and tangles: Intracellular A\u00df and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00088","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial alzheimer\u2019s disease mutations: Potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J Neurosci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00088\/abstract","article-title":"Using mice to model alzheimer\u2019s dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models","volume":"5","author":"Webster","year":"2014","journal-title":"Front Genet"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.it.2011.04.009","article-title":"Toward more predictive genetic mouse models of alzheimer\u2019s disease","volume":"122","author":"Onos","year":"2016","journal-title":"Brain Res Bull"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.03.009","article-title":"Neutrophil clearance: when the party is over, clean-up begins","volume":"32","author":"Bratton","year":"2011","journal-title":"Trends Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.03.009","article-title":"Expanding roles of neutrophils in aging hosts","volume":"29","author":"Tseng","year":"2014","journal-title":"Curr Opin Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41423-021-00832-3","article-title":"The dual role of neutrophils in inflammatory bowel diseases","volume":"5","author":"W\u00e9ra","year":"2016","journal-title":"J Clin Med"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00832-3","article-title":"Neutrophils in chronic inflammatory diseases","volume":"19","author":"Herrero-Cervera","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3389\/fnins.2019.00990","article-title":"A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild alzheimer\u2019s disease","volume":"17","author":"Bawa","year":"2020","journal-title":"J Neuroinflamma"},{"key":"B26","doi-asserted-by":"publisher","first-page":"990","DOI":"10.2202\/1544-6115.1027","article-title":"Myeloperoxidase deficiency inhibits cognitive decline in the 5XFAD mouse model of alzheimer\u2019s disease","volume":"13","author":"Volkman","year":"2019","journal-title":"Front Neurosci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fneur.2020.523798","article-title":"Linear models and empirical bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2022.02.024","article-title":"Analysis methods for the gut microbiome in neuropsychiatric and neurodegenerative disorders","volume":"20","author":"Song","year":"2022","journal-title":"Comput Struct Biotechnol J"},{"key":"B29","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s12916-022-02472-4","article-title":"Cellular transcriptional alterations of peripheral blood in alzheimer\u2019s disease","volume":"20","author":"Song","year":"2022","journal-title":"BMC Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/cbin.10618","article-title":"Basal neutrophil function in human aging: Implications in endothelial cell adhesion","volume":"40","author":"Nogueira-Neto","year":"2016","journal-title":"Cell Biol Int"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-259028","article-title":"In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days","volume":"116","author":"Pillay","year":"2010","journal-title":"Blood"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.52.37329","article-title":"Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase c-\u03b4","volume":"274","author":"Pongracz","year":"1999","journal-title":"J Biol Chem"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"a008656","DOI":"10.1101\/cshperspect.a008656","article-title":"Caspase functions in cell death and disease","volume":"5","author":"McIlwain","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.75","article-title":"Peculiarities of cell death mechanisms in neutrophils","volume":"18","author":"Geering","year":"2011","journal-title":"Cell Death Differ"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007672","article-title":"Increased mucosal neutrophil survival is associated with altered microbiota in HIV infection","volume":"15","author":"Hensley-McBain","year":"2019","journal-title":"PloS Pathog"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/cells2020330","article-title":"Targeting neutrophil apoptosis for enhancing the resolution of inflammation","volume":"2","author":"El Kebir","year":"2013","journal-title":"Cells"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01963","article-title":"Granulocytic myeloid-derived suppressor cells as negative regulators of anticancer immunity","volume":"11","author":"Kramer","year":"2020","journal-title":"Front Immunol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2844-6","article-title":"The potential importance of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of alzheimer\u2019s disease","volume":"75","author":"Salminen","year":"2018","journal-title":"Cell Mol Life Sci"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.5.2731","article-title":"Of mice and not men: Differences between mouse and human immunology","volume":"172","author":"Mestas","year":"2004","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13154","article-title":"Human neutrophils \u2260 murine neutrophils: Does it matter","author":"Nauseef","year":"2022","journal-title":"Immunol Rev"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121077119","article-title":"Human neutrophil development and functionality are enabled in a humanized mouse model","volume":"119","author":"Zheng","year":"2022","journal-title":"Proc Natl Acad Sci"},{"key":"B43","doi-asserted-by":"publisher","first-page":"15071","DOI":"10.1038\/s41598-021-94425-9","article-title":"Ly6G deficiency alters the dynamics of neutrophil recruitment and pathogen capture during leishmania major skin infection","volume":"11","author":"Kleinholz","year":"2021","journal-title":"Sci Rep"},{"key":"B44","doi-asserted-by":"publisher","first-page":"8246","DOI":"10.3390\/ijms23158246","article-title":"Myeloperoxidase as a marker to differentiate mouse Monocyte\/Macrophage subsets","volume":"23","author":"Gurski","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.3390\/cells8121477","article-title":"The brain entangled: The contribution of neutrophil extracellular traps to the diseases of the central nervous system","volume":"8","author":"Manda-Handzlik","year":"2019","journal-title":"Cells"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19873658","article-title":"Increasing cerebral blood flow improves cognition into late stages in alzheimer\u2019s disease mice","volume":"40","author":"Bracko","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/9480398","article-title":"HSPA1A, HSPA2, and HSPA8 are potential molecular biomarkers for prognosis among HSP70 family in alzheimer\u2019s disease","volume":"2022","author":"Dong","year":"2022","journal-title":"Dis Markers"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.913535","article-title":"Comprehensive analysis reveals a 5-gene signature and immune cell infiltration in alzheimer\u2019s disease with qPCR validation","volume":"13","author":"Jin","year":"2022","journal-title":"Front Genet"},{"key":"B49","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12920-022-01245-5","article-title":"Integrative analysis of eQTL and GWAS summary statistics reveals transcriptomic alteration in Alzheimer brains","volume":"15","author":"Varathan","year":"2022","journal-title":"BMC Med Genomic"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.901972","article-title":"Integrated analysis and identification of hub genes as novel biomarkers for alzheimer\u2019s disease","volume":"14","author":"Zhao","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"B51","doi-asserted-by":"publisher","first-page":"glac179","DOI":"10.1093\/gerona\/glac179","article-title":"Identification of five potential predictive biomarkers for alzheimer\u2019s disease by integrating the unified test for molecular signatures and weighted gene co-expression network analysis","author":"Zhou","year":"2022","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.947781","article-title":"Identification of genetic molecular markers and immune infiltration characteristics of alzheimer\u2019s disease through weighted gene co-expression network analysis","volume":"13","author":"Duan","year":"2022","journal-title":"Front Neurol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/ana.25159","article-title":"Neutrophil hyperactivation correlates with alzheimer\u2019s disease progression: Neutrophil hyperactivation in alzheimer\u2019s disease","volume":"83","author":"Dong","year":"2018","journal-title":"Ann Neurol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.630869","article-title":"Neutrophil extracellular traps: A perspective of neuroinflammation and complement activation in alzheimer\u2019s disease","volume":"8","author":"Kretzschmar","year":"2021","journal-title":"Front Mol Biosci"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220642","article-title":"Plasma myeloperoxidase as a potential biomarker of patient response to anti-dementia treatment in alzheimer\u2019s disease","volume":"89","author":"Wright","year":"2022","journal-title":"J Alzheimers Dis"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00346-3","article-title":"Neutrophils CD11b and fibroblasts PGE(2) are elevated in alzheimer\u2019s disease","volume":"23","author":"Scali","year":"2002","journal-title":"Neurobiol Aging"},{"key":"B57","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.dadm.2017.01.005","article-title":"Pathophysiologic relationship between alzheimer\u2019s disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis","volume":"7","author":"Santos","year":"2017","journal-title":"Alzheimers Dement Diagn Assess Dis Monit"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in alzheimer\u2019s disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.2857","article-title":"Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults","volume":"14","author":"Bowman","year":"2018","journal-title":"Alzheimers Dement"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-004-6243-4","article-title":"Oxidative stress level in circulating neutrophils is linked to neurodegenerative diseases","volume":"24","author":"Vitte","year":"2004","journal-title":"J Clin Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3233\/JAD-170124","article-title":"Polymorphonuclear neutrophil functions are differentially altered in amnestic mild cognitive impairment and mild alzheimer\u2019s disease patients","volume":"60","author":"Le Page","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1023\/B:BEBM.0000010950.53560.e2","article-title":"Phagocytic activity and state of bactericidal systems in polymorphonuclear leukocytes from patients with alzheimer\u2019s disease","volume":"136","author":"Davydova","year":"2003","journal-title":"Bull Exp Biol Med"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.2174\/1567205018666210823095044","article-title":"Neutrophil granule proteins inhibit amyloid beta aggregation and neurotoxicity","volume":"18","author":"Kasus-Jacobi","year":"2021","journal-title":"Curr Alzheimer Res"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12072","article-title":"Alzheimer\u2019s disease and granulocyte density diversity","volume":"43","author":"J\u00e4remo","year":"2013","journal-title":"Eur J Clin Invest"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137305","article-title":"Oral TNF\u03b1 modulation alters neutrophil infiltration, improves cognition and diminishes tau and amyloid pathology in the 3xTgAD mouse model","volume":"10","author":"Gabbita","year":"2015","journal-title":"PloS One"},{"key":"B66","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s13195-022-01072-x","article-title":"Immune-mediated diseases are associated with a higher incidence of dementia: a prospective cohort study of 375,894 individuals","volume":"14","author":"Zhang","year":"2022","journal-title":"Alzheimers Res Ther"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.652111","article-title":"Dysregulation of systemic immunity in aging and dementia","volume":"15","author":"Lutshumba","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"B68","article-title":"2022 alzheimer\u2019s disease facts and figures","volume-title":"Alzhimers dementia","year":""},{"key":"B69","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1006\/exnr.1998.6977","article-title":"Myeloperoxidase polymorphism is associated with gender specific risk for alzheimer\u2019s disease","volume":"155","author":"Reynolds","year":"1999","journal-title":"Exp Neurol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-021-00086-8","article-title":"Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex- and age-related functional regulation","volume":"1","author":"Lu","year":"2021","journal-title":"Nat Aging"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01269","article-title":"The confluence of sex hormones and aging on immunity","volume":"9","author":"Gubbels Bupp","year":"2018","journal-title":"Front Immunol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13072","article-title":"APOE\n             -modulated a\u03b2-induced neuroinflammation in alzheimer\u2019s disease: current landscape, novel data, and future perspective","volume":"133","author":"Tai","year":"2015","journal-title":"J Neurochem"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1188-4","article-title":"The gut microbiome alterations and inflammation-driven pathogenesis of alzheimer\u2019s disease\u2013a critical review","volume":"56","author":"Sochocka","year":"2019","journal-title":"Mol Neurobiol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glz262","article-title":"Gut microbiota: From the forgotten organ to a potential key player in the pathology of alzheimer\u2019s disease","volume":"75","author":"Seo","year":"2020","journal-title":"J Gerontol Ser A"},{"key":"B75","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/nu13010037","article-title":"The microbiota\u2013Gut\u2013Brain axis and alzheimer\u2019s disease: Neuroinflammation is to blame","volume":"13","author":"Megur","year":"2020","journal-title":"Nutrients"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.866747","article-title":"Targeting neutrophils for promoting the resolution of inflammation","volume":"13","author":"Filep","year":"2022","journal-title":"Front Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1123149\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:48:34Z","timestamp":1677804514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1123149\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,3]]},"references-count":76,"alternative-id":["10.3389\/fimmu.2023.1123149"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1123149","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,3]]},"article-number":"1123149"}}