{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:24:01Z","timestamp":1790663041135,"version":"4.1.0"},"reference-count":255,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The efficacious detection of pathogens and prompt induction of innate immune signaling serve as a crucial component of immune defense against infectious pathogens. Over the past decade, DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream signaling adaptor stimulator of interferon genes (STING) have emerged as key mediators of type I interferon (IFN) and nuclear factor-\u03baB (NF-\u03baB) responses in health and infection diseases. Moreover, both cGAS-STING pathway and pathogens have developed delicate strategies to resist each other for their survival. The mechanistic and functional comprehension of the interplay between cGAS-STING pathway and pathogens is opening the way for the development and application of pharmacological agonists and antagonists in the treatment of infectious diseases. Here, we briefly review the current knowledge of DNA sensing through the cGAS-STING pathway, and emphatically highlight the potent undertaking of cGAS-STING signaling pathway in the host against infectious pathogenic organisms.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1130423","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T04:45:51Z","timestamp":1675745151000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Function and regulation of cGAS-STING signaling in infectious diseases"],"prefix":"10.3389","volume":"14","author":[{"given":"Yang","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yien","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Fu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.03.040","article-title":"The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling","volume":"54","author":"Cai","year":"2014","journal-title":"Mol Cell"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.812774","article-title":"Toll-like receptor signaling and its role in cell-mediated immunity","volume":"13","author":"Duan","year":"2022","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS-STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00577-0","article-title":"Regulation of the nucleic acid-sensing toll-like receptors","volume":"22","author":"Lind","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1702","article-title":"An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome","volume":"10","author":"Burckstummer","year":"2009","journal-title":"Nat Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nature07710","article-title":"AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA","volume":"458","author":"Fernandes-Alnemri","year":"2009","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nature07725","article-title":"AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC","volume":"458","author":"Hornung","year":"2009","journal-title":"Nature"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1169841","article-title":"HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA","volume":"323","author":"Roberts","year":"2009","journal-title":"Science"},{"key":"B12","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.07.002","article-title":"Mechanisms of gasdermin family members in inflammasome signaling and cell death","volume":"430","author":"Feng","year":"2018","journal-title":"J Mol Biol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.814709","article-title":"The cGAS-STING pathway in bacterial infection and bacterial immunity","volume":"12","author":"Liu","year":"2021","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2343","article-title":"Crosstalk between RNA viruses and DNA sensors: Role of the cGAS-STING signalling pathway","volume":"32","author":"Fan","year":"2022","journal-title":"Rev Med Virol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800933","article-title":"Triggering of the cGAS-STING pathway in human plasmacytoid dendritic cells inhibits TLR9-mediated IFN production","volume":"205","author":"Deb","year":"2020","journal-title":"J Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat8657","article-title":"cGAS in action: Expanding roles in immunity and inflammation","volume":"363","author":"Ablasser","year":"2019","journal-title":"Science"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016394","article-title":"DNA Degradation and its defects","volume":"6","author":"Kawane","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229963","article-title":"Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA","volume":"339","author":"Wu","year":"2013","journal-title":"Science"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp854","article-title":"Comprehensive classification of nucleotidyltransferase fold proteins: Identification of novel families and their representatives in human","volume":"37","author":"Kuchta","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nature12305","article-title":"Structural mechanism of cytosolic DNA sensing by cGAS","volume":"498","author":"Civril","year":"2013","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.046","article-title":"Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase","volume":"153","author":"Gao","year":"2013","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.05.008","article-title":"Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity","volume":"3","author":"Kranzusch","year":"2013","journal-title":"Cell Rep"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nature12306","article-title":"cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING","volume":"498","author":"Ablasser","year":"2013","journal-title":"Nature"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.05.009","article-title":"The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING","volume":"3","author":"Diner","year":"2013","journal-title":"Cell Rep"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.019","article-title":"Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization","volume":"39","author":"Li","year":"2013","journal-title":"Immunity"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat1022","article-title":"DNA-Induced liquid phase condensation of cGAS activates innate immune signaling","volume":"361","author":"Du","year":"2018","journal-title":"Science"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3267","article-title":"Sequence-specific activation of the DNA sensor cGAS by y-form DNA structures as found in primary HIV-1 cDNA","volume":"16","author":"Herzner","year":"2015","journal-title":"Nat Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41586-018-0050-1","article-title":"SAMHD1 acts at stalled replication forks to prevent interferon induction","volume":"557","author":"Coquel","year":"2018","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00950-8","article-title":"Stalled replication fork protection limits cGAS-STING and p-body-dependent innate immune signalling","volume":"24","author":"Emam","year":"2022","journal-title":"Nat Cell Biol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/j.cell.2019.01.016","article-title":"Acetylation blocks cGAS activity and inhibits self-DNA-Induced autoimmunity","volume":"176","author":"Dai","year":"2019","journal-title":"Cell"},{"key":"B34","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.coi.2014.10.005","article-title":"Type I interferonopathies: Mendelian type I interferon up-regulation","volume":"32","author":"Crow","year":"2015","journal-title":"Curr Opin Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jaut.2019.03.001","article-title":"cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model","volume":"100","author":"Xiao","year":"2019","journal-title":"J Autoimmun"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151464","article-title":"RNase H2 catalytic core aicardi-gouti\u00e8res syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice","volume":"213","author":"Pokatayev","year":"2016","journal-title":"J Exp Med"},{"key":"B37","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s13238-021-00869-0","article-title":"Nuclear cGAS: Sequestration and beyond","volume":"13","author":"Bai","year":"2022","journal-title":"Protein Cell"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.47491","article-title":"Tight nuclear tethering of cGAS is essential for preventing autoreactivity","volume":"8","author":"Volkman","year":"2019","journal-title":"Elife"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2749-z","article-title":"The molecular basis of tight nuclear tethering and inactivation of cGAS","volume":"587","author":"Zhao","year":"2020","journal-title":"Nature"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2748-0","article-title":"Structural basis for sequestration and autoinhibition of cGAS by chromatin","volume":"587","author":"Michalski","year":"2020","journal-title":"Nature"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd0237","article-title":"Structural basis for the inhibition of cGAS by nucleosomes","volume":"370","author":"Kujirai","year":"2020","journal-title":"Science"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd0609","article-title":"Structural basis of nucleosome-dependent cGAS inhibition","volume":"370","author":"Boyer","year":"2020","journal-title":"Science"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00422-4","article-title":"Structural basis for nucleosome-mediated inhibition of cGAS activity","volume":"30","author":"Cao","year":"2020","journal-title":"Cell Res"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2750-6","article-title":"Structural mechanism of cGAS inhibition by the nucleosome","volume":"587","author":"Pathare","year":"2020","journal-title":"Nature"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc5386","article-title":"Phosphorylation and chromatin tethering prevent cGAS activation during mitosis","volume":"371","author":"Li","year":"2021","journal-title":"Science"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2331","article-title":"Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system","volume":"19","author":"Shu","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.03.019","article-title":"Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding","volume":"36","author":"Ouyang","year":"2012","journal-title":"Immunity"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2333","article-title":"The structural basis for the sensing and binding of cyclic di-GMP by STING","volume":"19","author":"Huang","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2332","article-title":"Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP","volume":"19","author":"Shang","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-0998-5","article-title":"Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP","volume":"567","author":"Shang","year":"2019","journal-title":"Nature"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911267106","article-title":"Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response","volume":"106","author":"Saitoh","year":"2009","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.07.001","article-title":"STING activation by translocation from the ER is associated with infection and autoinflammatory disease","volume":"18","author":"Dobbs","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1006-9","article-title":"Autophagy induction via STING trafficking is a primordial function of the cGAS pathway","volume":"567","author":"Gui","year":"2019","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0287-8","article-title":"The Ca(2+) sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum","volume":"20","author":"Srikanth","year":"2019","journal-title":"Nat Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0730-5","article-title":"STEEP mediates STING ER exit and activation of signaling","volume":"21","author":"Zhang","year":"2020","journal-title":"Nat Immunol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200600","article-title":"Mutations in COPA lead to abnormal trafficking of STING to the golgi and interferon signaling","volume":"217","author":"Lepelley","year":"2020","journal-title":"J Exp Med"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.888147","article-title":"Post-translational modifications of STING: A potential therapeutic target","volume":"13","author":"Kang","year":"2022","journal-title":"Front Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16137","article-title":"cGAS-STING pathway: Post-translational modifications and functions in sterile inflammatory diseases","volume":"289","author":"Hong","year":"2022","journal-title":"FEBS J"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2022.09.003","article-title":"The cGAS-STING pathway: Post-translational modifications and functional implications in diseases","volume":"68","author":"Liu","year":"2022","journal-title":"Cytokine Growth factor Rev"},{"key":"B61","doi-asserted-by":"publisher","first-page":"11932","DOI":"10.1038\/ncomms11932","article-title":"Activation of STING requires palmitoylation at the golgi","volume":"7","author":"Mukai","year":"2016","journal-title":"Nat Commun"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0287-8","article-title":"Targeting STING with covalent small-molecule inhibitors","volume":"559","author":"Haag","year":"2018","journal-title":"Nature"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1000-2","article-title":"Structural basis of STING binding with and phosphorylation by TBK1","volume":"567","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1228-x","article-title":"A conserved PLPLRT\/SD motif of STING mediates the recruitment and activation of TBK1","volume":"569","author":"Zhao","year":"2019","journal-title":"Nature"},{"key":"B65","doi-asserted-by":"publisher","first-page":"ra20","DOI":"10.1126\/scisignal.2002521","article-title":"STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway","volume":"5","author":"Tanaka","year":"2012","journal-title":"Sci Signaling"},{"key":"B66","doi-asserted-by":"publisher","first-page":"aaa2630","DOI":"10.1126\/science.aaa2630","article-title":"Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347","author":"Liu","year":"2015","journal-title":"Science"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.09.003","article-title":"The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation","volume":"29","author":"Zhong","year":"2008","journal-title":"Immunity"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161674","article-title":"Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes","volume":"214","author":"Cerboni","year":"2017","journal-title":"J Exp Med"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aah7119","article-title":"Ubiquitination of STING at lysine 224 controls IRF3 activation","volume":"2","author":"Ni","year":"2017","journal-title":"Sci Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018100983","article-title":"The herpesviral antagonist m152 reveals differential activation of STING-dependent IRF and NF-kappaB signaling and STING's dual role during MCMV infection","volume":"38","author":"Stempel","year":"2019","journal-title":"EMBO J"},{"key":"B71","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/j.celrep.2019.03.098","article-title":"Modular architecture of the STING c-terminal tail allows interferon and NF-kappaB signaling adaptation","volume":"27","author":"de Oliveira Mann","year":"2019","journal-title":"Cell Rep"},{"key":"B72","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.molcel.2018.07.034","article-title":"Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-kappaB signaling after nuclear DNA damage","volume":"71","author":"Dunphy","year":"2018","journal-title":"Mol Cell"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/nature00937","article-title":"Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria","volume":"418","author":"Schofield","year":"2002","journal-title":"Nature"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.75","article-title":"Synthetic GPI array to study antitoxic malaria response","volume":"4","author":"Kamena","year":"2008","journal-title":"Nat Chem Biol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.pt.2007.09.003","article-title":"TLR-mediated cell signaling by malaria GPIs","volume":"23","author":"Gowda","year":"2007","journal-title":"Trends Parasitol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413541200","article-title":"Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity","volume":"280","author":"Krishnegowda","year":"2005","journal-title":"J Biol Chem"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.1.145","article-title":"Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites","volume":"177","author":"Schofield","year":"1993","journal-title":"J Exp Med"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608745104","article-title":"Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to toll-like receptor 9","volume":"104","author":"Parroche","year":"2007","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006957","article-title":"Synthetic plasmodium-like hemozoin activates the immune response: A morphology - function study","volume":"4","author":"Jaramillo","year":"2009","journal-title":"PloS One"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1371\/annotation\/abca067d-b82b-4de6-93c5-0fcc38e3df05","article-title":"Malarial hemozoin activates the NLRP3 inflammasome through Lyn and syk kinases","volume":"5","author":"Shio","year":"2009","journal-title":"PloS Pathog"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006510","article-title":"Malarial hemozoin is a Nalp3 inflammasome activating danger signal","volume":"4","author":"Dostert","year":"2009","journal-title":"PloS One"},{"key":"B82","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1084\/jem.20041836","article-title":"Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin","volume":"201","author":"Coban","year":"2005","journal-title":"J Exp Med"},{"key":"B83","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.chom.2012.12.003","article-title":"Combined action of nucleic acid-sensing toll-like receptors and TLR11\/TLR12 heterodimers imparts resistance to toxoplasma gondii in mice","volume":"13","author":"Andrade","year":"2013","journal-title":"Cell Host Microbe"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.8.4926","article-title":"Malaria blood stage parasites activate human plasmacytoid dendritic cells and murine dendritic cells through a toll-like receptor 9-dependent pathway","volume":"172","author":"Pichyangkul","year":"2004","journal-title":"J Immunol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903824","article-title":"Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses","volume":"184","author":"Wu","year":"2010","journal-title":"J Immunol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.immuni.2011.05.016","article-title":"Innate immune recognition of an AT-rich stem-loop DNA motif in the plasmodium falciparum genome","volume":"35","author":"Sharma","year":"2011","journal-title":"Immunity"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316467111","article-title":"Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality","volume":"111","author":"Wu","year":"2014","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103701","article-title":"Activation of cGAS-STING by lethal malaria N67C dictates immunity and mortality through induction of CD11b(+) Ly6C(hi) proinflammatory monocytes","volume":"9","author":"Du","year":"2022","journal-title":"Adv Sci (Weinh)"},{"key":"B89","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nm.3424","article-title":"Host-cell sensors for plasmodium activate innate immunity against liver-stage infection","volume":"20","author":"Liehl","year":"2014","journal-title":"Nat Med"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00923-13","article-title":"Toll-like receptor 7 mediates early innate immune responses to malaria","volume":"81","author":"Baccarella","year":"2013","journal-title":"Infect Immun"},{"key":"B91","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/imr.12830","article-title":"Innate immunity to malaria-the role of monocytes","volume":"293","author":"Dobbs","year":"2020","journal-title":"Immunol Rev"},{"key":"B92","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.pt.2012.10.002","article-title":"Monocytes and macrophages in malaria: protection or pathology","volume":"29","author":"Chua","year":"2013","journal-title":"Trends Parasitol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2019.08.002","article-title":"Monocyte-derived dendritic cells in malaria","volume":"52","author":"Hirako","year":"2019","journal-title":"Curr Opin Microbiol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01597","article-title":"The impact of malaria parasites on dendritic cell-T cell interaction","volume":"11","author":"Osii","year":"2020","journal-title":"Front Immunol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052450","article-title":"Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells","volume":"203","author":"Sponaas","year":"2006","journal-title":"J Exp Med"},{"key":"B96","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1146\/annurev.immunol.23.021704.115633","article-title":"IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors","volume":"23","author":"Liu","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/nature01097","article-title":"Genome sequence of the human malaria parasite plasmodium falciparum","volume":"419","author":"Gardner","year":"2002","journal-title":"Nature"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00999-10","article-title":"The n-ethyl-N-nitrosourea-induced goldenticket mouse mutant reveals an essential function of sting in the in vivo interferon response to listeria monocytogenes and cyclic dinucleotides","volume":"79","author":"Sauer","year":"2011","journal-title":"Infect Immun"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.001","article-title":"Cross-regulation of two type I interferon signaling pathways in plasmacytoid dendritic cells controls anti-malaria immunity and host mortality","volume":"45","author":"Yu","year":"2016","journal-title":"Immunity"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701048","article-title":"Cyclic GMP-AMP synthase is the cytosolic sensor of plasmodium falciparum genomic DNA and activates type I IFN in malaria","volume":"200","author":"Gallego-Marin","year":"2018","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B101","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1038\/s41467-017-02083-1","article-title":"Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors","volume":"8","author":"Sisquella","year":"2017","journal-title":"Nat Commun"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.594621","article-title":"Type I interferons and malaria: A double-edge sword against a complex parasitic disease","volume":"10","author":"He","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.3909-3915.2000","article-title":"Low interleukin-12 activity in severe plasmodium falciparum malaria","volume":"68","author":"Luty","year":"2000","journal-title":"Infect Immun"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-012-1175-1","article-title":"Reduced interferon (IFN)-\u03b1 conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality","volume":"131","author":"Kempaiah","year":"2012","journal-title":"Hum Genet"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005975","article-title":"STING-licensed macrophages prime type I IFN production by plasmacytoid dendritic cells in the bone marrow during severe plasmodium yoelii malaria","volume":"12","author":"Spaulding","year":"2016","journal-title":"PloS Pathog"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006492117","article-title":"RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology","volume":"117","author":"He","year":"2020","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94142","article-title":"cGAS-mediated control of blood-stage malaria promotes plasmodium-specific germinal center responses","volume":"3","author":"Hahn","year":"2018","journal-title":"JCI Insight"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.610121","article-title":"Accelerator or brake: Immune regulators in malaria","volume":"10","author":"Cai","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004332117","article-title":"The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation","volume":"117","author":"Wu","year":"2020","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005930","article-title":"Increased CD40 expression enhances early STING-mediated type I interferon response and host survival in a rodent malaria model","volume":"12","author":"Yao","year":"2016","journal-title":"PloS Pathog"},{"key":"B111","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.matbio.2021.01.004","article-title":"TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease","author":"Herhaus","year":"2021","journal-title":"Matrix Biol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.cell.2018.03.015","article-title":"SnapShot: CGAS-STING signaling","volume":"173","author":"Galluzzi","year":"2018","journal-title":"Cell"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02161-16","article-title":"FOSL1 inhibits type I interferon responses to malaria and viral infections by blocking TBK1 and TRAF3\/TRIF interactions","volume":"8","author":"Cai","year":"2017","journal-title":"mBio"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2019.07.001","article-title":"Toxoplasma gondii","volume":"35","author":"Lourido","year":"2019","journal-title":"Trends Parasitol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00518-7","article-title":"Toxoplasma gondii infection and its implications within the central nervous system","volume":"19","author":"Matta","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2020.10.013","article-title":"Toxoplasma effectors that affect pregnancy outcome","volume":"37","author":"Arranz-Sol\u00eds","year":"2021","journal-title":"Trends Parasitol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.009172","article-title":"The GRA15 protein from toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING","volume":"294","author":"Wang","year":"2019","journal-title":"J Biol Chem"},{"key":"B118","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/s41419-019-1420-9","article-title":"Tryptophan-kynurenine pathway attenuates \u03b2-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in toxoplasma gondii infection","volume":"10","author":"Majumdar","year":"2019","journal-title":"Cell Death Dis"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004779","article-title":"Induction of interferon-stimulated genes by IRF3 promotes replication of toxoplasma gondii","volume":"11","author":"Majumdar","year":"2015","journal-title":"PloS Pathog"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.08.002","article-title":"STING requires the adaptor TRIF to trigger innate immune responses to microbial infection","volume":"20","author":"Wang","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02361-22","article-title":"Inflammasome activation dampens type I IFN signaling to strengthen anti-toxoplasma immunity","volume":"13","author":"Hu","year":"2022","journal-title":"mBio"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101347R","article-title":"Toxoplasma gondii ROP18(I) inhibits host innate immunity through cGAS-STING signaling","volume":"36","author":"Chen","year":"2022","journal-title":"FASEB J"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16889","article-title":"FAF1 downregulation by toxoplasma gondii enables host IRF3 mobilization and promotes parasite growth","volume":"25","author":"Gao","year":"2021","journal-title":"J Cell Mol Med"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010","journal-title":"Lancet"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1410150","article-title":"Chagas' disease","volume":"373","author":"Bern","year":"2015","journal-title":"N Engl J Med"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2012.03.002","article-title":"American Trypanosomiasis (Chagas disease)","volume":"26","author":"Rassi","year":"2012","journal-title":"Infect Dis Clin North Am"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(21)00265-2","article-title":"Immunity, and the fate of infections: Lessons learned from trypanosoma cruzi human-host interactions","volume":"3","author":"Magalh\u00e3es","year":"2022","journal-title":"Lancet Microbe"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008474","article-title":"PARP1-cGAS-NF-\u03baB pathway of proinflammatory macrophage activation by extracellular vesicles released during trypanosoma cruzi infection and chagas disease","volume":"16","author":"Choudhuri","year":"2020","journal-title":"PloS Pathog"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.775346","article-title":"STING signaling drives production of innate cytokines, generation of CD8(+) T cells and enhanced protection against trypanosoma cruzi infection","volume":"12","author":"Vieira","year":"2021","journal-title":"Front Immunol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005300","article-title":"Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against trypanosoma cruzi","volume":"11","author":"Matos","year":"2017","journal-title":"PloS Negl Trop Dis"},{"key":"B131","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41541-017-0010-z","article-title":"Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against trypanosoma cruzi infection","volume":"2","author":"Sanchez Alberti","year":"2017","journal-title":"NPJ Vaccines"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00128","article-title":"Mucosal heterologous Prime\/Boost vaccination induces polyfunctional systemic immunity, improving protection against trypanosoma cruzi","volume":"11","author":"Sanchez Alberti","year":"2020","journal-title":"Front Immunol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04638-9","article-title":"Herpes simplex virus infections","volume":"357","author":"Whitley","year":"2001","journal-title":"Lancet"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244040","article-title":"Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects","volume":"341","author":"Li","year":"2013","journal-title":"Science"},{"key":"B135","doi-asserted-by":"publisher","first-page":"13348","DOI":"10.1038\/ncomms13348","article-title":"Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS","volume":"7","author":"Reinert","year":"2016","journal-title":"Nat Commun"},{"key":"B136","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.immuni.2020.06.009","article-title":"Interferon-independent activities of mammalian STING mediate antiviral response and tumor immune evasion","volume":"53","author":"Wu","year":"2020","journal-title":"Immunity"},{"key":"B137","doi-asserted-by":"publisher","first-page":"3382","DOI":"10.1038\/s41467-020-17156-x","article-title":"Interferon-independent STING signaling promotes resistance to HSV-1 in vivo","volume":"11","author":"Yamashiro","year":"2020","journal-title":"Nat Commun"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2100225118","article-title":"TBK1 recruitment to STING activates both IRF3 and NF-kappaB that mediate immune defense against tumors and viral infections","volume":"118","author":"Yum","year":"2021","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B139","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12985-016-0495-5","article-title":"Evasion of host antiviral innate immunity by HSV-1, an update","volume":"13","author":"Su","year":"2016","journal-title":"Virol J"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00099-17","article-title":"Evasion of cytosolic DNA-stimulated innate immune responses by herpes simplex virus 1","volume":"92","author":"Zheng","year":"2018","journal-title":"J Virol"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.647992","article-title":"Evasion of intracellular DNA sensing by human herpesviruses","volume":"11","author":"Bhowmik","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02414-16","article-title":"Herpes simplex virus 1 abrogates the cGAS\/STING-mediated cytosolic DNA-sensing pathway via its virion host shutoff protein, UL41","volume":"91","author":"Su","year":"2017","journal-title":"J Virol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00841-18","article-title":"Herpes simplex virus 1 tegument protein VP22 abrogates cGAS\/STING-mediated antiviral innate immunity","volume":"92","author":"Huang","year":"2018","journal-title":"J Virol"},{"key":"B144","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.chom.2018.07.004","article-title":"Species-specific deamidation of cGAS by herpes simplex virus UL37 protein facilitates viral replication","volume":"24","author":"Zhang","year":"2018","journal-title":"Cell Host Microbe"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20191422","article-title":"HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection","volume":"217","author":"Bodda","year":"2020","journal-title":"J Exp Med"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00186-16","article-title":"Herpes simplex virus 1 serine protease VP24 blocks the DNA-sensing signal pathway by abrogating activation of interferon regulatory factor 3","volume":"90","author":"Zhang","year":"2016","journal-title":"J Virol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593458","article-title":"HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression","volume":"35","author":"Christensen","year":"2016","journal-title":"EMBO J"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00025-17","article-title":"Herpes simplex virus 1 UL24 abrogates the DNA sensing signal pathway by inhibiting NF-kappaB activation","volume":"91","author":"Xu","year":"2017","journal-title":"J Virol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009950","article-title":"Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis","volume":"17","author":"Sharma","year":"2021","journal-title":"PloS Pathog"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.083","article-title":"The biology and life-cycle of human papillomaviruses","author":"Doorbar","year":"2012","journal-title":"Vaccine"},{"key":"B151","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.coviro.2015.09.001","article-title":"Human papillomaviruses: shared and distinct pathways for pathogenesis","volume":"14","author":"Galloway","year":"2015","journal-title":"Curr Opin Virol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001540","article-title":"The human papillomavirus oncoproteins: A review of the host pathways targeted on the road to transformation","volume":"102","author":"Scarth","year":"2021","journal-title":"J Gen Virol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2017-0113","article-title":"Mechanisms and strategies of papillomavirus replication","volume":"398","author":"McBride","year":"2017","journal-title":"Biol Chem"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers","year":"1999","journal-title":"J Pathol"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641","article-title":"International agency for research on cancer multicenter cervical cancer study, epidemiologic classification of human papillomavirus types associated with cervical cancer","volume":"348","author":"Munoz","year":"2003","journal-title":"N Engl J Med"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3291","article-title":"DNA Tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway","volume":"350","author":"Lau","year":"2015","journal-title":"Science"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2019.05.004","article-title":"cGAS-STING responses are dampened in high-risk HPV type 16 positive head and neck squamous cell carcinoma cells","volume":"132","author":"Shaikh","year":"2019","journal-title":"Microb Pathog"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2020.07.010","article-title":"Loss of HPV type 16 E7 restores cGAS-STING responses in human papilloma virus-positive oropharyngeal squamous cell carcinomas cells","volume":"54","author":"Bortnik","year":"2021","journal-title":"J Microbiol Immunol Infect"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129497","article-title":"HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING","volume":"130","author":"Luo","year":"2020","journal-title":"J Clin Invest"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01812-19","article-title":"Human papillomavirus E7 oncoprotein subverts host innate immunity via SUV39H1-mediated epigenetic silencing of immune sensor genes","volume":"94","author":"Lo Cigno","year":"2020","journal-title":"J Virol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009028","article-title":"Vesicular trafficking permits evasion of cGAS\/STING surveillance during initial human papillomavirus infection","volume":"16","author":"Uhlorn","year":"2020","journal-title":"PloS Pathog"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.01.010","article-title":"The cGAS-STING defense pathway and its counteraction by viruses","volume":"19","author":"Ma","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cGAS-STING signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abi9002","article-title":"A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection","volume":"6","author":"Humphries","year":"2021","journal-title":"Sci Immunol"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abi9007","article-title":"Pharmacological activation of STING blocks SARS-CoV-2 infection","volume":"6","author":"Li","year":"2021","journal-title":"Sci Immunol"},{"key":"B166","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/s41392-021-00800-3","article-title":"Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection","volume":"6","author":"Zhou","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B167","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/s41392-021-00515-5","article-title":"Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins","volume":"6","author":"Rui","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abg8744","article-title":"SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response","volume":"15","author":"Liu","year":"2022","journal-title":"Sci Signaling"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04421-w","article-title":"The cGAS-STING pathway drives type I IFN immunopathology in COVID-19","volume":"603","author":"Domizio","year":"2022","journal-title":"Nature"},{"key":"B170","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s42003-021-02983-5","article-title":"SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-kappaB","volume":"5","author":"Neufeldt","year":"2022","journal-title":"Commun Biol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced host response to SARS-CoV-2 drives development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"},{"key":"B172","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.chom.2020.04.017","article-title":"Heightened innate immune responses in the respiratory tract of COVID-19 patients","volume":"27","author":"Zhou","year":"2020","journal-title":"Cell Host Microbe"},{"key":"B173","doi-asserted-by":"publisher","first-page":"e28175","DOI":"10.1002\/jmv.28175","article-title":"SARS-CoV-2 ORF3a inhibits cGAS-STING-mediated autophagy flux and antiviral function","volume":"95","author":"Su","year":"2022","journal-title":"J Med Virol"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27965","article-title":"SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy","volume":"94","author":"Han","year":"2022","journal-title":"J Med Virol"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27050","article-title":"SARS-CoV-2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG-I\/MDA-5-MAVS, TLR3-TRIF, and cGAS-STING signaling pathways","volume":"93","author":"Han","year":"2021","journal-title":"J Med Virol"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-102215-095605","article-title":"Detection of microbial infections through innate immune sensing of nucleic acids","volume":"72","author":"Tan","year":"2018","journal-title":"Annu Rev Microbiol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240933","article-title":"Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses","volume":"341","author":"Gao","year":"2013","journal-title":"Science"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.09.023","article-title":"HIV Triggers a cGAS-dependent, vpu- and vpr-regulated type I interferon response in CD4(+) T cells","volume":"17","author":"Vermeire","year":"2016","journal-title":"Cell Rep"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1038\/nature12769","article-title":"HIV-1 evades innate immune recognition through specific cofactor recruitment","volume":"503","author":"Rasaiyaah","year":"2013","journal-title":"Nature"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1941","article-title":"The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1","volume":"11","author":"Yan","year":"2010","journal-title":"Nat Immunol"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01247-0","article-title":"Evasion of cGAS and TRIM5 defines pandemic HIV","volume":"7","author":"Zuliani-Alvarez","year":"2022","journal-title":"Nat Microbiol"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00802-9","article-title":"HIV-1 vif suppresses antiviral immunity by targeting STING","volume":"19","author":"Wang","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1920631117","article-title":"HIV-1 uncoats in the nucleus near sites of integration","volume":"117","author":"Burdick","year":"2020","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41800","article-title":"HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex","volume":"8","author":"Bejarano","year":"2019","journal-title":"Elife"},{"key":"B185","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.cell.2021.01.025","article-title":"Cone-shaped HIV-1 capsids are transported through intact nuclear pores","volume":"184","author":"Zila","year":"2021","journal-title":"Cell"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2019467118","article-title":"HIV-1 cores retain their integrity until minutes before uncoating in the nucleus","volume":"118","author":"Li","year":"2021","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64776","article-title":"HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells","volume":"10","author":"Muller","year":"2021","journal-title":"Elife"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.11.002","article-title":"The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells","volume":"39","author":"Lahaye","year":"2013","journal-title":"Immunity"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2002481117","article-title":"Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells","volume":"117","author":"Elsner","year":"2020","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019103958","article-title":"Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA","volume":"39","author":"Sumner","year":"2020","journal-title":"EMBO J"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1038\/nri1573","article-title":"Immunology of hepatitis b virus and hepatitis c virus infection","volume":"5","author":"Rehermann","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.3390\/v12060592","article-title":"Hepatitis b virus DNA is a substrate for the cGAS\/STING pathway but is not sensed in infected hepatocytes","volume":"12","author":"Lauterbach-Riviere","year":"2020","journal-title":"Viruses"},{"key":"B193","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1096\/fba.1022","article-title":"High-level expression of STING restricts susceptibility to HBV by mediating type III IFN induction","volume":"1","author":"Dansako","year":"2019","journal-title":"FASEB Bioadv"},{"key":"B194","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41423-021-00801-w","article-title":"STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis","volume":"19","author":"Li","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000647","article-title":"Inhibition of hepatitis b virus replication by activation of the cGAS-STING pathway","volume":"97","author":"He","year":"2016","journal-title":"J Gen Virol"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30054","article-title":"Hepatitis b virus evasion from cyclic guanosine monophosphate-adenosine monophosphate synthase sensing in human hepatocytes","volume":"68","author":"Verrier","year":"2018","journal-title":"Hepatology"},{"key":"B197","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41572-018-0002-y","article-title":"Influenza","volume":"4","author":"Krammer","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"B198","doi-asserted-by":"publisher","first-page":"10680","DOI":"10.1038\/ncomms10680","article-title":"Influenza a virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses","volume":"7","author":"Holm","year":"2016","journal-title":"Nat Commun"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"key":"B200","doi-asserted-by":"publisher","first-page":"17037","DOI":"10.1038\/nmicrobiol.2017.37","article-title":"Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection","volume":"2","author":"Aguirre","year":"2017","journal-title":"Nat Microbiol"},{"key":"B201","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1038\/s41598-017-03932-1","article-title":"Dengue virus activates cGAS through the release of mitochondrial DNA","volume":"7","author":"Sun","year":"2017","journal-title":"Sci Rep"},{"key":"B202","doi-asserted-by":"publisher","first-page":"4624","DOI":"10.1038\/s41467-019-12632-5","article-title":"Influenza a virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses","volume":"10","author":"Moriyama","year":"2019","journal-title":"Nat Commun"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402764","article-title":"cGAS and Ifi204 cooperate to produce type I IFNs in response to francisella infection","volume":"194","author":"Storek","year":"2015","journal-title":"J Immunol"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.05.005","article-title":"Cyclic GMP-AMP synthase is an innate immune DNA sensor for mycobacterium tuberculosis","volume":"17","author":"Collins","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B205","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1016\/j.chom.2015.05.003","article-title":"Mycobacterium tuberculosis differentially activates cGAS- and inflammasome-dependent intracellular immune responses through ESX-1","volume":"17","author":"Wassermann","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.05.004","article-title":"The cytosolic sensor cGAS detects mycobacterium tuberculosis DNA to induce type I interferons and activate autophagy","volume":"17","author":"Watson","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00849-17","article-title":"The cGAS\/STING pathway detects streptococcus pneumoniae but appears dispensable for antipneumococcal defense in mice and humans","volume":"86","author":"Ruiz-Moreno","year":"2018","journal-title":"Infect Immun"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201488029","article-title":"Listeria monocytogenes induces IFNbeta expression through an IFI16-, cGAS- and STING-dependent pathway","volume":"33","author":"Hansen","year":"2014","journal-title":"EMBO J"},{"key":"B209","doi-asserted-by":"publisher","first-page":"101928","DOI":"10.1016\/j.isci.2020.101928","article-title":"Identification of cGAS as an innate immune sensor of extracellular bacterium pseudomonas aeruginosa","volume":"24","author":"Zhou","year":"2021","journal-title":"iScience"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.05.029","article-title":"Cyclic di-GMP sensing via the innate immune signaling protein STING","volume":"46","author":"Yin","year":"2012","journal-title":"Mol Cell"},{"key":"B211","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/MMBR.00043-12","article-title":"Cyclic di-GMP: The first 25 years of a universal bacterial second messenger","volume":"77","author":"Romling","year":"2013","journal-title":"Microbiol Mol Biol Rev"},{"key":"B212","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.cell.2017.09.034","article-title":"STING senses microbial viability to orchestrate stress-mediated autophagy of the endoplasmic reticulum","volume":"171","author":"Moretti","year":"2017","journal-title":"Cell"},{"key":"B213","article-title":"Chlamydia trachomatis infections: screening, diagnosis, and management","volume":"86","author":"Mishori","year":"2012","journal-title":"Am Fam Physician"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.016","article-title":"The roles of type I interferon in bacterial infection","volume":"19","author":"Boxx","year":"2016","journal-title":"Cell Host Microbe"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302718","article-title":"The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-beta during chlamydia trachomatis infection","volume":"193","author":"Zhang","year":"2014","journal-title":"J Immunol"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00670-21","article-title":"Evidence for cGAS-STING signaling in the female genital tract resistance to chlamydia trachomatis infection","volume":"90","author":"Su","year":"2022","journal-title":"Infection Immun"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00018-13","article-title":"STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during chlamydia trachomatis infection","volume":"4","author":"Barker","year":"2013","journal-title":"mBio"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006383","article-title":"Detection of a microbial metabolite by STING regulates inflammasome activation in response to chlamydia trachomatis infection","volume":"13","author":"Webster","year":"2017","journal-title":"PloS Pathog"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: Epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin Microbiol Rev"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00447-16","article-title":"Cyclic di-AMP released from staphylococcus aureus biofilm induces a macrophage type I interferon response","volume":"84","author":"Gries","year":"2016","journal-title":"Infect Immun"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1038\/nri3133","article-title":"Immunomodulatory functions of type I interferons","volume":"12","author":"Gonzalez-Navajas","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002794","article-title":"Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo","volume":"186","author":"Thurlow","year":"2011","journal-title":"J Immunol"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006496","article-title":"Opposing roles of toll-like receptor and cytosolic DNA-STING signaling pathways for staphylococcus aureus cutaneous host defense","volume":"13","author":"Scumpia","year":"2017","journal-title":"PloS Pathog"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.636861","article-title":"STING contributes to host defense against staphylococcus aureus pneumonia through suppressing necroptosis","volume":"12","author":"Liu","year":"2021","journal-title":"Front Immunol"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0122-7","article-title":"Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis","volume":"26","author":"Sarhan","year":"2019","journal-title":"Cell Death Differ"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701492","article-title":"Intracellular nucleic acid sensing triggers necroptosis through synergistic type I IFN and TNF signaling","volume":"200","author":"Brault","year":"2018","journal-title":"J Immunol"},{"key":"B227","first-page":"4","article-title":"Listeria\u2013review of epidemiology and pathogenesis","volume":"40","author":"Ramaswamy","year":"2007","journal-title":"J Microbiol Immunol Infect"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-01846-6_6","article-title":"Listeria as an enteroinvasive gastrointestinal pathogen","volume":"337","author":"Barbuddhe","year":"2009","journal-title":"Curr Top Microbiol Immunol"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0367-z","article-title":"Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling","volume":"4","author":"Nandakumar","year":"2019","journal-title":"Nat Microbiol"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040976","article-title":"Mice lacking the type I interferon receptor are resistant to listeria monocytogenes","volume":"200","author":"Auerbuch","year":"2004","journal-title":"J Exp Med"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040712","article-title":"Type I interferon production enhances susceptibility to listeria monocytogenes infection","volume":"200","author":"O'Connell","year":"2004","journal-title":"J Exp Med"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040769","article-title":"Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to listeria infection","volume":"200","author":"Carrero","year":"2004","journal-title":"J Exp Med"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601420","article-title":"The complement anaphylatoxins C5a and C3a suppress IFN-beta production in response to listeria monocytogenes by inhibition of the cyclic dinucleotide-activated cytosolic surveillance pathway","volume":"198","author":"Mueller-Ortiz","year":"2017","journal-title":"J Immunol"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00407-20","article-title":"Secretion of c-di-AMP by listeria monocytogenes leads to a STING-dependent antibacterial response during enterocolitis","volume":"88","author":"Louie","year":"2020","journal-title":"Infect Immun"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201788","article-title":"STING\/MPYS mediates host defense against listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration","volume":"190","author":"Jin","year":"2013","journal-title":"J Immunol"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.GPP3-0004-2018","article-title":"Streptococcus pneumoniae: Invasion and inflammation","volume":"7","author":"Loughran","year":"2019","journal-title":"Microbiol Spectr"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00769-13","article-title":"Two DHH subfamily 1 proteins in streptococcus pneumoniae possess cyclic di-AMP phosphodiesterase activity and affect bacterial growth and virulence","volume":"195","author":"Bai","year":"2013","journal-title":"J Bacteriol"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00554","article-title":"Unique roles for streptococcus pneumoniae phosphodiesterase 2 in cyclic di-AMP catabolism and macrophage responses","volume":"11","author":"Wooten","year":"2020","journal-title":"Front Immunol"},{"key":"B239","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.chom.2020.02.004","article-title":"TMEM173 drives lethal coagulation in sepsis","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Host Microbe"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000104950.52577.97","article-title":"Plasma interferon-gamma and interleukin-10 concentrations in systemic meningococcal disease compared with severe systemic gram-positive septic shock","volume":"32","author":"Bjerre","year":"2004","journal-title":"Crit Care Med"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201687","article-title":"Inflammasome-dependent IFN-gamma drives pathogenesis in streptococcus pneumoniae meningitis","volume":"189","author":"Mitchell","year":"2012","journal-title":"J Immunol"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.699702","article-title":"cGAS-STING and MyD88 pathways synergize in Ly6C(hi) monocyte to promote streptococcus pneumoniae-induced late-stage lung IFNgamma production","volume":"12","author":"Patel","year":"2021","journal-title":"Front Immunol"},{"key":"B243","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/s41579-018-0013-4","article-title":"Metabolic principles of persistence and pathogenicity in mycobacterium tuberculosis","volume":"16","author":"Ehrt","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.03.007","article-title":"Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages","volume":"11","author":"Manzanillo","year":"2012","journal-title":"Cell Host Microbe"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.03254-19","article-title":"Mycobacterium tuberculosis MmsA (Rv0753c) interacts with STING and blunts the type I interferon response","volume":"11","author":"Sun","year":"2020","journal-title":"mBio"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00444","article-title":"Identification of a mycobacterium tuberculosis cyclic dinucleotide phosphodiesterase inhibitor","volume":"7","author":"Karanja","year":"2021","journal-title":"ACS Infect Dis"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2254","article-title":"Inhibition of innate immune cytosolic surveillance by an m. tuberculosis phosphodiesterase","volume":"13","author":"Dey","year":"2017","journal-title":"Nat Chem Biol"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.04.003","article-title":"STING-activating adjuvants elicit a Th17 immune response and protect against mycobacterium tuberculosis infection","volume":"23","author":"Van Dis","year":"2018","journal-title":"Cell Rep"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.55","article-title":"Fungal dysbiosis: Immunity and interactions at mucosal barriers","volume":"17","author":"Iliev","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-052016-100342","article-title":"Immunity to commensal fungi: Detente and disease","volume":"12","author":"Wheeler","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1038\/nri3897","article-title":"Immune defence against candida fungal infections","volume":"15","author":"Netea","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00233-4","article-title":"Fungal beta-glucans and mammalian immunity","volume":"19","author":"Brown","year":"2003","journal-title":"Immunity"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.1038\/nri3684","article-title":"The mycobiota: Interactions between commensal fungi and the host immune system","volume":"14","author":"Underhill","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002811","article-title":"Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during candida infections","volume":"8","author":"Majer","year":"2012","journal-title":"PloS Pathog"},{"key":"B255","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.cell.2020.09.058","article-title":"Innate immune training of granulopoiesis promotes anti-tumor activity","volume":"183","author":"Kalafati","year":"2020","journal-title":"Cell"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1130423\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T04:45:57Z","timestamp":1675745157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1130423\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,6]]},"references-count":255,"alternative-id":["10.3389\/fimmu.2023.1130423"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1130423","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,6]]},"article-number":"1130423"}}