{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:24:16Z","timestamp":1789269856154,"version":"build-2803163510"},"reference-count":95,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004242","name":"Princess Nourah Bint Abdulrahman University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    One of the most crucial approaches for treating human diseases, particularly parasite infections, is nanomedicine. One of the most significant protozoan diseases that impact farm and domestic animals is coccidiosis. While, amprolium is one of the traditional anticoccidial medication, the advent of drug-resistant strains of\n                    <jats:italic>Eimeria<\/jats:italic>\n                    necessitates the development of novel treatments. The goal of the current investigation was to determine whether biosynthesized selenium nanoparticles (Bio-SeNPs) using\n                    <jats:italic>Azadirachta indica<\/jats:italic>\n                    leaves extract might treat mice with\n                    <jats:italic>Eimeria papillata<\/jats:italic>\n                    infection in the jejunal tissue. Five groups of seven mice each were used, as follows:\n                    <jats:italic>Group 1<\/jats:italic>\n                    : Non-infected-non-treated (negative control).\n                    <jats:italic>Group 2<\/jats:italic>\n                    : Non-infected treated group with Bio-SeNPs (0.5 mg\/kg of body weight).\n                    <jats:italic>Groups 3-5<\/jats:italic>\n                    were orally inoculated with 1\u00d710\n                    <jats:sup>3<\/jats:sup>\n                    sporulated oocysts of\n                    <jats:italic>E. papillata<\/jats:italic>\n                    .\n                    <jats:italic>Group 3<\/jats:italic>\n                    : Infected-non-treated (positive control).\n                    <jats:italic>Group 4:<\/jats:italic>\n                    Infected and treated group with Bio-SeNPs (0.5 mg\/kg).\n                    <jats:italic>Group 5<\/jats:italic>\n                    : Infected and treated group with the Amprolium. Groups 4 and 5 daily received oral administration (for 5 days) of Bio-SeNPs and anticoccidial medication, respectively, after infection. Bio-SeNPs caused a considerable reduction in oocyst output in mice feces (97.21%). This was also accompanied by a significant reduction in the number of developmental parasitic stages in the jejunal tissues. Glutathione reduced (GSH), glutathione peroxidase (GPx), and superoxide dismutase (SOD) levels were dramatically reduced by the\n                    <jats:italic>Eimeria<\/jats:italic>\n                    parasite, whereas, nitric oxide (NO) and malonaldehyde (MDA) levels were markedly elevated. The amount of goblet cells and\n                    <jats:italic>MUC2<\/jats:italic>\n                    gene expression were used as apoptotic indicators, and both were considerably downregulated by infection. However, infection markedly increased the expression of inflammatory cytokines (\n                    <jats:italic>IL-6<\/jats:italic>\n                    and\n                    <jats:italic>TNF-\u03b1<\/jats:italic>\n                    ) and the apoptotic genes (\n                    <jats:italic>Caspase-3<\/jats:italic>\n                    and\n                    <jats:italic>BCL2<\/jats:italic>\n                    ). Bio-SeNPs were administrated to mice to drastically lower body weight, oxidative stress, and inflammatory and apoptotic indicators in the jejunal tissue. Our research thus showed the involvement of Bio-SeNPs in protecting mice with\n                    <jats:italic>E. papillata<\/jats:italic>\n                    infections against jejunal damage.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2023.1139899","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T03:35:35Z","timestamp":1676604935000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Biosynthesized selenium nanoparticles to rescue coccidiosis-mediated oxidative stress, apoptosis and inflammation in the jejunum of mice"],"prefix":"10.3389","volume":"14","author":[{"given":"Rewaida","family":"Abdel-Gaber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysar Abu","family":"Hawsah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahani","family":"Al-Otaibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"Alojayri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esam M.","family":"Al-Shaebi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama B.","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal F.","family":"Elkhadragy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Al-Quraishy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Dkhil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-27769-6","volume-title":"Encyclopedic reference of parasitology. 4th edn","author":"Mehlhorn","year":"2014"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182019001562","article-title":"Life cycle stages, specific organelles and invasion mechanisms of eimeria species","volume":"147","author":"Burrell","year":"2019","journal-title":"Parasitology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1128\/CMR.15.1.58-65.2002","article-title":"Recent advances in biology and immunobiology of eimeria species and in diagnosis and control of infection with these coccidian parasites of poultry","volume":"15","author":"Allen","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2018.02.008","article-title":"Evaluation of nanoselenium and nanogold activities against murine intestinal schistosomiasis","volume":"26","author":"Dkhil","year":"2019","journal-title":"Saudi J Biol Sci"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2003101p51","article-title":"Coccidiosis of the wild rabbit (Oryctolagus cuniculus) in France","volume":"10","author":"Gres","year":"2003","journal-title":"Parasite"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2478\/s11756-013-0297-9","article-title":"Anti-coccidial and anti-apoptotic activities of palm pollen grains on eimeria papillata-induced infection in mice","volume":"69","author":"Metwaly","year":"2014","journal-title":"Biologia"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/219670","article-title":"Anti-oxidant and anti-inflammatory activities of pomegranate (Punica granatum) on eimeria papillata induced infection in mice","volume":"2015","author":"Amer","year":"2015","journal-title":"Biomed Res Int"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vetpar.2005.10.012","article-title":"Tracing the emergence of drug-resistance in coccidia (Eimeria spp.) of commercial broiler flocks medicated with decoquinate for the first time in the united kingdom","volume":"135","author":"Williams","year":"2006","journal-title":"Vet Parasitol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1017\/S004393391100033X","article-title":"Anticoccidial drug resistance in fowl coccidia: the state of play revisited","volume":"67","author":"Abbas","year":"2011","journal-title":"World\u2019s Poult Sci J"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s12639-014-0517-4","article-title":"Anticoccidial effects of herbal extracts on eimeria tenella infection in broiler chickens: in vitro and in vivo study","volume":"40","author":"Habibi","year":"2016","journal-title":"J Parasite Dis"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-014-4101-8","article-title":"Towards identifying novel anti-eimeria agents: Trace elements, vitamins, and plant-based natural products","volume":"113","author":"Wunderlich","year":"2014","journal-title":"Parasitol Res"},{"key":"B12","first-page":"98","article-title":"Therapeutic potential of azadirachta indica (Neem) and their active phytoconstituents against diseases prevention","volume":"10","author":"Latif","year":"2020","journal-title":"J Chem Chem Sci"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.5530\/pj.2019.11.244","article-title":"Azadirachta indica: Antibacterial activity of neem against different strains of bacteria and their active constituents as preventive in various diseases","volume":"11","author":"Herrera-Calderon","year":"2019","journal-title":"Pharmacogn J"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7382506","article-title":"Therapeutics role of azadirachta indica (Neem) and their active constituents in diseases prevention and treatment","volume":"2016","author":"Alzohairy","year":"2016","journal-title":"eCAM"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1960","article-title":"Exploration of antifungal potential of azadirachta indica against microsporum gypseum","volume":"13","author":"Sudan","year":"2020","journal-title":"Biomed Pharmacol J"},{"key":"B16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12936-019-2671-8","article-title":"Effects of azadirachta indica seed kernel extracts on early erythrocytic schizogony of plasmodium berghei and pro-inflammatory response in inbred mice","volume":"18","author":"Habluetzel","year":"2019","journal-title":"Malar J"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.9790\/3013-0411-34-38","article-title":"Anti inflammatory effect of azadirachta indica (Neem) in albino rats-an experimental study","volume":"4","author":"Jagadeesh","year":"2014","journal-title":"IOSR J Phram"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3178","article-title":"Protective effects of neem (Azadirachta indica a. juss.) leaf extract against cigarette smoke- and lipopolysaccharide-induced pulmonary inflammation","volume":"40","author":"Lee","year":"2017","journal-title":"Inter J Mol Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-012-3109-1","article-title":"Protective effect of azadirachta indica extract against eimeria papillata-induced coccidiosis","volume":"112","author":"Dkhil","year":"2013","journal-title":"Parasitol Res"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.parepi.2022.e00244","article-title":"Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malaria","volume":"17","author":"Gujjari","year":"2022","journal-title":"Parasite Epidemiol Control"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s40097-018-0267-4","article-title":"Biogenesis of metal nanoparticles and their pharmacological applications: present status and application prospects","volume":"8","author":"Khandel","year":"2018","journal-title":"J Nanostruct Chem"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2019.1692968","article-title":"Nanoparticles for antiparasitic drug delivery","volume":"26","author":"Sun","year":"2019","journal-title":"Drug Deliv"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61452-9","article-title":"Selenium and human health","volume":"379","author":"Rayman","year":"2012","journal-title":"Lancet"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2012.11.002","article-title":"Efficacy of biogenic selenium nanoparticles against leishmania major: in vitro and in vivo studies","volume":"27","author":"Beheshti","year":"2013","journal-title":"J Trace Elem Med Biol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.11.031","article-title":"Gene expression in rabbit appendices infected with eimeria coecicola","volume":"186","author":"Dkhil","year":"2012","journal-title":"Vet Parasitol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.2147\/IJN.S162355","article-title":"Nanoselenium prevents eimeriosis-induced inflammation and regulates mucin gene expression in mice jejunum","volume":"13","author":"Alkhudhayri","year":"2018","journal-title":"Int J Nanomed"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765202020191107","article-title":"Antioxidant and anti-apoptotic effects of selenium nanoparticles against murine eimeriosis","volume":"92","author":"Alkhudhayri","year":"2020","journal-title":"An Acad Bras Cienc"},{"key":"B28","article-title":"Protective role of selenium nanoparticles against schistosoma mansoni induced hepatic injury in mice","volume":"27","author":"Dkhil","year":"2016","journal-title":"Biomed Res"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.18502\/ijpa.v15i3.4206","article-title":"In vitro assessment antiparasitic effect of selenium and copper nanoparticles on giardia deodenalis cyst","volume":"15","author":"Malekifard","year":"2020","journal-title":"Iran J Parasitol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X22000359","article-title":"Egyptian Propolis and selenium nanoparticles against murine trichinosis: A novel therapeutic insight","volume":"96","author":"Sarhan","year":"2022","journal-title":"J Helminthol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.03.013","article-title":"Evaluation of azadirachta indica leaf fractions for in vitro antioxidant potential and in vivo modulation of biomarkers of chemoprevention in the hamster buccal pouch carcinogenesis model","volume":"46","author":"Manikandan","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.833520","article-title":"Treatment of trypanosoma evansi-infected mice with eucalyptus camaldulensis led to a change in brain response and spleen immunomodulation","volume":"13","author":"Dkhil","year":"2022","journal-title":"Front Microbiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/s41598-019-57333-7","article-title":"Synthesis and characterization of selenium nanoparticles-lysozyme nanohybrid system with synergistic antibacterial properties","volume":"10","author":"Vahdati","year":"2020","journal-title":"Sci Rep"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2020.03.016","article-title":"In vivo and in vitro anticoccidial efficacy of astragalus membranaceus against eimeria papillata infection","volume":"32","author":"Abdel-Tawab","year":"2020","journal-title":"J King Saud Uni Sci"},{"key":"B35","article-title":"Comparative efficacy of selected anticoccidial drugs in ambarorow sheep naturally infected with enteric coccidia in south darfur, Sudan","volume":"20","author":"Abakar","year":"2005","journal-title":"Sudan J Vet Res"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2020.02.034","article-title":"Rumex nervosus changed the oxidative status of chicken caecum infected with eimeria tenella","volume":"32","author":"Al-Quraishy","year":"2020","journal-title":"J King Saud Uni Sci"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.2307\/3284157","article-title":"Comparison of four murine eimeria species in immunocompetent and immunodeficient mice","volume":"82","author":"Schito","year":"1996","journal-title":"J Parasitol"},{"key":"B38","volume-title":"Grosses zoologisches parktikum tell. arbeitsmethoden der makroskopischen und mikroskopischen anatomic. mit 283 abbildungen","author":"Adam","year":"1964"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-05217-4","article-title":"Chlorogenic acid prevents hepatotoxicity in arsenic-treated mice: role of oxidative stress and apoptosis","volume":"47","author":"Dkhil","year":"2020","journal-title":"Mol Biol Rep"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2003.11.006","article-title":"Protective effect of l-cysteine and glutathione on the modulated suckling rat brain na+, k+, -ATPase and Mg2+ -ATPase activities induced by the in vitro galactosaemia","volume":"49","author":"Tsakiris","year":"2004","journal-title":"Pharm Res"},{"key":"B41","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J Lab Clin Med"},{"key":"B42","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Pagila","year":"1967","journal-title":"J Lab Clin Med"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"B44","article-title":"Determination of nitrite in water","volume":"86","author":"Montgomery","year":"1961","journal-title":"Analyst"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem Biophys Res Commun"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2013\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B47","first-page":"1","volume-title":"Resistance to anticoccidial drugs: Alternative strategies to control coccidiosis in broilers","author":"Peek","year":"2010"},{"key":"B48","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1042\/BA20100042","article-title":"Biosynthesis and recovery of selenium nanoparticles and the effects on matrix metalloproteinase-2 expression","volume":"56","author":"Shakibaie","year":"2010","journal-title":"Biotechnol Appl Biochem"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.12374","article-title":"Biogenic selenium nanoparticles: Characterization, antimicrobial activity and effects on human dendritic cells and fibroblasts","volume":"9","author":"Cermonini","year":"2016","journal-title":"Microb Biotechnol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/polym14050955","article-title":"Novel antiviral and antibacterial durable polyester fabrics printed with selenium nanoparticles (SeNPs)","volume":"14","author":"Elmaaty","year":"2022","journal-title":"Polymers"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1080\/10826068.2018.1431784","article-title":"Extraction of total phenolic content from azadirachta indica or (neem) leaves: Kinetics study","volume":"48","author":"Shewale","year":"2018","journal-title":"Prep Biochem Biotechnol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.rineng.2020.100160","article-title":"Phenoilc compound extraction from Nigerian azadirachta indica leaves: Response surface and neuro-fuzzy modelling performance evaluation with cuckoo search multi objective optimization","volume":"8","author":"Oke","year":"2020","journal-title":"RINENG"},{"key":"B53","article-title":"Antimicrobial activity in leaf extract of neem (Azadirachta indica linn.)","volume":"3","author":"Maragathavalli","year":"2012","journal-title":"Inter J Sci Nat"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3329\/ralf.v6i2.43063","article-title":"Antimicrobial activity in leaf extract of neem in broiler","volume":"6","author":"Akhter","year":"2019","journal-title":"Res Agric Livest Fish"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.624621","article-title":"Comparative study of the antimicrobial activity of selenium nanoparticles with different surface chemistry and structure","volume":"8","author":"Filipovi\u0107","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.891535","article-title":"The antimicrobial potential of the neem tree Azadirachta indica","volume":"13","author":"Wylie","year":"2022","journal-title":"Front Pharmacol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-008-1171-5","article-title":"Field evaluation of eimeria tenella (local isolates) gametocytes vaccine and its comparative efficacy with imported live vaccine, LivaCox\u00ae","volume":"104","author":"Anwar","year":"2008","journal-title":"Parasitol Res"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014636","article-title":"Eimeria species and genetic background influence the serum protein profile of broilers with coccidiosis","volume":"6","author":"Gilbert","year":"2011","journal-title":"PloS One"},{"key":"B59","doi-asserted-by":"publisher","first-page":"100902","DOI":"10.1016\/j.psj.2020.11.071","article-title":"Anticoccidial effectivity of a traditional medicinal plant, cinnamomum verum, in broiler chickens infected with eimeria tenella","volume":"100","author":"Qaid","year":"2021","journal-title":"Poult Sci"},{"key":"B60","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1186\/s12906-017-1900-3","article-title":"Combined antioxidant effects of neem extract, bacteria, red blood cells and lysozyme: possible relation to periodontal disease. BMC complement","volume":"17","author":"Heyman","year":"2017","journal-title":"Altern Med"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1080\/00439339.2020.1789535","article-title":"Nutraceutical role of selenium nanoparticles in poultry nutrition: a review","volume":"76","author":"Nabi","year":"2020","journal-title":"World\u2019s Poult Sci J"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2021.e00851","article-title":"Azadirachta indica aqueous leaf extracts ameliorates coccidiosis in broiler chickens experimentally infected with eimeria oocyts","volume":"13","author":"Onyiche","year":"2021","journal-title":"Sci Afri"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.09.046","article-title":"Antioxidant and antimicrobial activities of spirulina platensis extracts and biogenic selenium nanoparticles against selected pathogenic bacteria and fungi","volume":"29","author":"Abdel-Moneim","year":"2022","journal-title":"Saudi J Biol Sci"},{"key":"B64","first-page":"20","article-title":"Effects of some alternative plant extracts used as natural coccidiostat for pigeons","volume":"3","author":"Qudoos","year":"2020","journal-title":"JASP"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.adcanc.2022.100061","article-title":"Potentiation of the therapeutic effect of intravesical BCG through synthetic and biogenic selenium nanoparticles in a nitrosamine-induced bladder cancer mouse model","volume":"6","author":"Ajideh","year":"2022","journal-title":"Adv Cancer Biol Metastasis"},{"key":"B66","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1080\/09712119.2022.2096037","article-title":"Methanolic extract of neem (Azadirachta indica) leaves mitigates experimentally induced coccidiosis challenge in Japanese quails","volume":"50","author":"Ishaq","year":"2022","journal-title":"J Appl Anim Res"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/jof8030262","article-title":"Myco-synthesized molluscicidal and larvicidal selenium nanoparticles: A new strategy to control biomphalaria alexandrina snails and larvae of schistosoma mansoni with an in silico study on induced oxidative stress","volume":"8","author":"Morad","year":"2022","journal-title":"J Fungi"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2005.07.016","article-title":"Antioxidant status during the course of eimeria tenella infection in broiler chickens","volume":"172","author":"Georgieva","year":"2006","journal-title":"Vet J"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8070235","article-title":"Antioxidant defence systems and oxidative stress in poultry biology: An update","volume":"8","author":"Surai","year":"2019","journal-title":"Antioxid (Basel)"},{"key":"B70","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.vetpar.2010.09.009","article-title":"Anticoccidial and anti-inflammatory activity of garlic in murine eimeria papillata infections","volume":"175","author":"Dkhil","year":"2011","journal-title":"Vet Parasitol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.754991","article-title":"S-methylcysteine ameliorates the intestinal damage induced by eimeria tenella infection via targeting oxidative stress and inflammatory modulators","volume":"8","author":"Elmahallawy","year":"2021","journal-title":"Front Vet Sci"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4692424","article-title":"Therapeutic and safety evaluation of combined aqueous extracts of azadirachta indica and khaya senegalensis in chickens experimentally infected with eimeria oocysts","volume":"2016","author":"Gotep","year":"2016","journal-title":"J Parasitol Res"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.4314\/sajas.v50i2.5","article-title":"Selenium and nano-selenium ameliorations in two breeds of broiler chickens exposed to heat stress","volume":"50","author":"Hassan","year":"2020","journal-title":"S. Afr J Anim Sci"},{"key":"B74","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1080\/01652176.2022.2073399","article-title":"The effect of metal-containing nanoparticles on the health, performance and production of livestock animals and poultry","volume":"42","author":"Michalak","year":"2022","journal-title":"Vet Q"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.4141\/cjas-2014-083","article-title":"Concurrent supplementation of arginine and antioxidant vitamins e and c reduces oxidative stress in broiler chickens after a challenge with eimeria spp","volume":"95","author":"Dominquez","year":"2015","journal-title":"Can J Anim Sci"},{"key":"B76","article-title":"Antibacterial activity of various phytoconstituents of neem","volume":"46","author":"Aslam","year":"2009","journal-title":"Pak J Agric Sci"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtusci.2013.05.003","article-title":"Identification and characterization of chemical compounds in different crude extracts from leaves of omani neem","volume":"7","author":"Hossain","year":"2013","journal-title":"J Taibah Uni Sci"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7970424","article-title":"Neem leaf (Azadirachta indica a. juss) ethanolic extract on the liver and kidney function of rats","volume":"2021","author":"Seriana","year":"2021","journal-title":"Sci World J"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02054","article-title":"Mucins in intestinal mucosal defense and inflammation: Learning from clinical and experimental studies","volume":"11","author":"Grondin","year":"2020","journal-title":"Front Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0130-3","article-title":"Intestinal stem cells","volume":"12","author":"Umar","year":"2011","journal-title":"Curr Gastroenterol Rep"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.67.311","article-title":"Murine goblet cell hypoplasia during eimeria pragensis infection is ameliorated by clindamycin treatment","volume":"67","author":"Yunus","year":"2005","journal-title":"J Vet Sci"},{"key":"B82","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3390\/pathogens2010055","article-title":"Goblet cells and mucins: Role in innate defense in enteric infections","volume":"2","author":"Kim","year":"2013","journal-title":"Pathogens"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S318327","article-title":"Role of goblet cells in intestinal barrier and mucosal immunity","volume":"12","author":"Yang","year":"2022","journal-title":"J Inflamm Res"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1097\/mcg.0b013e3182688e73","article-title":"Mucin function in inflammatory bowel disease, an update","volume":"47","author":"Boltin","year":"2013","journal-title":"J Clin Gastroenterol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.276.3.G666","article-title":"Goblet cell-specific expression mediated by the MUC2 mucin gene promoter in the intestine of transgenic mice","volume":"276","author":"Gum","year":"1999","journal-title":"Am J Physiol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21625","article-title":"Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation","volume":"17","author":"Larsson","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050576","article-title":"Proinflammatory cytokines trigger MUC gene expression and mucin release in the intestinal cancer cell line LS180","volume":"49","author":"Enss","year":"2000","journal-title":"Inflamm Res"},{"key":"B88","doi-asserted-by":"publisher","first-page":"5823","DOI":"10.1038\/s41598-017-04952-7","article-title":"Mucins 2 silencing promotes colon cancer metastasis through interleukin-6 signaling","volume":"7","author":"Hsu","year":"2017","journal-title":"Sci Rep"},{"key":"B89","article-title":"Immunomodulatory effect of honeybee flower pollen load","volume":"66","author":"Dudov","year":"1994","journal-title":"Ukr Biokhim Zh"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706246","article-title":"Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase c theta phosphorylation in human mast cells","volume":"145","author":"Kempuraj","year":"2005","journal-title":"Br J Pharmacol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(01)02016-5","article-title":"Intracellular protozoan parasites and apoptosis: Diverse strategies to modulate parasite-host interactions","volume":"17","author":"L\u00fcder","year":"2001","journal-title":"Trends Parasitol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(02)01115-2","article-title":"Chromium (III)-induced apoptosis of lymphocytes: Death decision by ROS and src-family tyrosine kinases","volume":"33","author":"Balamurugan","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-013-3430-3","article-title":"Anti-coccidial, anthelmintic and antioxidant activities of pomegranate (Punica granatum) peel extract","volume":"112","author":"Dkhil","year":"2013","journal-title":"Parasitol Res"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-010-0194-6","article-title":"Anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (Azadirachta indica) leaf extract are mediated via modulation of the nuclear factor-kB pathway","volume":"6","author":"Schumacher","year":"2011","journal-title":"Genes Nutr"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120098","article-title":"Anti-oxidant, anti-apoptotic, and mitochondrial regulatory effects of selenium nanoparticles against vancomycin induced nephrotoxixity in experimental rats","volume":"288","author":"Mehanna","year":"2022","journal-title":"Life Sci"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1139899\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T03:35:52Z","timestamp":1676604952000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1139899\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":95,"alternative-id":["10.3389\/fimmu.2023.1139899"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1139899","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,17]]},"article-number":"1139899"}}