{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:27:56Z","timestamp":1778509676481,"version":"3.51.4"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>MRGPRX2, a G-protein-coupled-seven transmembrane domain receptor, is mainly expressed in mast cells and neurons and is involved in skin immunity and pain. It is implicated in the pathophysiology of non-IgE-mediated immediate hypersensitivity and has been related to adverse drug reactions. Moreover, a role has been proposed in asthma, atopic dermatitis, contact dermatitis, and chronic spontaneous urticaria. Although it has a prominent role in disease, its signaling transduction is poorly understood. This study shows that MRGPRX2 activation with substance P increased Lysyl t-RNA synthetase (LysRS) translocation to the nucleus. LysRS is a moonlighting protein with a dual role in protein translation and IgE signaling in mast cells. Upon allergen- IgE-Fc\u03b5RI crosslinking, LysRS is translocated to the nucleus and activates microphthalmia-associated transcription factor (MITF) activity. In this study, we found that MRGPRX2 triggering led to MITF phosphorylation and increased MITF activity. Therefore, overexpression of LysRS increased MITF activity after MRGPRX2 activation. MITF silencing reduced MRGPRX2-dependent calcium influx and mast cell degranulation. Furthermore, a MITF pathway inhibitor, ML329, impaired MITF expression, calcium influx, and mast cell degranulation. Moreover, drugs such as atracurium, vancomycin, and morphine, reported to induce MRGPRX2-dependent degranulation, increased MITF activity. Altogether, our data show that MRGPRX2 signaling enhances MITF activity, and its abrogation by silencing or inhibition resulted in defective MRGPRX2 degranulation. We conclude that MRGPRX2 signaling involves the LysRS and MITF pathway. Thus, MITF and MITF-dependent targets may be considered therapeutic approaches to treat pathologies where MRGPRX2 is implicated.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1154108","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T17:49:24Z","timestamp":1683740964000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway"],"prefix":"10.3389","volume":"14","author":[{"given":"Yanru","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Oll\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Proa\u00f1o-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Aparicio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Mu\u00f1oz-Cano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.jaci.2021.03.049","article-title":"Multifaceted MRGPRX2: new insight into the role of mast cells in health and disease","volume":"148","author":"Roy","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094421","article-title":"The multifaceted mas-related G protein-coupled receptor member X2 in allergic diseases and beyond","volume":"22","author":"Quan","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.051","article-title":"Roles of mas-related G protein\u2013coupled receptor X2 on mast cell\u2013mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases","volume":"138","author":"Subramanian","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/S11882-020-00979-5","article-title":"Mast cell-specific MRGPRX2: a key modulator of neuro-immune interaction in allergic diseases","volume":"21","author":"Thapaliya","year":"2021","journal-title":"Curr Allergy Asthma Rep"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1016\/J.JACI.2022.02.021","article-title":"Mast cells, cortistatin, and its receptor, MRGPRX2, are linked to the pathogenesis of chronic prurigo","volume":"149","author":"Kolkhir","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/J.JID.2020.06.030","article-title":"MRGPRX2 activation causes increased skin reactivity in patients with chronic spontaneous urticaria","volume":"141","author":"Shtessel","year":"2021","journal-title":"J Invest Dermatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature14022","article-title":"Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"McNeil","year":"2015","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"11628","DOI":"10.1038\/s41598-018-29965-8","article-title":"MRGPRX2-mediated mast cell response to drugs used in perioperative procedures and anaesthesia","volume":"8","author":"Navin\u00e9s-Ferrer","year":"2018","journal-title":"Sci Rep"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2022.12.805","article-title":"Novel small molecule MRGPRX2 antagonists inhibit a murine model of allergic reaction","volume":"151","author":"Kumar","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2022.1033794","article-title":"Inhibition of MRGPRX2 but not Fc\u03f5RI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist","volume":"13","author":"Bawazir","year":"2022","journal-title":"Front Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/PTR.7445","article-title":"Dehydroandrographolide targets CD300f and negatively regulated MRGPRX2-induced pseudo-allergic reaction","volume":"36","author":"Che","year":"2022","journal-title":"Phytother Res"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04126-6","article-title":"Structure, function and pharmacology of human itch GPCRs","volume":"600","author":"Cao","year":"2021","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04077-y","article-title":"Structure, function and pharmacology of human itch receptor complexes","volume":"600","author":"Yang","year":"2021","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85538","article-title":"Different activation signals induce distinct mast cell degranulation strategies","volume":"126","author":"Gaudenzio","year":"2016","journal-title":"J Clin Invest"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS11060953","article-title":"MRGPRX2-mediated degranulation of human skin mast cells requires the operation of g\u03b1i, g\u03b1q, ca++ channels, ERK1\/2 and PI3K-interconnection between early and late signaling","volume":"11","author":"Wang","year":"2022","journal-title":"Cells"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001211","article-title":"MYO1F regulates IgE and MRGPRX2-dependent mast cell exocytosis","volume":"206","author":"Navin\u00e9s-Ferrer","year":"2021","journal-title":"J Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/FALGY.2022.930233","article-title":"\u03b2-arrestin-1 and \u03b2-arrestin-2 restrain MRGPRX2-triggered degranulation and ERK1\/2 activation in human skin mast cells","volume":"3","author":"Wang","year":"2022","journal-title":"Front Allergy"},{"key":"B18","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1101\/gad.324657.119","article-title":"MITF\u2013the first 25 years","volume":"33","author":"Goding","year":"2019","journal-title":"Genes Dev"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)89143-X","article-title":"Insight into the microphthalmia gene","volume":"11","author":"Moore","year":"1995","journal-title":"Trends Genet"},{"key":"B20","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.immuni.2013.06.012","article-title":"Antagonistic regulation by the transcription factors C\/EBP\u03b1 and MITF specifies basophil and mast cell fates","volume":"39","author":"Qi","year":"2013","journal-title":"Immunity"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00058-5","article-title":"Effect of MITF on mast cell differentiation","volume":"38","author":"Kitamura","year":"2002","journal-title":"Mol Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-293548","article-title":"KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation","volume":"117","author":"Lee","year":"2011","journal-title":"Blood"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00020-2","article-title":"The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in Fc\u0404RI-activated mast cells","volume":"20","author":"Lee","year":"2004","journal-title":"Immunity"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2009.00578.x","article-title":"Frequent mutations in the MITF pathway in melanoma","volume":"22","author":"Cronin","year":"2009","journal-title":"Pigment Cell Melanoma Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2017.9","article-title":"The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology","volume":"97","author":"Kawakami","year":"2017","journal-title":"Lab Investig"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65172-3","article-title":"Microphthalmia transcription factor. a sensitive and specific melanocyte marker for MelanomaDiagnosis","volume":"155","author":"King","year":"1999","journal-title":"Am J Pathol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1791-0","article-title":"MITF in melanoma: mechanisms behind its expression and activity","volume":"72","author":"Hartman","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2006.07.008","article-title":"MITF: master regulator of melanocyte development and melanoma oncogene","volume":"12","author":"Levy","year":"2006","journal-title":"Trends Mol Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.3.301","article-title":"C-kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor mi","volume":"14","author":"Wu","year":"2000","journal-title":"Genes Dev"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.4161\/cc.20765","article-title":"The tumor suppressor HINT1 regulates MITF and \u03b2-catenin transcriptional activity in melanoma cells","volume":"11","author":"Genovese","year":"2012","journal-title":"Cell Cycle"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.10.043","article-title":"The transcription factors GATA2 and microphthalmia-associated transcription factor regulate hdc gene expression in mast cells and are required for IgE\/mast cell\u2013mediated anaphylaxis","volume":"142","author":"Li","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.9.3210","article-title":"Systematic method to obtain novel genes that are regulated bymi transcription factor: impaired expression of granzyme b and tryptophan hydroxylase in mi\/mi cultured mast cells","volume":"91","author":"Ito","year":"1998","journal-title":"Blood"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407026200","article-title":"MITF is necessary for generation of prostaglandin d 2 in mouse mast cells","volume":"279","author":"Morii","year":"2004","journal-title":"J Biol Chem"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.12.637","article-title":"Mutation in KARS: a novel mechanism for severe anaphylaxis","volume":"147","author":"Rib\u00f3","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00343-0","article-title":"Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma\/leukemia; activation following aggregation of Fc\u03f5RI or Fc\u03b3RI","volume":"27","author":"Kirshenbaum","year":"2003","journal-title":"Leuk Res"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-3-294","article-title":"REAP: a two minute cell fractionation method","volume":"3","author":"Suzuki","year":"2010","journal-title":"BMC Res Notes"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200380","article-title":"The adaptor 3BP2 is required for early and late events in Fc\u03f5RI signaling in human mast cells","volume":"189","author":"Ainsua-Enrich","year":"2012","journal-title":"J Immunol"},{"key":"B38","article-title":"A small molecule inhibitor of the MITF molecular pathway","author":"Faloon","year":"2010","journal-title":"Probe Reports from the NIH Molecular Libraries Program"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.05.019","article-title":"LysRS serves as a key signaling molecule in the immune response by regulating gene expression","volume":"34","author":"Yannay-Cohen","year":"2009","journal-title":"Mol Cell"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.08.177","article-title":"Immunoglobulin e-independent activation of mast cell is mediated by mrg receptors","volume":"349","author":"Tatemoto","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"B41","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.jaci.2014.05.004","article-title":"Expression of mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria","volume":"134","author":"Fujisawa","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"4664","DOI":"10.1038\/s41467-019-12710-8","article-title":"Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc\u03f5RI-activated mast cells","volume":"10","author":"Yu","year":"2019","journal-title":"Nat Commun"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810498115","article-title":"BRAF\/MAPK and GSK3 signaling converges to control MITF nuclear export","volume":"115","author":"Ngeow","year":"2018","journal-title":"Proc Natl Acad Sci"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2440","article-title":"Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma","volume":"64","author":"Miller","year":"2004","journal-title":"Cancer Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1600-0560.2010.01504.x","article-title":"The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia-associated transcription factor (MITF) and other melanogenesis-related proteins in normal and pathological skin, hair follicles and melanocytic nevi","volume":"37","author":"Lu","year":"2010","journal-title":"J Cutan Pathol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00762-6","article-title":"Bcl2 regulation by the melanocyte master regulator mitf modulates lineage survival and melanoma cell viability","volume":"109","author":"McGill","year":"2002","journal-title":"Cell"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-022-00539-1","article-title":"The microphthalmia-associated transcription factor is involved in gastrointestinal stromal tumor growth","volume":"30","author":"Proa\u00f1o-P\u00e9rez","year":"2023","journal-title":"Cancer Gene Ther"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030782","article-title":"Uveal melanoma cell line proliferation is inhibited by ricolinostat, a histone deacetylase inhibitor","volume":"14","author":"Sundaramurthi","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B49","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/JLB.3MA1219-210RR","article-title":"A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions","volume":"107","author":"Mencarelli","year":"2020","journal-title":"J Leukoc Biol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACI.2017.05.046","article-title":"A single amino acid in MRGPRX2 necessary for binding and activation by pruritogens","volume":"140","author":"Reddy","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/NCHEMBIO.2334","article-title":"In silico design of novel probes for the atypical opioid receptor MRGPRX2","volume":"13","author":"Lansu","year":"2017","journal-title":"Nat Chem Biol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/NRM2956","article-title":"New functions of aminoacyl-tRNA synthetases beyond translation","volume":"11","author":"Guo","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1982.0050","article-title":"Mast cells in spotted mutant mice (W ph mi)","volume":"215","author":"Stevens","year":"1982","journal-title":"Proc R Soc London - Biol Sci"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/JCP.1041320321","article-title":"Effect of the mi allele on mast cells, basophils, natural killer cells, and osteoclasts in C57Bl\/6J mice","volume":"132","author":"Stechschulte","year":"1987","journal-title":"J Cell Physiol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1159\/000048178","article-title":"Regulation of mast cell phenotype by MITF","volume":"127","author":"Kitamura","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/34681","article-title":"MAP kinase links the transcription factor microphthalmia to c-kit signalling in melanocytes","volume":"391","author":"Hemesath","year":"1998","journal-title":"Nature"},{"key":"B57","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3858\/emm.2010.42.5.038","article-title":"Involvement of MITF-a, an alternative isoform of mi transcription factor, on the expression of tryptase gene in human mast cells","volume":"42","author":"Lee","year":"2010","journal-title":"Exp Mol Med"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424576112","article-title":"MITF drives endolysosomal biogenesis and potentiates wnt signaling in melanoma cells","volume":"112","author":"Ploper","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.1.378","article-title":"Distinct and shared transcriptomes are regulated by microphthalmia-associated transcription factor isoforms in mast cells","volume":"178","author":"Shahlaee","year":"2007","journal-title":"J Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2019.03143\/FULL","article-title":"Store-operated calcium entry via STIM1 contributes to MRGPRX2 induced mast cell functions","volume":"10","author":"Occhiuto","year":"2020","journal-title":"Front Immunol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/J.1582-4934.2010.01168.X","article-title":"Activation and regulation of store-operated calcium entry","volume":"14","author":"Smyth","year":"2010","journal-title":"J Cell Mol Med"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/NI1546","article-title":"Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses","volume":"9","author":"Baba","year":"2008","journal-title":"Nat Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/J.JBC.2022.102681","article-title":"MITF is a novel transcriptional regulator of the calcium sensor STIM1: significance in physiological melanogenesis","volume":"298","author":"Tanwar","year":"2022","journal-title":"J Biol Chem"},{"key":"B64","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jaci.2016.09.047","article-title":"Pyruvate dehydrogenase has a major role in mast cell function, and its activity is regulated by mitochondrial microphthalmia transcription factor","volume":"140","author":"Sharkia","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030589","article-title":"The critical role played by mitochondrial MITF serine 73 phosphorylation in immunologically activated mast cells","volume":"11","author":"Paruchuru","year":"2022","journal-title":"Cells"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-021-00529-0","article-title":"The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis","volume":"11","author":"Oppezzo","year":"2021","journal-title":"Cell Biosci"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD.V88.4.1225.BLOODJOURNAL8841225","article-title":"Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice","volume":"88","author":"Tsujimura","year":"1996","journal-title":"Blood"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.6.1454.1454","article-title":"Low c-kit expression of cultured mast cells of mi\/mi genotype may be involved in their defective responses to fibroblasts that express the ligand for c-kit","volume":"80","author":"Ebi","year":"1992","journal-title":"Blood"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402887","article-title":"The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival","volume":"194","author":"Ainsua-Enrich","year":"2015","journal-title":"J Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1634\/STEMCELLS.2007-0777","article-title":"Thrombopoietin inhibits murine mast cell differentiation","volume":"26","author":"Martelli","year":"2008","journal-title":"Stem Cells"},{"key":"B71","article-title":"Involvement of transcription factor encoded by the mouse mi locus (MITF) in apoptosis of cultured mast cells induced by removal of interleukin-3","volume":"151","author":"Tsujimura","year":"1997","journal-title":"Am J Pathol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V108.11.3601.3601","article-title":"Kit signaling regulates mitf expression in mastocytosis","volume":"108","author":"Lee","year":"2006","journal-title":"Blood"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043515","article-title":"MITF downregulation induces death in human mast cell leukemia cells and impairs IgE-dependent degranulation","volume":"24","author":"Proa\u00f1o-P\u00e9rez","year":"2023","journal-title":"Int J Mol Sci"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1154108\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T17:49:32Z","timestamp":1683740972000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1154108\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,10]]},"references-count":73,"alternative-id":["10.3389\/fimmu.2023.1154108"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1154108","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,10]]},"article-number":"1154108"}}