{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:46:40Z","timestamp":1787168800935,"version":"build-2736575974"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"\n Introduction<\/jats:title>\n \n The opportunistic filamentous fungus\n Aspergillus<\/jats:italic>\n causes invasive pulmonary aspergillosis (IPA) that often turns into a fatal infection in immunocompromised hosts. However, the virulence capacity of different\n Aspergillus<\/jats:italic>\n species and host inflammation induced by different species in IPA are not well understood.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In the present study, host inflammation, antimicrobial susceptibilities and virulence were compared among clinical\n Aspergillus<\/jats:italic>\n strains isolated from IPA patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 46 strains were isolated from 45 patients with the invasive infection, of which 35 patients were diagnosed as IPA.\n Aspergillus flavus<\/jats:italic>\n was the dominant etiological agent appearing in 25 cases (54.3%). We found that the CRP level and leukocyte counts (elevated neutrophilic granulocytes and monocytes, and reduced lymphocytes) were significantly different in IPA patients when compared with healthy individuals (\n P<\/jats:italic>\n &lt; 0.05). Antifungal susceptibilities of these Aspergillus isolates from IPA showed that 91%, 31%, 14%, and 14% were resistant to Fluconazole, Micafungin, Amphotericin B and Terbinafine, respectively. The survival rate of larvae infected by\n A. flavus<\/jats:italic>\n was lower than larvae infected by\n A. niger<\/jats:italic>\n or\n A. fumigatus<\/jats:italic>\n (\n P<\/jats:italic>\n &lt; 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n \n Aspergillus flavus<\/jats:italic>\n was the dominant clinical etiological agent. Given the prevalence of\n A. flavus<\/jats:italic>\n in our local clinical settings, we may face greater challenges when treating IPA patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fimmu.2023.1155184","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T02:04:38Z","timestamp":1680055478000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Virulence capacity of different Aspergillus species from invasive pulmonary 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