{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:33:52Z","timestamp":1793871232976,"version":"4.6.1"},"reference-count":230,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PR00P3_193084"],"award-info":[{"award-number":["PR00P3_193084"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Soil-transmitted helminths affect approximately 1.5 billion people worldwide. However, as no vaccine is currently available for humans, the current strategy for elimination as a public health problem relies on preventive chemotherapy. Despite more than 20 years of intense research effort, the development of human helminth vaccines (HHVs) has not yet come to fruition. Current vaccine development focuses on peptide antigens that trigger strong humoral immunity, with the goal of generating neutralizing antibodies against key parasite molecules. Notably, this approach aims to reduce the pathology of infection, not worm burden, with only partial protection observed in laboratory models. In addition to the typical translational hurdles that vaccines struggle to overcome, HHVs face several challenges (1): helminth infections have been associated with poor vaccine responses in endemic countries, probably due to the strong immunomodulation caused by these parasites, and (2) the target population displays pre-existing type 2 immune responses to helminth products, increasing the likelihood of adverse events such as allergy or anaphylaxis. We argue that such traditional vaccines are unlikely to be successful on their own and that, based on laboratory models, mucosal and cellular-based vaccines could be a way to move forward in the fight against helminth infection. Here, we review the evidence for the role of innate immune cells, specifically the myeloid compartment, in controlling helminth infections. We explore how the parasite may reprogram myeloid cells to avoid killing, notably using excretory\/secretory (ES) proteins and extracellular vesicles (EVs). Finally, learning from the field of tuberculosis, we will discuss how anti-helminth innate memory could be harnessed in a mucosal-trained immunity-based vaccine.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1163364","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T13:08:07Z","timestamp":1685538487000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["How to train your myeloid cells: a way forward for helminth vaccines?"],"prefix":"10.3389","volume":"14","author":[{"given":"Rory","family":"Doolan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namitha","family":"Putananickal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucienne","family":"Tritten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Bouchery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1017\/S0031182020000426","article-title":"Assessing anthelmintic resistance risk in the post-genomic era: a proof-of-concept study assessing the potential for widespread benzimidazole-resistant gastrointestinal nematodes in north American cattle and bison","volume":"147","author":"Avramenko","year":"2020","journal-title":"Parasitology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S332378","article-title":"Anthelmintic resistance and its mechanism: a review","volume":"14","author":"Fissiha","year":"2021","journal-title":"Infect Drug Resist"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182099005727","article-title":"Vaccine development and diagnostics of dictyocaulus viviparus","author":"McKeand","year":"2000","journal-title":"Parasitology"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8030555","article-title":"Advances in the development of anti-haemonchus contortus vaccines: challenges, opportunities, and perspectives","volume":"8","author":"Ehsan","year":"2020","journal-title":"Vaccines (Basel)"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2019.10.001","article-title":"Helminth vaccines in ruminants: from development to application","volume":"36","author":"Claerebout","year":"2020","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2021.1999810","article-title":"Identifying novel candidates and configurations for human helminth vaccines","volume":"20","author":"Maizels","year":"2021","journal-title":"Expert Rev Vaccines"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.11.034","article-title":"The human hookworm vaccine","volume":"31","author":"Hotez","year":"2013","journal-title":"Vaccine"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2016.1131127","article-title":"Development of a schistosomiasis vaccine","volume":"15","author":"Molehin","year":"2016","journal-title":"Expert Rev Vaccines"},{"key":"B9","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.pt.2016.10.010","article-title":"Sm-p80-Based schistosomiasis vaccine: preparation for human clinical trials","volume":"33","author":"Siddiqui","year":"2017","journal-title":"Trends Parasitol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2018.11.006","article-title":"Trials with the haemonchus vaccine, Barbervax((R)), in ewes and lambs in a tropical environment: nutrient supplementation improves protection in periparturient ewes","volume":"264","author":"Bassetto","year":"2018","journal-title":"Vet Parasitol"},{"key":"B11","unstructured":""},{"key":"B12","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jaci.2012.04.027","article-title":"Generalized urticaria induced by the Na-ASP-2 hookworm vaccine: implications for the development of vaccines against helminths","volume":"130","author":"Diemert","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009732","article-title":"Characterization of T cell responses to co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in healthy adults in Gabon","volume":"15","author":"Mouwenda","year":"2021","journal-title":"PloS Negl Trop Dis"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204351","article-title":"Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation","volume":"332","author":"Jenkins","year":"2011","journal-title":"Science"},{"key":"B15","doi-asserted-by":"publisher","first-page":"6970","DOI":"10.1038\/ncomms7970","article-title":"ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms","volume":"6","author":"Bouchery","year":"2015","journal-title":"Nat Commun"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2984","article-title":"Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion","volume":"15","author":"Chen","year":"2014","journal-title":"Nat Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003771","article-title":"Antibodies trap tissue migrating helminth larvae and prevent tissue damage by driving IL-4Ralpha-independent alternative differentiation of macrophages","volume":"9","author":"Esser-von Bieren","year":"2013","journal-title":"PloS Pathog"},{"key":"B18","doi-asserted-by":"publisher","first-page":"34","DOI":"10.33160\/yam.2020.02.005","article-title":"Alternative activation of macrophages in mice peritoneal cavities and diaphragms by newborn larvae of trichinella spiralis","volume":"63","author":"Itami","year":"2020","journal-title":"Yonago Acta Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"6547","DOI":"10.1038\/s41598-019-43057-1","article-title":"Adoptive transfer of trichinella spiralis-activated macrophages can ameliorate both Th1- and Th2-activated inflammation in murine models","volume":"9","author":"Kang","year":"2019","journal-title":"Sci Rep"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00107-4","article-title":"Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology","volume":"20","author":"Herbert","year":"2004","journal-title":"Immunity"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.aai8132","article-title":"Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells","volume":"356","author":"Bosurgi","year":"2017","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaj2067","article-title":"Local amplifiers of IL-4Ralpha-mediated macrophage activation promote repair in lung and liver","volume":"356","author":"Minutti","year":"2017","journal-title":"Science"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005461","article-title":"Surfactant protein-d is essential for immunity to helminth infection","volume":"12","author":"Thawer","year":"2016","journal-title":"PloS Pathog"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0352-y","article-title":"The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation","volume":"20","author":"Svedberg","year":"2019","journal-title":"Nat Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"110215","DOI":"10.1016\/j.celrep.2021.110215","article-title":"Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion","volume":"38","author":"Chen","year":"2022","journal-title":"Cell Rep"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.866373","article-title":"Unbalanced arginine pathway and altered maturation of pleural macrophages in Th2-deficient mice during litomosoides sigmodontis filarial infection","volume":"13","author":"Remion","year":"2022","journal-title":"Front Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.150.6.1456","article-title":"Interactions between human eosinophils and schistosomula of Schistosoma mansoni. II. The mechanism of irreversible eosinophil adherence","volume":"150","author":"Butterworth","year":"1979","journal-title":"J Exp Med."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004676","article-title":"Concerted activity of IgG1 antibodies and IL-4\/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection","volume":"11","author":"Hewitson","year":"2015","journal-title":"PloS Pathog"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2007.04.006","article-title":"Impaired resistance in early secondary nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis","volume":"37","author":"Knott","year":"2007","journal-title":"Int J Parasitol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1996.0034","article-title":"Strongyloides stercoralis: eosinophil-dependent immune-mediated killing of third stage larvae in BALB\/cByJ mice","volume":"82","author":"Rotman","year":"1996","journal-title":"Exp Parasitol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-015933","article-title":"Schistosoma mansoni infection in eosinophil lineage-ablated mice","volume":"108","author":"Swartz","year":"2006","journal-title":"Blood"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000525","article-title":"Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy","volume":"8","author":"Babayan","year":"2010","journal-title":"PloS Biol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/s13071-019-3502-z","article-title":"Susceptibility to l. sigmodontis infection is highest in animals lacking IL-4R\/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils","volume":"12","author":"Frohberger","year":"2019","journal-title":"Parasit Vectors."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-021-00851-2","article-title":"Intestinal eosinophils: multifaceted roles in tissue homeostasis and disease","volume":"43","author":"Coakley","year":"2021","journal-title":"Semin Immunopathol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0102-8","article-title":"Intestinal helminth infection promotes IL-5- and CD4(+) T cell-dependent immunity in the lung against migrating parasites","volume":"12","author":"Filbey","year":"2019","journal-title":"Mucosal Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02132","article-title":"Nematode-infected mice acquire resistance to subsequent infection with unrelated nematode by inducing highly responsive group 2 innate lymphoid cells in the lung","volume":"9","author":"Yasuda","year":"2018","journal-title":"Front Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.immuni.2022.05.014","article-title":"Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization","volume":"55","author":"Ignacio","year":"2022","journal-title":"Immunity"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1989.tb00667.x","article-title":"The action of a mast cell protease on the cuticular collagens of necator americanus","volume":"11","author":"McKean","year":"1989","journal-title":"Parasite Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.immuni.2017.04.017","article-title":"Mast cells are crucial for induction of group 2 innate lymphoid cells and clearance of helminth infections","volume":"46","author":"Shimokawa","year":"2017","journal-title":"Immunity"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646738","article-title":"Acute infection with the intestinal parasite trichuris muris has long-term consequences on mucosal mast cell homeostasis and epithelial integrity","volume":"47","author":"Sorobetea","year":"2017","journal-title":"Eur J Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10080925","article-title":"Trichuris muris model: role in understanding intestinal immune response, inflammation and host defense","volume":"10","author":"Yousefi","year":"2021","journal-title":"Pathogens"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181771","article-title":"Role of mast cells in the generation of a T-helper type 2 dominated anti-helminthic immune response","volume":"39","author":"Ryan","year":"2019","journal-title":"Biosci Rep"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.56","article-title":"Mucosal mast cells are indispensable for the timely termination of strongyloides ratti infection","volume":"10","author":"Reitz","year":"2017","journal-title":"Mucosal Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"101529","DOI":"10.1016\/j.smim.2021.101529","article-title":"Basophils in antihelminth immunity","volume":"53","author":"Peng","year":"2021","journal-title":"Semin Immunol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200691","article-title":"Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection","volume":"189","author":"Giacomin","year":"2012","journal-title":"J Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130761","article-title":"The skin is an important bulwark of acquired immunity against intestinal helminths","volume":"210","author":"Obata-Ninomiya","year":"2013","journal-title":"J Exp Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1412663111","article-title":"Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion","volume":"111","author":"Schwartz","year":"2014","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006992","article-title":"Basophils are dispensable for the establishment of protective adaptive immunity against primary and challenge infection with the intestinal helminth parasite strongyloides ratti","volume":"12","author":"Reitz","year":"2018","journal-title":"PloS Negl Trop Dis"},{"key":"B49","doi-asserted-by":"publisher","first-page":"296","DOI":"10.4049\/immunohorizons.1800018","article-title":"Basophils are dispensable for the control of a filarial infection","volume":"2","author":"Hartmann","year":"2018","journal-title":"Immunohorizons"},{"key":"B50","doi-asserted-by":"publisher","first-page":"979491","DOI":"10.3389\/fimmu.2022.979491","article-title":"A newly identified secreted larval antigen elicits basophil-dependent protective immunity against n","volume":"13","author":"Thuma","year":"2022","journal-title":"brasiliensis infection. Front Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"87","DOI":"10.4269\/ajtmh.2003.69.87","article-title":"Lack of basophilia in human parasitic infections","volume":"69","author":"Mitre","year":"2003","journal-title":"Am J Trop Med Hyg"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-020-0318-2","article-title":"IL-17A both initiates, via IFNgamma suppression, and limits the pulmonary type-2 immune response to nematode infection","volume":"13","author":"Ajendra","year":"2020","journal-title":"Mucosal Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2628","article-title":"An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection","volume":"18","author":"Chen","year":"2012","journal-title":"Nat Med"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.715766","article-title":"Eosinophils and neutrophils eliminate migrating strongyloides ratti larvae at the site of infection in the context of extracellular DNA trap formation","volume":"12","author":"Ehrens","year":"2021","journal-title":"Front Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1981.tb00414.x","article-title":"Morphological studies on the killing of schistosomula of schistosoma mansoni by human eosinophil and neutrophil cationic proteins in vitro","volume":"3","author":"McLaren","year":"1981","journal-title":"Parasite Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003988","article-title":"Eosinophils are important for protection, immunoregulation and pathology during infection with nematode microfilariae","volume":"10","author":"Cadman","year":"2014","journal-title":"PloS Pathog"},{"key":"B57","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.chom.2021.02.004","article-title":"Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection","volume":"29","author":"Chetty","year":"2021","journal-title":"Cell Host Microbe"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.144.8.3166","article-title":"In vitro killing of microfilariae of brugia pahangi and brugia malayi by eosinophil granule proteins","volume":"144","author":"Hamann","year":"1990","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1984.33.104","article-title":"Human neutrophil-mediated killing of schistosomula of schistosoma mansoni: augmentation by schistosomal binding of eosinophil peroxidase","volume":"33","author":"Jong","year":"1984","journal-title":"Am J Trop Med Hyg"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.04.008","article-title":"Itch: a paradigm of neuroimmune crosstalk","volume":"52","author":"Wang","year":"2020","journal-title":"Immunity"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/nature13199","article-title":"Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation","volume":"510","author":"Riol-Blanco","year":"2014","journal-title":"Nature"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxab076","article-title":"The interaction between the immune system and the peripheral sensory nerves in pruritus","volume":"33","author":"Irie","year":"2021","journal-title":"Int Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.08.016","article-title":"Nociceptive sensory fibers drive interleukin-23 production from CD301b+ dermal dendritic cells and drive protective cutaneous immunity","volume":"43","author":"Kashem","year":"2015","journal-title":"Immunity"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132336","article-title":"Leukotriene B4 amplifies eosinophil accumulation in response to nematodes","volume":"211","author":"Patnode","year":"2014","journal-title":"J Exp Med"},{"key":"B65","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1051\/parasite\/198762147","article-title":"Macrophage-nematode interaction in vivo: nippostrongylus brasiliensis infective larvae in the peritoneum of unsensitized rats","volume":"62","author":"Wertheim","year":"1987","journal-title":"Ann Parasitol Hum Comp"},{"key":"B66","article-title":"The cellular responses of the rat to an intraperitoneal inoculation of nippostrongylus brasiliensis larvae","volume":"24","author":"Greenberg","year":"1973","journal-title":"Immunology"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073793","article-title":"The expanding role of extracellular traps in inflammation and autoimmunity: the new players in casting dark webs","volume":"23","author":"Huang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.621311","article-title":"Multiple origins of extracellular DNA traps","volume":"12","author":"Ramos-Martinez","year":"2021","journal-title":"Front Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12911","article-title":"Hookworm infections: reappraising the evidence for a role of neutrophils in light of NETosis","volume":"44","author":"Doolan","year":"2022","journal-title":"Parasite Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"101531","DOI":"10.1016\/j.smim.2021.101531","article-title":"Lessons in type 2 immunity: neutrophils in helminth infections","volume":"53","author":"Ajendra","year":"2021","journal-title":"Semin Immunol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2014.02.012","article-title":"Extracellular traps are associated with human and mouse neutrophil and macrophage mediated killing of larval strongyloides stercoralis","volume":"16","author":"Bonne-Annee","year":"2014","journal-title":"Microbes Infect"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12572","article-title":"Ovine vital neutrophil extracellular traps bind and impair haemonchus contortus L3 in a breed-dependent manner","volume":"40","author":"Garza","year":"2018","journal-title":"Parasite Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1186\/s13071-015-1219-1","article-title":"Leucocyte-derived extracellular trap formation significantly contributes to haemonchus contortus larval entrapment","volume":"8","author":"Munoz-Caro","year":"2015","journal-title":"Parasit Vectors."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005279","article-title":"Human leukocytes kill brugia malayi microfilariae independently of DNA-based extracellular trap release","volume":"11","author":"McCoy","year":"2017","journal-title":"PloS Negl Trop Dis"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00968","article-title":"Dirofilaria immitis microfilariae and third-stage larvae induce canine NETosis resulting in different types of neutrophil extracellular traps","volume":"9","author":"Munoz-Caro","year":"2018","journal-title":"Front Immunol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"35559","DOI":"10.1038\/srep35559","article-title":"Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis","volume":"6","author":"Tamarozzi","year":"2016","journal-title":"Sci Rep"},{"key":"B77","doi-asserted-by":"publisher","first-page":"17598","DOI":"10.1038\/s41598-018-36070-3","article-title":"Bovine neutrophils form extracellular traps in response to the gastrointestinal parasite ostertagia ostertagi","volume":"8","author":"Mendez","year":"2018","journal-title":"Sci Rep"},{"key":"B78","doi-asserted-by":"publisher","first-page":"103787","DOI":"10.1016\/j.dci.2020.103787","article-title":"Fasciola hepatica induces weak NETosis and low production of intra- and extracellular ROS in exposed bovine polymorphonuclear neutrophils","volume":"114","author":"Peixoto","year":"2021","journal-title":"Dev Comp Immunol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"102178","DOI":"10.1016\/j.parint.2020.102178","article-title":"Natural nodular worm infection in goats induces eosinophil extracellular DNA trap (EET) formation","volume":"79","author":"Anisuzzaman","year":"2020","journal-title":"Parasitol Int"},{"key":"B80","doi-asserted-by":"publisher","first-page":"108283","DOI":"10.1016\/j.exppara.2022.108283","article-title":"Determination of extracellular traps structures from sheep polymorphonuclear leukocytes to echinococcus granulosus protoscoleces","volume":"239","author":"Yildiz","year":"2022","journal-title":"Exp Parasitol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1212653","article-title":"Spatial and temporal transcriptomics of schistosoma japonicum-induced hepatic granuloma formation reveals novel roles for neutrophils","volume":"94","author":"Chuah","year":"2013","journal-title":"J Leukoc Biol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.chom.2020.01.011","article-title":"Hookworms evade host immunity by secreting a deoxyribonuclease to degrade neutrophil extracellular traps","volume":"27","author":"Bouchery","year":"2020","journal-title":"Cell Host Microbe"},{"key":"B83","doi-asserted-by":"publisher","first-page":"108621","DOI":"10.1016\/j.celrep.2020.108621","article-title":"Microfilariae trigger eosinophil extracellular DNA traps in a dectin-1-Dependent manner","volume":"34","author":"Ehrens","year":"2021","journal-title":"Cell Rep"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.03.016","article-title":"Host liver-derived extracellular vesicles deliver miR-142a-3p induces neutrophil extracellular traps via targeting WASL to block the development of schistosoma japonicum","volume":"30","author":"Wang","year":"2022","journal-title":"Mol Ther"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.10.016","article-title":"Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules","volume":"49","author":"Maizels","year":"2018","journal-title":"Immunity"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/nri3476","article-title":"Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths","volume":"13","author":"Gause","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600063","article-title":"Downregulation of the syk signaling pathway in intestinal dendritic cells is sufficient to induce dendritic cells that inhibit colitis","volume":"197","author":"Hang","year":"2016","journal-title":"J Immunol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425167","article-title":"Selective maturation of dendritic cells by nippostrongylus brasiliensis-secreted proteins drives Th2 immune responses","volume":"34","author":"Balic","year":"2004","journal-title":"Eur J Immunol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400374","article-title":"Helminth-conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo","volume":"193","author":"Connor","year":"2014","journal-title":"J Immunol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1128\/IAI.73.1.395-402.2005","article-title":"Dendritic cells activated with products released by schistosome larvae drive Th2-type immune responses, which can be inhibited by manipulation of CD40 costimulation","volume":"73","author":"Jenkins","year":"2005","journal-title":"Infect Immun"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2018.08.004","article-title":"Dectin-1 on macrophages modulates the immune response to fasciola hepatica products through the ERK signaling pathway","volume":"223","author":"Guasconi","year":"2018","journal-title":"Immunobiology"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00011","article-title":"Trichinella spiralis excretory-secretory products induce tolerogenic properties in human dendritic cells via toll-like receptors 2 and 4","volume":"9","author":"Ilic","year":"2018","journal-title":"Front Immunol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines7040085","article-title":"Cystatin from filarial parasites suppress the clinical symptoms and pathology of experimentally induced colitis in mice by inducing T-regulatory cells, B1-cells, and alternatively activated macrophages","volume":"7","author":"Bisht","year":"2019","journal-title":"Biomedicines"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.6.3207","article-title":"Modulation of human T cell responses and macrophage functions by onchocystatin, a secreted protein of the filarial nematode onchocerca volvulus","volume":"167","author":"Schonemeyer","year":"2001","journal-title":"J Immunol"},{"key":"B95","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.molbiopara.2004.11.008","article-title":"Bm-CPI-2, a cystatin from brugia malayi nematode parasites, differs from caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP","volume":"139","author":"Murray","year":"2005","journal-title":"Mol Biochem Parasitol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13071-015-1288-1","article-title":"Therapeutic potential of recombinant cystatin from schistosoma japonicum in TNBS-induced experimental colitis of mice","volume":"9","author":"Wang","year":"2016","journal-title":"Parasit Vectors."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008192","article-title":"A novel cystatin derived from trichinella spiralis suppresses macrophage-mediated inflammatory responses","volume":"14","author":"Kobpornchai","year":"2020","journal-title":"PloS Negl Trop Dis"},{"key":"B98","doi-asserted-by":"publisher","first-page":"108907","DOI":"10.1016\/j.intimp.2022.108907","article-title":"Trichinella spiralis cystatin alleviates polymicrobial sepsis through activating regulatory macrophages","volume":"109","author":"Li","year":"2022","journal-title":"Int Immunopharmacol."},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.060368","article-title":"Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3","volume":"285","author":"Donnelly","year":"2010","journal-title":"J Biol Chem"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12049","article-title":"Modulation of dendritic cell function and immune response by cysteine protease inhibitor from murine nematode parasite heligmosomoides polygyrus","volume":"138","author":"Sun","year":"2013","journal-title":"Immunology"},{"key":"B101","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13071-016-1962-y","article-title":"Characterization of schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function","volume":"10","author":"Ke","year":"2017","journal-title":"Parasit Vectors."},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401864","article-title":"Treatment with recombinant trichinella spiralis cathepsin b-like protein ameliorates intestinal Ischemia\/Reperfusion injury in mice by promoting a switch from M1 to M2 macrophages","volume":"195","author":"Liu","year":"2015","journal-title":"J Immunol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02015","article-title":"Trichinella spiralis thioredoxin peroxidase 2 regulates protective Th2 immune response in mice by directly inducing alternatively activated macrophages","volume":"11","author":"Jin","year":"2020","journal-title":"Front Immunol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01834","article-title":"Recombinant trichinella pseudospiralis serine protease inhibitors alter macrophage polarization in vitro","volume":"8","author":"Xu","year":"2017","journal-title":"Front Microbiol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1038\/s41598-020-60155-7","article-title":"Effect of t. spiralis serine protease inhibitors on TNBS-induced experimental colitis mediated by macrophages","volume":"10","author":"Xu","year":"2020","journal-title":"Sci Rep"},{"key":"B106","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1051\/parasite\/2022016","article-title":"Molecular characterization of a novel GSTO2 of fasciola hepatica and its roles in modulating murine macrophages","volume":"29","author":"Wang","year":"2022","journal-title":"Parasite"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.10.200","article-title":"Filarial thioredoxin reductase exerts anti-inflammatory effects upon lipopolysaccharide induced inflammation in macrophages","volume":"193","author":"Joardar","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-022-07495-7","article-title":"Crude protein fraction with high thioredoxin reductase (TrxR) enzyme activity from filarial parasite setaria cervi counters lipopolysaccharide (LPS)-induced inflammation in macrophages","volume":"121","author":"Joardar","year":"2022","journal-title":"Parasitol Res"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1017\/S003118201900115X","article-title":"Glutathione-s-transferase of trichinella spiralis regulates maturation and function of dendritic cells","volume":"146","author":"Jin","year":"2019","journal-title":"Parasitology"},{"key":"B110","doi-asserted-by":"publisher","first-page":"362ra143","DOI":"10.1126\/scitranslmed.aaf8807","article-title":"Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma","volume":"8","author":"Navarro","year":"2016","journal-title":"Sci Transl Med"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006438","article-title":"Profiling extracellular vesicle release by the filarial nematode brugia malayi reveals sex-specific differences in cargo and a sensitivity to ivermectin","volume":"12","author":"Harischandra","year":"2018","journal-title":"PloS Negl Trop Dis"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0808459","article-title":"MIF homologues from a filarial nematode parasite synergize with IL-4 to induce alternative activation of host macrophages","volume":"85","author":"Prieto-Lafuente","year":"2009","journal-title":"J Leukoc Biol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay0605","article-title":"An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products","volume":"12","author":"de Los Reyes Jimenez","year":"2020","journal-title":"Sci Transl Med"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.69","article-title":"A double edged sword: schistosoma mansoni Sm29 regulates both Th1 and Th2 responses in inflammatory mucosal diseases","volume":"9","author":"Oliveira","year":"2016","journal-title":"Mucosal Immunol"},{"key":"B115","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1038\/s41467-019-09996-z","article-title":"The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function","volume":"10","author":"Bancroft","year":"2019","journal-title":"Nat Commun"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202154096","article-title":"Helminthic dehydrogenase drives PGE(2) and IL-10 production in monocytes to potentiate treg induction","volume":"23","author":"Prodjinotho","year":"2022","journal-title":"EMBO Rep"},{"key":"B117","doi-asserted-by":"publisher","first-page":"106615","DOI":"10.1016\/j.actatropica.2022.106615","article-title":"A secreted MIF homologue from trichinella spiralis binds to and interacts with host monocytes","volume":"234","author":"Huang","year":"2022","journal-title":"Acta Trop"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00851-18","article-title":"Hookworm-derived metabolites suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes","volume":"87","author":"Wangchuk","year":"2019","journal-title":"Infect Immun"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molbiopara.2014.03.003","article-title":"ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode acanthocheilonema viteae","volume":"194","author":"Pineda","year":"2014","journal-title":"Mol Biochem Parasitol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00926.x","article-title":"Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells","volume":"29","author":"Goodridge","year":"2007","journal-title":"Parasite Immunol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2016.11.006","article-title":"Schistosomal-derived lysophosphatidylcholine triggers M2 polarization of macrophages through PPARgamma dependent mechanisms","volume":"1862","author":"Assuncao","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids."},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2017.11.058","article-title":"The schistosoma mansoni lipidome: leads for immunomodulation","volume":"1037","author":"Giera","year":"2018","journal-title":"Anal Chim Acta"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600841R","article-title":"The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells","volume":"31","author":"Laan","year":"2017","journal-title":"FASEB J"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00332","article-title":"Hemozoin from the liver fluke, opisthorchis felineus, modulates dendritic cell responses in bronchial asthma patients","volume":"6","author":"Saltykova","year":"2019","journal-title":"Front Vet Sci"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00701-12","article-title":"Schistosoma mansoni hemozoin modulates alternative activation of macrophages via specific suppression of retnla expression and secretion","volume":"81","author":"Truscott","year":"2013","journal-title":"Infect Immun"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1038\/s41467-017-01886-6","article-title":"A structurally distinct TGF-beta mimic from an intestinal helminth parasite potently induces regulatory T cells","volume":"8","author":"Johnston","year":"2017","journal-title":"Nat Commun"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.974332","article-title":"Extracellular vesicles derived from trichinella spiralis larvae promote the polarization of macrophages to M2b type and inhibit the activation of fibroblasts","volume":"13","author":"Wu","year":"2022","journal-title":"Front Immunol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"105761","DOI":"10.1016\/j.actatropica.2020.105761","article-title":"Extracellular vesicles derived from trichinella spiralis prevent colitis by inhibiting M1 macrophage polarization","volume":"213","author":"Gao","year":"2021","journal-title":"Acta Trop"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006870","article-title":"Schistosoma mansoni SmKI-1 serine protease inhibitor binds to elastase and impairs neutrophil function and inflammation","volume":"14","author":"Morais","year":"2018","journal-title":"PloS Pathog"},{"key":"B130","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1186\/s13071-015-1022-z","article-title":"Functional expression of a novel kunitz type protease inhibitor from the human blood fluke schistosoma mansoni","volume":"8","author":"Ranasinghe","year":"2015","journal-title":"Parasit Vectors."},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004268","article-title":"Cloning and characterization of two potent kunitz type protease inhibitors from echinococcus granulosus","volume":"9","author":"Ranasinghe","year":"2015","journal-title":"PloS Negl Trop Dis"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.572326","article-title":"Trichinella spiralis calreticulin s-domain binds to human complement C1q to interfere with C1q-mediated immune functions","volume":"11","author":"Shao","year":"2020","journal-title":"Front Immunol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aar6689","article-title":"Gasdermin d plays a vital role in the generation of neutrophil extracellular traps","volume":"3","author":"Sollberger","year":"2018","journal-title":"Sci Immunol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36982-X","article-title":"A hookworm glycoprotein that inhibits neutrophil function is a ligand of the integrin CD11b\/CD18","volume":"269","author":"Moyle","year":"1994","journal-title":"J Biol Chem"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2007.11.014","article-title":"Necator americanus: the Na-ASP-2 protein secreted by the infective larvae induces neutrophil recruitment in vivo and in vitro","volume":"118","author":"Bower","year":"2008","journal-title":"Exp Parasitol"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X14000200","article-title":"Immunosuppressive PAS-1 is an excretory\/secretory protein released by larval and adult worms of the ascarid nematode ascaris suum","volume":"89","author":"Antunes","year":"2015","journal-title":"J Helminthol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/j.1365-3083.2010.02465.x","article-title":"PAS-1, an ascaris suum protein, modulates allergic airway inflammation via CD8+gammadeltaTCR+ and CD4+CD25+FoxP3+ T cells","volume":"72","author":"de Araujo","year":"2010","journal-title":"Scand J Immunol"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02268.x","article-title":"Modulation of murine experimental asthma by ascaris suum components","volume":"35","author":"Itami","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1038\/nm1654","article-title":"Inhibition of fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes","volume":"13","author":"Melendez","year":"2007","journal-title":"Nat Med"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1086\/656477","article-title":"Schistosomal-derived lysophosphatidylcholine are involved in eosinophil activation and recruitment through toll-like receptor-2-dependent mechanisms","volume":"202","author":"Magalhaes","year":"2010","journal-title":"J Infect Dis"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03161","article-title":"Schistosomal lipids activate human eosinophils via toll-like receptor 2 and PGD(2) receptors: 15-LO role in cytokine secretion","volume":"9","author":"Magalhaes","year":"2018","journal-title":"Front Immunol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.4161\/viru.22832","article-title":"How helminths use excretory secretory fractions to modulate dendritic cells","volume":"3","author":"White","year":"2012","journal-title":"Virulence"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001248","article-title":"A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages","volume":"7","author":"Klotz","year":"2011","journal-title":"PloS Pathog"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2021.695262","article-title":"Allergological importance of invertebrate glutathione transferases in tropical environments","volume":"2","author":"Zakzuk","year":"2021","journal-title":"Front Allergy"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.1c00428","article-title":"Identification of small molecules of the infective stage of human hookworm using LCMS-based metabolomics and lipidomics protocols","volume":"7","author":"Wangchuk","year":"2021","journal-title":"ACS Infect Dis"},{"key":"B146","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s11306-019-1561-y","article-title":"Metabolomic profiling of the excretory-secretory products of hookworm and whipworm","volume":"15","author":"Wangchuk","year":"2019","journal-title":"Metabolomics"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10110446","article-title":"Metabolomes and lipidomes of the infective stages of the gastrointestinal nematodes, nippostrongylus brasiliensis and trichuris muris","volume":"10","author":"Yeshi","year":"2020","journal-title":"Metabolites"},{"key":"B148","doi-asserted-by":"publisher","first-page":"100018","DOI":"10.1016\/j.crpvbd.2021.100018","article-title":"Helminth lipidomics: technical aspects and future prospects","volume":"1","author":"Wang","year":"2021","journal-title":"Curr Res Parasitol Vector Borne Dis"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2016.10.005","article-title":"Schistosoma hemozoin and its possible roles","volume":"47","author":"Xiao","year":"2017","journal-title":"Int J Parasitol"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2015.12.003","article-title":"Hemozoin is a product of heme detoxification in the gut of the most medically important species of the family opisthorchiidae","volume":"46","author":"Lvova","year":"2016","journal-title":"Int J Parasitol"},{"key":"B151","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1186\/s13071-015-1061-5","article-title":"Hemozoin \"knobs\" in opisthorchis felineus infected liver","volume":"8","author":"Pershina","year":"2015","journal-title":"Parasit Vectors."},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006931","article-title":"A novel blood-feeding detoxification pathway in nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development","volume":"14","author":"Bouchery","year":"2018","journal-title":"PloS Pathog"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00763-8","article-title":"The roles of extracellular vesicles in the immune system","volume":"23","author":"Buzas","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00460-3","article-title":"Challenges and directions in studying cell-cell communication by extracellular vesicles","volume":"23","author":"van Niel","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02349","article-title":"Immunomodulation by helminths: intracellular pathways and extracellular vesicles","volume":"9","author":"Zakeri","year":"2018","journal-title":"Front Immunol"},{"key":"B157","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1038\/s41467-021-22126-y","article-title":"Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells","volume":"12","author":"Bonsergent","year":"2021","journal-title":"Nat Commun"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.041152","article-title":"Microenvironmental pH is a key factor for exosome traffic in tumor cells","volume":"284","author":"Parolini","year":"2009","journal-title":"J Biol Chem"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007087","article-title":"Surface molecules of extracellular vesicles secreted by the helminth pathogen fasciola hepatica direct their internalisation by host cells","volume":"13","author":"de la Torre-Escudero","year":"2019","journal-title":"PloS Negl Trop Dis"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2020.04.010","article-title":"The protein and microRNA cargo of extracellular vesicles from parasitic helminths - current status and research priorities","volume":"50","author":"Sotillo","year":"2020","journal-title":"Int J Parasitol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007817","article-title":"Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism","volume":"15","author":"Liu","year":"2019","journal-title":"PloS Pathog"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007811","article-title":"Comparative analysis of small RNAs released by the filarial nematode litomosoides sigmodontis in vitro and in vivo","volume":"13","author":"Quintana","year":"2019","journal-title":"PloS Negl Trop Dis"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2020.04.011","article-title":"Extracellular vesicles: new targets for vaccines against helminth parasites","volume":"50","author":"Drurey","year":"2020","journal-title":"Int J Parasitol"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12479","article-title":"The parasite cytokine mimic hp-TGM potently replicates the regulatory effects of TGF-beta on murine CD4(+) T cells","volume":"99","author":"White","year":"2021","journal-title":"Immunol Cell Biol"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpara.2015.09.002","article-title":"Extracellular vesicles secreted by schistosoma mansoni contain protein vaccine candidates","volume":"46","author":"Sotillo","year":"2016","journal-title":"Int J Parasitol"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3965","article-title":"Towards a molecular understanding of microRNA-mediated gene silencing","volume":"16","author":"Jonas","year":"2015","journal-title":"Nat Rev Genet"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11010061","article-title":"microRNAs: critical players during helminth infections","volume":"11","author":"Rojas-Pirela","year":"2022","journal-title":"Microorganisms"},{"key":"B168","doi-asserted-by":"publisher","first-page":"5488","DOI":"10.1038\/ncomms6488","article-title":"Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity","volume":"5","author":"Buck","year":"2014","journal-title":"Nat Commun"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00850","article-title":"Hookworm secreted extracellular vesicles interact with host cells and prevent inducible colitis in mice","volume":"9","author":"Eichenberger","year":"2018","journal-title":"Front Immunol"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.05.001","article-title":"Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity","volume":"19","author":"Coakley","year":"2017","journal-title":"Cell Rep"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004069","article-title":"Release of small RNA-containing exosome-like vesicles from the human filarial parasite brugia malayi","volume":"9","author":"Zamanian","year":"2015","journal-title":"PloS Negl Trop Dis"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201947882","article-title":"Schistosomal extracellular vesicle-enclosed miRNAs modulate host T helper cell differentiation","volume":"21","author":"Meningher","year":"2020","journal-title":"EMBO Rep"},{"key":"B173","doi-asserted-by":"publisher","first-page":"6712","DOI":"10.1038\/s41598-021-86125-1","article-title":"Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses","volume":"11","author":"Tran","year":"2021","journal-title":"Sci Rep"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.909312","article-title":"Nematode microRNAs can individually regulate interferon regulatory factor 4 and mTOR in differentiating T helper 2 lymphocytes and modulate cytokine production in macrophages","volume":"9","author":"Soichot","year":"2022","journal-title":"Front Mol Biosci"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008884","article-title":"Extracellular vesicles released from the filarial parasite brugia malayi downregulate the host mTOR pathway","volume":"15","author":"Ricciardi","year":"2021","journal-title":"PloS Negl Trop Dis"},{"key":"B176","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.vetpar.2017.01.012","article-title":"Regulatory effects of echinococcus multilocularis extracellular vesicles on RAW264.7 macrophages","volume":"235","author":"Zheng","year":"2017","journal-title":"Vet Parasitol"},{"key":"B177","doi-asserted-by":"publisher","first-page":"12718","DOI":"10.1038\/s41598-021-92001-9","article-title":"Helminth derived factors inhibit neutrophil extracellular trap formation and inflammation in bacterial peritonitis","volume":"11","author":"Chauhan","year":"2021","journal-title":"Sci Rep"},{"key":"B178","doi-asserted-by":"publisher","first-page":"104630","DOI":"10.1016\/j.cellimm.2022.104630","article-title":"Trichinella spiralis excretory-secretory antigens selectively inhibit the release of extracellular traps from neutrophils without affecting their additional antimicrobial functions","volume":"382","author":"Rios-Lopez","year":"2022","journal-title":"Cell Immunol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009828","article-title":"Mining nematode protein secretomes to explain lifestyle and host specificity","volume":"15","author":"Tritten","year":"2021","journal-title":"PloS Negl Trop Dis"},{"key":"B180","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.molbiopara.2008.11.002","article-title":"Peroxiredoxin-1 from schistosoma japonicum functions as a scavenger against hydrogen peroxide but not nitric oxide","volume":"164","author":"Kumagai","year":"2009","journal-title":"Mol Biochem Parasitol"},{"key":"B181","doi-asserted-by":"publisher","first-page":"4497","DOI":"10.1038\/s41598-018-22716-9","article-title":"IL-33\/ST2 signalling and crosstalk with FcepsilonRI and TLR4 is targeted by the parasitic worm product, ES-62","volume":"8","author":"Ball","year":"2018","journal-title":"Sci Rep"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204114200","article-title":"Cloning and characterization of a calcium-binding, histamine-releasing protein from schistosoma mansoni","volume":"277","author":"Rao","year":"2002","journal-title":"J Biol Chem"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2004.11.006","article-title":"Immunobiology of hookworm infection","volume":"43","author":"Loukas","year":"2005","journal-title":"FEMS Immunol Med Microbiol"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078357","article-title":"The effect of different adjuvants on immune parameters and protection following vaccination of sheep with a larval-specific antigen of the gastrointestinal nematode, haemonchus contortus","volume":"8","author":"Piedrafita","year":"2013","journal-title":"PloS One"},{"key":"B185","doi-asserted-by":"publisher","first-page":"109243","DOI":"10.1016\/j.vetpar.2020.109243","article-title":"A simplified Barbervax(R) vaccination regimen in lambs to evoke immunological protection to haemonchus contortus","volume":"287","author":"Broomfield","year":"2020","journal-title":"Vet Parasitol"},{"key":"B186","doi-asserted-by":"publisher","first-page":"109386","DOI":"10.1016\/j.vetpar.2021.109386","article-title":"Protective efficacy of Barbervax(R) in merino weaner sheep trickle infected with five doses of haemonchus contortus infective larvae","volume":"292","author":"Kebeta","year":"2021","journal-title":"Vet Parasitol"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.01.032","article-title":"Vaccination against haemonchus contortus: performance of native parasite gut membrane glycoproteins in merino lambs grazing contaminated pasture","volume":"153","author":"LeJambre","year":"2008","journal-title":"Vet Parasitol"},{"key":"B188","doi-asserted-by":"publisher","first-page":"29496","DOI":"10.1038\/srep29496","article-title":"Host protective ASP-based vaccine against the parasitic nematode ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response","volume":"6","author":"Gonzalez-Hernandez","year":"2016","journal-title":"Sci Rep"},{"key":"B189","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41541-020-00276-2","article-title":"Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice","volume":"6","author":"Ryan","year":"2021","journal-title":"NPJ Vaccines"},{"key":"B190","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1186\/s13071-022-05597-w","article-title":"Oral immunization of mice with recombinant lactobacillus plantarum expressing a trichinella spiralis galectin induces an immune protection against larval challenge","volume":"15","author":"Xu","year":"2022","journal-title":"Parasit Vectors."},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1038\/ni1332","article-title":"T Cell- and b cell-independent adaptive immunity mediated by natural killer cells","volume":"7","author":"O'Leary","year":"2006","journal-title":"Nat Immunol"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198687","article-title":"Innate or adaptive immunity? the example of natural killer cells","volume":"331","author":"Vivier","year":"2011","journal-title":"Science"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1038\/nature07665","article-title":"Adaptive immune features of natural killer cells","volume":"457","author":"Sun","year":"2009","journal-title":"Nature"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202870109","article-title":"Bacille calmette-guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes","volume":"109","author":"Kleinnijenhuis","year":"2012","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B195","doi-asserted-by":"publisher","first-page":"1250684","DOI":"10.1126\/science.1250684","article-title":"mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Science"},{"key":"B196","doi-asserted-by":"publisher","first-page":"1251086","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity","volume":"345","author":"Saeed","year":"2014","journal-title":"Science"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1172\/JCI139298","article-title":"Lymphocyte crosstalk is required for monocyte-intrinsic trained immunity to plasmodium falciparum","volume":"132","author":"Crabtree","year":"2022","journal-title":"J Clin Invest"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.03225","article-title":"Trained immunity carried by non-immune cells","volume":"9","author":"Hamada","year":"2018","journal-title":"Front Microbiol"},{"key":"B199","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.chom.2020.05.014","article-title":"BCG Vaccination in humans elicits trained immunity via the hematopoietic progenitor compartment","volume":"28","author":"Cirovic","year":"2020","journal-title":"Cell Host Microbe"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01354-4","article-title":"Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut-lung axis","volume":"23","author":"Jeyanathan","year":"2022","journal-title":"Nat Immunol"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01109","article-title":"Anti-inflammatory trained immunity mediated by helminth products attenuates the induction of T cell-mediated autoimmune disease","volume":"10","author":"Quinn","year":"2019","journal-title":"Front Immunol"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155919","article-title":"Antigens from the parasitic nematode trichuris suis induce metabolic reprogramming and trained immunity to constrain inflammatory responses in macrophages","volume":"156","author":"Zakeri","year":"2022","journal-title":"Cytokine"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.969340","article-title":"NKp46(+) natural killer cells develop an activated\/memory-like phenotype and contribute to innate immunity against experimental filarial infection","volume":"13","author":"Pionnier","year":"2022","journal-title":"Front Immunol"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001225","article-title":"Helminth imprinting of hematopoietic stem cells sustains anti-inflammatory trained innate immunity that attenuates autoimmune disease","volume":"206","author":"Cunningham","year":"2021","journal-title":"J Immunol"},{"key":"B205","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.jaci.2021.02.031","article-title":"Fetomaternal immune cross talk modifies T-cell priming through sustained changes to DC function","volume":"148","author":"Lacorcia","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14261","article-title":"From trained immunity in allergy to trained immunity-based allergen vaccines","volume":"53","author":"Martin-Cruz","year":"2022","journal-title":"Clin Exp Allergy"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.699563","article-title":"DAMPs and innate immune training","volume":"12","author":"Jentho","year":"2021","journal-title":"Front Immunol"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201901071","article-title":"Beta-1,3\/1,6-Glucans and immunity: state of the art and future directions","volume":"65","author":"De Marco Castro","year":"2021","journal-title":"Mol Nutr Food Res"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01782","article-title":"Could the induction of trained immunity by beta-glucan serve as a defense against COVID-19","volume":"11","author":"Geller","year":"2020","journal-title":"Front Immunol"},{"key":"B210","doi-asserted-by":"publisher","first-page":"107548","DOI":"10.1016\/j.celrep.2020.107548","article-title":"The Set7 lysine methyltransferase regulates plasticity in oxidative phosphorylation necessary for trained immunity induced by beta-glucan","volume":"31","author":"Keating","year":"2020","journal-title":"Cell Rep"},{"key":"B211","doi-asserted-by":"publisher","first-page":"107634","DOI":"10.1016\/j.celrep.2020.107634","article-title":"Beta-glucan induces protective trained immunity against mycobacterium tuberculosis infection: a key role for IL-1","volume":"31","author":"Moorlag","year":"2020","journal-title":"Cell Rep"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.807821","article-title":"Helminth glycans at the host-parasite interface and their potential for developing novel therapeutics","volume":"8","author":"Bunte","year":"2021","journal-title":"Front Mol Biosci"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12536","article-title":"Beta-glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping","volume":"100","author":"Bouchery","year":"2022","journal-title":"Immunol Cell Biol"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2005504","article-title":"Dectin-1\/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses","volume":"16","author":"Kaisar","year":"2018","journal-title":"PloS Biol"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2015.02.001","article-title":"Fasciola hepatica excretory-secretory products induce CD4+T cell anergy via selective up-regulation of PD-L2 expression on macrophages in a dectin-1 dependent way","volume":"220","author":"Guasconi","year":"2015","journal-title":"Immunobiology"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701010","article-title":"Cutting edge: plasmodium falciparum induces trained innate immunity","volume":"200","author":"Schrum","year":"2018","journal-title":"J Immunol"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.671966","article-title":"The fate of activated group 2 innate lymphoid cells","volume":"12","author":"Matha","year":"2021","journal-title":"Front Immunol"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.135961","article-title":"Lung group 2 innate lymphoid cells are trained by endogenous IL-33 in the neonatal period","volume":"5","author":"Steer","year":"2020","journal-title":"JCI Insight"},{"key":"B219","doi-asserted-by":"publisher","first-page":"101532","DOI":"10.1016\/j.smim.2021.101532","article-title":"IL-33: a central cytokine in helminth infections","volume":"53","author":"McSorley","year":"2021","journal-title":"Semin Immunol"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1050271","article-title":"Extracellular vesicles produced by the human gut commensal bacterium bacteroides thetaiotaomicron elicit anti-inflammatory responses from innate immune cells","volume":"13","author":"Fonseca","year":"2022","journal-title":"Front Microbiol"},{"key":"B221","doi-asserted-by":"publisher","first-page":"111674","DOI":"10.1016\/j.celrep.2022.111674","article-title":"Extracellular vesicles carrying HIV-1 nef induce long-term hyperreactivity of myeloid cells","volume":"41","author":"Dubrovsky","year":"2022","journal-title":"Cell Rep"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-015-4373-7","article-title":"Exosome-like vesicles derived by schistosoma japonicum adult worms mediates M1 type immune- activity of macrophage","volume":"114","author":"Wang","year":"2015","journal-title":"Parasitol Res"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206941200","article-title":"A novel host-parasite lipid cross-talk. schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization","volume":"277","author":"van der Kleij","year":"2002","journal-title":"J Biol Chem"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01010","article-title":"Schistosoma mansoni-derived lipids in extracellular vesicles: potential agonists for eosinophillic tissue repair","volume":"10","author":"Coakley","year":"2019","journal-title":"Front Immunol"},{"key":"B225","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.chom.2017.12.010","article-title":"BCG Vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity","volume":"23","author":"Arts","year":"2018","journal-title":"Cell Host Microbe"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133935","article-title":"BCG Vaccination in humans inhibits systemic inflammation in a sex-dependent manner","volume":"130","author":"Koeken","year":"2020","journal-title":"J Clin Invest."},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02936","article-title":"Trained immunity-based vaccines: a new paradigm for the development of broad-spectrum anti-infectious formulations","volume":"9","author":"Sanchez-Ramon","year":"2018","journal-title":"Front Immunol"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.868343","article-title":"Trained immunity contribution to autoimmune and inflammatory disorders","volume":"13","author":"Funes","year":"2022","journal-title":"Front Immunol"},{"key":"B229","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13071-015-1244-0","article-title":"Praziquantel coverage in schools and communities targeted for the elimination of urogenital schistosomiasis in Zanzibar: a cross-sectional survey","volume":"9","author":"Knopp","year":"2016","journal-title":"Parasit Vectors."},{"key":"B230","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13071-016-1311-1","article-title":"Compliance with anthelmintic treatment in the neglected tropical diseases control programmes: a systematic review","volume":"9","author":"Shuford","year":"2016","journal-title":"Parasit Vectors."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1163364\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T13:08:12Z","timestamp":1685538492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1163364\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,30]]},"references-count":230,"alternative-id":["10.3389\/fimmu.2023.1163364"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1163364","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,30]]},"article-number":"1163364"}}