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Inducing pyroptosis and activating the cyclic guanosine monophosphate-adenosine monophosphate synthase\/interferon gene stimulator (cGAS\/STING) signaling pathway to upregulate innate immunity have become an emerging strategy for enhancing tumor immunotherapy. In this study, albumin nanospheres were constructed with photosensitizer-IR780 encapsulated in the core and cGAS\u2013STING agonists\/H<jats:sub>2<\/jats:sub>S producer-ZnS loaded on the shell (named IR780-ZnS@HSA). <jats:italic>In vitro<\/jats:italic>, IR780-ZnS@HSA produced photothermal therapy (PTT) and photodynamic therapy (PDT) effects. In addition, it stimulated immunogenic cell death (ICD) and activated pyroptosis in tumor cells <jats:italic>via<\/jats:italic> the caspase-3\u2013GSDME signaling pathway. IR780-ZnS@HSA also activated the cGAS\u2013STING signaling pathway. The two pathways synergistically boost immune response. <jats:italic>In vivo<\/jats:italic>, IR780-ZnS@HSA + laser significantly inhibited tumor growth in 4T1 tumor-bearing mice and triggered an immune response, improving the efficacy of the anti-APD-L1 antibody (aPD-L1). In conclusion, IR780-ZnS@HSA, as a novel inducer of pyroptosis, can significantly inhibit tumor growth and improve the efficacy of aPD-L1.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1173487","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T13:59:41Z","timestamp":1685023181000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Self-assembled albumin nanoparticles induce pyroptosis for photodynamic\/photothermal\/immuno synergistic therapies in triple-negative breast 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