{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:36:04Z","timestamp":1792402564233,"version":"4.4.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Among all types of central nervous system cancers, glioma remains the most frequent primary brain tumor in adults. Despite significant advances in immunomodulatory therapies, notably immune checkpoint inhibitors, their effectiveness remains constrained due to glioma resistance. The discovery of TMIGD2 (Transmembrane and Immunoglobulin Domain Containing 2) as an immuno-stimulatory receptor, constitutively expressed on naive T cells and most natural killer (NK) cells, has emerged as an attractive immunotherapy target in a variety of cancers. The expression profile of TMIGD2 and its significance in the overall survival of glioma patients remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the present study, we first assessed TMIGD2 mRNA expression using the Cancer Genome Atlas (TCGA) glioma transcriptome dataset (667 patients), followed by validation with the Chinese Glioma Genome Atlas (CGGA) cohort (693 patients). Secondly, we examined TMIGD2 protein staining in a series of 25 paraffin-embedded blocks from Moroccan glioma patients. The statistical analysis was performed using GraphPad Prism 8 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TMIGD2 expression was found to be significantly higher in astrocytoma, IDH-1 mutations, low-grade, and young glioma patients. TMIGD2 was expressed on immune cells and, surprisingly, on tumor cells of glioma patients. Interestingly, our study demonstrated that TMIGD2 expression was negatively correlated with angiogenesis, hypoxia, G2\/M checkpoint, and epithelial to mesenchymal transition signaling pathways. We also demonstrated that dendritic cells, monocytes, NK cells, gd T cells, and naive CD8 T cell infiltration correlates positively with TMIGD2 expression. On the other hand, Mantel-Cox analysis demonstrated that increased expression of TMIGD2 in human gliomas is associated with good overall survival. Cox multivariable analysis revealed that TMIGD2 is an independent predictor of a good prognosis in glioma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Taken together, our results highlight the tight implication of TMIGD2 in glioma progression and show its promising therapeutic potential as a stimulatory target for immunotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2023.1173518","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T01:31:26Z","timestamp":1684200686000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["TMIGD2 as a potential therapeutic target in glioma patients"],"prefix":"10.3389","volume":"14","author":[{"given":"Chaimae","family":"Boulhen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadia","family":"AIT SSI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Benthami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibtissam","family":"Razzouki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelhakim","family":"Lakhdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Karkouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Badou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"B1","first-page":"58\u221269","article-title":"Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye","volume":"29","author":"Medawar","year":"1948","journal-title":"Br J Exp Pathol F\u00e9vr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"991\u22129","DOI":"10.1084\/jem.20142290","article-title":"A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules","volume":"212","author":"Aspelund","year":"2015","journal-title":"J Exp Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"337\u221241","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","first-page":"25\u221237","DOI":"10.1016\/j.gendis.2019.12.004","article-title":"Immune checkpoint: the novel target for antitumor therapy","volume":"8","author":"Jiang","year":"2019","journal-title":"Genes Dis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3390\/diagnostics12010124","article-title":"Cancer immunotherapy with immune checkpoint inhibitors-biomarkers of response and toxicity; current limitations and future 351 promise","volume":"12","author":"Healey Bird","year":"2022","journal-title":"Diagn Basel"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.685213","article-title":"Prognostic gene expression signature in patients with distinct glioma grades","volume":"12","author":"Ait Ssi","year":"2021","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"459\u221266","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"Stupp","year":"2009","journal-title":"Lancet Oncol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"v1\u2212100","DOI":"10.1093\/neuonc\/noz150","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the united states in 2012\u20132016","volume":"21","author":"Ostrom","year":"2019","journal-title":"Neuro- Oncol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2042\u22122042","DOI":"10.1200\/JCO.2017.35.15_suppl.2042","article-title":"Phase 2 study to evaluate safety and efficacy of MEDI4736 (durvalumab [DUR]) in glioblastoma (GBM) patients: an update","volume":"35","author":"Reardon","year":"2017","journal-title":"J Clin Oncol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"iii21","DOI":"10.1093\/neuonc\/nox036.071","article-title":"OS10.3 randomized phase 3 study evaluating the efficacy and safety of nivolumab vs bevacizumab in patients with recurrent glioblastoma: CheckMate 143","volume":"19","author":"Reardon","year":"2017","journal-title":"Neuro-Oncol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"317\u221239","DOI":"10.2217\/imt-2017-0122","article-title":"Current state and future prospects of immunotherapy for glioma","volume":"10","author":"Kamran","year":"2018","journal-title":"Immunotherapy"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.17179\/excli2021-352","article-title":"Co-Stimulatory agonists: an insight into the immunotherapy of cancer","volume":"20","author":"P","year":"2021","journal-title":"EXCLI J"},{"key":"B13","doi-asserted-by":"publisher","first-page":"333\u221244","DOI":"10.1093\/neuonc\/noz204","article-title":"ICOSLG-mediated regulatory T-cell expansion and IL-10 production promote progression of glioblastoma","volume":"22","author":"Iwata","year":"2020","journal-title":"Neuro-Oncol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"771\u221282","DOI":"10.1084\/jem.20041130","article-title":"Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells","volume":"200","author":"Turk","year":"2004","journal-title":"J Exp Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"376\u221286","DOI":"10.1172\/JCI33365","article-title":"Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice","volume":"118","author":"McNamara","year":"2008","journal-title":"J Clin Invest"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2845\u221251","DOI":"10.1182\/blood-2004-07-2959","article-title":"Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR","volume":"105","author":"Valzasina","year":"2005","journal-title":"Blood"},{"key":"B17","doi-asserted-by":"publisher","first-page":"13424","DOI":"10.3390\/ijms232113424","article-title":"BTN3A: a promising immune checkpoint for cancer prognosis and treatment","volume":"23","author":"Kone","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1\u221212","DOI":"10.1038\/ncomms3043","article-title":"B7-H5 costimulates human T cells via CD28H","volume":"4","author":"Zhu","year":"2013","journal-title":"Nat Commun"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1495","article-title":"Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein","volume":"21","author":"J","year":"2015","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1038\/ncomms3043","article-title":"B7-H5 costimulates human T cells via CD28H","volume":"4","author":"Zhu","year":"2013","journal-title":"Nat Commun"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1646\u221256","DOI":"10.1091\/mbc.e11-11-0934","article-title":"Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis","volume":"23","author":"Rahimi","year":"2012","journal-title":"Mol Biol Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"939\u221251","DOI":"10.1158\/2326-6066.CIR-18-0733","article-title":"CD28 homolog is a strong activator of natural killer cells for lysis of B7H7+ tumor cells","volume":"7","author":"Zhuang","year":"2019","journal-title":"Cancer Immunol Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1360\u22129","DOI":"10.1111\/jcmm.14812","article-title":"Overexpression of B7H5\/CD28H is associated with worse survival in human gastric cancer","volume":"24","author":"Hu","year":"2020","journal-title":"J Cell Mol Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"530\u22129","DOI":"10.1111\/cas.13914","article-title":"B7\u2212H5\/CD28H is a co\u2212stimulatory pathway and correlates with improved prognosis in pancreatic ductal adenocarcinoma","volume":"110","author":"Chen","year":"2019","journal-title":"Cancer Sci"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2309\u221222","DOI":"10.3892\/or.2019.7343","article-title":"HHLA2 is a novel prognostic predictor and potential therapeutic target in malignant glioma","volume":"42","author":"Qi","year":"2019","journal-title":"Oncol Rep"},{"key":"B26","doi-asserted-by":"publisher","first-page":"21504","DOI":"10.1038\/s41598-021-00835-0","article-title":"The immune checkpoint VISTA exhibits high expression levels in human gliomas and associates with a poor prognosis","volume":"11","author":"Ghouzlani","year":"2021","journal-title":"Sci Rep"},{"key":"B27","doi-asserted-by":"publisher","first-page":"97\u2212109","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol (Berl)"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1574\u22129","DOI":"10.2967\/jnumed.116.188557","article-title":"In vivo relationship between hypoxia and angiogenesis in human glioblastoma: a multimodal imaging study","volume":"58","author":"da Ponte","year":"2017","journal-title":"J Nucl Med Off Publ Soc Nucl Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"6515","DOI":"10.3390\/ijms21186515","article-title":"Markers of angiogenesis, lymphangiogenesis, and epithelial\u2013mesenchymal transition (Plasticity) in CIN and early invasive carcinoma of the cervix: exploring putative molecular mechanisms involved in early tumor invasion","volume":"21","author":"Kurmyshkina","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B30","doi-asserted-by":"publisher","first-page":"50747\u221260","DOI":"10.18632\/oncotarget.17096","article-title":"Curcumin induces G2\/M cell cycle arrest and apoptosis of head and neck squamous cell carcinoma in vitro and in vivo through ATM\/Chk2\/p53-dependent pathway","volume":"8","author":"Hu","year":"2017","journal-title":"Oncotarget"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2697\u2212705","DOI":"10.1111\/cas.13744","article-title":"Genetic and clinical characterization of B7\u2212H3 (CD276) expression and epigenetic regulation in diffuse brain glioma","volume":"109","author":"Wang","year":"2018","journal-title":"Cancer Sci"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.588552","article-title":"PD-L1-Mediated immunosuppression in glioblastoma is associated with the infiltration and M2-polarization of tumor-associated macrophages","volume":"11","author":"Zhu","year":"2020","journal-title":"Front Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"37435\u221247","DOI":"10.18632\/oncotarget.16391","article-title":"High expression of B7-H6 in human glioma tissues promotes tumor progression","volume":"8","author":"Jiang","year":"2017","journal-title":"Oncotarget"},{"key":"B34","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12885-017-3909-x","article-title":"Relationship between the extent of resection and the survival of patients with low-grade gliomas: a systematic review and meta-analysis","volume":"18","author":"Xia","year":"2018","journal-title":"BMC Cancer"},{"key":"B35","doi-asserted-by":"publisher","first-page":"4\u221227","DOI":"10.1093\/neuonc\/nos273","article-title":"Standards of care for treatment of recurrent glioblastoma\u2013are we there yet","volume":"15","author":"Weller","year":"2013","journal-title":"Neuro-Oncol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1616\u221226","DOI":"10.1172\/JCI24480","article-title":"Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells","volume":"115","author":"Gattinoni","year":"2005","journal-title":"J Clin Invest"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1423\u22127","DOI":"10.1126\/science.aaf0683","article-title":"Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent","volume":"355","author":"Kamphorst","year":"2017","journal-title":"Science"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyz167","article-title":"Missing na\u00efve T cells in the setting of glioblastoma are found to be sequestered in the bone marrow","volume":"85","author":"Schneider","year":"2019","journal-title":"Neurosurgery"},{"key":"B39","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s12935-019-0972-1","article-title":"Identification of 3 subpopulations of tumor-infiltrating immune cells for malignant transformation of low-grade glioma","volume":"19","author":"Lu","year":"2019","journal-title":"Cancer Cell Int"},{"key":"B40","doi-asserted-by":"publisher","first-page":"7871814","DOI":"10.1155\/2018\/7871814","article-title":"Effect of aging on NK cell population and their proliferation at ex vivo culture condition","volume":"2018","author":"Gounder","year":"2018","journal-title":"Anal Cell Pathol Amst"},{"key":"B41","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1742-4933-3-10","article-title":"Ageing is associated with a decline in peripheral blood CD56bright NK cells","volume":"3","author":"Chidrawar","year":"2006","journal-title":"Immun Ageing"},{"key":"B42","first-page":"595\u2212608","article-title":"T Cell ageing: effects of age on development, survival & function","volume":"138","author":"Salam","year":"2013","journal-title":"Indian J Med Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"3021\u22127","DOI":"10.7150\/jca.30723","article-title":"Aging, cancer and immunity","volume":"10","author":"Hong","year":"2019","journal-title":"J Cancer"},{"key":"B44","doi-asserted-by":"publisher","first-page":"87\u221294","DOI":"10.1007\/s00381-010-1264-1","article-title":"IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the children\u2019s oncology group","volume":"27","author":"Pollack","year":"2011","journal-title":"Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg"},{"key":"B45","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s11910-013-0345-4","article-title":"IDH1 and IDH2 mutations in gliomas","volume":"13","author":"Cohen","year":"2013","journal-title":"Curr Neurol Neurosci Rep"},{"key":"B46","doi-asserted-by":"publisher","first-page":"4150\u22124","DOI":"10.1200\/JCO.2009.21.9832","article-title":"Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas","volume":"27","author":"Sanson","year":"2009","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3061\u22128","DOI":"10.1200\/JCO.2009.26.7252","article-title":"Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease","volume":"28","author":"Paugh","year":"2010","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"55\u221260","DOI":"10.1007\/s13193-018-0820-0","article-title":"Prognostic significance of anatomic origin and evaluation of survival statistics of astrocytoma patients\u2013a tertiary experience","volume":"10","author":"Deshpande","year":"2019","journal-title":"Indian J Surg Oncol"},{"key":"B49","first-page":"972\u221281","article-title":"Long-term follow-up of intramedullary spinal cord tumors: a series of 202 cases","volume":"56","author":"Raco","year":"2005","journal-title":"Neurosurgery"},{"key":"B50","doi-asserted-by":"publisher","first-page":"587\u2212600","DOI":"10.1053\/j.seminoncol.2015.05.013","article-title":"Antagonists of PD-1 and PD-L1 in cancer treatment","volume":"42","author":"Lipson","year":"2015","journal-title":"Semin Oncol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"116\u221229","DOI":"10.1016\/j.ejca.2017.01.035","article-title":"Cancer immunotherapy: opportunities and challenges in the rapidly evolving clinical landscape","volume":"81","author":"Emens","year":"2017","journal-title":"Eur J Cancer Oxf Engl"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1\u22128","DOI":"10.1038\/s41467-020-18570-x","article-title":"PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade","volume":"11","author":"Peng","year":"2020","journal-title":"Nat Commun"},{"key":"B53","doi-asserted-by":"publisher","first-page":"29480\u221291","DOI":"10.18632\/oncotarget.8784","article-title":"B7-H3 as a promising target for cytotoxicity T cell in human cancer therapy","volume":"7","author":"Ma","year":"2016","journal-title":"Oncotarget"},{"key":"B54","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13045-020-01024-8","article-title":"Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes","volume":"14","author":"Liu","year":"2021","journal-title":"J Hematol OncolJ Hematol Oncol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"5305\u221211","DOI":"10.4049\/jimmunol.1402517","article-title":"B7H6-specific bispecific T cell engagers lead to tumor elimination and host antitumor immunity","volume":"194","author":"Wu","year":"2015","journal-title":"J Immunol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s40425-019-0700-3","article-title":"PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors","volume":"7","author":"Beyrend","year":"2019","journal-title":"J Immunother Cancer"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1115\u221224","DOI":"10.3171\/jns.1999.90.6.1115","article-title":"Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens","volume":"90","author":"Liau","year":"1999","journal-title":"J Neurosurg"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1\u221215","DOI":"10.1038\/s42003-022-03402-z","article-title":"Infiltrating natural killer cells bind, lyse and increase chemotherapy efficacy in glioblastoma stem-like tumorospheres","volume":"5","author":"Breznik","year":"2022","journal-title":"Commun Biol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"357\u221267","DOI":"10.1215\/15228517-2008-111","article-title":"Characterization and immunotherapeutic potential of \u03b3\u03b4 T-cells in patients with glioblastoma","volume":"11","author":"Bryant","year":"2009","journal-title":"Neuro-Oncol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"2560\u22128","DOI":"10.1038\/bjc.2014.162","article-title":"Tumour-infiltrating CD4+ and CD8+ lymphocytes as predictors of clinical outcome in glioma","volume":"110","author":"Han","year":"2014","journal-title":"Br J Cancer"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00116","article-title":"Targeting tregs in malignant brain cancer: overcoming IDO","volume":"4","author":"Wainwright","year":"2013","journal-title":"Front Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"19065\u221278","DOI":"10.18632\/oncotarget.24897","article-title":"Correlation between lower balance of Th2 helper T-cells and expression of PD-L1\/PD-1 axis genes enables prognostic prediction in patients with glioblastoma","volume":"9","author":"Takashima","year":"2018","journal-title":"Oncotarget"},{"key":"B63","doi-asserted-by":"publisher","first-page":"5421985","DOI":"10.1155\/2019\/5421985","article-title":"The expression patterns and associated clinical parameters of human endogenous retrovirus-h long terminal repeat-associating protein 2 and transmembrane and immunoglobulin domain containing 2 in oral squamous cell carcinoma","volume":"2019","author":"Xiao","year":"2019","journal-title":"Dis Markers"},{"key":"B64","doi-asserted-by":"publisher","first-page":"492\u22129","DOI":"10.1158\/2159-8290.CD-18-1314","article-title":"Na\u00efve T-cell deficits at diagnosis and after chemotherapy impair cell therapy potential in pediatric cancers","volume":"9","author":"Das","year":"2019","journal-title":"Cancer Discovery"},{"key":"B65","doi-asserted-by":"publisher","first-page":"830","DOI":"10.3390\/cancers15030830","article-title":"Exploring the past, present, and future of anti-angiogenic therapy in glioblastoma","volume":"15","author":"Zhang","year":"2023","journal-title":"Cancers"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1173518\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T01:31:31Z","timestamp":1684200691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1173518\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":65,"alternative-id":["10.3389\/fimmu.2023.1173518"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1173518","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]},"article-number":"1173518"}}