{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T17:18:03Z","timestamp":1781543883408,"version":"3.54.5"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>IgE antibodies are likely involved in host protection. <jats:italic>Trichinella spiralis<\/jats:italic> is a helminth that induces protection through IgE antibodies. The present study examined <jats:italic>T. spiralis<\/jats:italic> susceptibility in high and low IgE responder mice, with a specific focus on the inheritance of IgE responsiveness, which controls IgE production specific for the IgE isotype and non-specific for antigens. Furthermore, low IgE responsiveness is inherited as a recessive trait under a single gene, which is not linked to the H-2 gene. This study determined the total IgE and anti-<jats:italic>T. spiralis<\/jats:italic> IgE antibody levels after <jats:italic>T. spiralis<\/jats:italic> infection in low IgE responder SJL\/J mice were several times lower than those in high IgE responders, such as the BALB\/c mice. An IgE-dependent susceptibility to <jats:italic>T. spiralis<\/jats:italic>, evaluated in mice treated with anti-IgE antibodies and in control mice, was observed in high IgE responder mice but not in low IgE responder mice. The inheritance of IgE responsiveness and susceptibility to <jats:italic>T. spiralis<\/jats:italic> was investigated using crosses of SJL\/J with high IgE responders. All of the (BALB\/c \u00d7 SJL\/J) F1 and half of the (BALB\/c \u00d7 SJL\/J) F1 \u00d7 SJL backcross progenies were high IgE responders after <jats:italic>T. spiralis<\/jats:italic> infection. Total IgE and antigen-specific IgE antibody levels were correlated and not linked to H-2. It should be noted that high IgE responders always exhibited low susceptibility, suggesting that the trait of IgE responsiveness functions as a trait of susceptibility to <jats:italic>T. spiralis<\/jats:italic>.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1185094","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T04:57:01Z","timestamp":1684731421000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of inheritance of IgE responsiveness on the susceptibility of mice to Trichinella spiralis infection"],"prefix":"10.3389","volume":"14","author":[{"given":"Naohiro","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.168.3933.852","article-title":"Immune responses of inbred mice to repeated low doses of antigen: relationship to histocompatibility (H\u20132) type","volume":"168","author":"Vaz","year":"1970","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.3.949","article-title":"A T cell activity that enhances polyclonal IgE production and its inhibition by interferon\u2013gamma","volume":"136","author":"Coffman","year":"1986","journal-title":"J Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1159\/000235358","article-title":"Interleukin\u20134 gene expression and IgE responsiveness","volume":"94","author":"Okudaira","year":"1991","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1084\/jem.143.4.833","article-title":"Suppression of IgE antibody production in SJL mice. i. nonspecific suppressor T cells","volume":"143","author":"Watanabe","year":"1976","journal-title":"J Exp Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1600\u2013065x.1978.tb01459.x","article-title":"Regulation of IgE in mice","volume":"41","author":"Ovary","year":"1978","journal-title":"Immunol Rev"},{"key":"B6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.1600\u2013065x.1978.tb01461.x","article-title":"The allergic phenotype: manifestation of 'allergic breakthrough' and imbalance in normal 'damping' of IgE antibody production","volume":"41","author":"Katz","year":"1978","journal-title":"Immunol Rev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.118.2.485","article-title":"Suppression of IgE antibody production in SJL mice. 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