{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:21:01Z","timestamp":1789399261003,"version":"build-2803163510"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disease and linked to abnormal deposition of amyloid-\u03b2 (A\u03b2), neurofibrillary tangles (NFTs), synaptic dysfunction, and neuroinflammation. Despite significant progress in unravelling the pathogenesis of AD, currently main therapeutic interventions is limited to symptomatic alleviation. Methylprednisolone (MP), a synthetic glucocorticoid, is recognized for its extensive anti-inflammatory properties. Our study assessed the neuroprotective effect of MP (25 mg\/kg) administration to an A\u03b2<jats:sub>1-42<\/jats:sub>-induced AD mouse model. Our findings demonstrate that MP treatment can ameliorate cognitive impairment in A\u03b2<jats:sub>1-42<\/jats:sub>-induced AD mice and suppress microglial activation in the cortex and hippocampus. RNA-Sequencing analysis reveals that MP ultimately rescues cognitive dysfunction through improving the synapse function and inhibiting the immune and inflammatory processes. Our study suggests that MP could be a promising drug alternative for the treatment of AD, either alone or in combination with other existing drugs.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1192940","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T04:22:37Z","timestamp":1682914957000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer\u2019s 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