{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:12:19Z","timestamp":1791843139921,"version":"4.3.4"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p><jats:italic>Cryptosporidium<\/jats:italic> is a zoonotic apicomplexan parasite that infects the gastrointestinal epithelium and other mucosal surfaces in humans. It is an important opportunistic pathogen in AIDS patients and a leading cause of infectious diarrhea and diarrheal-related death in children worldwide. The intestinal epithelial cells provide the first line of defense against <jats:italic>Cryptosporidium<\/jats:italic> infection and play a central role in activating and regulating the host\u2019s antiparasitic response. Increasing evidence suggests that long noncoding RNAs (lncRNAs) participate in host-pathogen interactions and play a regulatory role in the pathogenesis of diseases but the underlying molecular mechanisms are not fully understood. We previously identified a panel of host lncRNAs that are upregulated in murine intestinal epithelial cells following <jats:italic>Cryptosporidium<\/jats:italic> infection, including U90926. We demonstrate here that U90926 is acting in a pro-parasitic manner in regulating intestinal epithelial cell-autonomous antiparasitic defense. Inhibition of U90926 resulted in a decreased infection burden of the parasite while overexpression of U90926 showed an increase in infection burden in cultured murine intestinal epithelial cells. Induction of U90926 suppressed transcription of epithelial defense genes involved in controlling <jats:italic>Cryptosporidium<\/jats:italic> infection through epigenetic mechanisms. Specifically, transcription of Aebp1, which encodes the Aebp1 protein, a potent modulator of inflammation and NF-\u03baB signaling, was suppressed by U90926. Gain- or loss-of-function of Aebp1 in the host\u2019s epithelial cells caused reciprocal alterations in the infection burden of the parasite. Interestingly, <jats:italic>Cryptosporidium<\/jats:italic> carries the <jats:italic>Cryptosporidium<\/jats:italic> virus 1 (CSpV1), a double-stranded (ds) RNA virus coding two dsRNA fragments, CSpV1-dsRdRp and CSpV1-dsCA. Both CSpV1-dsRdRp and CSpV1-dsCA can be delivered into infected cells as previously reported. We found that cells transfected with <jats:italic>in vitro<\/jats:italic> transcribed CSpV1-dsCA or CSpV1-dsRdRp displayed an increased level of U90926, suggesting that CSpV1 is involved in the upregulation of U90926 during <jats:italic>Cryptosporidium<\/jats:italic> infection. Our study highlights a new strategy by <jats:italic>Cryptosporidium<\/jats:italic> to hijack a host lncRNA to suppress epithelial cell-autonomous antiparasitic defense and allow for a robust infection.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1205468","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T20:24:50Z","timestamp":1686083090000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Cryptosporidium parvum hijacks a host\u2019s long noncoding RNA U90926 to evade intestinal epithelial cell-autonomous antiparasitic defense"],"prefix":"10.3389","volume":"14","author":[{"given":"Marion L.","family":"Graham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Yu","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1645\/GE-495R.1","article-title":"Distribution of Cryptosporidium parvum sporozoite apical organelles during attachment to and internalization by cultured biliary epithelial cells","volume":"91","author":"O\u2019Hara","year":"2005","journal-title":"J Parasitol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the global enteric multicenter study, GEMS): a prospective, case-control study","volume":"382","author":"Kotloff","year":"2013","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(18)30283-3","article-title":"Morbidity, mortality, and long-term consequences associated with diarrhoea from Cryptosporidium infection in children younger than 5 years: a meta-analyses study","volume":"6","author":"Khalil","year":"2018","journal-title":"Lancet Global Health"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/753512","article-title":"Global distribution, public health and clinical impact of the protozoan pathogen Cryptosporidium","volume":"2010","author":"Putignani","year":"2010","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/mog.0b013e32831da7dd","article-title":"Update on human infections caused by intestinal protozoa","volume":"25","author":"Pierce","year":"2009","journal-title":"Curr Opin Gastroenterol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/503189a","article-title":"Parasitic infections: time to tackle cryptosporidiosis","volume":"503","author":"Striepen","year":"2013","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S1473-3099(14)70772-8","article-title":"A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium","volume":"15","author":"Checkley","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1051\/parasite\/2020011","article-title":"Update on Cryptosporidium spp.: highlights from the seventh international Giardia and Cryptosporidium conference","volume":"27","author":"Widmer","year":"2020","journal-title":"Parasite"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fawpar.2021.e00131","article-title":"Cryptosporidium spp. diagnosis and research in the 21st century","volume":"24","author":"O'Leary","year":"2021","journal-title":"Food Waterborne Parasitol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.watres.2017.01.036","article-title":"Waterborne transmission of protozoan parasites: review of worldwide outbreaks - an update 2011-2016","volume":"114","author":"Efstratiou","year":"2017","journal-title":"Water Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra013170","article-title":"Cryptosporidoisis","volume":"346","author":"Chen","year":"2002","journal-title":"N Engl J Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/pim.12020","article-title":"Innate immune responses against Cryptosporidium parvum infection","volume":"35","author":"McDonald","year":"2013","journal-title":"Parasite Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12408","article-title":"Regulation of host epithelial responses to Cryptosporidium infection by microRNAs","volume":"39","author":"Ming","year":"2017","journal-title":"Parasite Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00248-06","article-title":"Intestinal microvascular endothelium and innate immunity in inflammatory bowel disease: a second line of defense","volume":"74","author":"Heidemann","year":"2006","journal-title":"Infect Immun"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.4.1787-1790.1998","article-title":"Human intestinal epithelial cells respond to Cryptosporidium parvum infection with increased prostaglandin h synthase 2 expression and prostaglandin E2 and F2\u03b1 production","volume":"66","author":"Laurent","year":"1998","journal-title":"Infect Immun"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002702","article-title":"miR-27b targets KSRP to coordinate TLR4-mediated epithelial defense against Cryptosporidium parvum infection","volume":"8","author":"Zhou","year":"2012","journal-title":"PloS Pathog"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1491-1","article-title":"Mechanisms of cellular invasion by intracellular parasites","volume":"71","author":"Walker","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2521","article-title":"Long non-coding RNAs: insights into functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nat Rev Genet"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elp038","article-title":"Pervasive transcription of the eukaryotic genome: functional indices and conceptual implications","volume":"8","author":"Dinger","year":"2009","journal-title":"Brief Funct Genomics Proteomics"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nature07672","article-title":"Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals","volume":"458","author":"Guttman","year":"2009","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R116.760884","article-title":"Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses","volume":"292","author":"Mathy","year":"2017","journal-title":"J Biol Chem"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-051410-092902","article-title":"Genome regulation by long noncoding RNAs","volume":"81","author":"Rinn","year":"2012","journal-title":"Annu Rev Biochem"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00206-10","article-title":"Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling","volume":"1","author":"Peng","year":"2010","journal-title":"mBio"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800566","article-title":"Induction of a long noncoding RNA transcript, NR_045064, promotes defense gene transcription and facilitates intestinal epithelial cell responses against Cryptosporidium infection","volume":"201","author":"Li","year":"2018","journal-title":"J Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444558","article-title":"Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression","volume":"46","author":"Elling","year":"2016","journal-title":"Eur J Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.09.002","article-title":"Long non-coding RNAs and control of gene expression in the immune system","volume":"20","author":"Atianand","year":"2014","journal-title":"Trends Mol Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-279166","article-title":"LincRNA-Cox2 modulates TNF-\u03b1-induced transcription of Il12b gene in intestinal epithelial cells through regulation of mi-2\/NuRD-mediated epigenetic histone modifications","volume":"30","author":"Tong","year":"2016","journal-title":"FASEB J"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502146","article-title":"LincRNA-Cox2 promotes late inflammatory gene transcription in macrophages through modulating SWI\/SNF-mediated chromatin remodeling","volume":"196","author":"Hu","year":"2016","journal-title":"J Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17069","article-title":"Chlamydia trachomatis induces lncRNA MIAT upregulation to regulate mitochondria-mediated host cell apoptosis and chlamydial development","volume":"26","author":"Luo","year":"2022","journal-title":"J Cell Mol Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1186\/s13071-018-2697-8","article-title":"Microarray analysis of long non-coding RNA expression profiles uncovers a Toxoplasma-induced negative regulation of host immune signaling","volume":"11","author":"Liu","year":"2018","journal-title":"Parasit Vectors"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200215","article-title":"Long noncoding RNA U90926 is induced in activated macrophages, is protective in endotoxic shock, and encodes a novel secreted protein","volume":"210","author":"Sabikunnahar","year":"2023","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1046\/j.1365-2958.1997.5721933.x","article-title":"Virus-like, double-stranded RNAs in the parasitic protozoan Cryptosporidium parvum","volume":"26","author":"Khramtsov","year":"1997","journal-title":"Mol Microbiol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix392","article-title":"Involvement of Cryptosporidium parvum Cdg7_FLc_1000 RNA in the attenuation of intestinal epithelial cell migration via trans-suppression of host cell SMPD3","volume":"217","author":"Ming","year":"2017","journal-title":"J Infect Dis"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1635-1642.2001","article-title":"Cryptosporidium parvum-specific mucosal immune response in C57BL\/6 neonatal and gamma interferon-deficient mice: role of tumor necrosis factor alpha in protection","volume":"69","author":"Lacroix","year":"2001","journal-title":"Infect Immun"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-009-0513-7","article-title":"Cryspovirus: a new genus of protozoan viruses in the family partitiviridae","volume":"154","author":"Nibert","year":"2009","journal-title":"Arch Virol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.13.5788-5795.2000","article-title":"Association of RNA polymerase complexes of the parasitic protozoan Cryptosporidium parvum with virus-like particles: heterogeneous system","volume":"74","author":"Khramtsov","year":"2000","journal-title":"J Virol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2004.03.007","article-title":"Characterization and potential use of a Cryptosporidium parvum virus (CPV) antigen for detecting c. parvum oocysts","volume":"58","author":"Kniel","year":"2004","journal-title":"J Microbiol Methods"},{"key":"B39","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.chom.2019.05.007","article-title":"A stem-cell-derived platform enables complete Cryptosporidium development in vitro and genetic tractability","volume":"26","author":"Wilke","year":"2019","journal-title":"Cell Host Microbe"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00960-07","article-title":"Intestinal immune response to human Cryptosporidium sp. infection","volume":"76","author":"Pantenburg","year":"2008","journal-title":"Infect Immun"},{"key":"B41","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ijpara.2003.10.001","article-title":"Cryptosporidium parvum regulation of human epithelial cell gene expression","volume":"34","author":"Deng","year":"2004","journal-title":"Int J Parasitol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1177\/1535370214529398","article-title":"Human enteroids as an ex-vivo model of host\u2013pathogen interactions in the gastrointestinal tract","volume":"239","author":"Foulke-Abel","year":"2014","journal-title":"Exp Biol Med (Maywood)"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003801","article-title":"Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice","volume":"9","author":"Lantier","year":"2013","journal-title":"PloS Pathog"},{"key":"B44","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.immuni.2018.07.016","article-title":"A map of toll-like receptor expression in the intestinal epithelium reveals distinct spatial, cell type-specific, and temporal patterns","volume":"49","author":"Price","year":"2018","journal-title":"Immunity"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050182","article-title":"Kinetics of mucosal ileal gamma-interferon response during cryptosporidiosis in immunocompetent neonatal mice","volume":"82","author":"Kapel","year":"1996","journal-title":"Parasitol Res"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13060","article-title":"Cryptosporidium parvum infection attenuates the ex vivo propagation of murine intestinal enteroids","volume":"4","author":"Zhang","year":"2016","journal-title":"Physiol Rep"},{"key":"B47","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.vetpar.2017.12.015","article-title":"Nuclear delivery of parasite Cdg2_FLc_0220 RNA transcript to epithelial cells during Cryptosporidium parvum infection modulates host gene transcription","volume":"251","author":"Zhao","year":"2018","journal-title":"Vet Parasitol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.6.3373","article-title":"Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin\/ricin loop in the 28S rRNA","volume":"17","author":"Iordanov","year":"1997","journal-title":"Mol Cell Biol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(00)70219-8","article-title":"Mechanisms of attachment and internalization of Cryptosporidium parvum to biliary and intestinal epithelial cells","volume":"118","author":"Chen","year":"2000","journal-title":"Gastroenterology"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601967","article-title":"Dynamic histone H3 methylation during gene induction: HYPB\/Setd2 mediates all H3K36 trimethylation","volume":"27","author":"Edmunds","year":"2008","journal-title":"EMBO J"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.08.027","article-title":"Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions","volume":"44","author":"Chu","year":"2011","journal-title":"Mol Cell"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.14.4004","article-title":"Transcriptional regulation by the gamma5 subunit of a heterotrimeric G protein during adipogenesis","volume":"18","author":"Park","year":"1999","journal-title":"EMBO J"},{"key":"B53","doi-asserted-by":"publisher","first-page":"39","DOI":"10.2119\/2005-00021.Ro","article-title":"The role of AEBP1 in sex-specific diet-induced obesity","volume":"11","author":"Zhang","year":"2005","journal-title":"Mol Med"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508139103","article-title":"Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation","volume":"103","author":"Majdalawieh","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-014-3765-4","article-title":"Genome-wide identification and functional annotation of Plasmodium falciparum long noncoding RNAs from RNA-seq data","volume":"113","author":"Liao","year":"2014","journal-title":"Parasitol Res"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw607","article-title":"Delivery of parasite RNA transcripts into infected epithelial cells during Cryptosporidium infection and its potential impact on host gene transcription","volume":"215","author":"Wang","year":"2017","journal-title":"J Infect Dis"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/s41467-023-37129-0","article-title":"Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses","volume":"14","author":"Deng","year":"2023","journal-title":"Nat Commun"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/BF01322752","article-title":"Detection of a picobirnavirus associated with Cryptosporidium positive stools from humans","volume":"140","author":"Gallimore","year":"1995","journal-title":"Arch Virol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2007.11.005","article-title":"Fecundity of cryptosporidium parvum is correlated with intracellular levels of the viral symbiont CPV","volume":"38","author":"Jenkins","year":"2008","journal-title":"Int J Parasitol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233028","article-title":"Cellular self-defense: how cell-autonomous immunity protects against pathogens","volume":"340","author":"Randow","year":"2013","journal-title":"Science"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/nri3877","article-title":"The cytoskeleton in cell-autonomous immunity: structural determinants of host defence","volume":"15","author":"Mostowy","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tim.2014.01.005","article-title":"Programmed necrosis in microbial pathogenesis","volume":"22","author":"Sridharan","year":"2014","journal-title":"Trends Microbiol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.202.Supp.190.12","article-title":"Induction of a long non-coding RNA, lncRNA-Chr1:1226, by Cryptosporidium infection primes intestinal epithelial cells for IFN-\u03b3-mediated host antimicrobial gene transcription","volume":"202","author":"Deng","year":"2019","journal-title":"J Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700091","article-title":"The NF-\u03baB\u2013responsive long noncoding RNA FIRRE regulates posttranscriptional regulation of inflammatory gene expression through interacting with hnRNPU","volume":"199","author":"Lu","year":"2017","journal-title":"J Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-03-0217","article-title":"Adipocyte enhancer-binding protein-1 promotes macrophage inflammatory responsiveness by up-regulating NF-\u03baB via I\u03baB\u03b1 negative regulation","volume":"18","author":"Majdalawieh","year":"2007","journal-title":"Mol Biol Cell"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.404293","article-title":"Stromal adipocyte enhancer-binding protein (AEBP1) promotes mammary epithelial cell hyperplasia via proinflammatory and hedgehog signaling","volume":"287","author":"Holloway","year":"2012","journal-title":"J Biol Chem"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1177\/107424840200700304","article-title":"Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions","volume":"7","author":"Li","year":"2002","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2007.00009.x","article-title":"Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis","volume":"25","author":"Chen","year":"2007","journal-title":"Cardiovasc Drug Rev"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/art.10504","article-title":"Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis","volume":"46","author":"Nakagawa","year":"2002","journal-title":"Arthritis Rheum"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1159\/000095230","article-title":"Structural and functional characterization of the bovine solute carrier family 27 member 1 (SLC27A1) gene","volume":"115","author":"Ordov\u00e1s","year":"2006","journal-title":"Cytogenet Genome Res"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00377-09","article-title":"Roles for NK cells and an NK cell-independent source of intestinal gamma interferon for innate immunity to Cryptosporidium parvum infection","volume":"77","author":"Barakat","year":"2009","journal-title":"Infect Immun"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000681","article-title":"NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses","volume":"5","author":"Zhou","year":"2009","journal-title":"PloS Pathog"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240925","article-title":"A long noncoding RNA mediates both activation and repression of immune response genes","volume":"341","author":"Carpenter","year":"2013","journal-title":"Science"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1205468\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T20:24:54Z","timestamp":1686083094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1205468\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,5]]},"references-count":74,"alternative-id":["10.3389\/fimmu.2023.1205468"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2023.1205468","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,5]]},"article-number":"1205468"}}