{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:51:50Z","timestamp":1793109110018,"version":"4.5.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Infection-induced T cell responses must be properly tempered and terminated to prevent immuno-pathology. Using transgenic mice, we demonstrate that T cell intrinsic STAT1 signaling is required to curb inflammation during acute infection with <jats:italic>Toxoplasma gondii<\/jats:italic>. Specifically, we report that mice lacking STAT1 selectively in T cells expel parasites but ultimately succumb to lethal immuno-pathology characterized by aberrant Th1-type responses with reduced IL-10 and increased IL-13 production. We also find that, unlike STAT1, STAT3 is not required for induction of IL-10 or suppression of IL-13 during acute toxoplasmosis. Each of these findings was confirmed <jats:italic>in vitro<\/jats:italic> and ChIP-seq data mining showed that STAT1 and STAT3 co-localize at the <jats:italic>Il10<\/jats:italic> locus, as well as loci encoding other transcription factors that regulate IL-10 production, most notably <jats:italic>Maf<\/jats:italic> and <jats:italic>Irf4<\/jats:italic>. These data advance basic understanding of how infection-induced T cell responses are managed to prevent immuno-pathology and provide specific insights on the anti-inflammatory properties of STAT1, highlighting its role in shaping the character of Th1-type responses.<\/jats:p>","DOI":"10.3389\/fimmu.2023.1212190","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T08:55:27Z","timestamp":1690275327000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis"],"prefix":"10.3389","volume":"14","author":[{"given":"Aaron B.","family":"Schultz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David 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